carnitine has been researched along with Muscle Cramp in 18 studies
Muscle Cramp: A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted electronic searches in PubMed, Embase and Cochrane Central Register of Controlled Trials from January 1960 to 19th November 2021 to identify randomized controlled studies (RCTs), which examined the effects of oral or intravenous levocarnitine (L-carnitine) on dialysis-related hypotension among hemodialysis patients." | 9.22 | The effect of levocarnitine supplementation on dialysis-related hypotension: A systematic review, meta-analysis, and trial sequential analysis. ( Cellini, J; Chewcharat, A; Chewcharat, P; Liu, W; Melendez Young, JA; Nigwekar, SU; Phipps, EA, 2022) |
| "Leg cramping is a common side effect of hemodialysis, and this is frequently treated by the administration of carnitine, but this is not effective in every patient." | 9.12 | The pathophysiology of leg cramping during dialysis and the use of carnitine in its treatment. ( Takahashi, A, 2021) |
| "L-Carnitine is an endogenous compound thought to be helpful in treating patients with dialysis-related hypotension and muscle cramps; however, sufficient evidence for these indications is lacking." | 8.84 | Effects of L-carnitine on dialysis-related hypotension and muscle cramps: a meta-analysis. ( Berlin, JA; Brunelli, SM; Feldman, HI; Flory, J; Lynch, KE; Rowan, CG, 2008) |
| "l-carnitine, a compound responsible for transportation of acyl groups across cell membranes and modulating intracellular acyl-coenzyme A levels, is reported to reduce muscle cramps in patients with liver cirrhosis and diabetes and those on dialysis." | 7.96 | Effect of l-carnitine supplementation on muscle cramps induced by stroke: A case report. ( Hanai, T; Katsumura, N; Miwa, T; Morino, K; Shimizu, M, 2020) |
| "The aim of this study was to elucidate the efficacy of the combination of L-carnitine and exercise, reported to prevent muscle wasting, for muscle complications (function, volume, and cramping) in patients with liver cirrhosis (LC) who received branched-chain amino acid supplementation." | 7.91 | Can L-carnitine supplementation and exercise improve muscle complications in patients with liver cirrhosis who receive branched-chain amino acid supplementation? ( Abe, M; Hiasa, Y; Hiraoka, A; Hirooka, M; Kiguchi, D; Matsuura, B; Michitaka, K; Ninomiya, T, 2019) |
| "We performed a prospective study to evaluate the ability of L-carnitine, which is involved in the β-oxidation of fatty acids, to reduce muscle cramps in patients with cirrhosis." | 7.81 | L-carnitine Reduces Muscle Cramps in Patients With Cirrhosis. ( Asano, Y; Gondo, K; Hattori, N; Hosokawa, T; Itakura, J; Izumi, N; Kurosaki, M; Matsuda, S; Nakakuki, N; Nakanishi, H; Suzuki, S; Takada, H; Takahashi, Y; Tamaki, N; Tsuchiya, K; Yasui, Y, 2015) |
| "Carnitine plays a crucial role in the metabolism of fatty acids as well as energy production." | 5.72 | Evaluation of the relationship between serum carnitine levels and intradialytic complications in children with kidney failure. ( Abbasi, A; Askarian, F; Bakhtiari Koohsorkhi, M; Bazargani, B; Fahimi, D; Moghtaderi, M; Mojtahedi, SY; Samimi, M, 2022) |
| "Muscle cramps are side effects commonly associated with tyrosine kinase inhibitor (TKI) treatment." | 5.43 | [Efficacy of levocarnitine for tyrosine kinase inhibitor-induced painful muscle cramps in patients with chronic myelogenous leukemia]. ( Abe, T; Fujii, S; Hamaguchi, K; Horiguchi, H; Ito, R; Kato, J; Kuroda, H; Maeda, M; Nakamura, H; Sato, K; Shimoyama, S; Sugama, Y; Yamada, M; Yamauchi, N, 2016) |
| "We conducted electronic searches in PubMed, Embase and Cochrane Central Register of Controlled Trials from January 1960 to 19th November 2021 to identify randomized controlled studies (RCTs), which examined the effects of oral or intravenous levocarnitine (L-carnitine) on dialysis-related hypotension among hemodialysis patients." | 5.22 | The effect of levocarnitine supplementation on dialysis-related hypotension: A systematic review, meta-analysis, and trial sequential analysis. ( Cellini, J; Chewcharat, A; Chewcharat, P; Liu, W; Melendez Young, JA; Nigwekar, SU; Phipps, EA, 2022) |
| "Leg cramping is a common side effect of hemodialysis, and this is frequently treated by the administration of carnitine, but this is not effective in every patient." | 5.12 | The pathophysiology of leg cramping during dialysis and the use of carnitine in its treatment. ( Takahashi, A, 2021) |
| "L-Carnitine is an endogenous compound thought to be helpful in treating patients with dialysis-related hypotension and muscle cramps; however, sufficient evidence for these indications is lacking." | 4.84 | Effects of L-carnitine on dialysis-related hypotension and muscle cramps: a meta-analysis. ( Berlin, JA; Brunelli, SM; Feldman, HI; Flory, J; Lynch, KE; Rowan, CG, 2008) |
| "l-carnitine, a compound responsible for transportation of acyl groups across cell membranes and modulating intracellular acyl-coenzyme A levels, is reported to reduce muscle cramps in patients with liver cirrhosis and diabetes and those on dialysis." | 3.96 | Effect of l-carnitine supplementation on muscle cramps induced by stroke: A case report. ( Hanai, T; Katsumura, N; Miwa, T; Morino, K; Shimizu, M, 2020) |
| "The aim of this study was to elucidate the efficacy of the combination of L-carnitine and exercise, reported to prevent muscle wasting, for muscle complications (function, volume, and cramping) in patients with liver cirrhosis (LC) who received branched-chain amino acid supplementation." | 3.91 | Can L-carnitine supplementation and exercise improve muscle complications in patients with liver cirrhosis who receive branched-chain amino acid supplementation? ( Abe, M; Hiasa, Y; Hiraoka, A; Hirooka, M; Kiguchi, D; Matsuura, B; Michitaka, K; Ninomiya, T, 2019) |
| "We performed a prospective study to evaluate the ability of L-carnitine, which is involved in the β-oxidation of fatty acids, to reduce muscle cramps in patients with cirrhosis." | 3.81 | L-carnitine Reduces Muscle Cramps in Patients With Cirrhosis. ( Asano, Y; Gondo, K; Hattori, N; Hosokawa, T; Itakura, J; Izumi, N; Kurosaki, M; Matsuda, S; Nakakuki, N; Nakanishi, H; Suzuki, S; Takada, H; Takahashi, Y; Tamaki, N; Tsuchiya, K; Yasui, Y, 2015) |
| "L-carnitine treatment was associated with a significant drop in pre-dialysis concentrations of serum urea nitrogen, creatinine and phosphorus (means +/- SEM, 101 +/- 4." | 2.67 | Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. ( Ahmad, S; Ashbrook, DW; Golper, TA; Hirschberg, R; Katz, LA; Kopple, JD; Kurtin, P; Nicora, R; Robertson, HT; Wolfson, M, 1990) |
| "Carnitine plays a crucial role in the metabolism of fatty acids as well as energy production." | 1.72 | Evaluation of the relationship between serum carnitine levels and intradialytic complications in children with kidney failure. ( Abbasi, A; Askarian, F; Bakhtiari Koohsorkhi, M; Bazargani, B; Fahimi, D; Moghtaderi, M; Mojtahedi, SY; Samimi, M, 2022) |
| "Muscle cramps are side effects commonly associated with tyrosine kinase inhibitor (TKI) treatment." | 1.43 | [Efficacy of levocarnitine for tyrosine kinase inhibitor-induced painful muscle cramps in patients with chronic myelogenous leukemia]. ( Abe, T; Fujii, S; Hamaguchi, K; Horiguchi, H; Ito, R; Kato, J; Kuroda, H; Maeda, M; Nakamura, H; Sato, K; Shimoyama, S; Sugama, Y; Yamada, M; Yamauchi, N, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 5 (27.78) | 2.80 |
| Authors | Studies |
|---|---|
| Takahashi, A | 1 |
| Bazargani, B | 1 |
| Mojtahedi, SY | 1 |
| Fahimi, D | 1 |
| Askarian, F | 1 |
| Moghtaderi, M | 1 |
| Abbasi, A | 1 |
| Samimi, M | 1 |
| Bakhtiari Koohsorkhi, M | 1 |
| Chewcharat, A | 1 |
| Chewcharat, P | 1 |
| Liu, W | 1 |
| Cellini, J | 1 |
| Phipps, EA | 1 |
| Melendez Young, JA | 1 |
| Nigwekar, SU | 1 |
| Chae, H | 1 |
| Ryu, MH | 1 |
| Ma, J | 1 |
| Beck, M | 1 |
| Kang, YK | 1 |
| Miwa, T | 1 |
| Hanai, T | 1 |
| Morino, K | 1 |
| Katsumura, N | 1 |
| Shimizu, M | 1 |
| Imbe, A | 1 |
| Tanimoto, K | 1 |
| Inaba, Y | 1 |
| Sakai, S | 1 |
| Shishikura, K | 1 |
| Imbe, H | 1 |
| Tanimoto, Y | 1 |
| Terasaki, J | 1 |
| Imagawa, A | 1 |
| Hanafusa, T | 1 |
| Hiraoka, A | 2 |
| Kiguchi, D | 1 |
| Ninomiya, T | 1 |
| Hirooka, M | 1 |
| Abe, M | 1 |
| Matsuura, B | 1 |
| Hiasa, Y | 1 |
| Michitaka, K | 2 |
| Yoshiji, H | 1 |
| Iwasa, M | 1 |
| Nakanishi, H | 2 |
| Karino, Y | 1 |
| Nakajima, T | 1 |
| Miyaaki, H | 1 |
| Shiraki, M | 1 |
| Kawaguchi, T | 1 |
| Sawada, Y | 1 |
| Okita, K | 1 |
| Vidot, H | 1 |
| Carey, S | 1 |
| Allman-Farinelli, M | 1 |
| Shackel, N | 1 |
| Kurosaki, M | 1 |
| Tsuchiya, K | 1 |
| Nakakuki, N | 1 |
| Takada, H | 1 |
| Matsuda, S | 1 |
| Gondo, K | 1 |
| Asano, Y | 1 |
| Hattori, N | 1 |
| Tamaki, N | 1 |
| Suzuki, S | 1 |
| Yasui, Y | 1 |
| Hosokawa, T | 1 |
| Itakura, J | 1 |
| Takahashi, Y | 1 |
| Izumi, N | 1 |
| Mehta, SS | 1 |
| Fallon, MB | 1 |
| Yamada, M | 1 |
| Kuroda, H | 1 |
| Shimoyama, S | 1 |
| Ito, R | 1 |
| Sugama, Y | 1 |
| Sato, K | 1 |
| Yamauchi, N | 1 |
| Horiguchi, H | 1 |
| Nakamura, H | 1 |
| Hamaguchi, K | 1 |
| Abe, T | 1 |
| Fujii, S | 1 |
| Maeda, M | 1 |
| Kato, J | 1 |
| Lynch, KE | 1 |
| Feldman, HI | 1 |
| Berlin, JA | 1 |
| Flory, J | 1 |
| Rowan, CG | 1 |
| Brunelli, SM | 1 |
| Rathod, R | 1 |
| Baig, MS | 1 |
| Khandelwal, PN | 1 |
| Kulkarni, SG | 1 |
| Gade, PR | 1 |
| Siddiqui, S | 1 |
| Bellinghieri, G | 1 |
| Savica, V | 1 |
| Mallamace, A | 1 |
| Di Stefano, C | 1 |
| Consolo, F | 1 |
| Spagnoli, LG | 1 |
| Villaschi, S | 1 |
| Palmieri, G | 1 |
| Corsi, M | 1 |
| Maccari, F | 1 |
| Ionasescu, V | 1 |
| Hug, G | 1 |
| Hoppel, C | 1 |
| Mujais, SK | 1 |
| Ahmad, S | 1 |
| Robertson, HT | 1 |
| Golper, TA | 1 |
| Wolfson, M | 1 |
| Kurtin, P | 1 |
| Katz, LA | 1 |
| Hirschberg, R | 1 |
| Nicora, R | 1 |
| Ashbrook, DW | 1 |
| Kopple, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Study of L-carnitine vs Placebo for the Treatment of Muscle Cramps After Imatinib in Patients With Gastrointestinal Stromal Tumors (GISTs) (Single-center Study)[NCT03426722] | Phase 3 | 4 participants (Actual) | Interventional | 2018-03-01 | Completed | ||
| Effect of Branched-chain Amino Acids (BCAA) to Muscle Cramps in Patients With Cirrhosis[NCT05724485] | Phase 4 | 50 participants (Anticipated) | Interventional | 2023-04-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for carnitine and Muscle Cramp
| Article | Year |
|---|---|
The pathophysiology of leg cramping during dialysis and the use of carnitine in its treatment.
Topics: Animals; Carnitine; Humans; Leg; Muscle Cramp; Neuromuscular Agents; Renal Dialysis | 2021 |
The effect of levocarnitine supplementation on dialysis-related hypotension: A systematic review, meta-analysis, and trial sequential analysis.
Topics: Carnitine; Dietary Supplements; Humans; Hypotension; Muscle Cramp; Renal Dialysis | 2022 |
Systematic review: the treatment of muscle cramps in patients with cirrhosis.
Topics: Albumins; Amino Acids, Branched-Chain; Carnitine; Humans; Liver Cirrhosis; Muscle Cramp; Propiopheno | 2014 |
Effects of L-carnitine on dialysis-related hypotension and muscle cramps: a meta-analysis.
Topics: Carnitine; Humans; Hypotension; Muscle Cramp; Renal Dialysis | 2008 |
Muscle cramps during hemodialysis.
Topics: Blood Volume; Carnitine; Glucose; Humans; Mannitol; Muscle Cramp; Quinine; Renal Dialysis; Saline So | 1994 |
4 trials available for carnitine and Muscle Cramp
| Article | Year |
|---|---|
Impact of L-carnitine on imatinib-related muscle cramps in patients with gastrointestinal stromal tumor.
Topics: Activities of Daily Living; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carni | 2020 |
Results of a single blind, randomized, placebo-controlled clinical trial to study the effect of intravenous L-carnitine supplementation on health-related quality of life in Indian patients on maintenance hemodialysis.
Topics: Adult; Carnitine; Dietary Supplements; Female; Humans; India; Injections, Intravenous; Kidney Failur | 2006 |
Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients.
Topics: Adult; Asthenia; Carnitine; Double-Blind Method; Female; Humans; Kidney Failure, Chronic; Male; Midd | 1983 |
Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects.
Topics: Carnitine; Double-Blind Method; Exercise; Female; Humans; Hypotension; Kidney Failure, Chronic; Male | 1990 |
9 other studies available for carnitine and Muscle Cramp
| Article | Year |
|---|---|
Evaluation of the relationship between serum carnitine levels and intradialytic complications in children with kidney failure.
Topics: Adolescent; Cardiomyopathies; Carnitine; Child; Humans; Hyperammonemia; Hypotension; Kidney Failure, | 2022 |
Effect of l-carnitine supplementation on muscle cramps induced by stroke: A case report.
Topics: Aged; Carnitine; Dietary Supplements; Humans; Leg; Male; Muscle Cramp; Stroke | 2020 |
Effects of L-carnitine supplementation on the quality of life in diabetic patients with muscle cramps.
Topics: Adult; Aged; Carnitine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hypogl | 2018 |
Can L-carnitine supplementation and exercise improve muscle complications in patients with liver cirrhosis who receive branched-chain amino acid supplementation?
Topics: Aged; Amino Acids, Branched-Chain; Carnitine; Dietary Supplements; Electric Impedance; Exercise Ther | 2019 |
Clinical features of liver cirrhosis patients with muscle cramping: a multicenter study.
Topics: Aged; Carnitine; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Liver Cirrhosis; Male; | 2019 |
L-carnitine Reduces Muscle Cramps in Patients With Cirrhosis.
Topics: Carnitine; Drug-Related Side Effects and Adverse Reactions; Humans; Liver Cirrhosis; Muscle Cramp; P | 2015 |
Muscle Cramps in Cirrhosis: A Moving Target.
Topics: Carnitine; Humans; Liver Cirrhosis; Muscle Cramp | 2015 |
[Efficacy of levocarnitine for tyrosine kinase inhibitor-induced painful muscle cramps in patients with chronic myelogenous leukemia].
Topics: Adult; Carnitine; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Muscl | 2016 |
Combined partial deficiency of muscle carnitine palmitoyltransferase and carnitine with autosomal dominant inheritance.
Topics: Acyltransferases; Adult; Carnitine; Carnitine O-Palmitoyltransferase; Female; Humans; Middle Aged; M | 1980 |