carnitine has been researched along with Myocardial Ischemia in 74 studies
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Long-chain acylcarnitines accumulate during myocardial ischemia and contribute to membrane dysfunction in ischemic zones." | 7.69 | Accumulation of unsaturated acylcarnitine molecular species during acute myocardial ischemia: metabolic compartmentalization of products of fatty acyl chain elongation in the acylcarnitine pool. ( Ford, DA; Gross, RW; Han, X; Horner, CC, 1996) |
| "During myocardial ischemia, inhibition of the carnitine-mediated transportation of fatty acid may be beneficial because it facilitates glucose utilization and prevents an accumulation of fatty acid metabolites." | 7.69 | Inhibition of carnitine synthesis protects against left ventricular dysfunction in rats with myocardial ischemia. ( Aoyagi, T; Eto, Y; Hayashi, Y; Kirimoto, T; Kobayakawa, N; Matsumoto, A; Momomura, S; Omata, M; Sugiura, S; Yokoyama, I; Yonekura, K, 1997) |
| "Carnitine and its derivatives have recently been shown to protect cardiac metabolism and function in ischemic heart disease and other clinical conditions of myocardial ischemia." | 4.81 | Influence of L-carnitine and its derivatives on myocardial metabolism and function in ischemic heart disease and during cardiopulmonary bypass. ( Lango, R; Lysiak-Szydlowska, W; Narkiewicz, M; Smolenski, RT; Suchorzewska, J, 2001) |
| "Long-chain acylcarnitines accumulate during myocardial ischemia and contribute to membrane dysfunction in ischemic zones." | 3.69 | Accumulation of unsaturated acylcarnitine molecular species during acute myocardial ischemia: metabolic compartmentalization of products of fatty acyl chain elongation in the acylcarnitine pool. ( Ford, DA; Gross, RW; Han, X; Horner, CC, 1996) |
| "During myocardial ischemia, inhibition of the carnitine-mediated transportation of fatty acid may be beneficial because it facilitates glucose utilization and prevents an accumulation of fatty acid metabolites." | 3.69 | Inhibition of carnitine synthesis protects against left ventricular dysfunction in rats with myocardial ischemia. ( Aoyagi, T; Eto, Y; Hayashi, Y; Kirimoto, T; Kobayakawa, N; Matsumoto, A; Momomura, S; Omata, M; Sugiura, S; Yokoyama, I; Yonekura, K, 1997) |
| "Long-chain acylcarnitines (LCA) have been shown to accumulate during myocardial ischemia and to contribute to malignant derangements characteristic of ischemia." | 3.68 | Reperfusion-induced accumulation of long-chain acylcarnitines in previously ischemic myocardium. ( Adames, VR; Heathers, GP; Higgins, AJ; Su, CM, 1993) |
| "L-carnitine is a necessary nutrient for the transport of fatty acids that are required for generating energy." | 2.84 | Effect of L-Carnitine Supplementation on Reverse Remodeling in Patients with Ischemic Heart Disease Undergoing Coronary Artery Bypass Grafting: A Randomized, Placebo-Controlled Trial. ( Boaventura, G; Colafranceschi, A; Costa, B; D'Ippolito, JA; da Costa, C; da Silva Guimarães, S; da Silva, G; da Silva, L; de Carvalho, M; de Souza Cruz, W; Huguenin, AB; Maciel, G; Scalco, F, 2017) |
| "L-Carnitine treatment in combination with other traditional pharmacological therapy might have an additive effect for the improvement of left ventricular function in ischemic cardiomyopathy." | 2.69 | The effects of L-carnitine treatment on left ventricular function and erythrocyte superoxide dismutase activity in patients with ischemic cardiomyopathy. ( Akçil, E; Dinçer, I; Erol, C; Gürlek, A; Kocatürk, PA; Oral, D; Tutar, E, 2000) |
| "Carnitine treatment has cardiovascular benefits including modulation of myocardial metabolism, reduction in necrotic cell death and infarct size, decrease in the incidence of arrhythmias and preservation of mechanical function." | 2.48 | Value of carnitine therapy in kidney dialysis patients and effects on cardiac function from human and animal studies. ( Bhandari, S; Molyneux, R; Seymour, AM, 2012) |
| "Many patients with ischemic heart disease continue to experience anginal symptoms despite revascularization and treatment with antianginal medications." | 2.43 | Metabolic modulators for chronic cardiac ischemia. ( Arora, R; Parang, P; Singh, B, 2005) |
| "L-carnitine has an important role in the metabolism of fatty acids." | 2.38 | New thoughts of pathophysiology and therapy of ischemic heart disease. ( Pepine, CJ, 1991) |
| "Carnitine is a vital biologic substance facilitating fatty acids transport into mitochondria for ATP production." | 1.36 | Pharmacological preconditioning with L-carnitine: relevance to myocardial hemodynamic function and glycogen and lactate content. ( Garjani, A; Ghorbani-Haghjo, A; Javidnia, A; Mohammadi, S; Najafi, M, 2010) |
| "As L-carnitine plays a pivotal role in the balanced metabolism of fatty acids and carbohydrates, this study was carried out to investigate whether long-term mildronate treatment could influence glucose levels and prevent diabetic complications in an experimental model of type 2 diabetes in Goto-Kakizaki (GK) rats." | 1.35 | Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats. ( Cirule, H; Dambrova, M; Grinberga, S; Kalvinsh, I; Kuka, J; Liepinsh, E; Skapare, E; Svalbe, B; Vilskersts, R; Zvejniece, L, 2009) |
| "Carnitine deficiency was induced in Sprague-Dawley rats by supplementing the drinking water with sodium pivalate for a period of 2 weeks." | 1.31 | Short-term carnitine deficiency does not alter aerobic rat heart function but depresses reperfusion recovery after ischemia. ( Broderick, TL; Cifuentes, J; Green, D; Paulson, DJ, 2001) |
| "Carnitine kinetics were investigated in 28 normotensive patients with significant left coronary artery disease, during and after incremental atrial pacing." | 1.30 | Acute myocardial ischaemia induces cardiac carnitine release in man. ( Bartels, GL; Remme, WJ; Scholte, HR, 1997) |
| "L-carnitine was administered to the carnitine series at doses of 250 mg/kg/day starting 7 days before the ischemic protocol and continuing during the follow-up period (10 and 15 days)." | 1.30 | [Effects of L-carnitine on the regional function of the stunned myocardium caused by ischemia of short duration]. ( Andrés Conejos, F; Capdevila Carbonell, C; Cosín Aguilar, J; Hernándiz Martínez, A; Pallarés Carratalá, V; Portolés Sanz, M, 1997) |
| "L-Carnitine is a key regulatory compound of glucose and fatty acid metabolism in the myocardium." | 1.30 | [The effect of L-carnitine on ischemic heart disease: experimental results]. ( Lerch, R, 1998) |
| "L-Carnitine has been shown to improve the post-ischemic recovery of myocardial function and metabolic measurements that are reduced in the course of ischemia and reperfusion of the heart." | 1.30 | The dose-dependent effects of L-carnitine in myocardial protection in normothermic ischemia. ( Ersöz, A; Gökgöz, L; Kalaycioğlu, S; Oktar, L; Oz, E; Sinci, V; Soncul, H; Tatlican, O; Türközkan, N; Yener, A, 1998) |
| "Carnitine can cause overall improvement in cardiac performance in patients with CAD as well as in cardiomyopathy." | 1.30 | L-carnitine administration in coronary artery disease and cardiomyopathy. ( Aslam, M; Singh, RB, 1998) |
| "L-Propionylcarnitine-treated animals displayed slightly better postischemic recovery of systolic SS than did control animals; to 39 and 28% (p = 0." | 1.29 | L-propionylcarnitine does not affect myocardial metabolic or functional response to chronotropic and inotropic stimulation after repetitive ischemia in anesthetized pigs. ( Bartels, GL; Bezstarosti, K; Duncker, DJ; Krams, R; Lamers, JM; McFalls, EO; Sassen, LM; van Meegen, JR; Verdouw, PD, 1993) |
| "L-carnitine treatment stimulated glucose oxidation during reperfusion in control and diabetic rat hearts." | 1.29 | L-carnitine increases glucose metabolism and mechanical function following ischaemia in diabetic rat heart. ( Broderick, TL; Lopaschuk, GD; Quinney, HA, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 49 (66.22) | 18.2507 |
| 2000's | 19 (25.68) | 29.6817 |
| 2010's | 5 (6.76) | 24.3611 |
| 2020's | 1 (1.35) | 2.80 |
| Authors | Studies |
|---|---|
| Sánchez-Quintero, MJ | 1 |
| Delgado, J | 1 |
| Medina-Vera, D | 1 |
| Becerra-Muñoz, VM | 1 |
| Queipo-Ortuño, MI | 1 |
| Estévez, M | 1 |
| Plaza-Andrades, I | 1 |
| Rodríguez-Capitán, J | 1 |
| Sánchez, PL | 1 |
| Crespo-Leiro, MG | 1 |
| Jiménez-Navarro, MF | 1 |
| Pavón-Morón, FJ | 1 |
| da Silva Guimarães, S | 1 |
| de Souza Cruz, W | 1 |
| da Silva, L | 1 |
| Maciel, G | 1 |
| Huguenin, AB | 1 |
| de Carvalho, M | 1 |
| Costa, B | 1 |
| da Silva, G | 1 |
| da Costa, C | 1 |
| D'Ippolito, JA | 1 |
| Colafranceschi, A | 1 |
| Scalco, F | 1 |
| Boaventura, G | 1 |
| Ussher, JR | 1 |
| Lopaschuk, GD | 4 |
| Arduini, A | 2 |
| Liepinsh, E | 1 |
| Vilskersts, R | 1 |
| Zvejniece, L | 1 |
| Svalbe, B | 1 |
| Skapare, E | 1 |
| Kuka, J | 1 |
| Cirule, H | 1 |
| Grinberga, S | 1 |
| Kalvinsh, I | 2 |
| Dambrova, M | 2 |
| Najafi, M | 1 |
| Javidnia, A | 1 |
| Ghorbani-Haghjo, A | 1 |
| Mohammadi, S | 1 |
| Garjani, A | 1 |
| Ceccarelli, SM | 1 |
| Chomienne, O | 1 |
| Gubler, M | 1 |
| Molyneux, R | 1 |
| Seymour, AM | 1 |
| Bhandari, S | 1 |
| Hwang, YC | 1 |
| Bakr, S | 2 |
| Ramasamy, R | 2 |
| Bergmann, SR | 2 |
| Onnis, E | 1 |
| Iliceto, S | 4 |
| Schofield, RS | 1 |
| Hill, JA | 1 |
| Daĭia, D | 1 |
| Liepin'sh, E | 1 |
| Kir'ianova, O | 1 |
| Kalvin'sh, I | 1 |
| Sjakste, N | 1 |
| Kleschyov, AL | 1 |
| Boucher, JL | 1 |
| Baumane, L | 1 |
| Dzintare, M | 1 |
| Meirena, D | 1 |
| Sjakste, J | 1 |
| Sydow, K | 1 |
| Münzel, T | 1 |
| Broderick, TL | 5 |
| Paulson, DJ | 4 |
| Gillis, M | 1 |
| Pauly, DF | 1 |
| Pepine, CJ | 2 |
| Ferrari, R | 1 |
| Merli, E | 1 |
| Cicchitelli, G | 1 |
| Mele, D | 1 |
| Fucili, A | 1 |
| Ceconi, C | 1 |
| Su, X | 1 |
| Han, X | 2 |
| Mancuso, DJ | 1 |
| Abendschein, DR | 1 |
| Gross, RW | 2 |
| Mason, KE | 1 |
| Stofan, DA | 1 |
| Szweda, LI | 1 |
| Parang, P | 1 |
| Singh, B | 1 |
| Arora, R | 1 |
| Duncker, DJ | 2 |
| Sassen, LM | 2 |
| Bartels, GL | 4 |
| van Meegen, JR | 1 |
| McFalls, EO | 2 |
| Krams, R | 2 |
| Bezstarosti, K | 2 |
| Lamers, JM | 2 |
| Verdouw, PD | 2 |
| Heathers, GP | 1 |
| Su, CM | 1 |
| Adames, VR | 1 |
| Higgins, AJ | 1 |
| Corr, PB | 2 |
| Yamada, KA | 2 |
| Madden, MC | 1 |
| Wołkowicz, PE | 1 |
| Pohost, GM | 1 |
| McMillin, JB | 2 |
| Pike, MM | 1 |
| Palazzuoli, V | 2 |
| Mondillo, S | 2 |
| Faglia, S | 2 |
| D'Aprile, N | 2 |
| Camporeale, A | 1 |
| Gennari, C | 1 |
| Allely, MC | 1 |
| Brown, CM | 1 |
| Kenny, BA | 1 |
| Kilpatrick, AT | 1 |
| Martin, A | 1 |
| Spedding, M | 1 |
| Quinney, HA | 2 |
| Ribeiro, C | 1 |
| Gamble, J | 1 |
| Hülsmann, WC | 3 |
| Peschechera, A | 2 |
| Arrigoni-Martelli, E | 3 |
| Yamamoto, M | 1 |
| Lee, JD | 1 |
| Shimizu, H | 1 |
| Kawasaki, N | 1 |
| Hara, A | 1 |
| Ishii, Y | 1 |
| Nakamura, T | 1 |
| Remme, WJ | 3 |
| Pillay, M | 1 |
| Schönfeld, DH | 1 |
| Kruijssen, DA | 2 |
| Di Lisa, F | 1 |
| Menabò, R | 1 |
| Barbato, R | 1 |
| Siliprandi, N | 1 |
| Sundqvist, KE | 1 |
| Vuorinen, KH | 1 |
| Peuhkurinen, KJ | 1 |
| Hassinen, IE | 1 |
| Kobayashi, A | 2 |
| Fujisawa, S | 2 |
| Riva, E | 1 |
| Leopaldi, D | 1 |
| Simkhovich, BZ | 1 |
| Hale, SL | 1 |
| Ovize, M | 1 |
| Przyklenk, K | 1 |
| Kloner, RA | 1 |
| McHowat, J | 1 |
| Yan, GX | 1 |
| Donahue, K | 1 |
| Peirick, J | 1 |
| Kléber, AG | 1 |
| Arita, M | 1 |
| Sato, T | 1 |
| Ishida, H | 1 |
| Nakazawa, H | 1 |
| Barker, CC | 1 |
| Tedesco, MA | 1 |
| Ratti, G | 1 |
| Aquino, D | 1 |
| Iacono, A | 1 |
| Ford, DA | 1 |
| Horner, CC | 1 |
| Mangiacotti, L | 1 |
| Campolo, MA | 1 |
| Agricola, E | 1 |
| Serafini, F | 1 |
| Ferrari, LE | 1 |
| Clarke, B | 1 |
| Wyatt, KM | 1 |
| May, GR | 1 |
| McCormack, JG | 1 |
| Rizzon, P | 3 |
| Marangelli, V | 1 |
| den Hartog, FR | 1 |
| Wielenga, RP | 1 |
| Scholte, HR | 1 |
| Aoyagi, T | 1 |
| Sugiura, S | 1 |
| Eto, Y | 1 |
| Yonekura, K | 1 |
| Matsumoto, A | 1 |
| Yokoyama, I | 1 |
| Kobayakawa, N | 1 |
| Omata, M | 1 |
| Kirimoto, T | 1 |
| Hayashi, Y | 1 |
| Momomura, S | 1 |
| Hernándiz Martínez, A | 1 |
| Pallarés Carratalá, V | 1 |
| Cosín Aguilar, J | 1 |
| Andrés Conejos, F | 1 |
| Capdevila Carbonell, C | 1 |
| Portolés Sanz, M | 1 |
| Atar, D | 1 |
| Spiess, M | 1 |
| Mandinova, A | 1 |
| Cierpka, H | 1 |
| Noll, G | 1 |
| Lüscher, TF | 1 |
| Lerch, R | 1 |
| Tatlican, O | 1 |
| Kalaycioğlu, S | 1 |
| Gökgöz, L | 1 |
| Oktar, L | 1 |
| Oz, E | 1 |
| Soncul, H | 1 |
| Sinci, V | 1 |
| Türközkan, N | 1 |
| Yener, A | 1 |
| Ersöz, A | 1 |
| Keller, VA | 1 |
| Toporoff, B | 1 |
| Raziano, RM | 1 |
| Pigott, JD | 1 |
| Mills, NL | 1 |
| Löster, H | 1 |
| Keller, T | 1 |
| Grommisch, J | 1 |
| Gründer, W | 1 |
| Lopaschuk, G | 1 |
| Calvani, M | 1 |
| Reda, E | 1 |
| Driedzic, W | 1 |
| Gürlek, A | 1 |
| Tutar, E | 1 |
| Akçil, E | 1 |
| Dinçer, I | 1 |
| Erol, C | 1 |
| Kocatürk, PA | 1 |
| Oral, D | 1 |
| Nemoto, S | 1 |
| Aoki, M | 1 |
| Dehua, C | 1 |
| Imai, Y | 1 |
| Singh, RB | 1 |
| Aslam, M | 1 |
| Lango, R | 1 |
| Smolenski, RT | 1 |
| Narkiewicz, M | 1 |
| Suchorzewska, J | 1 |
| Lysiak-Szydlowska, W | 1 |
| Hwang, Y | 1 |
| Cifuentes, J | 1 |
| Green, D | 1 |
| Hironaka, Y | 1 |
| Yamazaki, N | 1 |
| Lazzarino, G | 1 |
| Corsico, N | 1 |
| Tavazzi, B | 1 |
| di Pierro, D | 1 |
| Giardina, B | 1 |
| Bertelli, A | 1 |
| Ronca, F | 1 |
| Ronca, G | 1 |
| Palmieri, L | 1 |
| Zucchi, R | 1 |
| Bick, RJ | 1 |
| Benedict, CR | 1 |
| Dubelaar, ML | 1 |
| Shug, AL | 1 |
| Zhao, J | 1 |
| Hogendoorn, A | 1 |
| Di Biase, M | 1 |
| Biasco, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Estudio clínico Fase III Para Evaluar la Eficacia terapéutica en Pacientes Mexicanos Con Dislipidemia Mediante el Uso vía Oral de L-Carnitina + Atorvastatina Comparado Con Atorvastatina[NCT03696940] | Phase 3 | 120 participants (Actual) | Interventional | 2018-05-28 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 reviews available for carnitine and Myocardial Ischemia
| Article | Year |
|---|---|
Gut microbiota metabolism of L-carnitine and cardiovascular risk.
Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Diet; Dietary Supplements; Humans; Ins | 2013 |
Value of carnitine therapy in kidney dialysis patients and effects on cardiac function from human and animal studies.
Topics: Carnitine; Heart; Humans; Kidney Failure, Chronic; Myocardial Ischemia; Myocardium; Renal Dialysis | 2012 |
[An old strategy which comes up again: metabolic therapy of acute myocardial infarction].
Topics: Carnitine; Glucose; Humans; Insulin; Muscle Cells; Myocardial Infarction; Myocardial Ischemia; Potas | 1999 |
Role of metabolically active drugs in the management of ischemic heart disease.
Topics: Acetanilides; Animals; Cardiovascular Agents; Carnitine; Clinical Trials as Topic; Dichloroacetic Ac | 2001 |
[Biochemical mechanisms of mildronate action during ischemic stress].
Topics: Animals; Cardiovascular Agents; Carnitine; Clinical Trials as Topic; Humans; Methylhydrazines; Myoca | 2004 |
Ischemic heart disease: metabolic approaches to management.
Topics: Acetanilides; Cardiovascular Agents; Carnitine; Dichloroacetic Acid; Energy Metabolism; Humans; Myoc | 2004 |
Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review.
Topics: Cardiotonic Agents; Cardiovascular Diseases; Carnitine; Humans; Kidney Failure, Chronic; Liver; Myoc | 2004 |
Metabolic modulators for chronic cardiac ischemia.
Topics: Acetanilides; Animals; Carnitine; Chronic Disease; Drug Evaluation, Preclinical; Enzyme Inhibitors; | 2005 |
Selected metabolic alterations in the ischemic heart and their contributions to arrhythmogenesis.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Carnitine; Carnitine O-Palmitoyltransferase; | 1995 |
The 1993 Merck Frosst Award. Acetyl-CoA carboxylase: an important regulator of fatty acid oxidation in the heart.
Topics: Acetyl Coenzyme A; Acetyl-CoA Carboxylase; Animals; Carbohydrate Metabolism; Carnitine; Carnitine O- | 1994 |
Carnitine and cardiac interstitium.
Topics: Animals; Calcium Channels; Carnitine; Heart; Humans; Myocardial Ischemia; Myocardium; Oxygen; Rats | 1994 |
[Preconditioning of the ischemic myocardium].
Topics: Adenosine; Angioplasty, Balloon, Coronary; Animals; Calcium Channel Blockers; Carnitine; Dogs; Elect | 1995 |
Metabolic approach to myocardial ischemia: a novel therapeutic strategy for patients with coronary artery disease?
Topics: Acetanilides; Carnitine; Clinical Trials as Topic; Coenzymes; Coronary Disease; Enzyme Inhibitors; H | 1995 |
Carnitine--from cellular mechanisms to potential clinical applications in heart disease.
Topics: Carnitine; Heart Failure; Humans; Myocardial Ischemia | 1997 |
[Consensus conference on the therapeutic effects of L-carnitine in patients with myocardial ischemia and left ventricular remodeling].
Topics: Carnitine; Coronary Disease; Humans; Myocardial Infarction; Myocardial Ischemia; Ventricular Functio | 1998 |
Regulation of carbohydrate metabolism in ischemia and reperfusion.
Topics: Animals; Carbohydrate Metabolism; Carnitine; Energy Metabolism; Fatty Acids, Nonesterified; Glucose; | 2000 |
Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions.
Topics: Animals; Carbohydrate Metabolism; Carnitine; Fatty Acids; Humans; Myocardial Ischemia; Myocardial Re | 2000 |
Influence of L-carnitine and its derivatives on myocardial metabolism and function in ischemic heart disease and during cardiopulmonary bypass.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Cardiopulmonary Bypass; Carnitine; Energy Met | 2001 |
New thoughts of pathophysiology and therapy of ischemic heart disease.
Topics: Animals; Carnitine; Heart; Heart Failure; Humans; Myocardial Infarction; Myocardial Ischemia; Myocar | 1991 |
[The role of metabolic therapy in myocardial infarct].
Topics: Adenosine Triphosphate; Animals; Carnitine; Heart; Humans; Lipid Metabolism; Myocardial Infarction; | 1991 |
6 trials available for carnitine and Myocardial Ischemia
| Article | Year |
|---|---|
Effect of L-Carnitine Supplementation on Reverse Remodeling in Patients with Ischemic Heart Disease Undergoing Coronary Artery Bypass Grafting: A Randomized, Placebo-Controlled Trial.
Topics: Aged; Body Mass Index; Carnitine; Coronary Artery Bypass; Dietary Supplements; Female; Follow-Up Stu | 2017 |
[The evaluation of the antiarrhythmic activity of L-carnitine and propafenone in ischemic cardiopathy].
Topics: Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Carnitine; Drug Therapy, Combination; El | 1993 |
Effects of L-propionylcarnitine on ischemia-induced myocardial dysfunction in men with angina pectoris.
Topics: Aged; Angina Pectoris; Cardiac Output; Cardiotonic Agents; Carnitine; Coronary Disease; Electrocardi | 1994 |
[Therapy of arrhythmia induced by myocardial ischemia. Association of L-carnitine, propafenone and mexiletine].
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Carnitine; Drug Sy | 1995 |
Additional antiischemic effects of long-term L-propionylcarnitine in anginal patients treated with conventional antianginal therapy.
Topics: Adult; Aged; Angina Pectoris; Carnitine; Exercise Test; Female; Humans; Male; Middle Aged; Myocardia | 1995 |
The effects of L-carnitine treatment on left ventricular function and erythrocyte superoxide dismutase activity in patients with ischemic cardiomyopathy.
Topics: Aged; Carnitine; Erythrocytes; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Superoxide Di | 2000 |
48 other studies available for carnitine and Myocardial Ischemia
| Article | Year |
|---|---|
Beneficial Effects of Essential Oils from the Mediterranean Diet on Gut Microbiota and Their Metabolites in Ischemic Heart Disease and Type-2 Diabetes Mellitus.
Topics: Animals; Carnitine; Diabetes Mellitus, Type 2; Diet, Mediterranean; Emulsions; Fatty Acids, Volatile | 2022 |
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.
Topics: 3-Hydroxybutyric Acid; Administration, Oral; Animals; Blood Glucose; Cardiovascular Agents; Carnitin | 2009 |
Pharmacological preconditioning with L-carnitine: relevance to myocardial hemodynamic function and glycogen and lactate content.
Topics: Adenosine Triphosphate; Animals; Carnitine; Glycogen; Hemodynamics; Ischemic Preconditioning, Myocar | 2010 |
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Catalytic Domain; Diabetes Mellitus, Type 2; E | 2011 |
Relative importance of enhanced glucose uptake versus attenuation of long-chain acyl carnitines in protecting ischemic myocardium.
Topics: Animals; Carnitine; Creatine Kinase; Cytochalasin B; Disease Models, Animal; Glucose; Models, Cardio | 2002 |
Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate.
Topics: Animals; Aorta, Thoracic; Betaine; Carnitine; Ditiocarb; Drug Combinations; Drug Evaluation, Preclin | 2004 |
Effects of propionyl-carnitine on mitochondrial respiration and post-ischaemic cardiac function in the ischaemic underperfused diabetic rat heart.
Topics: Animals; Blood Pressure; Body Weight; Cardiotonic Agents; Carnitine; Diabetes Mellitus, Experimental | 2004 |
Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics.
Topics: Animals; Base Sequence; Cardiomyopathies; Carnitine; Cricetinae; Diabetes Mellitus, Experimental; DN | 2005 |
Inhibition of very long chain acyl-CoA dehydrogenase during cardiac ischemia.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine; Cell Respiration; Male; Mitochondria, Muscle | 2005 |
L-propionylcarnitine does not affect myocardial metabolic or functional response to chronotropic and inotropic stimulation after repetitive ischemia in anesthetized pigs.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Pressure; Cardiotonic Agents; Carnitin | 1993 |
Reperfusion-induced accumulation of long-chain acylcarnitines in previously ischemic myocardium.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Epoxy Compounds; Male; Molecular Weight; Myoca | 1993 |
Acylcarnitine accumulation does not correlate with reperfusion recovery in palmitate-perfused rat hearts.
Topics: Acylation; Adenosine Triphosphate; Animals; Blood Pressure; Caproates; Carnitine; Carnitine O-Palmit | 1995 |
Modulation of alpha 1-adrenoceptors in rat left ventricle by ischaemia and acyl carnitines: protection by ranolazine.
Topics: Acetanilides; Animals; Carnitine; Carnitine O-Palmitoyltransferase; Dihydroalprenolol; Dihydropyridi | 1993 |
L-carnitine increases glucose metabolism and mechanical function following ischaemia in diabetic rat heart.
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Glucose; Glycolysis; Heart; In Vitro Techniques | 1995 |
[Therapeutic application of myocardial cytoprotection].
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Carnitine; Hum | 1994 |
Evaluation of post-ischemic myocardial metabolism by 1H-magnetic resonance spectroscopy in the rabbit heart.
Topics: Alanine; Animals; Carnitine; Hydrogen; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Myoca | 1994 |
Contrasting effects of propionate and propionyl-L-carnitine on energy-linked processes in ischemic hearts.
Topics: Animals; Cardiotonic Agents; Carnitine; Coenzyme A; Energy Metabolism; Esters; In Vitro Techniques; | 1994 |
Metabolic effects of propionate, hexanoate and propionylcarnitine in normoxia, ischaemia and reperfusion. Does an anaplerotic substrate protect the ischaemic myocardium?
Topics: Animals; Caproates; Cardiotonic Agents; Carnitine; Energy Metabolism; Heart; In Vitro Techniques; Ma | 1994 |
Effect of L-carnitine on mitochondrial acyl CoA esters in the ischemic dog heart.
Topics: Animals; Carnitine; Coenzyme A; Dogs; Dose-Response Relationship, Drug; Esters; Male; Mitochondria; | 1994 |
Control of the cardiac consequences of myocardial ischemia and reperfusion by L-propionylcarnitine: age-response and dose-response studies in the rat heart.
Topics: Aging; Animals; Animals, Newborn; Cardiotonic Agents; Carnitine; Coronary Circulation; Dose-Response | 1993 |
Ischemic preconditioning and long-chain acyl carnitine in the canine heart.
Topics: Acetylcarnitine; Adenosine Triphosphate; Animals; Carnitine; Coronary Circulation; Dogs; Myocardial | 1993 |
Cellular uncoupling induced by accumulation of long-chain acylcarnitine during ischemia.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Electrophysiology; Epoxy Compounds; Glycine; H | 1994 |
[Cellular electrophysiological basis of proarrhythmic and antiarrhythmic effects of ischemia-related lipid metabolites].
Topics: Animals; Arrhythmias, Cardiac; Carnitine; Electrophysiology; Guinea Pigs; Heart; Lysophosphatidylcho | 1993 |
Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation.
Topics: Acyl Coenzyme A; Adenosine Triphosphate; Animals; Carnitine; Esters; Glucose; Glycolysis; Heart; In | 1993 |
Accumulation of unsaturated acylcarnitine molecular species during acute myocardial ischemia: metabolic compartmentalization of products of fatty acyl chain elongation in the acylcarnitine pool.
Topics: Animals; Carnitine; Chromatography, High Pressure Liquid; In Vitro Techniques; Kinetics; Mass Spectr | 1996 |
Release of ischemia in paced rat Langendorff hearts by supply of L-carnitine: role of endogenous long-chain acylcarnitine.
Topics: Aerobiosis; Animals; Cardiac Pacing, Artificial; Carnitine; Cations; Cell Membrane; Cells, Cultured; | 1996 |
On the roles of long-chain acyl carnitine accumulation and impaired glucose utilization in ischaemic contracture development and tissue damage in the guinea-pig heart.
Topics: Animals; Calcium; Carnitine; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Female | 1996 |
[L-carnitine in the treatment of left ventricular dysfunction in post-infarction].
Topics: Animals; Carnitine; Humans; Myocardial Infarction; Myocardial Ischemia; Ventricular Dysfunction, Lef | 1995 |
Acute myocardial ischaemia induces cardiac carnitine release in man.
Topics: Adult; Aged; Cardiac Pacing, Artificial; Carnitine; Coronary Disease; Female; Hemodynamics; Humans; | 1997 |
Inhibition of carnitine synthesis protects against left ventricular dysfunction in rats with myocardial ischemia.
Topics: Animals; Carnitine; Hypoxia; Male; Myocardial Ischemia; Rats; Rats, Sprague-Dawley; Ventricular Dysf | 1997 |
[Effects of L-carnitine on the regional function of the stunned myocardium caused by ischemia of short duration].
Topics: Animals; Carnitine; Coronary Circulation; Dogs; Female; Male; Myocardial Contraction; Myocardial Isc | 1997 |
[The effect of L-carnitine on ischemic heart disease: experimental results].
Topics: Carnitine; Coronary Disease; Fatty Acids; Glucose; Humans; Myocardial Ischemia | 1998 |
[Therapeutic action of L-carnitine in myocardial ischemia and left ventricular remodeling: clinical data].
Topics: Carnitine; Echocardiography; Humans; Hypertrophy, Left Ventricular; Myocardial Infarction; Myocardia | 1998 |
The dose-dependent effects of L-carnitine in myocardial protection in normothermic ischemia.
Topics: Adenosine Deaminase; Analysis of Variance; Animals; Carnitine; Chick Embryo; Disease Models, Animal; | 1998 |
Carnitine supplementation improves myocardial function in hearts from ischemic diabetic and euglycemic rats.
Topics: Animals; Blood Glucose; Carnitine; Diabetes Mellitus, Experimental; Heart; Hemodynamics; In Vitro Te | 1998 |
Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy.
Topics: Acetylcarnitine; Adenosine Triphosphate; Animals; Carnitine; Energy Metabolism; Female; Heart; In Vi | 1999 |
Propionyl-L-carnitine effects on postischemic recovery of heart function and substrate oxidation in the diabetic rat.
Topics: Animals; Cardiotonic Agents; Carnitine; Diabetes Mellitus, Experimental; Glucose; Heart; Male; Myoca | 2000 |
Effects of carnitine on cardiac function after cardioplegic ischemia in neonatal rabbit hearts.
Topics: Animals; Animals, Newborn; Carnitine; Coronary Circulation; Heart; Heart Arrest, Induced; Myocardial | 2001 |
L-carnitine administration in coronary artery disease and cardiomyopathy.
Topics: Carnitine; Coronary Disease; Dietary Supplements; Heart; Humans; Myocardial Ischemia | 1998 |
Protection of ischemic hearts perfused with an anion exchange inhibitor, DIDS, is associated with beneficial changes in substrate metabolism.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Anion Exchange Pr | 2001 |
Short-term carnitine deficiency does not alter aerobic rat heart function but depresses reperfusion recovery after ischemia.
Topics: Aerobiosis; Animals; Blood Pressure; Body Weight; Carnitine; Energy Metabolism; Heart; Male; Myocard | 2001 |
Effect of L-carnitine on the cellular distribution of carnitine and its acyl derivatives in the ischemic heart.
Topics: Acylation; Animals; Carnitine; Cytosol; Dogs; Fatty Acids, Nonesterified; Male; Mitochondria, Heart; | 1992 |
[L-propionylcarnitine taurine amide induces the metabolic recovery of the isolated postischemic rat heart].
Topics: Animals; Carnitine; Drug Evaluation, Preclinical; Energy Metabolism; Heart; In Vitro Techniques; Mal | 1992 |
L-carnitine and coenzyme Q10 protective action against ischaemia and reperfusion of working rat heart.
Topics: Animals; Carnitine; Chromatography, High Pressure Liquid; Coenzymes; Drug Combinations; Hemodynamics | 1992 |
Influence of dietary fish oil on mitochondrial function and response to ischemia.
Topics: Animals; Carnitine; Dogs; Electron Transport Complex IV; Fish Oils; Kinetics; Mitochondria, Heart; M | 1992 |
Carnitine requirement of vascular endothelial and smooth muscle cells in imminent ischemia.
Topics: Animals; Carboxy-Lyases; Carnitine; Carnitine O-Acetyltransferase; Cells, Cultured; Endothelium, Vas | 1992 |
Protection of the ischemic diabetic heart by L-propionylcarnitine therapy.
Topics: Animals; Cardiotonic Agents; Carnitine; Diabetes Mellitus, Experimental; Male; Myocardial Contractio | 1992 |
L-propionylcarnitine and myocardial performance in stunned porcine myocardium.
Topics: Animals; Cardiotonic Agents; Carnitine; Female; Hemodynamics; Male; Myocardial Contraction; Myocardi | 1992 |