carnitine has been researched along with Parkinson Disease in 11 studies
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is thought that Parkinson's disease is caused by the accumulation of abnormally folded alpha-synuclein protein, accompanied by persistent neuroinflammation, oxidative stress, and subsequent neuronal injury/death." | 1.48 | l-Carnitine Inhibits Lipopolysaccharide-Induced Nitric Oxide Production of SIM-A9 Microglia Cells. ( Garrett, TJ; Gill, EL; Raman, S; Vedam-Mai, V; Yost, RA, 2018) |
| "The plasma analyses identified 18 Parkinson's disease-specific metabolites and revealed decreased levels of seven long-chain acylcarnitines in two Parkinson's disease cohorts (n = 109, 145) compared with controls (n = 32, 45), respectively." | 1.46 | Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson's disease. ( Amo, T; Fujimaki, M; Fukuhara, T; Furuya, N; Hatano, T; Hattori, N; Imamichi, Y; Ishikawa, KI; Koinuma, T; Mori, A; Nagumo, M; Nojiri, S; Oji, Y; Okuzumi, A; Saiki, S; Yamashiro, K, 2017) |
| "Two groups of 10 patients with Parkinson's disease received doses of either 1g acetyl-L-carnitine (ALC) per day for seven days or 2g." | 1.28 | Clinical pharmacodynamics of acetyl-L-carnitine in patients with Parkinson's disease. ( Brancasi, B; D'Ursi, R; Genco, S; Martino, R; Miccoli, A; Prudenzano, A; Puca, FM; Savarese, M; Scarcia, R; Specchio, LM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 4 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Albillos, SM | 1 |
| Montero, O | 1 |
| Calvo, S | 1 |
| Solano-Vila, B | 1 |
| Trejo, JM | 1 |
| Cubo, E | 1 |
| Chai, JF | 1 |
| Raichur, S | 1 |
| Khor, IW | 1 |
| Torta, F | 1 |
| Chew, WS | 1 |
| Herr, DR | 1 |
| Ching, J | 1 |
| Kovalik, JP | 1 |
| Khoo, CM | 1 |
| Wenk, MR | 1 |
| Tai, ES | 1 |
| Sim, X | 1 |
| Molsberry, S | 1 |
| Bjornevik, K | 1 |
| Hughes, KC | 1 |
| Zhang, ZJ | 1 |
| Jeanfavre, S | 1 |
| Clish, C | 1 |
| Healy, B | 1 |
| Schwarzschild, M | 1 |
| Ascherio, A | 1 |
| Sinclair, E | 1 |
| Trivedi, DK | 1 |
| Sarkar, D | 1 |
| Walton-Doyle, C | 1 |
| Milne, J | 1 |
| Kunath, T | 1 |
| Rijs, AM | 1 |
| de Bie, RMA | 1 |
| Goodacre, R | 1 |
| Silverdale, M | 1 |
| Barran, P | 1 |
| Saiki, S | 2 |
| Hatano, T | 2 |
| Fujimaki, M | 2 |
| Ishikawa, KI | 2 |
| Mori, A | 1 |
| Oji, Y | 1 |
| Okuzumi, A | 1 |
| Fukuhara, T | 1 |
| Koinuma, T | 1 |
| Imamichi, Y | 1 |
| Nagumo, M | 1 |
| Furuya, N | 1 |
| Nojiri, S | 2 |
| Amo, T | 1 |
| Yamashiro, K | 1 |
| Hattori, N | 2 |
| Gill, EL | 1 |
| Raman, S | 1 |
| Yost, RA | 1 |
| Garrett, TJ | 1 |
| Vedam-Mai, V | 1 |
| Crooks, SA | 1 |
| Bech, S | 1 |
| Halling, J | 1 |
| Christiansen, DH | 1 |
| Ritz, B | 1 |
| Petersen, MS | 1 |
| Ueno, SI | 1 |
| Takeshige-Amano, H | 1 |
| Oyama, G | 1 |
| Yamaguchi, A | 1 |
| Akamatsu, W | 1 |
| Irwin, MH | 1 |
| Moos, WH | 1 |
| Faller, DV | 1 |
| Steliou, K | 1 |
| Pinkert, CA | 1 |
| Jiménez-Jiménez, FJ | 1 |
| Rubio, JC | 1 |
| Molina, JA | 1 |
| Martín, MA | 1 |
| Campos, Y | 1 |
| Benito-León, J | 1 |
| Ortí-Pareja, M | 1 |
| Gasalla, T | 1 |
| Arenas, J | 1 |
| Puca, FM | 1 |
| Genco, S | 1 |
| Specchio, LM | 1 |
| Brancasi, B | 1 |
| D'Ursi, R | 1 |
| Prudenzano, A | 1 |
| Miccoli, A | 1 |
| Scarcia, R | 1 |
| Martino, R | 1 |
| Savarese, M | 1 |
1 review available for carnitine and Parkinson Disease
| Article | Year |
|---|---|
Epigenetic Treatment of Neurodegenerative Disorders: Alzheimer and Parkinson Diseases.
Topics: Alzheimer Disease; Antioxidants; Carnitine; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Hum | 2016 |
1 trial available for carnitine and Parkinson Disease
| Article | Year |
|---|---|
Cerebrospinal fluid carnitine levels in patients with Parkinson's disease.
Topics: Acylation; Aged; Antiparkinson Agents; Carnitine; Female; Humans; Levodopa; Male; Middle Aged; Oxida | 1997 |
9 other studies available for carnitine and Parkinson Disease
| Article | Year |
|---|---|
Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study.
Topics: Aged; Bilirubin; Biomarkers; Carnitine; Case-Control Studies; Cognition; Cortodoxone; Diagnosis, Dif | 2021 |
Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer's and Parkinson's diseases.
Topics: Alzheimer Disease; Asian People; ATP-Binding Cassette Transporters; Carnitine; China; DNA-Binding Pr | 2020 |
Plasma Metabolomic Markers of Insulin Resistance and Diabetes and Rate of Incident Parkinson's Disease.
Topics: Adult; Aged; Biomarkers; Carnitine; Diabetes Mellitus; Female; Humans; Insulin Resistance; Male; Met | 2020 |
Metabolomics of sebum reveals lipid dysregulation in Parkinson's disease.
Topics: Aged; Arachidonic Acid; Biomarkers; Carnitine; Chromatography, Liquid; Fatty Acids; Female; Humans; | 2021 |
Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson's disease.
Topics: Aged; Biomarkers; Carnitine; Cohort Studies; Fatty Acids; Female; Humans; Male; Metabolome; Metabolo | 2017 |
l-Carnitine Inhibits Lipopolysaccharide-Induced Nitric Oxide Production of SIM-A9 Microglia Cells.
Topics: Animals; Carnitine; Cell Line; Dopaminergic Neurons; Lipopolysaccharides; Macrophages; Mice; Microgl | 2018 |
Carnitine levels and mutations in the SLC22A5 gene in Faroes patients with Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Cardiomyopathies; Carnitine; Case-Control Studies; Denmark; Female; | 2018 |
Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Carnitine; Fatty Acids; Female; Humans; Levodopa; Mal | 2018 |
Clinical pharmacodynamics of acetyl-L-carnitine in patients with Parkinson's disease.
Topics: Acetylcarnitine; Adult; Aged; Carnitine; Electroencephalography; Electromyography; Female; Humans; M | 1990 |