carnitine has been researched along with Overweight in 33 studies
Overweight: A status with BODY WEIGHT that is above certain standards. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal over fat.
| Excerpt | Relevance | Reference |
|---|---|---|
| "12-week L-carnitine supplementation in overweight or obese women with PCOS ameliorate insulin resistance, but has no effect on SHBG and lipid profile." | 9.51 | The effect of L-carnitine supplementation on insulin resistance, sex hormone-binding globulin and lipid profile in overweight/obese women with polycystic ovary syndrome: a randomized clinical trial. ( Fallahzadeh, H; Ghadiri-Anari, A; Hosseinzadeh, M; Nadjarzadeh, A; Pakravanfar, F; Sangouni, AA, 2022) |
| "The present study aimed to investigate the effect of l-carnitine supplementation on liver fat content and cardiometabolic outcomes in overweight/obese women with PCOS." | 9.41 | Effect of l-carnitine supplementation on liver fat content and cardiometabolic indices in overweight/obese women with polycystic ovary syndrome: A randomized controlled trial. ( Ghadiri-Anari, A; Hosseinzadeh, M; Sangouni, AA; Sasanfar, B, 2021) |
| "In a prospective, randomized, double-blind, placebo-controlled trial, 60 overweight patients diagnosed with PCOS were randomized to receive either 250 mg carnitine supplements (n = 30) or placebo (n = 30) for 12 weeks." | 9.22 | Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. ( Asemi, Z; Ebrahimi, FA; Jamilian, M; Rahimi, M; Samimi, M; Tajbakhsh, B, 2016) |
| " Lower carnitine concentrations were found in overweight compared to lean dogs." | 7.91 | Plasma metabolomics reveals lower carnitine concentrations in overweight Labrador Retriever dogs. ( Dicksved, J; Eriksson Röhnisch, H; Hagman, R; Höglund, K; Moazzami, AA; Söder, J; Wernersson, S, 2019) |
| "Circulating acyl-carnitines (acyl-CNTs) are associated with insulin resistance (IR) and type 2 diabetes (T2D) in both rodents and humans." | 7.85 | Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women. ( Abate, N; Asghar, R; Brasier, AR; Camacho-Hughes, M; Chondronikola, M; Dillon, EL; Durham, WJ; Porter, C; Sheffield-Moore, M; Sidossis, L; Tuvdendorj, D; Volpi, E; Wu, Z; Zhang, X; Zhao, Y, 2017) |
| "The crucial role of L-carnitine in pregnancy metabolism suggests that nutritional supplementation of this amino acid can be offered to women who are either overweight or obese at the beginning of the pregnancy." | 7.79 | Lowered serum total L-carnitine levels are associated with obesity at term pregnancy. ( Arioz, DT; Kanat-Pektas, M; Koken, G; Koken, T; Tipi-Akbas, P; Yilmazer, M, 2013) |
| "To investigate the influence of dietary supplementation with l-carnitine on metabolic rate, fatty acid oxidation, weight loss, and lean body mass (LBM) in overweight cats undergoing rapid weight reduction." | 7.78 | Influence of dietary supplementation with (L)-carnitine on metabolic rate, fatty acid oxidation, body condition, and weight loss in overweight cats. ( Center, SA; Randolph, JF; Sunvold, GD; Vickers, JR; Warner, KL, 2012) |
| "Overweight patients with hyperlipidemia (serum triglyceride ≥ 1." | 6.80 | Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial. ( Du, S; Jiang, S; Li, Y; Na, L; Niu, Y; Sun, C; Zhang, Q; Zhang, W, 2015) |
| "12-week L-carnitine supplementation in overweight or obese women with PCOS ameliorate insulin resistance, but has no effect on SHBG and lipid profile." | 5.51 | The effect of L-carnitine supplementation on insulin resistance, sex hormone-binding globulin and lipid profile in overweight/obese women with polycystic ovary syndrome: a randomized clinical trial. ( Fallahzadeh, H; Ghadiri-Anari, A; Hosseinzadeh, M; Nadjarzadeh, A; Pakravanfar, F; Sangouni, AA, 2022) |
| "The present study aimed to investigate the effect of l-carnitine supplementation on liver fat content and cardiometabolic outcomes in overweight/obese women with PCOS." | 5.41 | Effect of l-carnitine supplementation on liver fat content and cardiometabolic indices in overweight/obese women with polycystic ovary syndrome: A randomized controlled trial. ( Ghadiri-Anari, A; Hosseinzadeh, M; Sangouni, AA; Sasanfar, B, 2021) |
| "Our findings underscore the importance of changes in TMAO, choline and L-carnitine in improving insulin sensitivity during a weight-loss intervention for obese patients." | 5.30 | Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial. ( Bray, GA; DiDonato, JA; Heianza, Y; Li, X; Qi, L; Sacks, FM; Sun, D, 2019) |
| " We examined associations of weight loss diet-induced changes in a gut microbiota-related metabolite trimethylamine N-oxide (TMAO), and its precursors (choline and l-carnitine), with changes in bone mineral density (BMD) considering diabetes-related factors." | 5.30 | Circulating Gut Microbiota Metabolite Trimethylamine N-Oxide (TMAO) and Changes in Bone Density in Response to Weight Loss Diets: The POUNDS Lost Trial. ( Bray, GA; Chen, Y; DiDonato, JA; Heianza, Y; LeBoff, MS; Li, X; Pei, X; Qi, L; Sacks, FM; Sun, D; Zhou, T, 2019) |
| "In a prospective, randomized, double-blind, placebo-controlled trial, 60 overweight patients diagnosed with PCOS were randomized to receive either 250 mg carnitine supplements (n = 30) or placebo (n = 30) for 12 weeks." | 5.22 | Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. ( Asemi, Z; Ebrahimi, FA; Jamilian, M; Rahimi, M; Samimi, M; Tajbakhsh, B, 2016) |
| "This randomized, double blind, placebo-controlled, 8 week trial assessed the efficacy on metabolic changes produced by a consumption of a combination of bioactive food ingredients (epigallocatechin gallate, capsaicins, piperine and L-carnitine) versus a placebo, as part of a therapeutic 'lifestyle change' diet, in 86 overweight subjects." | 5.17 | Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects. ( Castellaneta, E; Cava, E; Ceccarelli, P; Claudia, S; Donini, LM; Edda, C; Emanuela, C; Faliva, M; Fioravanti, M; Klersy, C; Luciano, S; Maddalena, P; Opizzi, A; Paola, C; Paolini, M; Perna, S; Rondanelli, M; Savina, C; Scavone, L; Solerte, SB, 2013) |
| "Plasma carnitine status was overall lower in spontaneously overweight dogs than in lean dogs in this cohort of healthy Labrador Retriever dogs, indicating a potential carnitine insufficiency in the overweight group." | 3.91 | Indication of metabolic inflexibility to food intake in spontaneously overweight Labrador Retriever dogs. ( Dicksved, J; Hagman, R; Höglund, K; Moazzami, AA; Östman, JR; Söder, J; Wernersson, S, 2019) |
| "Circulating acyl-carnitines (acyl-CNTs) are associated with insulin resistance (IR) and type 2 diabetes (T2D) in both rodents and humans." | 3.85 | Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women. ( Abate, N; Asghar, R; Brasier, AR; Camacho-Hughes, M; Chondronikola, M; Dillon, EL; Durham, WJ; Porter, C; Sheffield-Moore, M; Sidossis, L; Tuvdendorj, D; Volpi, E; Wu, Z; Zhang, X; Zhao, Y, 2017) |
| "The crucial role of L-carnitine in pregnancy metabolism suggests that nutritional supplementation of this amino acid can be offered to women who are either overweight or obese at the beginning of the pregnancy." | 3.79 | Lowered serum total L-carnitine levels are associated with obesity at term pregnancy. ( Arioz, DT; Kanat-Pektas, M; Koken, G; Koken, T; Tipi-Akbas, P; Yilmazer, M, 2013) |
| "To investigate the influence of dietary supplementation with l-carnitine on metabolic rate, fatty acid oxidation, weight loss, and lean body mass (LBM) in overweight cats undergoing rapid weight reduction." | 3.78 | Influence of dietary supplementation with (L)-carnitine on metabolic rate, fatty acid oxidation, body condition, and weight loss in overweight cats. ( Center, SA; Randolph, JF; Sunvold, GD; Vickers, JR; Warner, KL, 2012) |
| "Higher acylcarnitine factor scores were associated with lower levels of objectively measured physical performance in this group of older, largely overweight men." | 3.77 | Plasma acylcarnitines are associated with physical performance in elderly men. ( Bain, JR; Cohen, HJ; Huffman, KM; Kraus, VB; Kraus, WE; Lum, H; Morey, MC; Newgard, CB; Pieper, CF; Sloane, R; Stevens, R; Taylor, GA; Thompson, DK, 2011) |
| "Overweight patients with hyperlipidemia (serum triglyceride ≥ 1." | 2.80 | Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial. ( Du, S; Jiang, S; Li, Y; Na, L; Niu, Y; Sun, C; Zhang, Q; Zhang, W, 2015) |
| "Hyperlipidemia and obesity are associated with metabolic syndrome and increased risk in developing diabetes and cardiovascular disease." | 2.76 | A combination of (ω-3) polyunsaturated fatty acids, polyphenols and L-carnitine reduces the plasma lipid levels and increases the expression of genes involved in fatty acid oxidation in human peripheral blood mononuclear cells and HepG2 cells. ( Anderwald, C; Anzur, C; Brachinger, M; Eller-Berndl, D; Fischer, A; Krepp, R; Laschan, C; Lechner, S; Lienbacher, G; Lohninger, A; Mascher, D; Radler, U; Schoerg, G; Stangl, H; Zeller, E, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 26 (78.79) | 24.3611 |
| 2020's | 6 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, Y | 1 |
| Sun, Y | 1 |
| Sun, L | 1 |
| Liu, X | 1 |
| Zeng, R | 1 |
| Lin, X | 1 |
| Li, Y | 2 |
| Sangouni, AA | 2 |
| Pakravanfar, F | 1 |
| Ghadiri-Anari, A | 2 |
| Nadjarzadeh, A | 1 |
| Fallahzadeh, H | 1 |
| Hosseinzadeh, M | 2 |
| Sasanfar, B | 1 |
| Rastgoo, S | 1 |
| Fateh, ST | 1 |
| Nikbaf-Shandiz, M | 1 |
| Rasaei, N | 1 |
| Aali, Y | 1 |
| Zamani, M | 1 |
| Shiraseb, F | 1 |
| Asbaghi, O | 1 |
| Kim, KW | 1 |
| Shin, WC | 1 |
| Choi, MS | 1 |
| Cho, JH | 1 |
| Park, HJ | 1 |
| Yoo, HH | 1 |
| Song, MY | 1 |
| Rico, JE | 1 |
| Zang, Y | 1 |
| Haughey, NJ | 1 |
| Rius, AG | 1 |
| McFadden, JW | 1 |
| Heianza, Y | 2 |
| Sun, D | 2 |
| Li, X | 2 |
| DiDonato, JA | 2 |
| Bray, GA | 2 |
| Sacks, FM | 2 |
| Qi, L | 2 |
| Kang, M | 2 |
| Yoo, HJ | 2 |
| Kim, M | 5 |
| Lee, JH | 3 |
| Söder, J | 2 |
| Höglund, K | 2 |
| Dicksved, J | 2 |
| Hagman, R | 2 |
| Eriksson Röhnisch, H | 1 |
| Moazzami, AA | 2 |
| Wernersson, S | 2 |
| Östman, JR | 1 |
| Jamilian, M | 2 |
| Foroozanfard, F | 1 |
| Kavossian, E | 1 |
| Kia, M | 1 |
| Aghadavod, E | 1 |
| Amirani, E | 1 |
| Asemi, Z | 2 |
| Zhou, T | 1 |
| Chen, Y | 1 |
| Pei, X | 1 |
| LeBoff, MS | 1 |
| Tipi-Akbas, P | 1 |
| Arioz, DT | 1 |
| Kanat-Pektas, M | 1 |
| Koken, T | 1 |
| Koken, G | 1 |
| Yilmazer, M | 1 |
| Patel, MJ | 1 |
| Batch, BC | 1 |
| Svetkey, LP | 1 |
| Bain, JR | 5 |
| Turer, CB | 1 |
| Haynes, C | 1 |
| Muehlbauer, MJ | 3 |
| Stevens, RD | 4 |
| Newgard, CB | 5 |
| Shah, SH | 2 |
| Larsen, S | 1 |
| Danielsen, JH | 1 |
| Søndergård, SD | 1 |
| Søgaard, D | 1 |
| Vigelsoe, A | 1 |
| Dybboe, R | 1 |
| Skaaby, S | 1 |
| Dela, F | 1 |
| Helge, JW | 1 |
| Jung, S | 1 |
| Lee, SH | 1 |
| Fiamoncini, J | 1 |
| Lima, TM | 1 |
| Hirabara, SM | 1 |
| Ecker, J | 1 |
| Gorjão, R | 1 |
| Romanatto, T | 1 |
| ELolimy, A | 1 |
| Worsch, S | 1 |
| Laumen, H | 1 |
| Bader, B | 1 |
| Daniel, H | 1 |
| Curi, R | 1 |
| Na, L | 1 |
| Zhang, Q | 1 |
| Jiang, S | 1 |
| Du, S | 1 |
| Zhang, W | 1 |
| Sun, C | 1 |
| Niu, Y | 1 |
| Malek Mahdavi, A | 1 |
| Mahdavi, R | 1 |
| Kolahi, S | 1 |
| Zemestani, M | 1 |
| Vatankhah, AM | 1 |
| Samimi, M | 1 |
| Ebrahimi, FA | 1 |
| Rahimi, M | 1 |
| Tajbakhsh, B | 1 |
| Allam-Ndoul, B | 1 |
| Guénard, F | 1 |
| Garneau, V | 1 |
| Cormier, H | 1 |
| Barbier, O | 1 |
| Pérusse, L | 1 |
| Vohl, MC | 1 |
| Chondronikola, M | 1 |
| Asghar, R | 1 |
| Zhang, X | 1 |
| Dillon, EL | 1 |
| Durham, WJ | 1 |
| Wu, Z | 1 |
| Porter, C | 1 |
| Camacho-Hughes, M | 1 |
| Zhao, Y | 1 |
| Brasier, AR | 1 |
| Volpi, E | 1 |
| Sheffield-Moore, M | 1 |
| Abate, N | 1 |
| Sidossis, L | 1 |
| Tuvdendorj, D | 1 |
| Tovar, J | 1 |
| de Mello, VD | 1 |
| Nilsson, A | 1 |
| Johansson, M | 1 |
| Paananen, J | 1 |
| Lehtonen, M | 1 |
| Hanhineva, K | 1 |
| Björck, I | 1 |
| Bobillo, C | 1 |
| Finlayson, G | 1 |
| Martínez, A | 1 |
| Fischman, D | 1 |
| Beneitez, A | 1 |
| Ferrero, AJ | 1 |
| Fernández, BE | 1 |
| Mayer, MA | 1 |
| Kim, MS | 1 |
| Ahn, YT | 1 |
| Sim, JH | 1 |
| Jee, SH | 1 |
| Huffman, KM | 4 |
| Muehlbauer, M | 1 |
| Slentz, CA | 1 |
| Tanner, CJ | 1 |
| Kuchibhatla, M | 1 |
| Houmard, JA | 1 |
| Kraus, WE | 4 |
| Redman, LM | 2 |
| Landerman, LR | 2 |
| Pieper, CF | 3 |
| Wenner, BR | 2 |
| Kraus, VB | 3 |
| Ravussin, E | 2 |
| Lum, H | 1 |
| Sloane, R | 1 |
| Thompson, DK | 1 |
| Stevens, R | 1 |
| Taylor, GA | 1 |
| Cohen, HJ | 1 |
| Morey, MC | 1 |
| Radler, U | 1 |
| Stangl, H | 1 |
| Lechner, S | 1 |
| Lienbacher, G | 1 |
| Krepp, R | 1 |
| Zeller, E | 1 |
| Brachinger, M | 1 |
| Eller-Berndl, D | 1 |
| Fischer, A | 1 |
| Anzur, C | 1 |
| Schoerg, G | 1 |
| Mascher, D | 1 |
| Laschan, C | 1 |
| Anderwald, C | 1 |
| Lohninger, A | 1 |
| Ramos-Roman, MA | 1 |
| Sweetman, L | 1 |
| Valdez, MJ | 1 |
| Parks, EJ | 1 |
| Center, SA | 1 |
| Warner, KL | 1 |
| Randolph, JF | 1 |
| Sunvold, GD | 1 |
| Vickers, JR | 1 |
| Rondanelli, M | 1 |
| Opizzi, A | 1 |
| Perna, S | 1 |
| Faliva, M | 1 |
| Solerte, SB | 1 |
| Fioravanti, M | 1 |
| Klersy, C | 1 |
| Cava, E | 1 |
| Edda, C | 1 |
| Paolini, M | 1 |
| Maddalena, P | 1 |
| Scavone, L | 1 |
| Luciano, S | 1 |
| Ceccarelli, P | 1 |
| Paola, C | 1 |
| Castellaneta, E | 1 |
| Emanuela, C | 1 |
| Savina, C | 1 |
| Claudia, S | 1 |
| Donini, LM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Low-Carbohydrate or Restricted-Calories Diet on Body Weight[NCT01358890] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Effects of Acupuncture on Serum Metabolic Parameters in Pre-menopausal Obese Women: A Randomized Controlled Trial[NCT02066090] | 120 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
| Preventing Overweight Using Novel Dietary Strategies (Pounds Lost)[NCT00072995] | 811 participants | Interventional | 2003-09-30 | Completed | |||
| Metabolomics Identifies Increases in Acylcarnitine Profiles in Plasma of Overweight Subjects in Response to Mild Weight Loss[NCT03135132] | 100 participants (Actual) | Interventional | 2015-06-30 | Completed | |||
| Efficacy of Vitamin C Supplement Addiction vs. High-speed Spinal Manipulation to Routine Physiotherapy Treatment in Lateral Epicondylitis[NCT04445727] | 130 participants (Actual) | Interventional | 2020-05-21 | Enrolling by invitation | |||
| Calorie Restriction Intervention Induces Enterotype-associated BMI Loss in Nonobese Individuals[NCT04044118] | 41 participants (Actual) | Interventional | 2017-04-01 | Completed | |||
| Life 2: Improving Fitness and Function in Elders[NCT00435188] | 400 participants (Actual) | Interventional | 2004-11-30 | Completed | |||
| Pilot Study to Test Dietary Fat Delivery[NCT02101996] | 9 participants (Actual) | Observational | 2014-06-30 | Completed | |||
| Effect of Dietary Macronutrient Composition on Liver Substrate Metabolism[NCT01371396] | 24 participants (Actual) | Interventional | 2007-09-01 | Completed | |||
| Metabolic Adaptations to Six Month Caloric Restriction[NCT00099151] | 48 participants | Interventional | 2002-03-31 | Completed | |||
| Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE)[NCT00427193] | 238 participants (Actual) | Interventional | 2007-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Distance walked in two minutes in meters (NCT00435188)
Timeframe: 12 month
| Intervention | meters (Mean) |
|---|---|
| Arm 1 | 150.9 |
| Arm 2 | 147.5 |
Distance walked in two minutes in meters (NCT00435188)
Timeframe: 3 month
| Intervention | meters (Mean) |
|---|---|
| Arm 1 | 151.7 |
| Arm 2 | 145.6 |
Distance walked in two minutes in meters (NCT00435188)
Timeframe: Baseline
| Intervention | meters (Mean) |
|---|---|
| Arm 1 | 146 |
| Arm 2 | 145.4 |
Exercise frequency derived from Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire; The Champs assesses the frequency of a range of physical activities (NCT00435188)
Timeframe: 12 month
| Intervention | times per week (Mean) |
|---|---|
| Arm 1, Physical Activity Counseling | 22.4 |
| Arm 2, Usual Care | 16.8 |
Exercise frequency derived from Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire; The Champs assesses the frequency of a range of physical activities (NCT00435188)
Timeframe: 3 month
| Intervention | times per week (Mean) |
|---|---|
| Arm 1, Physical Activity Counseling | 22.7 |
| Arm 2, Usual Care | 17.6 |
Exercise frequency derived from Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire; The Champs assesses the frequency of a range of physical activities (NCT00435188)
Timeframe: Baseline
| Intervention | times per week (Mean) |
|---|---|
| Arm 1, Physical Activity Counseling | 15.9 |
| Arm 2, Usual Care | 16.8 |
(NCT00435188)
Timeframe: 12-month
| Intervention | meters/second (Mean) |
|---|---|
| Arm 1 | 1.68 |
| Arm 2 | 1.59 |
(NCT00435188)
Timeframe: 3-month
| Intervention | meters/second (Mean) |
|---|---|
| Arm 1 | 1.62 |
| Arm 2 | 1.58 |
(NCT00435188)
Timeframe: Baseline
| Intervention | meters/second (Mean) |
|---|---|
| Arm 1 | 1.56 |
| Arm 2 | 1.57 |
This is a subscale of the SF-36 Medical Outcomes Study. The Physical Function subscale assesses a self-reported ability to perform physical tasks. It is normalized for scores to range from 0 to 100 with a higher score indicating better function. (NCT00435188)
Timeframe: 12 month
| Intervention | units on a scale (Mean) |
|---|---|
| Arm 1 | 69.9 |
| Arm 2 | 62.7 |
This is a subscale of the SF-36 Medical Outcomes Study. The Physical Function subscale assesses a self-reported ability to perform physical tasks. It is normalized for scores to range from 0 to 100 with a higher score indicating better function. (NCT00435188)
Timeframe: 3 month
| Intervention | units on a scale (Mean) |
|---|---|
| Arm 1 | 70 |
| Arm 2 | 63.1 |
This is a subscale of the SF-36 Medical Outcomes Study. The Physical Function subscale assesses a self-reported ability to perform physical tasks. It is normalized for scores to range from 0 to 100 with a higher score indicating better function. (NCT00435188)
Timeframe: Baseline
| Intervention | units on a scale (Mean) |
|---|---|
| Arm 1 | 68 |
| Arm 2 | 62.9 |
(NCT00435188)
Timeframe: 12-month
| Intervention | meters/second (Mean) |
|---|---|
| Arm 1 | 1.15 |
| Arm 2 | 1.12 |
(NCT00435188)
Timeframe: 3 month
| Intervention | meters/second (Mean) |
|---|---|
| Arm 1 | 1.09 |
| Arm 2 | 1.07 |
Best of two trials over 8-foot walk (NCT00435188)
Timeframe: Baseline
| Intervention | meters/second (Mean) |
|---|---|
| Arm 1 | 1.03 |
| Arm 2 | 1.03 |
Self-report of overall health, reported as the number of participants reporting health as Excellent or Very good (NCT00435188)
Timeframe: 12 month
| Intervention | participants (Number) | |
|---|---|---|
| Overall health is excellent or very good | Overall health is good, fair or poor | |
| Arm 1 | 78 | 100 |
| Arm 2 | 70 | 107 |
Self-report of overall health, reported as the number of participants reporting health as Excellent or Very good (NCT00435188)
Timeframe: 3 month
| Intervention | participants (Number) | |
|---|---|---|
| Overall health is excellent or very good | Overall health is good, fair or poor | |
| Arm 1 | 82 | 102 |
| Arm 2 | 75 | 114 |
Self-report of overall health, reported as the number of participants reporting health as Excellent or Very good (NCT00435188)
Timeframe: Baseline
| Intervention | participants (Number) | |
|---|---|---|
| Overall health is excellent or very good | Overall health is good, fair or poor | |
| Arm 1 | 71 | 128 |
| Arm 2 | 76 | 123 |
(NCT00427193)
Timeframe: Baseline to 12 months
| Intervention | degrees Celsius (Mean) |
|---|---|
| Caloric Restriction (CR) | -0.05 |
| Ad Libitum | -0.03 |
(NCT00427193)
Timeframe: Baseline to 24 months
| Intervention | degrees Celsius (Mean) |
|---|---|
| Prescribed 25% Caloric Restriction | -0.05 |
| Ad Libitum | -0.02 |
Difference in change in Fat Mass between prescribed 25% Caloric Restriction (CR) and Ad Libitum (AL) at 12 and 24 months as measured by dual X-ray absorptiometry (DXA) using the Hologic 4500A, Delphi W or Discovery A, by a standardized protocol according to a standardized protocol. Fat Mass (FM) was determined for the whole body. (NCT00427193)
Timeframe: baseline, 12 months
| Intervention | Kg (Mean) |
|---|---|
| Prescribed 25% Caloric Restriction | -6.1 |
| Ad Libitum | -0.3 |
Difference in change in Fat Mass between prescribed 25% Caloric Restriction (CR) and Ad Libitum (AL) at 12 and 24 months as measured by dual X-ray absorptiometry (DXA) using the Hologic 4500A, Delphi W or Discovery A, by a standardized protocol according to a standardized protocol. Fat Mass (FM) was determined for the whole body. (NCT00427193)
Timeframe: change 0 to 24 months
| Intervention | kg (Mean) |
|---|---|
| Prescribed 25% Caloric Restriction | -6.1 |
| Ad Libitum | -0.2 |
(NCT00427193)
Timeframe: Baseline, 24 months
| Intervention | Kcal/day (Mean) |
|---|---|
| Caloric Restriction (CR) | -71 |
| Ad Libitum | -7 |
(NCT00427193)
Timeframe: Baseline, 12 months
| Intervention | Kcal/day (Mean) |
|---|---|
| Caloric Restriction (CR) | -83 |
| Ad Libitum | -1 |
(NCT00427193)
Timeframe: change baseline to 12 months
| Intervention | pg/mL (Mean) |
|---|---|
| Caloric Restriction (CR) | -0.30 |
| Ad Libitum | -0.34 |
1 review available for carnitine and Overweight
| Article | Year |
|---|---|
The effects of L-carnitine supplementation on inflammatory and anti-inflammatory markers in adults: a systematic review and dose-response meta-analysis.
Topics: Adult; Anti-Inflammatory Agents; Antioxidants; Biomarkers; C-Reactive Protein; Carnitine; Dietary Su | 2023 |
19 trials available for carnitine and Overweight
| Article | Year |
|---|---|
Effects of gut microbiota and fatty acid metabolism on dyslipidemia following weight-loss diets in women: Results from a randomized controlled trial.
Topics: Adult; Caloric Restriction; Carnitine; Diet, Carbohydrate-Restricted; Diet, Reducing; Dyslipidemias; | 2021 |
The effect of L-carnitine supplementation on insulin resistance, sex hormone-binding globulin and lipid profile in overweight/obese women with polycystic ovary syndrome: a randomized clinical trial.
Topics: Carnitine; Cholesterol, HDL; Dietary Supplements; Double-Blind Method; Female; Humans; Insulin; Insu | 2022 |
Effect of l-carnitine supplementation on liver fat content and cardiometabolic indices in overweight/obese women with polycystic ovary syndrome: A randomized controlled trial.
Topics: Cardiovascular Diseases; Carnitine; Dietary Supplements; Female; Humans; Iran; Liver; Obesity; Overw | 2021 |
Effects of acupuncture on anthropometric and serum metabolic parameters in premenopausal overweight and obese women: a randomized, patient- and assessor-blind, sham-controlled clinical trial.
Topics: Acupuncture Therapy; Adult; Amino Acids; Anthropometry; Carnitine; Electroacupuncture; Female; Human | 2021 |
Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial.
Topics: Adult; Amino Acids; Carnitine; Choline; Diet, Reducing; Female; Gastrointestinal Microbiome; Glucose | 2019 |
Metabolomics identifies increases in the acylcarnitine profiles in the plasma of overweight subjects in response to mild weight loss: a randomized, controlled design study.
Topics: Adult; Caloric Restriction; Carnitine; Fatty Acids, Nonesterified; Female; Humans; Intra-Abdominal F | 2018 |
Effects of Chromium and Carnitine Co-supplementation on Body Weight and Metabolic Profiles in Overweight and Obese Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Body Weight; Carnitine; Chromium; Dietary Supplements; Double-Blind Method; Female; Gene Expr | 2020 |
Circulating Gut Microbiota Metabolite Trimethylamine N-Oxide (TMAO) and Changes in Bone Density in Response to Weight Loss Diets: The POUNDS Lost Trial.
Topics: Absorptiometry, Photon; Adult; Bone Density; Carnitine; Choline; Diabetes Mellitus, Type 2; Diet, Re | 2019 |
Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Blood Glucose; Carnitine; Cholesterol, HDL; Dietary Supplement | 2015 |
L-Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis.
Topics: Ascorbic Acid; Benzothiazoles; Body Mass Index; Carnitine; Cholesterol, HDL; Cholesterol, LDL; Dieta | 2015 |
Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Blood Glucose; Body Weights and Measures; Carnitine; Dietar | 2016 |
Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by nontargeted metabolite profiling approach.
Topics: Aged; Cardiovascular Diseases; Carnitine; Cholesterol, LDL; Diet; Fasting; Fatty Acids; Female; Huma | 2017 |
Short-term effects of a green coffee extract-, Garcinia c ambogia- and L-carnitine-containing chewing gum on snack intake and appetite regulation.
Topics: Adult; Appetite Depressants; Appetite Regulation; Argentina; Body Mass Index; Carnitine; Chewing Gum | 2018 |
Effects of weight loss using supplementation with Lactobacillus strains on body fat and medium-chain acylcarnitines in overweight individuals.
Topics: Adipose Tissue; Carnitine; Dietary Supplements; Double-Blind Method; Humans; Lactobacillus; Lactobac | 2017 |
Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women.
Topics: Adiposity; Adult; Aging; Amino Acids; Body Composition; Caloric Restriction; Carnitine; Cross-Sectio | 2011 |
A combination of (ω-3) polyunsaturated fatty acids, polyphenols and L-carnitine reduces the plasma lipid levels and increases the expression of genes involved in fatty acid oxidation in human peripheral blood mononuclear cells and HepG2 cells.
Topics: Adult; Carnitine; Double-Blind Method; Fatty Acids; Fatty Acids, Omega-3; Female; Flavonoids; Functi | 2011 |
Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity.
Topics: Adult; Aged; Biological Transport; Biomarkers; Body Composition; Carnitine; Fatty Acids; Female; Hum | 2012 |
Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity.
Topics: Adult; Aged; Biological Transport; Biomarkers; Body Composition; Carnitine; Fatty Acids; Female; Hum | 2012 |
Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity.
Topics: Adult; Aged; Biological Transport; Biomarkers; Body Composition; Carnitine; Fatty Acids; Female; Hum | 2012 |
Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity.
Topics: Adult; Aged; Biological Transport; Biomarkers; Body Composition; Carnitine; Fatty Acids; Female; Hum | 2012 |
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
Topics: Adult; Amino Acids; Caloric Restriction; Carnitine; Energy Intake; Exercise; Fasting; Fatty Acids, N | 2012 |
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
Topics: Adult; Amino Acids; Caloric Restriction; Carnitine; Energy Intake; Exercise; Fasting; Fatty Acids, N | 2012 |
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
Topics: Adult; Amino Acids; Caloric Restriction; Carnitine; Energy Intake; Exercise; Fasting; Fatty Acids, N | 2012 |
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
Topics: Adult; Amino Acids; Caloric Restriction; Carnitine; Energy Intake; Exercise; Fasting; Fatty Acids, N | 2012 |
Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects.
Topics: Adipokines; Adult; Alkaloids; Benzodioxoles; Capsaicin; Carnitine; Catechin; Diet, Reducing; Dietary | 2013 |
13 other studies available for carnitine and Overweight
| Article | Year |
|---|---|
Short communication: Circulating fatty acylcarnitines are elevated in overweight periparturient dairy cows in association with sphingolipid biomarkers of insulin resistance.
Topics: Animals; Biomarkers; Carnitine; Cattle; Cattle Diseases; Ceramides; Fatty Acids; Female; Insulin Res | 2018 |
Plasma metabolomics reveals lower carnitine concentrations in overweight Labrador Retriever dogs.
Topics: Animals; Carnitine; Dogs; Magnetic Resonance Spectroscopy; Male; Metabolome; Metabolomics; Overweigh | 2019 |
Indication of metabolic inflexibility to food intake in spontaneously overweight Labrador Retriever dogs.
Topics: Animals; Carnitine; Dog Diseases; Dogs; Eating; Lipid Metabolism; Male; Overweight; Phospholipids | 2019 |
Lowered serum total L-carnitine levels are associated with obesity at term pregnancy.
Topics: Adult; Body Height; Body Mass Index; Carnitine; Dietary Supplements; Female; Fetal Weight; Gestation | 2013 |
Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.
Topics: Aged; Amino Acids, Branched-Chain; Black or African American; Carnitine; Cross-Sectional Studies; Fe | 2013 |
The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue.
Topics: Adult; Carnitine; Exercise; Female; Humans; Male; Mitochondria; Mitochondria, Muscle; Muscle, Skelet | 2015 |
Association between arterial stiffness and serum L-octanoylcarnitine and lactosylceramide in overweight middle-aged subjects: 3-year follow-up study.
Topics: Adult; Antigens, CD; Blood Pressure; Body Mass Index; Carnitine; Case-Control Studies; Humans; Lacto | 2015 |
Medium-chain dicarboxylic acylcarnitines as markers of n-3 PUFA-induced peroxisomal oxidation of fatty acids.
Topics: Animals; Biomarkers; Carnitine; Diet, High-Fat; Dietary Fats; Dietary Fats, Unsaturated; Fatty Acids | 2015 |
Association between Metabolite Profiles, Metabolic Syndrome and Obesity Status.
Topics: Adult; Amino Acids; Body Mass Index; Cardiovascular Diseases; Carnitine; Cholesterol; Cholesterol, H | 2016 |
Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women.
Topics: Adult; Aged; Blood Cells; Blood Glucose; Body Mass Index; Carnitine; Diabetes Mellitus, Type 2; Fema | 2017 |
Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women.
Topics: Adolescent; Adult; Aged; Amino Acids; Blood Glucose; Carnitine; Cross-Sectional Studies; Fatty Acids | 2009 |
Plasma acylcarnitines are associated with physical performance in elderly men.
Topics: Aged; Carnitine; Gait; Hand Strength; Humans; Male; Mass Spectrometry; Motor Activity; Overweight | 2011 |
Influence of dietary supplementation with (L)-carnitine on metabolic rate, fatty acid oxidation, body condition, and weight loss in overweight cats.
Topics: Animals; Calorimetry, Indirect; Carnitine; Cat Diseases; Cats; Dietary Supplements; Energy Metabolis | 2012 |