carnitine has been researched along with Multiple Sclerosis in 9 studies
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The serum concentrations of total, free and acylcarnitine were compared in 25 patients with multiple sclerosis (MS) and among age- and sex-matched normal controls by the new enzymatic cycling method in order to clarify whether the fatigue in MS might be due to possible carnitine-related fatty acid metabolic abnormalities in the mitochondria of skeletal muscles." | 7.69 | Serum carnitine and disabling fatigue in multiple sclerosis. ( Fukazawa, T; Hamada, T; Kikuchi, S; Sasaki, H; Tashiro, K, 1996) |
| "Although frank symptomatic biotin deficiency is rare, some evidence suggests that marginal biotin deficiency occurs spontaneously in a substantial proportion of women during normal human pregnancy and might confer an increased risk of birth defects." | 4.95 | Biotin: From Nutrition to Therapeutics. ( Mock, DM, 2017) |
| " We included studies investigating pemoline and modafinil in participants with multiple sclerosis (MS)-associated fatigue and methylphenidate in patients suffering from advanced cancer and fatigue in meta-analysis." | 4.91 | Pharmacological treatments for fatigue associated with palliative care. ( Cuhls, H; Minton, O; Mücke, M; Peuckmann-Post, V; Radbruch, L; Stone, P, 2015) |
| "The serum concentrations of total, free and acylcarnitine were compared in 25 patients with multiple sclerosis (MS) and among age- and sex-matched normal controls by the new enzymatic cycling method in order to clarify whether the fatigue in MS might be due to possible carnitine-related fatty acid metabolic abnormalities in the mitochondria of skeletal muscles." | 3.69 | Serum carnitine and disabling fatigue in multiple sclerosis. ( Fukazawa, T; Hamada, T; Kikuchi, S; Sasaki, H; Tashiro, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Teixeira, CF | 1 |
| Azzolin, VF | 1 |
| Rodrigues Dos Passos, G | 1 |
| Turra, BO | 1 |
| Alves, AO | 1 |
| Bressanim, ACM | 1 |
| Canton, LEL | 1 |
| Vieira Dos Santos, AC | 1 |
| Mastella, MH | 1 |
| Barbisan, F | 1 |
| Ribeiro, EE | 1 |
| Duarte, T | 1 |
| Duarte, MMMF | 1 |
| Bonotto, NCA | 1 |
| Sato, DK | 1 |
| da Cruz, IBM | 1 |
| Mock, DM | 1 |
| Rossi, C | 3 |
| Cicalini, I | 2 |
| Zucchelli, M | 2 |
| di Ioia, M | 3 |
| Onofrj, M | 2 |
| Federici, L | 2 |
| Del Boccio, P | 3 |
| Pieragostino, D | 3 |
| Agnifili, L | 1 |
| Mastropasqua, L | 1 |
| De Luca, G | 1 |
| D'Alessandro, M | 1 |
| Urbani, A | 1 |
| Di Ilio, C | 1 |
| Lugaresi, A | 1 |
| Sacchetta, P | 1 |
| Akaishi, T | 1 |
| Nakashima, I | 1 |
| Misu, T | 1 |
| Fujihara, K | 1 |
| Aoki, M | 1 |
| Mücke, M | 1 |
| Cuhls, H | 1 |
| Peuckmann-Post, V | 1 |
| Minton, O | 1 |
| Stone, P | 1 |
| Radbruch, L | 1 |
| Laffon-Pioger, M | 1 |
| Rocher, F | 1 |
| Caruba, C | 1 |
| Cohen, M | 1 |
| Thomas, P | 1 |
| Lebrun, C | 1 |
| Fukazawa, T | 1 |
| Sasaki, H | 1 |
| Kikuchi, S | 1 |
| Hamada, T | 1 |
| Tashiro, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Proteomic and Lipidomic Profiling of Coronary Thrombus in Acute Myocardial Infarction[NCT03731884] | 50 participants (Anticipated) | Observational | 2017-01-01 | Recruiting | |||
| Feasibility Study of Adjunctive Bright Light Therapy (BLT) for Amelioration of Fatigue in Chinese Cancer Patients Admitted to a Palliative Care Unit[NCT04525924] | 42 participants (Anticipated) | Interventional | 2020-08-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for carnitine and Multiple Sclerosis
| Article | Year |
|---|---|
Biotin: From Nutrition to Therapeutics.
Topics: Animals; Biotin; Biotinylation; Carnitine; Female; Gene Expression; Hormones; Humans; Multiple Scler | 2017 |
Pharmacological treatments for fatigue associated with palliative care.
Topics: Adult; Amantadine; Benzhydryl Compounds; Carnitine; Central Nervous System Stimulants; Chronic Disea | 2015 |
1 trial available for carnitine and Multiple Sclerosis
| Article | Year |
|---|---|
Carnitine serum levels and levocarnitine administration in multiple sclerosis patients treated with natalizumab.
Topics: Antibodies, Monoclonal, Humanized; Carnitine; Cohort Studies; Fatigue Syndrome, Chronic; Female; Hum | 2011 |
6 other studies available for carnitine and Multiple Sclerosis
| Article | Year |
|---|---|
A coffee enriched with guarana, selenium, and l-carnitine (GSC) has nutrigenomic effects on oxi-inflammatory markers of relapsing-remitting multiple sclerosis patients: A pilot study.
Topics: Carnitine; Coffee; Cytokines; Humans; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; N | 2023 |
Metabolomic Signature in Sera of Multiple Sclerosis Patients during Pregnancy.
Topics: Adult; Amino Acids; Biomarkers; Carnitine; Case-Control Studies; Female; Gonadal Steroid Hormones; H | 2018 |
Integrated Lipidomics and Metabolomics Analysis of Tears in Multiple Sclerosis: An Insight into Diagnostic Potential of Lacrimal Fluid.
Topics: Adult; Amino Acids; Biomarkers; Carnitine; Central Nervous System; Chromatography, Liquid; Female; H | 2019 |
An integrated metabolomics approach for the research of new cerebrospinal fluid biomarkers of multiple sclerosis.
Topics: Biomarkers; Carnitine; Glutamic Acid; Humans; Lipids; Metabolome; Metabolomics; Multiple Sclerosis | 2015 |
Depressive state and chronic fatigue in multiple sclerosis and neuromyelitis optica.
Topics: Adult; Aged; Carnitine; Chronic Disease; Comorbidity; Depression; Fatigue; Female; Gait Disorders, N | 2015 |
Serum carnitine and disabling fatigue in multiple sclerosis.
Topics: Adult; Carnitine; Fatigue; Fatigue Syndrome, Chronic; Female; Humans; Male; Mitochondria, Muscle; Mu | 1996 |