Page last updated: 2024-08-21

carnosine and Cataract

carnosine has been researched along with Cataract in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.00)18.7374
1990's4 (10.00)18.2507
2000's16 (40.00)29.6817
2010's18 (45.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Huang, X; Liu, W; Wang, L1
Hu, H; Peng, T; Wang, Y; Xia, R1
Babizhayev, MA; Yegorov, YE3
Huang, KF; Kuo, PT; Liao, JH; Lin, IL; Wu, SH; Wu, TH1
Avetisov, SÉ; Muranov, KO; Ostrovskiĭ, MA; Polianskiĭ, NB; Polunin, GS; Sheremet, NL1
Abdelkader, H; Alany, RG; Pierscionek, BK; Swinden, J1
Hosseinkhani, S; Javadi, S; Tamaddon, AM; Uversky, VN; Yousefi, R1
Abdelkader, H; Alany, RG; Longman, M; Pierscionek, B1
Bastawrous, A; Dubois, VD1
Babizhayev, MA9
Babizhayev, MA; Guiotto, A; Kasus-Jacobi, A1
Ding, Z; Guo, Y; Ha, W; Harding, JJ; Yan, H; Zhang, J1
Akiyama, N; Natori, S; Nishigori, H; Sogo, S; Tsujimoto, M; Umeda, IO1
Babizhayev, MA; Kasus-Jacobi, A1
Attanasio, F; Cataldo, S; Fisichella, S; Nicoletti, S; Nicoletti, VG; Pignataro, B; Rizzarelli, E; Savarino, A1
Babizhayev, MA; Burke, L; Micans, P; Richer, SP1
Harding, JJ; Li, MY; Shi, Q; Yan, H1
Liu, HW; Liu, YF; Peng, SL1
Babizhayev, MA; Kasus-Jacobi, A; Khoroshilova-Maslova, IP1
Calhoun, J; Cebulla, CM; Cloud, A; Tandon, A1
Boldyrev, AA; Dizhevskaya, AK; Muranov, KO; Ostrovsky, MA1
Babizhayev, MA; Bours, J; Brikman, IV; Deyev, AI; Yermakova, VN1
Guo, Y; Yan, H1
Boldyrev, AA; Formazuyk, VE; Quinn, PJ1
Babizhayev, MA; Davydova, NG; Deyev, AI; Goldman, IM; Kurysheva, NI; Semiletov, YA; Yermakova, VN; Zhukotskii, AV1
Babizhayev, MA; Davydova, NG; Deyev, AI; Doroshenko, VS; Goldman, IM; Semiletov, YA; Yermakova, VN; Zhukotskii, AV1
Formaziuk, VE; Sergienko, VI1
Dudina, EI; Formaziuk, VE; Sergienko, VI1
Boldyrev, AA; Chasovnikova, LV; Formazyuk, VE; Sergienko, VI; Severin, SE1
Babizhaev, MA; Boldyrev, AA; Dupin, AM; Severin, SE1

Reviews

13 review(s) available for carnosine and Cataract

ArticleYear
Biomarkers of oxidative stress and cataract. Novel drug delivery therapeutic strategies targeting telomere reduction and the expression of telomerase activity in the lens epithelial cells with N-acetylcarnosine lubricant eye drops: anti-cataract which hel
    Current drug delivery, 2014, Volume: 11, Issue:1

    Topics: Administration, Ophthalmic; Animals; Antioxidants; Biomarkers; Carnosine; Cataract; Cell Membrane; Cellular Senescence; Ceruloplasmin; Chemistry, Pharmaceutical; Dogs; Drug Carriers; Epithelial Cells; Lens, Crystalline; Ophthalmic Solutions; Oxidative Stress; Prodrugs; Technology, Pharmaceutical; Telomerase; Telomere

2014
Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Activity-
    Recent patents on drug delivery & formulation, 2016, Volume: 10, Issue:2

    Topics: Administration, Ophthalmic; Age Factors; Aging; Animals; Antioxidants; Carnosine; Cataract; Cornea; Drug Compounding; Drug Delivery Systems; Epithelial Cells; Humans; Lens, Crystalline; Ocular Absorption; Ophthalmic Solutions; Oxidative Stress; Solubility; Telomere Homeostasis

2016
N-acetylcarnosine (NAC) drops for age-related cataract.
    The Cochrane database of systematic reviews, 2017, 02-28, Volume: 2

    Topics: Aged; Aged, 80 and over; Aging; Carnosine; Cataract; Disease Progression; Humans; Middle Aged; Ophthalmic Solutions; Randomized Controlled Trials as Topic

2017
Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy.
    Frontiers in bioscience (Landmark edition), 2010, 06-01, Volume: 15, Issue:3

    Topics: Aged; Animals; Carnosine; Cataract; Disease Models, Animal; Humans; Lens, Crystalline; Telomere; Vision, Ocular; Visual Acuity

2010
Designation of imidazole-containing dipeptides as pharmacological chaperones.
    Human & experimental toxicology, 2011, Volume: 30, Issue:7

    Topics: Carnosine; Cataract; Drug Carriers; Humans; Imidazoles; Lipid Peroxidation; Macular Degeneration; Molecular Chaperones; Oxidative Stress

2011
Novel intraocular and systemic absorption drug delivery and efficacy of N-acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:5

    Topics: Administration, Ophthalmic; Animals; Carnosine; Cataract; Chromatography, High Pressure Liquid; Clinical Trials, Phase II as Topic; Drug Delivery Systems; Eye Diseases; Humans; Prodrugs; Randomized Controlled Trials as Topic; Vitreoretinopathy, Proliferative

2012
Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye d
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:1

    Topics: Administration, Ophthalmic; Administration, Oral; Animals; Biomarkers; Blindness; Carnosine; Cataract; Glaucoma, Open-Angle; Humans; Ophthalmic Solutions; Oxidative Stress; Trabecular Meshwork

2012
Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein
    Recent patents on drug delivery & formulation, 2012, Volume: 6, Issue:2

    Topics: Age Factors; alpha-Crystallins; Animals; Carnosine; Cataract; Drug Design; Humans; Lens, Crystalline; Molecular Chaperones; Oxidative Stress; Patents as Topic

2012
Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes.
    Drugs in R&D, 2004, Volume: 5, Issue:3

    Topics: Aging; Animals; Carnosine; Cataract; Dog Diseases; Dogs; Humans; Lipid Peroxidation; Randomized Controlled Trials as Topic

2004
[Preventive effect of carnosine on cataract development].
    Yan ke xue bao = Eye science, 2006, Volume: 22, Issue:2

    Topics: Animals; Carnosine; Cataract; Humans

2006
Carnosine: its properties, functions and potential therapeutic applications.
    Molecular aspects of medicine, 1992, Volume: 13, Issue:5

    Topics: Animals; Anserine; Antihypertensive Agents; Antineoplastic Agents; Antioxidants; Carnosine; Cataract; Dipeptidases; Dipeptides; Dogs; Free Radical Scavengers; Histidine; Humans; Membrane Lipids; Neurotransmitter Agents; Wound Healing

1992
[The use of carnosine in medical practice. Priorities: past and future].
    Biokhimiia (Moscow, Russia), 1992, Volume: 57, Issue:9

    Topics: Anions; Carnosine; Cataract; Humans; Hypochlorous Acid; Neutrophils

1992
The antioxidative properties of carnosine, a natural histidine containing dipeptide.
    Biochemistry international, 1987, Volume: 15, Issue:6

    Topics: Animals; Antioxidants; Carnosine; Cataract; Dipeptides; Glutathione; Humans; Lens, Crystalline

1987

Trials

6 trial(s) available for carnosine and Cataract

ArticleYear
N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications.
    Journal of drug targeting, 2009, Volume: 17, Issue:1

    Topics: Aged; Aged, 80 and over; Aldehydes; Aminooxyacetic Acid; Animals; Biological Availability; Carnosine; Cataract; Cornea; Cross-Over Studies; Diabetes Complications; Disease Models, Animal; Drug Administration Schedule; Drug Delivery Systems; Drug Synergism; Female; Glycosylation; Histidine; Humans; Hydrazines; Lubricants; Male; Middle Aged; Ophthalmic Solutions; Ophthalmologic Surgical Procedures; Ophthalmoscopy; Rabbits

2009
State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatm
    Current clinical pharmacology, 2009, Volume: 4, Issue:1

    Topics: Administration, Topical; Aged; Aged, 80 and over; Antioxidants; Carnosine; Cataract; Contact Lenses; Double-Blind Method; Drug Delivery Systems; Female; Glycation End Products, Advanced; Glycosylation; Histidine; Humans; Hydrazines; Lipid Peroxidation; Liposomes; Lubricants; Male; Middle Aged; Ophthalmic Solutions; Oxidative Stress; Prodrugs; Visual Acuity

2009
N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population.
    Clinical interventions in aging, 2009, Volume: 4

    Topics: Aged; Aged, 80 and over; Carnosine; Cataract; Delayed-Action Preparations; Female; Glare; Humans; Macular Degeneration; Male; Middle Aged; Ophthalmic Solutions; Vision, Ocular

2009
Rejuvenation of visual functions in older adult drivers and drivers with cataract during a short-term administration of N-acetylcarnosine lubricant eye drops.
    Rejuvenation research, 2004,Fall, Volume: 7, Issue:3

    Topics: Aged; Automobile Driving; Carnosine; Cataract; Double-Blind Method; Female; Glare; Humans; Male; Middle Aged; Ophthalmic Solutions; Vision Disorders; Visual Acuity

2004
N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts.
    Peptides, 2001, Volume: 22, Issue:6

    Topics: Age Factors; Aged; Carnosine; Cataract; Eye; Female; Humans; Lens, Crystalline; Male; Middle Aged; Observer Variation; Oxidative Stress; Sex Factors; Time Factors

2001
Efficacy of N-acetylcarnosine in the treatment of cataracts.
    Drugs in R&D, 2002, Volume: 3, Issue:2

    Topics: Aged; Aged, 80 and over; Carnosine; Cataract; Female; Humans; Male; Middle Aged

2002

Other Studies

21 other study(ies) available for carnosine and Cataract

ArticleYear
An approach to revolutionize cataract treatment by enhancing drug probing through intraocular cell line.
    The Libyan journal of medicine, 2018, Volume: 13, Issue:1

    Topics: Administration, Ophthalmic; Animals; Carnosine; Cataract; Cell Culture Techniques; Cell Line; Cornea; Delayed-Action Preparations; Drug Delivery Systems; Endothelial Cells; Goats; Humans; Nanoparticles; Ocular Absorption; Particle Size

2018
Biosynthesis, characterization and cytotoxicity of gold nanoparticles and their loading with N-acetylcarnosine for cataract treatment.
    Journal of photochemistry and photobiology. B, Biology, 2018, Volume: 187

    Topics: Animals; Biocompatible Materials; Carnosine; Cataract; Cell Line; Cell Survival; Cucurbitaceae; Gold; Green Chemistry Technology; Metal Nanoparticles; Mice; Particle Size; Plant Bark; Plant Extracts; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction

2018
Carnosine ameliorates lens protein turbidity formations by inhibiting calpain proteolysis and ultraviolet C-induced degradation.
    Journal of agricultural and food chemistry, 2014, Jun-25, Volume: 62, Issue:25

    Topics: Amino Acid Sequence; Animals; Calpain; Carnosine; Cataract; Crystallins; Glycoproteins; Humans; Lens, Crystalline; Molecular Sequence Data; Proteolysis; Sequence Alignment; Swine; Ultraviolet Rays

2014
[Deceleration of cataract development in rats under the action of N-acetylcarnosine and D-pantethine mixture].
    Eksperimental'naia i klinicheskaia farmakologiia, 2014, Volume: 77, Issue:11

    Topics: Animals; Carnosine; Cataract; Chromatography, Gel; Drug Combinations; Eye Proteins; Injections, Intraperitoneal; Lens, Crystalline; Male; Ophthalmic Solutions; Pantetheine; Protective Agents; Protein Aggregates; Radiation Injuries, Experimental; Rats; Rats, Wistar; Solubility; Ultraviolet Rays

2014
Analytical and physicochemical characterisation of the senile cataract drug dipeptide β-alanyl-L-histidine (carnosine).
    Journal of pharmaceutical and biomedical analysis, 2015, Oct-10, Volume: 114

    Topics: Acetonitriles; Carnosine; Cataract; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Hydrolysis; Lens, Crystalline; Linear Models; Octanols; Oxygen; Phospholipids; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Temperature

2015
Protective effects of carnosine on dehydroascorbate-induced structural alteration and opacity of lens crystallins: important implications of carnosine pleiotropic functions to combat cataractogenesis.
    Journal of biomolecular structure & dynamics, 2017, Volume: 35, Issue:8

    Topics: alpha-Crystallins; Animals; Aspirin; Carnosine; Cataract; Cattle; Dehydroascorbic Acid; Electrophoretic Mobility Shift Assay; gamma-Crystallins; Glycosylation; Lens, Crystalline; Protective Agents; Tissue Culture Techniques

2017
On the Anticataractogenic Effects of L-Carnosine: Is It Best Described as an Antioxidant, Metal-Chelating Agent or Glycation Inhibitor?
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Antioxidants; Carnosine; Cataract; Chelating Agents; Humans; Lens, Crystalline

2016
Ocular drug metabolism of the bioactivating antioxidant N-acetylcarnosine for vision in ophthalmic prodrug and codrug design and delivery.
    Drug development and industrial pharmacy, 2008, Volume: 34, Issue:10

    Topics: Animals; Antioxidants; Carnosine; Cataract; Chromatography, High Pressure Liquid; Cornea; Drug Design; Eye; Humans; Lens, Crystalline; Lipid Peroxidation; Liposomes; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Prodrugs; Rabbits

2008
Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats.
    Molecular vision, 2008, Volume: 14

    Topics: Animals; Aspirin; Blood Glucose; Body Weight; Carnosine; Cataract; Cornea; Diabetes Mellitus, Experimental; Disease Progression; Eye Proteins; Glycosylation; Guanidines; Lens, Crystalline; Male; Ophthalmic Solutions; Rats; Rats, Sprague-Dawley; Staining and Labeling; Streptozocin

2008
5-S-GAD, a novel radical scavenging compound, prevents lens opacity development.
    Free radical biology & medicine, 2009, Feb-15, Volume: 46, Issue:4

    Topics: alpha-Crystallins; Animals; Biphenyl Compounds; Carnosine; Cataract; Cells, Cultured; Chick Embryo; Cyclic N-Oxides; Diamide; Dihydroxyphenylalanine; Disease Progression; Dose-Response Relationship, Drug; Free Radical Scavengers; Galactose; Glucocorticoids; Glutathione; Insecta; Lens, Crystalline; Lipid Peroxidation; Male; Oxidative Stress; Picrates; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Spin Labels; Superoxides

2009
Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease.
    Biochemistry, 2009, Jul-14, Volume: 48, Issue:27

    Topics: alpha-Crystallins; Amyloid; Animals; Calorimetry, Differential Scanning; Carnosine; Cataract; Cattle; Circular Dichroism; Female; Microscopy, Atomic Force; Molecular Chaperones; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Stereoisomerism

2009
Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats.
    Molecular vision, 2009, Oct-21, Volume: 15

    Topics: Animals; Aspirin; Blood Glucose; Body Weight; Carnosine; Cataract; Diabetes Complications; Drinking Behavior; Drug Therapy, Combination; Feeding Behavior; Glycosuria; Lens, Crystalline; Male; Ophthalmic Solutions; Rats; Rats, Sprague-Dawley; Solubility; Streptozocin; Sulfhydryl Compounds; Time Factors

2009
[Effects of L-carnosine in preventing and treating rat cataract induced by sodium selenite].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2009, Volume: 45, Issue:6

    Topics: Animals; Carnosine; Cataract; Lens, Crystalline; Rats; Rats, Wistar; Sodium Selenite

2009
Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases.
    Drug metabolism and drug interactions, 2009, Volume: 24, Issue:2-4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antioxidants; Aqueous Humor; Carnosine; Cataract; Delayed-Action Preparations; Drug Synergism; Eye; Female; Humans; Lens, Crystalline; Lipid Peroxidation; Lipid Peroxides; Liposomes; Male; Microscopy, Electron; Middle Aged; Ophthalmic Solutions; Rabbits; Tissue Culture Techniques; Young Adult

2009
Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract
    Cell biochemistry and function, 2011, Volume: 29, Issue:3

    Topics: Aged; Aging; Animals; Antioxidants; Aqueous Humor; Carnosine; Cataract; Female; Humans; Hydrogen Peroxide; Lens, Crystalline; Lipid Peroxidation; Lipid Peroxides; Male; Mice; Mice, Inbred C57BL; Middle Aged; Mitochondria; Ophthalmic Solutions; Oxidation-Reduction; Oxidative Stress; Phospholipids; Prodrugs; Rabbits; Reactive Oxygen Species

2011
Rapid formation and resolution of cataracts following orthopedic surgery for a patient with Charcot-Marie-Tooth disease.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2012, Volume: 130, Issue:2

    Topics: Carnosine; Cataract; Charcot-Marie-Tooth Disease; Foot Deformities, Acquired; Humans; Male; Middle Aged; Orthopedic Procedures; Remission, Spontaneous; Self Medication

2012
Natural dipeptides as mini-chaperones: molecular mechanism of inhibition of lens βL-crystallin aggregation.
    Current aging science, 2012, Volume: 5, Issue:3

    Topics: Animals; Anserine; beta-Crystallins; Carnosine; Cataract; Cattle; Dipeptides; Hydrophobic and Hydrophilic Interactions; Kinetics; Lens, Crystalline; Molecular Chaperones; Protein Carbonylation; Protein Conformation; Ultraviolet Rays

2012
Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention.
    Drugs in R&D, 2005, Volume: 6, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Aqueous Humor; Biological Availability; Carnosine; Cataract; Chromatography, High Pressure Liquid; Female; Humans; Lens, Crystalline; Lipid Peroxidation; Liposomes; Lubrication; Male; Microscopy, Electron; Middle Aged; Ophthalmic Solutions; Prodrugs; Rabbits

2005
[Formation of stable chloramine complex in interactions of carnosine and hypochlorite anion].
    Biulleten' eksperimental'noi biologii i meditsiny, 1992, Volume: 113, Issue:2

    Topics: Animals; Carnosine; Cataract; Cattle; Chloramines; Drug Interactions; Humans; Sodium Hypochlorite

1992
The antioxidative properties of carnosine and other drugs.
    Biochemistry international, 1990, Volume: 20, Issue:6

    Topics: Acridines; alpha-Tocopherol; Animals; Aspirin; Carnosine; Cataract; Dipeptides; Ferrous Compounds; Kinetics; Lipid Peroxidation; Oxazines; Oxidation-Reduction; Rats; Thiobarbiturates; Tocopherols; Vitamin E

1990
Antioxidant activity of L-carnosine, a natural histidine-containing dipeptide in crystalline lens.
    Biochimica et biophysica acta, 1989, Aug-22, Volume: 1004, Issue:3

    Topics: Animals; Antioxidants; Carnosine; Cataract; Dipeptides; Histidine; In Vitro Techniques; Lens, Crystalline; Lipid Peroxidation; Rabbits

1989