carnitine has been researched along with Muscle Weakness in 33 studies
Muscle Weakness: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with cystic acne (CA) on Isotretinoin (Iso) therapy might present muscular symptoms as side effect of the drug." | 9.09 | L-carnitine supplementation in patients with cystic acne on isotretinoin therapy. ( Georgala, C; Georgala, S; Michas, T; Schulpis, KH, 1999) |
| "Patients with carnitine insufficiency had a significantly higher prevalence of muscle weakness and a lower 6-min walk distance than those without carnitine insufficiency (P < 0." | 8.31 | Association of carnitine insufficiency with sarcopenia and dynapenia in patients with heart failure. ( Hirai, M; Kato, M; Kinugasa, Y; Nakamura, K; Sota, T; Yamamoto, K, 2023) |
| "The aim of this study was to elucidate the efficacy of the combination of L-carnitine and exercise, reported to prevent muscle wasting, for muscle complications (function, volume, and cramping) in patients with liver cirrhosis (LC) who received branched-chain amino acid supplementation." | 7.91 | Can L-carnitine supplementation and exercise improve muscle complications in patients with liver cirrhosis who receive branched-chain amino acid supplementation? ( Abe, M; Hiasa, Y; Hiraoka, A; Hirooka, M; Kiguchi, D; Matsuura, B; Michitaka, K; Ninomiya, T, 2019) |
| "Weakness is common in both hyper- and hypothyroidism, and skeletal muscle L-carnitine may play a role in this regard, as suggested by studies indicating abnormal levels of carnitine in serum and urine of patients with thyroid dysfunction." | 7.73 | Muscle carnitine in hypo- and hyperthyroidism. ( Gilchrist, JM; Hennessey, JV; Kandula, M; Sinclair, C, 2005) |
| "To assess the role of carnitine in the skeletal myopathy present in anorexia nervosa." | 7.70 | Carnitine levels in patients with skeletal myopathy due to anorexia nervosa before and after refeeding. ( McLoughlin, DM; Morton, J; Russell, GF; Whiting, S, 1999) |
| "Patients with cystic acne (CA) on Isotretinoin (Iso) therapy might present muscular symptoms as side effect of the drug." | 5.09 | L-carnitine supplementation in patients with cystic acne on isotretinoin therapy. ( Georgala, C; Georgala, S; Michas, T; Schulpis, KH, 1999) |
| "Low serum levels of the carnitine in chronic uremic patients treated by hemodialysis is one of the causes of muscle weakness." | 5.08 | [Levels of L-carnitine in serum of patients with chronic renal failure treated by hemodialysis (HD)]. ( Bombicki, K; Czarnecki, R; Kozioł, L; Wanic-Kossowska, M, 1998) |
| "Patients with carnitine insufficiency had a significantly higher prevalence of muscle weakness and a lower 6-min walk distance than those without carnitine insufficiency (P < 0." | 4.31 | Association of carnitine insufficiency with sarcopenia and dynapenia in patients with heart failure. ( Hirai, M; Kato, M; Kinugasa, Y; Nakamura, K; Sota, T; Yamamoto, K, 2023) |
| "Our data suggest three possible clinically actionable endotypes in primary OA: muscle weakness, arginine deficit and low inflammatory OA." | 4.02 | Endotypes of primary osteoarthritis identified by plasma metabolomics analysis. ( Furey, A; Liu, M; Rahman, P; Randell, EW; Sun, G; Werdyani, S; Zhai, G; Zhang, H, 2021) |
| "A 28-year-old Taiwanese woman presented with dyspnoea, poor appetite, and muscle weakness after using antiobesity drugs, including metformin, triiodothyronine, and topiramate." | 4.02 | Exacerbation of myopathy triggered by antiobesity drugs in a patient with multiple acyl-CoA dehydrogenase deficiency. ( Liang, WC; Liao, WA; Lin, PY; Sun, YT, 2021) |
| "The aim of this study was to elucidate the efficacy of the combination of L-carnitine and exercise, reported to prevent muscle wasting, for muscle complications (function, volume, and cramping) in patients with liver cirrhosis (LC) who received branched-chain amino acid supplementation." | 3.91 | Can L-carnitine supplementation and exercise improve muscle complications in patients with liver cirrhosis who receive branched-chain amino acid supplementation? ( Abe, M; Hiasa, Y; Hiraoka, A; Hirooka, M; Kiguchi, D; Matsuura, B; Michitaka, K; Ninomiya, T, 2019) |
| "Since it is a treatable disorder, this diagnosis must be considered by performing an acylcarnitine profile in all patients presenting with an unexplained muscular weakness." | 3.76 | [Multiple acyl-CoA dehydrogenase deficiency (MADD): a curable cause of genetic muscular lipidosis]. ( Acquaviva-Bourdain, C; Brivet, M; Eymard, B; Jardel, C; Laforêt, P; Lombès, A; Maillart, E; Rigal, O; Vianey-Saban, C, 2010) |
| "Weakness is common in both hyper- and hypothyroidism, and skeletal muscle L-carnitine may play a role in this regard, as suggested by studies indicating abnormal levels of carnitine in serum and urine of patients with thyroid dysfunction." | 3.73 | Muscle carnitine in hypo- and hyperthyroidism. ( Gilchrist, JM; Hennessey, JV; Kandula, M; Sinclair, C, 2005) |
| "To assess the role of carnitine in the skeletal myopathy present in anorexia nervosa." | 3.70 | Carnitine levels in patients with skeletal myopathy due to anorexia nervosa before and after refeeding. ( McLoughlin, DM; Morton, J; Russell, GF; Whiting, S, 1999) |
| "Treatment with carnitine, a compound essential for normal mitochondrial function, has been suggested to have significant benefits in such patients, so we carried out a study to see if carnitine acts by improving muscle bioenergetics and function." | 2.71 | Effects of carnitine supplementation on muscle metabolism by the use of magnetic resonance spectroscopy and near-infrared spectroscopy in end-stage renal disease. ( Altmann, P; Bonomo, Y; Cooper, R; Graham, K; Rajagopalan, B; Styles, P; Taylor, DJ; Vaux, EC, 2004) |
| "Not surprisingly, a group of muscle disorders due to defects in this system usually leads to the development of acute rhabdomyolysis in conditions such as infection, fasting and prolonged exercise." | 2.46 | State of the art in muscle lipid diseases. ( Liang, WC; Nishino, I, 2010) |
| "Muscle weakness is a nonspecific finding of myopathy of any etiology that include iatrogenic, toxic, endocrinological, infectious, immunologic, and metabolic disorders." | 1.51 | Two cases of glutaric aciduria type II: how to differentiate from inflammatory myopathies? ( Armagan, B; Erden, A; Kalyoncu, U; Karadag, O; Koca, M; Ozdamar, S; Sari, A; Yildiz, F, 2019) |
| "Severe pneumonia was the initial diagnosis." | 1.42 | Refractory Hyperlactatemia with Organ Insufficiency in Lipid Storage Myopathy. ( He, W; Li, Y; Liang, W; Liang, X; Liu, X; Xu, Y; Zhong, N; Zhou, L, 2015) |
| "In patients with homozygous beta thalassemia, the reduction of serum carnitine levels might play an important role in the appearance of muscular dysfunction." | 1.33 | Serum carnitine levels in patients with homozygous beta thalassemia: a possible new role for carnitine? ( Liapi-Adamidou, G; Tsagris, V, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (12.12) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 14 (42.42) | 24.3611 |
| 2020's | 5 (15.15) | 2.80 |
| Authors | Studies |
|---|---|
| Kinugasa, Y | 1 |
| Sota, T | 1 |
| Nakamura, K | 1 |
| Hirai, M | 1 |
| Kato, M | 1 |
| Yamamoto, K | 1 |
| Han, J | 1 |
| Song, X | 1 |
| Lu, S | 1 |
| Ji, G | 1 |
| Xie, Y | 1 |
| Wu, H | 1 |
| Werdyani, S | 1 |
| Liu, M | 1 |
| Zhang, H | 1 |
| Sun, G | 1 |
| Furey, A | 1 |
| Randell, EW | 1 |
| Rahman, P | 1 |
| Zhai, G | 1 |
| Lin, PY | 1 |
| Liang, WC | 3 |
| Liao, WA | 1 |
| Sun, YT | 1 |
| Vasiljevski, ER | 2 |
| Burns, J | 1 |
| Bray, P | 1 |
| Donlevy, G | 1 |
| Mudge, AJ | 1 |
| Jones, KJ | 1 |
| Summers, MA | 2 |
| Biggin, A | 1 |
| Munns, CF | 1 |
| McKay, MJ | 1 |
| Baldwin, JN | 1 |
| Little, DG | 2 |
| Schindeler, A | 2 |
| Horton, L | 1 |
| Henry, M | 1 |
| Conway, R | 1 |
| Kumar, B | 1 |
| Rupasinghe, T | 1 |
| Evesson, FJ | 1 |
| Mikulec, K | 1 |
| Peacock, L | 1 |
| Quinlan, KG | 1 |
| Cooper, ST | 1 |
| Roessner, U | 1 |
| Stevenson, DA | 1 |
| Koca, M | 1 |
| Erden, A | 1 |
| Armagan, B | 1 |
| Sari, A | 1 |
| Yildiz, F | 1 |
| Ozdamar, S | 1 |
| Kalyoncu, U | 1 |
| Karadag, O | 1 |
| Hiraoka, A | 1 |
| Kiguchi, D | 1 |
| Ninomiya, T | 1 |
| Hirooka, M | 1 |
| Abe, M | 1 |
| Matsuura, B | 1 |
| Hiasa, Y | 1 |
| Michitaka, K | 1 |
| Gautschi, M | 1 |
| Weisstanner, C | 1 |
| Slotboom, J | 1 |
| Nava, E | 1 |
| Zürcher, T | 1 |
| Nuoffer, JM | 1 |
| Xu, Y | 1 |
| Zhou, L | 1 |
| Liang, W | 1 |
| He, W | 1 |
| Liu, X | 1 |
| Liang, X | 1 |
| Zhong, N | 1 |
| Li, Y | 1 |
| Al-sharefi, A | 1 |
| Bilous, R | 1 |
| Yamada, K | 1 |
| Kobayashi, H | 1 |
| Bo, R | 1 |
| Takahashi, T | 1 |
| Purevsuren, J | 1 |
| Hasegawa, Y | 1 |
| Taketani, T | 1 |
| Fukuda, S | 1 |
| Ohkubo, T | 1 |
| Yokota, T | 1 |
| Watanabe, M | 1 |
| Tsunemi, T | 1 |
| Mizusawa, H | 1 |
| Takuma, H | 1 |
| Shioya, A | 1 |
| Ishii, A | 1 |
| Tamaoka, A | 1 |
| Shigematsu, Y | 1 |
| Sugie, H | 1 |
| Yamaguchi, S | 1 |
| Fu, HX | 1 |
| Liu, XY | 1 |
| Wang, ZQ | 1 |
| Jin, M | 1 |
| Wang, DN | 1 |
| He, JJ | 1 |
| Lin, MT | 1 |
| Wang, N | 1 |
| Ohkuma, A | 1 |
| Hayashi, YK | 1 |
| López, LC | 1 |
| Hirano, M | 1 |
| Nonaka, I | 1 |
| Noguchi, S | 1 |
| Chen, LH | 1 |
| Jong, YJ | 1 |
| Nishino, I | 2 |
| Laforêt, P | 2 |
| Acquaviva-Bourdain, C | 2 |
| Rigal, O | 2 |
| Brivet, M | 2 |
| Penisson-Besnier, I | 1 |
| Chabrol, B | 1 |
| Chaigne, D | 1 |
| Boespflug-Tanguy, O | 1 |
| Laroche, C | 1 |
| Bedat-Millet, AL | 1 |
| Behin, A | 1 |
| Delevaux, I | 1 |
| Lombès, A | 2 |
| Andresen, BS | 1 |
| Eymard, B | 2 |
| Vianey-Saban, C | 2 |
| Maillart, E | 1 |
| Jardel, C | 1 |
| Filippo, CA | 1 |
| Ardon, O | 1 |
| Longo, N | 1 |
| Ushikai, M | 1 |
| Horiuchi, M | 1 |
| Kobayashi, K | 1 |
| Matuda, S | 1 |
| Inui, A | 1 |
| Takeuchi, T | 1 |
| Saheki, T | 1 |
| Răşanu, T | 1 |
| Mehedinţi-Hâncu, M | 1 |
| Alexianu, M | 1 |
| Mehedinţi, T | 1 |
| Gheorghe, E | 1 |
| Damian, I | 1 |
| Miller, B | 1 |
| Ahmad, S | 1 |
| Karmaniolas, K | 1 |
| Ioannidis, P | 1 |
| Liatis, S | 1 |
| Dalamanga, M | 1 |
| Papalambros, T | 1 |
| Migdalis, I | 1 |
| Davenport, A | 1 |
| Vaux, EC | 1 |
| Taylor, DJ | 1 |
| Altmann, P | 1 |
| Rajagopalan, B | 1 |
| Graham, K | 1 |
| Cooper, R | 1 |
| Bonomo, Y | 1 |
| Styles, P | 1 |
| Tsagris, V | 1 |
| Liapi-Adamidou, G | 1 |
| Sinclair, C | 1 |
| Gilchrist, JM | 1 |
| Hennessey, JV | 1 |
| Kandula, M | 1 |
| Rathod, R | 1 |
| Baig, MS | 1 |
| Khandelwal, PN | 1 |
| Kulkarni, SG | 1 |
| Gade, PR | 1 |
| Siddiqui, S | 1 |
| Barth, PG | 1 |
| Wanders, RJ | 1 |
| Ruitenbeek, W | 1 |
| Roe, C | 1 |
| Scholte, HR | 1 |
| van der Harten, H | 1 |
| van Moorsel, J | 1 |
| Duran, M | 1 |
| Dingemans, KP | 1 |
| Wanic-Kossowska, M | 1 |
| Bombicki, K | 1 |
| Kozioł, L | 1 |
| Czarnecki, R | 1 |
| Morton, J | 1 |
| McLoughlin, DM | 1 |
| Whiting, S | 1 |
| Russell, GF | 1 |
| Georgala, S | 1 |
| Schulpis, KH | 1 |
| Georgala, C | 1 |
| Michas, T | 1 |
| Lucas, M | 1 |
| Hinojosa, M | 1 |
| Rodríguez, A | 1 |
| Garcia-Guasch, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fat and Sugar Metabolism During Exercise in Patients With Metabolic Myopathy[NCT02635269] | 60 participants (Actual) | Interventional | 2016-01-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for carnitine and Muscle Weakness
| Article | Year |
|---|---|
State of the art in muscle lipid diseases.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Cardiomyopathies; Carnitine; Carnitine O-Palmitoyltransferase; H | 2010 |
A review of the impact of L-carnitine therapy on patient functionality in maintenance hemodialysis.
Topics: Activities of Daily Living; Carnitine; Humans; Kidney Failure, Chronic; Muscle Weakness; Quality of | 2003 |
5 trials available for carnitine and Muscle Weakness
| Article | Year |
|---|---|
L-carnitine supplementation for muscle weakness and fatigue in children with neurofibromatosis type 1: A Phase 2a clinical trial.
Topics: Cardiomyopathies; Carnitine; Child; Dietary Supplements; Fatigue; Female; Humans; Hyperammonemia; Ma | 2021 |
Effects of carnitine supplementation on muscle metabolism by the use of magnetic resonance spectroscopy and near-infrared spectroscopy in end-stage renal disease.
Topics: Blood Chemical Analysis; Carnitine; Double-Blind Method; Energy Metabolism; Exercise Test; Exercise | 2004 |
Results of a single blind, randomized, placebo-controlled clinical trial to study the effect of intravenous L-carnitine supplementation on health-related quality of life in Indian patients on maintenance hemodialysis.
Topics: Adult; Carnitine; Dietary Supplements; Female; Humans; India; Injections, Intravenous; Kidney Failur | 2006 |
[Levels of L-carnitine in serum of patients with chronic renal failure treated by hemodialysis (HD)].
Topics: Adult; Carnitine; Electromyography; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Musc | 1998 |
L-carnitine supplementation in patients with cystic acne on isotretinoin therapy.
Topics: Acne Vulgaris; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Carni | 1999 |
26 other studies available for carnitine and Muscle Weakness
| Article | Year |
|---|---|
Association of carnitine insufficiency with sarcopenia and dynapenia in patients with heart failure.
Topics: Carnitine; Hand Strength; Heart Failure; Humans; Muscle Strength; Muscle Weakness; Muscle, Skeletal; | 2023 |
Adolescent Hyperuricemia with Lipid Storage Myopathy: A Clinical Study.
Topics: Adolescent; Adult; Carnitine; Child; China; Electron-Transferring Flavoproteins; Female; Humans; Hyp | 2019 |
Endotypes of primary osteoarthritis identified by plasma metabolomics analysis.
Topics: Aged; Arginine; Body Mass Index; Carnitine; Case-Control Studies; Coronary Disease; Diabetes Mellitu | 2021 |
Exacerbation of myopathy triggered by antiobesity drugs in a patient with multiple acyl-CoA dehydrogenase deficiency.
Topics: Adult; Anti-Obesity Agents; Asian People; Carnitine; Female; Humans; Metformin; Multiple Acyl Coenzy | 2021 |
An Intriguing Case of Acute Left-Sided Weakness in a 4-Year-Old Boy.
Topics: Baclofen; Carnitine; Child, Preschool; Diagnosis, Differential; Diet, Ketogenic; Humans; Leigh Disea | 2021 |
Dietary intervention rescues myopathy associated with neurofibromatosis type 1.
Topics: Adolescent; Adult; Animals; Carnitine; Child; Child, Preschool; Fatty Acids; Female; Humans; Lipid M | 2018 |
Two cases of glutaric aciduria type II: how to differentiate from inflammatory myopathies?
Topics: Acyl-CoA Dehydrogenase; Adolescent; Biopsy; Carnitine; Diagnosis, Differential; Female; Humans; Late | 2019 |
Can L-carnitine supplementation and exercise improve muscle complications in patients with liver cirrhosis who receive branched-chain amino acid supplementation?
Topics: Aged; Amino Acids, Branched-Chain; Carnitine; Dietary Supplements; Electric Impedance; Exercise Ther | 2019 |
Highly efficient ketone body treatment in multiple acyl-CoA dehydrogenase deficiency-related leukodystrophy.
Topics: Brain; Carnitine; Child, Preschool; Coma; Consanguinity; Dietary Fats; Hereditary Central Nervous Sy | 2015 |
Refractory Hyperlactatemia with Organ Insufficiency in Lipid Storage Myopathy.
Topics: Adolescent; Bronchitis; Carnitine; Female; Humans; Hyperlactatemia; Lipid Metabolism, Inborn Errors; | 2015 |
Reversible weakness and encephalopathy while on long-term valproate treatment due to carnitine deficiency.
Topics: Adult; Antimanic Agents; Brain Diseases; Cardiomyopathies; Carnitine; Female; Humans; Hyperammonemia | 2015 |
Clinical, biochemical and molecular investigation of adult-onset glutaric acidemia type II: Characteristics in comparison with pediatric cases.
Topics: Adult; Age Factors; Carnitine; Humans; Male; Multiple Acyl Coenzyme A Dehydrogenase Deficiency; Musc | 2016 |
Significant clinical heterogeneity with similar ETFDH genotype in three Chinese patients with late-onset multiple acyl-CoA dehydrogenase deficiency.
Topics: Adolescent; Adult; Aged; Carnitine; Computational Biology; DNA Mutational Analysis; Electron-Transfe | 2016 |
ETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency.
Topics: Adult; Age of Onset; Asian People; Carnitine; Child; DNA Mutational Analysis; Electron Transport; El | 2009 |
Diagnostic assessment and long-term follow-up of 13 patients with Very Long-Chain Acyl-Coenzyme A dehydrogenase (VLCAD) deficiency.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Adult; Biomarkers; Carnitine; Cells, Cultured; Child | 2009 |
[Multiple acyl-CoA dehydrogenase deficiency (MADD): a curable cause of genetic muscular lipidosis].
Topics: Acyl-CoA Dehydrogenases; Adult; Biopsy; Brain Diseases, Metabolic; Carnitine; Coloring Agents; DNA M | 2010 |
Glycosylation of the OCTN2 carnitine transporter: study of natural mutations identified in patients with primary carnitine deficiency.
Topics: Amino Acid Substitution; Animals; Biological Transport; Blotting, Western; Cardiomyopathies; Carniti | 2011 |
Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart.
Topics: Animals; Cardiomyopathies; Carnitine; Disease Models, Animal; Female; Glucose; Hyperammonemia; Male; | 2011 |
Carnitine deficiency.
Topics: Biopsy; Carnitine; Child; Diagnosis, Differential; Disease Progression; Electromyography; Female; He | 2012 |
Primary carnitine deficiency in a male adult.
Topics: Adult; Carnitine; Creatine Kinase; Humans; Lipid Metabolism; Male; Muscle Weakness; Muscle, Skeletal | 2002 |
Carnitine: a false dawn in the treatment of muscle weakness in end-stage renal failure patients?
Topics: Carnitine; Exercise Tolerance; Humans; Kidney Failure, Chronic; Mitochondria, Muscle; Muscle Weaknes | 2004 |
Serum carnitine levels in patients with homozygous beta thalassemia: a possible new role for carnitine?
Topics: Adolescent; Adult; beta-Thalassemia; Carnitine; Case-Control Studies; Child; Child, Preschool; Fatty | 2005 |
Muscle carnitine in hypo- and hyperthyroidism.
Topics: Adult; Biopsy; Carnitine; Down-Regulation; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Mi | 2005 |
Infantile fibre type disproportion, myofibrillar lysis and cardiomyopathy: a disorder in three unrelated Dutch families.
Topics: Cardiomyopathy, Dilated; Carnitine; Fatty Acids; Female; Humans; Infant; Male; Microscopy, Electron; | 1998 |
Carnitine levels in patients with skeletal myopathy due to anorexia nervosa before and after refeeding.
Topics: Adult; Anorexia Nervosa; Body Mass Index; Carnitine; Female; Humans; Mitochondrial Myopathies; Muscl | 1999 |
Anaesthesia in lipid myopathy.
Topics: Anesthesia, Epidural; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Local; Carnitine; C | 2000 |