carnitine has been researched along with Injury, Myocardial Reperfusion in 45 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Long-chain acylcarnitines (LCA) have been shown to accumulate during myocardial ischemia and to contribute to malignant derangements characteristic of ischemia." | 3.68 | Reperfusion-induced accumulation of long-chain acylcarnitines in previously ischemic myocardium. ( Adames, VR; Heathers, GP; Higgins, AJ; Su, CM, 1993) |
| "L-carnitine was added to the crystalloid cardioplegic solution for experimental group 1 (3 g/L) and experimental group 2 (6 g/L), whereas no L-carnitine was used in the control group." | 2.82 | Myocardial Protective Effects of L-Carnitine on Ischemia-Reperfusion Injury in Patients With Rheumatic Valvular Heart Disease Undergoing Cardiac Surgery. ( Li, M; Sun, H; Xu, S; Xue, L, 2016) |
| "L-carnitine was added to the crystalloid cardioplegic solution for experimental group 1 (6 g/L) and experimental group 2 (12 g/L), whereas no L-carnitine was used in the control group." | 1.51 | The protective effects of L-carnitine on myocardial ischaemia-reperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF-κB pathway and the activation of Nrf2 pathway. ( Deng, C; Geng, Y; Hao, J; Li, M; Li, W; Li, Y; Sun, L; Wang, H; Wang, R; Xu, S; Xue, L; Yan, Y; Yi, Q; Zhang, Y, 2019) |
| "Carnitine is a vital biologic substance facilitating fatty acids transport into mitochondria for ATP production." | 1.36 | Pharmacological preconditioning with L-carnitine: relevance to myocardial hemodynamic function and glycogen and lactate content. ( Garjani, A; Ghorbani-Haghjo, A; Javidnia, A; Mohammadi, S; Najafi, M, 2010) |
| "Carnitine deficiency was induced in Sprague-Dawley rats by supplementing the drinking water with sodium pivalate for a period of 2 weeks." | 1.31 | Short-term carnitine deficiency does not alter aerobic rat heart function but depresses reperfusion recovery after ischemia. ( Broderick, TL; Cifuentes, J; Green, D; Paulson, DJ, 2001) |
| "L-Carnitine has been shown to improve the post-ischemic recovery of myocardial function and metabolic measurements that are reduced in the course of ischemia and reperfusion of the heart." | 1.30 | The dose-dependent effects of L-carnitine in myocardial protection in normothermic ischemia. ( Ersöz, A; Gökgöz, L; Kalaycioğlu, S; Oktar, L; Oz, E; Sinci, V; Soncul, H; Tatlican, O; Türközkan, N; Yener, A, 1998) |
| "3." | 1.28 | Effect of D,L-carnitine on the response of the isolated heart of the rat to ischaemia and reperfusion: relation to mitochondrial function. ( Duan, JM; Karmazyn, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.22) | 18.7374 |
| 1990's | 20 (44.44) | 18.2507 |
| 2000's | 14 (31.11) | 29.6817 |
| 2010's | 9 (20.00) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Li, M | 2 |
| Xu, S | 2 |
| Geng, Y | 1 |
| Sun, L | 1 |
| Wang, R | 1 |
| Yan, Y | 1 |
| Wang, H | 1 |
| Li, Y | 1 |
| Yi, Q | 1 |
| Zhang, Y | 1 |
| Hao, J | 1 |
| Deng, C | 1 |
| Li, W | 1 |
| Xue, L | 2 |
| Zhao, T | 1 |
| Chen, S | 1 |
| Wang, B | 1 |
| Cai, D | 1 |
| Xue, M | 1 |
| Chen, X | 1 |
| Guo, Z | 1 |
| Liu, X | 1 |
| Bi, Y | 1 |
| Yin, J | 1 |
| Hu, H | 1 |
| Zhu, P | 1 |
| Zhuang, J | 1 |
| Cates, C | 1 |
| Rousselle, T | 1 |
| Li, J | 1 |
| Wang, ZY | 1 |
| Liu, YY | 1 |
| Liu, GH | 1 |
| Lu, HB | 1 |
| Mao, CY | 1 |
| Liepinsh, E | 3 |
| Skapare, E | 1 |
| Kuka, J | 3 |
| Makrecka, M | 2 |
| Cirule, H | 2 |
| Vavers, E | 1 |
| Sevostjanovs, E | 2 |
| Grinberga, S | 1 |
| Pugovics, O | 2 |
| Dambrova, M | 3 |
| Lou, PH | 1 |
| Lucchinetti, E | 1 |
| Zhang, L | 1 |
| Affolter, A | 1 |
| Schaub, MC | 1 |
| Gandhi, M | 1 |
| Hersberger, M | 1 |
| Warren, BE | 1 |
| Lemieux, H | 1 |
| Sobhi, HF | 1 |
| Clanachan, AS | 1 |
| Zaugg, M | 1 |
| Makrecka-Kuka, M | 1 |
| Volska, K | 1 |
| Makarova, E | 1 |
| Antone, U | 1 |
| Vilskersts, R | 2 |
| Strods, A | 1 |
| Tars, K | 1 |
| Sun, H | 1 |
| Díaz, R | 1 |
| Lorita, J | 1 |
| Soley, M | 1 |
| Ramírez, I | 1 |
| Najafi, M | 2 |
| Garjani, A | 2 |
| Maleki, N | 1 |
| Eteraf Oskouei, T | 1 |
| Turer, AT | 1 |
| Stevens, RD | 1 |
| Bain, JR | 1 |
| Muehlbauer, MJ | 1 |
| van der Westhuizen, J | 1 |
| Mathew, JP | 1 |
| Schwinn, DA | 1 |
| Glower, DD | 1 |
| Newgard, CB | 1 |
| Podgoreanu, MV | 1 |
| Javidnia, A | 1 |
| Ghorbani-Haghjo, A | 1 |
| Mohammadi, S | 1 |
| Kalvinsh, I | 1 |
| Cerruti, S | 1 |
| Testoni, G | 1 |
| Dalamon, V | 1 |
| Kade, P | 1 |
| Varela, A | 1 |
| Savino, EA | 1 |
| Hwang, YC | 1 |
| Bakr, S | 1 |
| Ramasamy, R | 1 |
| Bergmann, SR | 1 |
| Kato, H | 1 |
| Xie, J | 1 |
| Zeng, Q | 1 |
| Wang, L | 1 |
| Heathers, GP | 1 |
| Su, CM | 1 |
| Adames, VR | 1 |
| Higgins, AJ | 1 |
| Odiet, JA | 1 |
| Boerrigter, ME | 1 |
| Wei, JY | 1 |
| Nakagawa, T | 1 |
| Sunamori, M | 1 |
| Suzuki, A | 1 |
| Tedesco, MA | 1 |
| Ratti, G | 1 |
| Aquino, D | 1 |
| Iacono, A | 1 |
| Biselli, R | 1 |
| Farrace, S | 1 |
| De Simone, C | 1 |
| Fattorossi, A | 1 |
| Tatlican, O | 1 |
| Kalaycioğlu, S | 1 |
| Gökgöz, L | 1 |
| Oktar, L | 1 |
| Oz, E | 1 |
| Soncul, H | 1 |
| Sinci, V | 1 |
| Türközkan, N | 1 |
| Yener, A | 1 |
| Ersöz, A | 1 |
| Löster, H | 2 |
| Keller, T | 1 |
| Grommisch, J | 1 |
| Gründer, W | 1 |
| Lopaschuk, G | 1 |
| Calvani, M | 1 |
| Reda, E | 1 |
| Arrigoni-Martelli, E | 2 |
| Katircioglu, SF | 1 |
| Işcan, HZ | 1 |
| Ulus, T | 1 |
| Saritaş, Z | 1 |
| Hayashi, Y | 1 |
| Tajima, K | 1 |
| Kirimoto, T | 1 |
| Miyake, H | 1 |
| Matsuura, N | 1 |
| Böhm, U | 1 |
| Akar, H | 1 |
| Saraç, A | 1 |
| Konuralp, C | 1 |
| Yildiz, L | 1 |
| Kolbakir, F | 1 |
| Broderick, TL | 1 |
| Cifuentes, J | 1 |
| Green, D | 1 |
| Paulson, DJ | 2 |
| Lazzarino, G | 1 |
| Corsico, N | 1 |
| Tavazzi, B | 1 |
| di Pierro, D | 1 |
| Giardina, B | 1 |
| Bertelli, A | 1 |
| Ronca, F | 1 |
| Ronca, G | 1 |
| Palmieri, L | 1 |
| Zucchi, R | 1 |
| Reznick, AZ | 1 |
| Kagan, VE | 1 |
| Ramsey, R | 1 |
| Tsuchiya, M | 1 |
| Khwaja, S | 1 |
| Serbinova, EA | 1 |
| Packer, L | 3 |
| Shug, AL | 1 |
| Zhao, J | 1 |
| Sassen, LM | 2 |
| Duncker, DJ | 1 |
| Hogendoorn, A | 1 |
| McFalls, EO | 1 |
| Krams, R | 1 |
| Bezstarosti, K | 2 |
| Lamers, JM | 2 |
| Verdouw, PD | 2 |
| Valenza, M | 1 |
| Serbinova, E | 1 |
| Starke-Reed, P | 1 |
| Frost, K | 1 |
| Kagan, V | 1 |
| Leipälä, JA | 1 |
| Bhatnagar, R | 1 |
| Pineda, E | 1 |
| Najibi, S | 1 |
| Massoumi, K | 1 |
| Bolukoglu, H | 1 |
| Eggleston, AM | 1 |
| Subramanian, R | 1 |
| Nellis, SH | 1 |
| Liedtke, AJ | 1 |
| Carbonin, PU | 1 |
| Ramacci, MT | 1 |
| Pahor, M | 1 |
| Di Gennaro, M | 1 |
| Gambassi, G | 1 |
| Lo Giudice, P | 1 |
| Sgadari, A | 1 |
| Pacifici, L | 1 |
| Mjøs, OD | 1 |
| Ichihara, K | 1 |
| Fellenius, E | 1 |
| Myrmel, T | 1 |
| Neely, JR | 1 |
| Ferrari, R | 1 |
| Ceconi, C | 1 |
| Cargnoni, A | 1 |
| Pasini, E | 1 |
| Boffa, GM | 1 |
| Curello, S | 1 |
| Visioli, O | 1 |
| Duan, J | 1 |
| Moffat, MP | 1 |
| Koning, MM | 1 |
| van der Giessen, WJ | 1 |
| Duan, JM | 1 |
| Karmazyn, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Acetyl L-Carnitine in Patients With Covid-19 Pneumonia[NCT04623619] | 100 participants (Anticipated) | Interventional | 2020-12-15 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for carnitine and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
l-Carnitine and heart disease.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Carnitine; Heart; Heart Diseases; Humans; Myocard | 2018 |
[Preconditioning of the ischemic myocardium].
Topics: Adenosine; Angioplasty, Balloon, Coronary; Animals; Calcium Channel Blockers; Carnitine; Dogs; Elect | 1995 |
Regulation of carbohydrate metabolism in ischemia and reperfusion.
Topics: Animals; Carbohydrate Metabolism; Carnitine; Energy Metabolism; Fatty Acids, Nonesterified; Glucose; | 2000 |
Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions.
Topics: Animals; Carbohydrate Metabolism; Carnitine; Fatty Acids; Humans; Myocardial Ischemia; Myocardial Re | 2000 |
1 trial available for carnitine and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Myocardial Protective Effects of L-Carnitine on Ischemia-Reperfusion Injury in Patients With Rheumatic Valvular Heart Disease Undergoing Cardiac Surgery.
Topics: Adult; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Cardioplegic Solutions; Cardiopulmonary By | 2016 |
40 other studies available for carnitine and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
The protective effects of L-carnitine on myocardial ischaemia-reperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF-κB pathway and the activation of Nrf2 pathway.
Topics: Biomarkers; Carnitine; Female; Heart Valve Diseases; Humans; Male; Middle Aged; Myocardial Reperfusi | 2019 |
L-Carnitine Reduces Myocardial Oxidative Stress and Alleviates Myocardial Ischemia-Reperfusion Injury by Activating Nuclear Transcription-Related Factor 2 (Nrf2)/Heme Oxygenase-1 (HO-1) Signaling Pathway.
Topics: Animals; Apoptosis; Carnitine; Cell Hypoxia; Cell Survival; Heme Oxygenase (Decyclizing); Male; Malo | 2020 |
L-Carnitine Attenuates Cardiac Dysfunction by Ischemic Insults Through Akt Signaling Pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Carnitine; Cell Hypoxia; Cell | 2017 |
Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Fatty Acids; Gene Expression Regulation; Male; | 2013 |
The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases.
Topics: Animals; Cardiotonic Agents; Carnitine; Electron Transport Complex IV; Emulsions; Heart; Male; MAP K | 2014 |
Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Male; Mitochondria, Heart; Myocardial Reperfus | 2016 |
Carnitine worsens both injury and recovery of contractile function after transient ischemia in perfused rat heart.
Topics: Animals; Carnitine; Glucose; In Vitro Techniques; Lactic Acid; Male; Myocardial Contraction; Myocard | 2008 |
Antiarrhythmic and arrhythmogenic effects of L-carnitine in ischemia and reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Carnitine; Coronary Occlusion; Epoxy Compound | 2008 |
Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion.
Topics: Aged; Anaerobic Threshold; Cardiac Output; Cardiopulmonary Bypass; Carnitine; Coronary Artery Diseas | 2009 |
Pharmacological preconditioning with L-carnitine: relevance to myocardial hemodynamic function and glycogen and lactate content.
Topics: Adenosine Triphosphate; Animals; Carnitine; Glycogen; Hemodynamics; Ischemic Preconditioning, Myocar | 2010 |
The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
Topics: Animals; Betaine; Cardiovascular Agents; Carnitine; Carnitine O-Palmitoyltransferase; Chromatography | 2012 |
Effects of fasting and hypoxic preconditioning on the hypoxic-reoxygenated ventricular strips of the rat heart.
Topics: Acyl Coenzyme A; Analysis of Variance; Animals; Carnitine; Fasting; Heart Ventricles; Hypoxia; Ische | 2002 |
Relative importance of enhanced glucose uptake versus attenuation of long-chain acyl carnitines in protecting ischemic myocardium.
Topics: Animals; Carnitine; Creatine Kinase; Cytochalasin B; Disease Models, Animal; Glucose; Models, Cardio | 2002 |
[Effect of L-carnitine to suppress the development of ischemic reperfusion injury in an excised heart of a diabetic rat].
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Myocardial Reperfusi | 2006 |
The protective effect of L-carnitine on ischemia-reperfusion heart.
Topics: Adenosine Triphosphate; Animals; Cardiotonic Agents; Carnitine; Creatine Kinase; Heart; L-Lactate De | 2006 |
Reperfusion-induced accumulation of long-chain acylcarnitines in previously ischemic myocardium.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Epoxy Compounds; Male; Molecular Weight; Myoca | 1993 |
Carnitine palmitoyl transferase-I activity in the aging mouse heart.
Topics: Aging; Animals; Cardiotonic Agents; Carnitine; Carnitine O-Palmitoyltransferase; Male; Mice; Mice, I | 1995 |
The effect of L-carnitine on myocardial protection in cold cardioplegia followed by reperfusion.
Topics: Adenosine Triphosphate; Animals; Carnitine; Heart Arrest, Induced; Hemodynamics; Hypothermia, Induce | 1994 |
Potentiation of human polymorphonuclear leukocyte activation by atrial natriuretic peptide. Inhibitory effect of carnitine congeners.
Topics: Atrial Natriuretic Factor; Carnitine; Cell Adhesion; Cell Membrane; Drug Synergism; Enzyme Inhibitor | 1996 |
The dose-dependent effects of L-carnitine in myocardial protection in normothermic ischemia.
Topics: Adenosine Deaminase; Analysis of Variance; Animals; Carnitine; Chick Embryo; Disease Models, Animal; | 1998 |
Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy.
Topics: Acetylcarnitine; Adenosine Triphosphate; Animals; Carnitine; Energy Metabolism; Female; Heart; In Vi | 1999 |
Myocardial preservation in acute coronary artery occlusion with coronary sinus retroperfusion and carnitine.
Topics: Animals; Carnitine; Dogs; Energy Metabolism; Hemodynamics; Myocardial Infarction; Myocardial Reperfu | 2000 |
Cardioprotective effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on cardiac dysfunction induced by ischemia/reperfusion in isolated rat hearts.
Topics: Animals; Carnitine; Enzyme Inhibitors; gamma-Butyrobetaine Dioxygenase; Heart Function Tests; Hemody | 2000 |
L-carnitine reduces malondialdehyde concentrations in isolated rat hearts in dependence on perfusion conditions.
Topics: Animals; Carnitine; Female; Glucose; Lipid Peroxidation; Malondialdehyde; Myocardial Reperfusion Inj | 2001 |
Comparison of histopathologic effects of carnitine and ascorbic acid on reperfusion injury.
Topics: Animals; Antioxidants; Ascorbic Acid; Carnitine; Disease Models, Animal; Female; Muscle Fibers, Skel | 2001 |
Short-term carnitine deficiency does not alter aerobic rat heart function but depresses reperfusion recovery after ischemia.
Topics: Aerobiosis; Animals; Blood Pressure; Body Weight; Carnitine; Energy Metabolism; Heart; Male; Myocard | 2001 |
[L-propionylcarnitine taurine amide induces the metabolic recovery of the isolated postischemic rat heart].
Topics: Animals; Carnitine; Drug Evaluation, Preclinical; Energy Metabolism; Heart; In Vitro Techniques; Mal | 1992 |
L-carnitine and coenzyme Q10 protective action against ischaemia and reperfusion of working rat heart.
Topics: Animals; Carnitine; Chromatography, High Pressure Liquid; Coenzymes; Drug Combinations; Hemodynamics | 1992 |
Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation.
Topics: Animals; Carnitine; Deferoxamine; Electron Spin Resonance Spectroscopy; Energy Metabolism; Free Radi | 1992 |
Protection of the ischemic diabetic heart by L-propionylcarnitine therapy.
Topics: Animals; Cardiotonic Agents; Carnitine; Diabetes Mellitus, Experimental; Male; Myocardial Contractio | 1992 |
L-propionylcarnitine and myocardial performance in stunned porcine myocardium.
Topics: Animals; Cardiotonic Agents; Carnitine; Female; Hemodynamics; Male; Myocardial Contraction; Myocardi | 1992 |
Free radical scavenging is involved in the protective effect of L-propionyl-carnitine against ischemia-reperfusion injury of the heart.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Carnitine; Creatine Kinase; Electron Spin Resonance | 1991 |
Protection of the reperfused heart by L-propionylcarnitine.
Topics: Animals; Blood Pressure; Carnitine; Coronary Circulation; Coronary Disease; Female; In Vitro Techniq | 1991 |
Effects of propionyl-L-carnitine in chronically hypoperfused ("hibernating") myocardium.
Topics: Animals; Carnitine; Cell Survival; Dobutamine; Myocardial Contraction; Myocardial Reperfusion Injury | 1991 |
Antiarrhythmic effect of L-propionylcarnitine in isolated cardiac preparations.
Topics: Animals; Anti-Arrhythmia Agents; Carnitine; Guinea Pigs; Male; Myocardial Reperfusion Injury; Papill | 1991 |
Fatty acids suppress recovery of heart function after hypothermic perfusion.
Topics: Acyl Coenzyme A; Adenosine Triphosphate; Animals; Calcium; Carnitine; Coronary Circulation; Fatty Ac | 1991 |
The effect of propionyl-L-carnitine on the ischemic and reperfused intact myocardium and on their derived mitochondria.
Topics: Adenosine Triphosphate; Animals; Carnitine; Coronary Disease; Heart; Mitochondria, Heart; Myocardial | 1991 |
Protective effects of D,L-carnitine against arrhythmias induced by lysophosphatidylcholine or reperfusion.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Carnitine; Disease Models, Animal; Guinea Pigs; | 1991 |
Effects of administration of L-propionylcarnitine during ischemia on the recovery of myocardial function in the anesthetised pig.
Topics: Adenosine Triphosphate; Animals; Carnitine; Coronary Circulation; Myocardial Contraction; Myocardial | 1990 |
Effect of D,L-carnitine on the response of the isolated heart of the rat to ischaemia and reperfusion: relation to mitochondrial function.
Topics: Animals; Carnitine; Coronary Disease; In Vitro Techniques; Male; Mitochondria, Heart; Mitochondrial | 1989 |