carnitine has been researched along with Infertility, Male in 81 studies
Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
| Excerpt | Relevance | Reference |
|---|---|---|
| " selenium, carnitine and coenzyme Q10, alone or in combination, on both semen parameters and pregnancy rates in couples with male factor infertility." | 9.22 | Systematic Review and Meta-analysis on Effect of Carnitine, Coenzyme Q10 and Selenium on Pregnancy and Semen Parameters in Couples With Idiopathic Male Infertility. ( Kumar, R; Sharma, AP; Sharma, G, 2022) |
| "To identify the role of L-carnitine in the treatment of varicocele." | 9.05 | L-carnitine as primary or adjuvant treatment in infertile patients with varicocele. A systematic review. ( Akhter, W; Buchholz, N; Deliveliotis, K; Katsouri, A; Khan, MF; Moussa, M; Papatsoris, A; Tsampoukas, G, 2020) |
| " The aim of our study was to determine the correlation between selenium and carnitine levels in the seminal fluid with HOS test for sperm membrane in low-grade varicocele patients." | 7.83 | A correlation between selenium and carnitine levels with hypo-osmotic swelling test for sperm membrane in low-grade varicocele patients. ( Dimitrovski, A; Pajovic, B; Radojevic, N; Vukovic, M, 2016) |
| "We obtained sperm by testis puncture from obstructive azoospermia patients and cultured them in vitro with normal culture solution (the control group) and the solution with L-carnitine at the concentration of 100 and 250 mmol/L, respectively." | 7.76 | [Expressions of sperm-specific genes in carnitine-cultured testis sperm of obstructive azoospermia patients]. ( Hua, JL; Liang, Q; Shi, JZ; Shi, Y; Sun, T; Zhang, SS; Zhang, Z, 2010) |
| " Nutritional therapies, particularly L-carnitine alone or combined with micronutrients, significantly improved sperm parameters and pregnancy rates even under severe conditions." | 5.41 | Effectiveness of Nutritional Therapies in Male Factor Infertility Treatment: A Systematic Review and Network Meta-analysis. ( Baird, CD; Jiang, H; Li, H; Mills, KE; Zafar, MI, 2023) |
| "Specific multi-nutrient combination l-carnitine/l-acetyl-carnitine, l-arginine, glutathione, co-enzyme-Q, zinc, folic acid, cyanocobalamin, and selenium can improve sperm quality in males with IMI and increase pregnancy rates." | 5.34 | Dietary supplementation with a novel l-carnitine multi-micronutrient in idiopathic male subfertility involving oligo-, astheno-, teratozoospermia: A randomized clinical study. ( Cherepanyn, V; Chernyavska, I; Fedevych, V; Gerasymov, S; Kopets, R; Kuibida, I; Mazo, R, 2020) |
| " selenium, carnitine and coenzyme Q10, alone or in combination, on both semen parameters and pregnancy rates in couples with male factor infertility." | 5.22 | Systematic Review and Meta-analysis on Effect of Carnitine, Coenzyme Q10 and Selenium on Pregnancy and Semen Parameters in Couples With Idiopathic Male Infertility. ( Kumar, R; Sharma, AP; Sharma, G, 2022) |
| "To observe the pregnancy promoting effect of L-carnitine combined with intracytoplasmic sperm injection (ICSI) in treating male infertility with oligoasthenozoospermia." | 5.16 | [Short-term medication of L-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia]. ( Cheng, HJ; Lu, X; Sun, J; Tao, JW; Wang, YW; Wu, ZM; Yin, FH, 2012) |
| "To identify the role of L-carnitine in the treatment of varicocele." | 5.05 | L-carnitine as primary or adjuvant treatment in infertile patients with varicocele. A systematic review. ( Akhter, W; Buchholz, N; Deliveliotis, K; Katsouri, A; Khan, MF; Moussa, M; Papatsoris, A; Tsampoukas, G, 2020) |
| " The aim of our study was to determine the correlation between selenium and carnitine levels in the seminal fluid with HOS test for sperm membrane in low-grade varicocele patients." | 3.83 | A correlation between selenium and carnitine levels with hypo-osmotic swelling test for sperm membrane in low-grade varicocele patients. ( Dimitrovski, A; Pajovic, B; Radojevic, N; Vukovic, M, 2016) |
| "We obtained sperm by testis puncture from obstructive azoospermia patients and cultured them in vitro with normal culture solution (the control group) and the solution with L-carnitine at the concentration of 100 and 250 mmol/L, respectively." | 3.76 | [Expressions of sperm-specific genes in carnitine-cultured testis sperm of obstructive azoospermia patients]. ( Hua, JL; Liang, Q; Shi, JZ; Shi, Y; Sun, T; Zhang, SS; Zhang, Z, 2010) |
| "L-carnitine was found to be superior to the combination of CoQ10 and Vitamin E in improving sperm parameters." | 3.11 | Comparison of L-Carnitine vs. Coq10 and Vitamin E for idiopathic male infertility: a randomized controlled trial. ( Ma, L; Sun, Y, 2022) |
| " Stimulation of spermatogenesis using the antioxidant complex SpermActin Forte is an effective and safe method of treating male infertility." | 2.90 | [Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin Forte) for treatment of male infertility]. ( Gamidov, SI; Ovchinnikov, RI; Popova, AY, 2019) |
| "L-carnitine is an essential molecule involved in mitochondrial metabolism, controlling the transport of acetyl and acyl groups across the mitochondrial inner membrane." | 2.71 | Correlation between seminal carnitine and functional spermatozoal characteristics in men with semen dysfunction of various origins. ( Amalfi, B; Boggia, B; Colao, A; De Rosa, M; Lombardi, G; Vita, A; Zarrilli, S, 2005) |
| "L-Carnitine was effective in improvement of percentile of motile sperms, grade A sperms, and normal-shaped sperms." | 2.71 | The effects of L-carnitine on sperm parameters in smoker and non-smoker patients with idiopathic sperm abnormalities. ( Alleyassin, A; Haghaninezhad, H; Hamed, EA; Khademi, A; Rabiee, E; Safdarian, L, 2005) |
| "L-carnitine was supplemented orally by a daily dosage of 3 g for three months." | 2.68 | Carnitine supplementation in human idiopathic asthenospermia: clinical results. ( Melotti, C; Parente, R; Vitali, G, 1995) |
| "Although male infertility affects 1:15 men, there is no obvious reason in the vast majority of cases." | 2.66 | l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility. ( Anderson, R; Khaw, SC; Martins da Silva, S; Wong, ZZ, 2020) |
| "Idiopathic male infertility is empirically managed using a number of drugs." | 2.52 | Empirical Drug Therapy for Idiopathic Male Infertility: What is the New Evidence? ( Garg, H; Kumar, R, 2015) |
| " As a consequence of the above-mentioned effects of L-carnitine the dosage of this substance in the evaluation of the integrity of the processes of maturation of the spermatozoa was proposed." | 2.38 | [Metabolism and action of L-carnitine: its possible role in sperm tail function]. ( Dondero, F; Gandini, L; Lenzi, A; Lombardo, F, 1992) |
| " Therapy for increasing sperm motility includes low dosage androgen and human chorionic gonadotropin." | 2.36 | Sperm motility. ( Amelar, RD; Dubin, L; Schoenfeld, C, 1980) |
| "When diagnosing and treating male infertility it is important to determine whether there are defects in the maturation process of sperm nuclei." | 1.56 | Changes in the Level of DNA Fragmentation in Sperm Cells detected by Acridine Orange Test in Men with Sub/infertility Treated with Nutritional Supplement PAPA. ( Atanasova, PK; Dechev, IY; Stoyanova, RS; Tomov, SN, 2020) |
| "l-carnitine has been found to improve the quality of spermatozoa in selected cases with male infertility." | 1.40 | Cryoprotective effect of L-carnitine on motility, vitality and DNA oxidation of human spermatozoa. ( Agarwal, A; Banihani, S; Bayachou, M; Sharma, R, 2014) |
| "Pretreatment with coenzyme Q10 (10 mg/kg/day, oral) and L-Carnitine (350 mg/kg/day, oral) were conducted for 5 consecutive weeks." | 1.40 | CoQ10 and L-carnitine attenuate the effect of high LDL and oxidized LDL on spermatogenesis in male rats. ( Garjani, A; Ghanbarzadeh, S; Khorrami, A; Ziaee, M, 2014) |
| "Aneuploidy was assessed using fluorescent in situ hybridisation (FISH) performed on chromosomes X, Y, 13, 15, 16, 17, 18, 21 and 22." | 1.38 | Reduction in sperm aneuploidy levels in severe oligoasthenoteratospermic patients after medical therapy: a preliminary report. ( Cavallini, G; Crippa, A; Ferraretti, AP; Gianaroli, L; Magli, MC, 2012) |
| "To improve the results of treatment for male infertility in patients with varicocele and to evaluate the efficiency of microsurgical varicocelectomy performed by the same surgeon in a large group of patients." | 1.38 | [Current approach to therapy for male infertility in patients with varicocele]. ( Gamidov, CI; Izhbaev, SKh; Ovchinnikov, RI; Popova, AIu; Tkhagapsoeva, RA, 2012) |
| "Oligospermia was seen in 13 (16%) patients." | 1.29 | Biochemical parameters in evaluation of oligospermia. ( Ahmad, M; Khan, DA; Khan, FA; Rahman, SB; Saeed, S, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (16.05) | 18.7374 |
| 1990's | 7 (8.64) | 18.2507 |
| 2000's | 23 (28.40) | 29.6817 |
| 2010's | 24 (29.63) | 24.3611 |
| 2020's | 14 (17.28) | 2.80 |
| Authors | Studies |
|---|---|
| Yaris, M | 1 |
| Akdogan, N | 1 |
| Öztürk, M | 1 |
| Bozkurt, A | 1 |
| Karabakan, M | 1 |
| Petrillo, T | 1 |
| Battipaglia, C | 1 |
| Virmani, MA | 1 |
| Genazzani, AR | 1 |
| Genazzani, AD | 1 |
| Sharma, AP | 1 |
| Sharma, G | 1 |
| Kumar, R | 3 |
| Khaw, SC | 1 |
| Wong, ZZ | 1 |
| Anderson, R | 1 |
| Martins da Silva, S | 1 |
| Ma, L | 1 |
| Sun, Y | 1 |
| de Siqueira Guedes, J | 1 |
| Pla, I | 1 |
| Sahlin, KB | 1 |
| Monnerat, G | 1 |
| Appelqvist, R | 1 |
| Marko-Varga, G | 1 |
| Giwercman, A | 1 |
| Domont, GB | 1 |
| Sanchez, A | 1 |
| Nogueira, FCS | 1 |
| Malm, J | 1 |
| Zafar, MI | 1 |
| Mills, KE | 1 |
| Baird, CD | 1 |
| Jiang, H | 2 |
| Li, H | 1 |
| Arslan, E | 1 |
| Koyuncu, I | 1 |
| Temız, E | 1 |
| Arı, M | 1 |
| Akmese, S | 1 |
| Ramat, M | 1 |
| Gamidov, SI | 1 |
| Ovchinnikov, RI | 2 |
| Popova, AY | 1 |
| Sun, LL | 1 |
| Wan, XX | 1 |
| Zhang, Y | 1 |
| Zhang, YH | 1 |
| Zhao, WJ | 1 |
| Wang, D | 1 |
| Wang, JG | 1 |
| Xie, JL | 1 |
| Ma, HG | 1 |
| Kopets, R | 1 |
| Kuibida, I | 1 |
| Chernyavska, I | 1 |
| Cherepanyn, V | 1 |
| Mazo, R | 1 |
| Fedevych, V | 1 |
| Gerasymov, S | 1 |
| Tomov, SN | 1 |
| Stoyanova, RS | 1 |
| Atanasova, PK | 1 |
| Dechev, IY | 1 |
| Nazari, L | 1 |
| Salehpour, S | 1 |
| Hosseini, S | 1 |
| Allameh, F | 1 |
| Jahanmardi, F | 1 |
| Azizi, E | 1 |
| Ghodssi-Ghassemabadi, R | 1 |
| Hashemi, T | 1 |
| Aboul-Naga, AM | 1 |
| Hamam, ET | 1 |
| Awadalla, A | 1 |
| Shokeir, AA | 1 |
| Tsampoukas, G | 1 |
| Khan, MF | 1 |
| Katsouri, A | 1 |
| Akhter, W | 1 |
| Moussa, M | 1 |
| Deliveliotis, K | 1 |
| Papatsoris, A | 1 |
| Buchholz, N | 1 |
| Kuang, W | 1 |
| Zhang, J | 2 |
| Lan, Z | 1 |
| Deepak, RNVK | 1 |
| Liu, C | 1 |
| Ma, Z | 1 |
| Cheng, L | 1 |
| Zhao, X | 1 |
| Meng, X | 1 |
| Wang, W | 1 |
| Wang, X | 2 |
| Xu, L | 1 |
| Jiao, Y | 1 |
| Luo, Q | 1 |
| Meng, Z | 1 |
| Kee, K | 1 |
| Liu, X | 1 |
| Deng, H | 1 |
| Li, W | 4 |
| Fan, H | 1 |
| Chen, L | 1 |
| Modarresi, R | 1 |
| Aminsharifi, A | 1 |
| Foroughinia, F | 1 |
| Lu, JC | 1 |
| Banihani, S | 1 |
| Agarwal, A | 2 |
| Sharma, R | 1 |
| Bayachou, M | 1 |
| Ghanbarzadeh, S | 1 |
| Garjani, A | 1 |
| Ziaee, M | 1 |
| Khorrami, A | 1 |
| Mu, X | 1 |
| Xia, Y | 1 |
| Martin, FL | 1 |
| Hang, W | 1 |
| Liu, L | 1 |
| Tian, M | 1 |
| Huang, Q | 1 |
| Shen, H | 1 |
| Gvozdjáková, A | 1 |
| Kucharská, J | 1 |
| Dubravicky, J | 1 |
| Mojto, V | 1 |
| Singh, RB | 1 |
| Zhang, W | 1 |
| Li, F | 1 |
| Cao, H | 1 |
| Li, C | 1 |
| Du, C | 1 |
| Yao, L | 1 |
| Mao, H | 1 |
| Lin, W | 1 |
| Gual-Frau, J | 1 |
| Abad, C | 2 |
| Amengual, MJ | 2 |
| Hannaoui, N | 2 |
| Checa, MA | 1 |
| Ribas-Maynou, J | 1 |
| Lozano, I | 1 |
| Nikolaou, A | 1 |
| Benet, J | 2 |
| García-Peiró, A | 2 |
| Prats, J | 2 |
| Garg, H | 1 |
| Pajovic, B | 1 |
| Dimitrovski, A | 1 |
| Radojevic, N | 1 |
| Vukovic, M | 1 |
| Roy, VK | 1 |
| Verma, R | 1 |
| Krishna, A | 1 |
| Mongioi, L | 1 |
| Calogero, AE | 3 |
| Vicari, E | 4 |
| Condorelli, RA | 1 |
| Russo, GI | 1 |
| Privitera, S | 1 |
| Morgia, G | 1 |
| La Vignera, S | 2 |
| Cao, Y | 1 |
| Li, S | 1 |
| Wang, H | 1 |
| Yu, L | 1 |
| Wang, P | 1 |
| Lipovac, M | 1 |
| Bodner, F | 1 |
| Imhof, M | 1 |
| Chedraui, P | 1 |
| Haseen Ahmed, SD | 1 |
| Ahsan, S | 2 |
| Iqbal, T | 1 |
| Ahmed Burney, SI | 1 |
| Tang, LF | 1 |
| Shang, XJ | 4 |
| Zhao, LM | 1 |
| Bai, Q | 1 |
| Hong, K | 1 |
| Liu, DF | 1 |
| Liu, JM | 1 |
| Yuan, RP | 1 |
| Chen, Q | 1 |
| Ma, LL | 1 |
| Shi, JZ | 1 |
| Zhang, SS | 1 |
| Zhang, Z | 1 |
| Liang, Q | 1 |
| Shi, Y | 1 |
| Hua, JL | 1 |
| Sun, T | 1 |
| Moradi, M | 1 |
| Moradi, A | 1 |
| Alemi, M | 1 |
| Ahmadnia, H | 1 |
| Abdi, H | 1 |
| Ahmadi, A | 1 |
| Bazargan-Hejazi, S | 1 |
| Ahmed, SD | 1 |
| Karira, KA | 1 |
| Wu, ZM | 1 |
| Lu, X | 1 |
| Wang, YW | 1 |
| Sun, J | 1 |
| Tao, JW | 1 |
| Yin, FH | 1 |
| Cheng, HJ | 1 |
| Cavallini, G | 1 |
| Magli, MC | 1 |
| Crippa, A | 1 |
| Ferraretti, AP | 1 |
| Gianaroli, L | 1 |
| Gosálvez, J | 1 |
| Coward, K | 1 |
| Gamidov, CI | 1 |
| Popova, AIu | 1 |
| Tkhagapsoeva, RA | 1 |
| Izhbaev, SKh | 1 |
| Lenzi, A | 2 |
| Lombardo, F | 2 |
| Sgrò, P | 1 |
| Salacone, P | 1 |
| Caponecchia, L | 1 |
| Dondero, F | 3 |
| Gandini, L | 2 |
| Gürbüz, B | 1 |
| Yalti, S | 1 |
| Fiçicioğlu, C | 1 |
| Zehir, K | 1 |
| Said, TM | 1 |
| Stradaioli, G | 1 |
| Sylla, L | 1 |
| Zelli, R | 1 |
| Chiodi, P | 1 |
| Monaci, M | 1 |
| Ng, CM | 1 |
| Blackman, MR | 1 |
| Wang, C | 1 |
| Swerdloff, RS | 1 |
| Garolla, A | 1 |
| Maiorino, M | 1 |
| Roverato, A | 1 |
| Roveri, A | 1 |
| Ursini, F | 1 |
| Foresta, C | 1 |
| De Rosa, M | 1 |
| Boggia, B | 1 |
| Amalfi, B | 1 |
| Zarrilli, S | 1 |
| Vita, A | 1 |
| Colao, A | 1 |
| Lombardi, G | 1 |
| Dokmeci, D | 1 |
| Khademi, A | 1 |
| Alleyassin, A | 1 |
| Safdarian, L | 1 |
| Hamed, EA | 1 |
| Rabiee, E | 1 |
| Haghaninezhad, H | 1 |
| Sigman, M | 1 |
| Glass, S | 1 |
| Campagnone, J | 1 |
| Pryor, JL | 1 |
| Marinoni, E | 1 |
| Vellucci, O | 1 |
| Letizia, C | 1 |
| Sessa, M | 1 |
| Moscarini, M | 1 |
| Di Iorio, R | 1 |
| Gautam, G | 1 |
| Gupta, NP | 1 |
| Wang, XL | 1 |
| Huang, YF | 3 |
| Li, K | 3 |
| Huang, Y | 1 |
| Zhou, X | 1 |
| Liu, F | 1 |
| Zhai, S | 1 |
| Ziyyat, A | 1 |
| Barraud-Lange, V | 1 |
| Sifer, C | 1 |
| Ducot, B | 2 |
| Wolf, JP | 1 |
| Soufir, JC | 3 |
| Amelar, RD | 1 |
| Dubin, L | 1 |
| Schoenfeld, C | 1 |
| Marson, J | 1 |
| Jouannet, P | 1 |
| Feneux, D | 1 |
| Soumah, A | 1 |
| Spira, A | 1 |
| Le Calvé, M | 1 |
| Segalen, J | 1 |
| Quernee, D | 1 |
| Lavault, MT | 1 |
| Lescoat, D | 1 |
| Saeed, S | 1 |
| Khan, FA | 1 |
| Rahman, SB | 1 |
| Khan, DA | 1 |
| Ahmad, M | 1 |
| Noguera Velasco, JA | 1 |
| Tovar Zapata, I | 1 |
| Martinez Hernandez, P | 1 |
| Perez Albacete, M | 1 |
| Tortosa Oltra, J | 1 |
| Parrilla Paricio, JJ | 1 |
| Vitali, G | 1 |
| Parente, R | 1 |
| Melotti, C | 1 |
| Meisser, A | 1 |
| Campana, A | 1 |
| Bischof, P | 1 |
| Mazzilli, F | 1 |
| Rossi, T | 1 |
| Ronconi, C | 1 |
| Germini, B | 1 |
| Zöpfgen, A | 1 |
| Priem, F | 1 |
| Sudhoff, F | 1 |
| Jung, K | 1 |
| Lenk, S | 1 |
| Loening, SA | 1 |
| Sinha, P | 1 |
| Rubino, C | 1 |
| De Palma, A | 1 |
| Longo, G | 1 |
| Lauretta, M | 1 |
| Consoli, S | 1 |
| Arancio, A | 1 |
| Schirren, C | 1 |
| Schütte, B | 2 |
| Kohengkul, S | 1 |
| Tanphaichitr, V | 1 |
| Muangmun, V | 1 |
| Tanphaichitr, N | 1 |
| Sade, M | 1 |
| Saverymuttu, I | 1 |
| Dinsdale, O | 1 |
| Gow, JG | 1 |
| Lewin, LM | 1 |
| Beer, R | 1 |
| Lunenfeld, B | 1 |
| Giridharan, N | 1 |
| Sesikeran, B | 1 |
| Bamji, MS | 1 |
| Madhyastha, MN | 1 |
| Wetterauer, U | 1 |
| Abbaticchio, G | 1 |
| Giagulli, VA | 1 |
| Defini, M | 1 |
| Micale, FM | 1 |
| Giorgino, R | 1 |
| Milingos, SD | 1 |
| Geer, BW | 1 |
| Newburgh, RW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Acetyl- L- Carnitine and Folic Acid Versus Coenzyme Q10 and Folic Acid on Semen and Hormonal Parameters and Semen Oxidative Status in Patients of Primary Infertility. A Double Blind Randomized Clinical Trial[NCT05616000] | Phase 2 | 86 participants (Actual) | Interventional | 2022-08-06 | Completed | ||
| Effect of COVID-19 on Spermiogram, Platelet Mitochondrial Bioenergetic, Antioxidants and Oxidative Stress in Infertile Men[NCT05421234] | 45 participants (Actual) | Interventional | 2022-04-01 | Active, not recruiting | |||
| A 5-year Prospective, Placebo-controlled, Crossover Evaluation of the Efficacy and Tolerability of Low-dose Lisinopril in Normotensives With Idiopathic Oligospermic Infertility[NCT01409837] | Phase 2 | 33 participants (Actual) | Interventional | 1998-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The patients were encouraged to report every event promptly by phone to one of the authors (NOG), no matter however minor.Blood pressure measurements were done with mercury sphygmomanometers fitted with adult-size cuffs (Accoson, England). Serum potassium levels were estimated using the flame photometric method as described by Davidson and Henry (NCT01409837)
Timeframe: At weeks 6, 12, 24, 48, 96, 102, 114,138, 186 and 282
| Intervention | participants (Number) |
|---|---|
| Group B (Lisinopril First, Then Placebo) | 0 |
| Group A (Placebo First, Then Lisinopril) | 0 |
The seminal fluid characteristics were assessed twice before the entry of each patient and both at least two-weeks apart. The two values were averaged and recorded as baseline for week 0 while subsequent changes from the baseline were monitored during each of the scheduled visits at weeks 6, 12, 24, 48, 96, 102, 114, 138, 186 and 282. The two groups swopped treatments at the 96th week. The number of pregnancies achieved was also documented throughout the study period. (NCT01409837)
Timeframe: Week 96.
| Intervention | ml (Geometric Mean) |
|---|---|
| Group B (Lisinopril First, Then Placebo) | 3.47 |
| Group A (Placebo First, Then Lisinopril) | 3.20 |
The volume in milliliters of seminal fluid produced per ejaculation. (NCT01409837)
Timeframe: Week 282
| Intervention | ml (Geometric Mean) |
|---|---|
| Group B (Lisinopril First, Then Placebo) | 3.73 |
| Group A (Placebo First, Then Lisinopril) | 3.55 |
Proportion (per cent) of sperm cells with abnormal appearance (NCT01409837)
Timeframe: Week 96
| Intervention | per cent (Geometric Mean) |
|---|---|
| Group B (Lisinopril First, Then Placebo) | 15.95 |
| Group A (Placebo First, Then Lisinopril) | 44.73 |
The proportion (per cent) of the total number of sperm cell with abnormal appearance. (NCT01409837)
Timeframe: Week 282
| Intervention | Per cent (Geometric Mean) |
|---|---|
| Group B (Lisinopril First, Then Placebo) | 28.55 |
| Group A (Placebo First, Then Lisinopril) | 12.14 |
The proportion (per cent) of the sperm cells exhibiting both rhythmic and propulsive movements considered to be of normal intensity. (NCT01409837)
Timeframe: Week 282
| Intervention | Per cent (Geometric Mean) |
|---|---|
| Group B (Lisinopril First, Then Placebo) | 14.45 |
| Group A (Placebo First, Then Lisinopril) | 29.99 |
This was determined as the proportion (percent) of the total sperm cells exhibiting both rhythmic and propulsive movements considered to be of normal intensity. (NCT01409837)
Timeframe: Week 96
| Intervention | Per cent (Geometric Mean) |
|---|---|
| Group B (Lisinopril First, Then Placebo) | 31.08 |
| Group A (Placebo First, Then Lisinopril) | 21.90 |
The total number of sperm cells found in each milliliter of seminal fluid. (NCT01409837)
Timeframe: Week 282
| Intervention | Millions/ml (Geometric Mean) |
|---|---|
| Group B (Lisinopril First, Then Placebo) | 12.86 |
| Group A (Placebo First, Then Lisinopril) | 13.81 |
the number of sperm cells counted per milliliter volume of seminal fluid (NCT01409837)
Timeframe: Week 96
| Intervention | Millions/ml (Mean) |
|---|---|
| Group B (Lisinopril First, Then Placebo) | 17.02 |
| Group A (Placebo First, Then Lisinopril) | 7.17 |
17 reviews available for carnitine and Infertility, Male
| Article | Year |
|---|---|
Neuroendocrine Effects of Carnitines on Reproductive Impairments.
Topics: Carnitine; Female; Humans; Infertility, Female; Infertility, Male; Male; Protective Agents; Reproduc | 2021 |
Systematic Review and Meta-analysis on Effect of Carnitine, Coenzyme Q10 and Selenium on Pregnancy and Semen Parameters in Couples With Idiopathic Male Infertility.
Topics: Antioxidants; Carnitine; Female; Humans; Infertility, Male; Male; Pregnancy; Selenium; Semen; Sperm | 2022 |
l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility.
Topics: Acetylcarnitine; Antioxidants; Carnitine; Dietary Supplements; Female; Humans; Infertility, Male; Ma | 2020 |
Effectiveness of Nutritional Therapies in Male Factor Infertility Treatment: A Systematic Review and Network Meta-analysis.
Topics: Adult; Carnitine; Female; Humans; Infertility, Male; Male; Micronutrients; Network Meta-Analysis; Pr | 2023 |
L-carnitine as primary or adjuvant treatment in infertile patients with varicocele. A systematic review.
Topics: Carnitine; Chemotherapy, Adjuvant; Humans; Infertility, Male; Male; Treatment Outcome; Urologic Surg | 2020 |
[Automatic detection and clinical application of semen biochemical markers].
Topics: Acid Phosphatase; alpha-Glucosidases; Biomarkers; Carnitine; Citric Acid; Epididymis; Fructose; gamm | 2018 |
Empirical Drug Therapy for Idiopathic Male Infertility: What is the New Evidence?
Topics: Antioxidants; Arginine; Aromatase Inhibitors; Carnitine; Carotenoids; Estrogen Receptor Modulators; | 2015 |
The role of carnitine in male infertility.
Topics: Carnitine; Humans; Infertility, Male; Male; Sperm Motility; Spermatozoa | 2016 |
Carnitines and male infertility.
Topics: Acetylcarnitine; Antioxidants; Carnitine; Humans; Infertility, Male; Male; Oligospermia; Sperm Count | 2004 |
The role of carnitine in the male reproductive system.
Topics: Animals; Apoptosis; Carnitine; Caspases; Genitalia, Male; Humans; Infertility, Male; Male; Mice; Tes | 2004 |
Oxidative stress, male infertility and the role of carnitines.
Topics: Antioxidants; Carnitine; Humans; Infertility, Male; Male; Oxidative Stress; Reactive Oxygen Species | 2005 |
Drug therapy for idiopathic male infertility: rationale versus evidence.
Topics: Antioxidants; Carnitine; Hormones; Humans; Infertility, Male; Male; Treatment Outcome; Vitamin B Com | 2006 |
[Progress of researches on carnitines in the clinical therapy of andrology].
Topics: Carnitine; Erectile Dysfunction; Humans; Infertility, Male; Male | 2006 |
Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review.
Topics: Acetylcarnitine; Adolescent; Adult; Aged; Carnitine; Female; Humans; Infertility, Male; Male; Meta-A | 2007 |
Sperm motility.
Topics: Alcoholism; Androgens; Caffeine; Carnitine; Chorionic Gonadotropin; Coitus; Cyclic AMP; Ejaculation; | 1980 |
[Metabolism and action of L-carnitine: its possible role in sperm tail function].
Topics: Adult; Animals; Carnitine; Cattle; Energy Metabolism; Epididymis; Fatty Acids; Female; Humans; Infer | 1992 |
[New diagnostic procedures in assessing male fertility].
Topics: Biopsy; Carnitine; Dysgerminoma; Female; Humans; Infertility, Male; Male; Semen; Sperm Count; Sperm- | 1989 |
17 trials available for carnitine and Infertility, Male
| Article | Year |
|---|---|
Comparison of L-Carnitine vs. Coq10 and Vitamin E for idiopathic male infertility: a randomized controlled trial.
Topics: Carnitine; Female; Humans; Infertility, Male; Luteinizing Hormone; Male; Pregnancy; Sperm Count; Spe | 2022 |
[Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin Forte) for treatment of male infertility].
Topics: Acetylcarnitine; Adult; Carnitine; Double-Blind Method; Female; Fumarates; Humans; Infertility, Male | 2019 |
[L-carnitine improves sperm acrosin activity in male infertility patients].
Topics: Acrosin; Carnitine; Humans; Infertility, Male; Male; Semen; Sperm Count; Sperm Motility; Spermatozoa | 2018 |
Dietary supplementation with a novel l-carnitine multi-micronutrient in idiopathic male subfertility involving oligo-, astheno-, teratozoospermia: A randomized clinical study.
Topics: Adult; Carnitine; Dietary Supplements; Double-Blind Method; Female; Humans; Infertility, Male; Male; | 2020 |
Impact of Spirulina Supplementation on Semen Parameters in Patients with Idiopathic Male Infertility: A Pilot Randomized Trial.
Topics: Adult; Carnitine; Clomiphene; Dietary Supplements; Estrogen Antagonists; Female; Humans; Infertility | 2019 |
Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters.
Topics: Adult; Arginine; Carnitine; Drug Combinations; Folic Acid; Glutathione; Humans; Infertility, Male; M | 2016 |
Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study.
Topics: Adult; Carnitine; Clomiphene; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, C | 2010 |
[Short-term medication of L-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia].
Topics: Adult; Asthenozoospermia; Carnitine; Female; Humans; Infertility, Male; Male; Oligospermia; Pregnanc | 2012 |
Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA.
Topics: Administration, Oral; Antioxidants; Ascorbic Acid; Asthenozoospermia; Carnitine; DNA Damage; DNA Fra | 2013 |
Antioxidant treatment with carnitines is effective in infertile patients with prostatovesiculoepididymitis and elevated seminal leukocyte concentrations after treatment with nonsteroidal anti-inflammatory compounds.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carnitine; Epididymitis; Female; Genit | 2002 |
Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial.
Topics: Carnitine; Cross-Over Studies; Double-Blind Method; Humans; Infertility, Male; Male; Placebos; Semen | 2003 |
Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels.
Topics: Administration, Oral; Adult; Carnitine; Glutathione Peroxidase; Humans; Infertility, Male; Male; Pho | 2005 |
Correlation between seminal carnitine and functional spermatozoal characteristics in men with semen dysfunction of various origins.
Topics: Acetylcarnitine; Acridine Orange; Adult; Carnitine; Eosine Yellowish-(YS); Humans; Infertility, Male | 2005 |
The effects of L-carnitine on sperm parameters in smoker and non-smoker patients with idiopathic sperm abnormalities.
Topics: Adult; Carnitine; Humans; Infertility, Male; Male; Middle Aged; Prospective Studies; Smoking; Sperm | 2005 |
Carnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Carnitine; Double-Blind Method; Humans; Infertility, | 2006 |
Carnitine supplementation in human idiopathic asthenospermia: clinical results.
Topics: Carnitine; Fertility Agents, Male; Humans; Infertility, Male; Male; Sperm Motility | 1995 |
[Antioxidant therapeutic efficiency after the use of carnitine in infertile patients with bacterial or non bacterial prostato-vesiculo-epididymitis].
Topics: Adult; Antioxidants; Carnitine; Epididymitis; Humans; Infertility, Male; Inflammation; Male; Prostat | 2001 |
47 other studies available for carnitine and Infertility, Male
| Article | Year |
|---|---|
The effects of two different antioxidant combinations on sperm parameters.
Topics: Acetylcarnitine; Adult; Antioxidants; Ascorbic Acid; Carnitine; Citric Acid; Female; Folic Acid; Fru | 2022 |
Plasma metabolome study reveals metabolic changes induced by pharmacological castration and testosterone supplementation in healthy young men.
Topics: Amino Acids; Carbohydrates; Carnitine; Dietary Supplements; Follicle Stimulating Hormone; Glyceropho | 2022 |
Comparison of sperm carnitine profiles of normospermic, oligospermic and azospermic individuals.
Topics: Carnitine; Humans; Infertility, Male; Male; Proteomics; Semen; Spermatozoa | 2023 |
Changes in the Level of DNA Fragmentation in Sperm Cells detected by Acridine Orange Test in Men with Sub/infertility Treated with Nutritional Supplement PAPA.
Topics: Acridine Orange; Adult; Antioxidants; Arginine; Asthenozoospermia; Carnitine; Dietary Supplements; D | 2020 |
Effect of antioxidant supplementation containing L-carnitine on semen parameters: a prospective interventional study.
Topics: Antioxidants; Carnitine; Dietary Supplements; Humans; Infertility, Male; Male; Prospective Studies; | 2021 |
The protective role of l-carnitine on spermatogenesis after cisplatin treatment during prepubertal period in rats: A pathophysiological study.
Topics: Animals; Antineoplastic Agents; Carnitine; Cisplatin; Infertility, Male; Male; Rats; Rats, Sprague-D | 2020 |
SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility.
Topics: Animals; Carnitine; Citric Acid Cycle; Diet; Fatty Acids; Female; Fertility; Fertilization in Vitro; | 2021 |
Cryoprotective effect of L-carnitine on motility, vitality and DNA oxidation of human spermatozoa.
Topics: Carnitine; Cell Survival; Cryopreservation; Cryoprotective Agents; DNA; Humans; Infertility, Male; M | 2014 |
CoQ10 and L-carnitine attenuate the effect of high LDL and oxidized LDL on spermatogenesis in male rats.
Topics: Animals; Antioxidants; Carnitine; Cell Survival; Cholesterol, Dietary; Cytoprotection; Disease Model | 2014 |
Metabolomic analysis reveals a unique urinary pattern in normozoospermic infertile men.
Topics: Adult; Aspartic Acid; Biomarkers; Carnitine; Humans; Infertility, Male; Leukotriene E4; Male; Metabo | 2014 |
Coenzyme Q₁₀, α-tocopherol, and oxidative stress could be important metabolic biomarkers of male infertility.
Topics: Administration, Oral; Adult; alpha-Tocopherol; Ascorbic Acid; Biomarkers; Carnitine; Drug Combinatio | 2015 |
Protective effects of l-carnitine on astheno- and normozoospermic human semen samples during cryopreservation.
Topics: Antioxidants; Asthenozoospermia; Carnitine; Cell Survival; Cryopreservation; DNA Fragmentation; Huma | 2016 |
Oral antioxidant treatment partly improves integrity of human sperm DNA in infertile grade I varicocele patients.
Topics: Antioxidants; Ascorbic Acid; Carnitine; Cell Survival; Dietary Supplements; DNA; DNA Damage; DNA Fra | 2015 |
A correlation between selenium and carnitine levels with hypo-osmotic swelling test for sperm membrane in low-grade varicocele patients.
Topics: Adult; Biomarkers; Carnitine; Humans; Infertility, Male; Male; Osmosis; Selenium; Sperm Motility; Sp | 2016 |
Carnitine-mediated antioxidant enzyme activity and Bcl2 expression involves peroxisome proliferator-activated receptor-γ coactivator-1α in mouse testis.
Topics: Animals; Antioxidants; Apoptosis; Carnitine; Dose-Response Relationship, Drug; Gene Expression Regul | 2017 |
The Effects of l-Carnitine Against Cyclophosphamide-Induced Injuries in Mouse Testis.
Topics: Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Carnitine; Cell Survival; Cyclophosph | 2017 |
Relationship of seminal free L-Carnitine with functional spermatozoal characteristics: Results from an observational study conducted in a tertiary care hospital of Karachi, Pakistan.
Topics: Adult; Carnitine; Humans; Infertility, Male; Male; Pakistan; Semen Analysis; Spermatozoa; Tertiary C | 2017 |
[Seminal plasma levocarnitine significantly correlated with semen quality].
Topics: Adult; Carnitine; Humans; Infertility, Male; Male; Semen; Sperm Count; Sperm Motility; Spermatozoa; | 2008 |
[Expressions of sperm-specific genes in carnitine-cultured testis sperm of obstructive azoospermia patients].
Topics: Azoospermia; Carnitine; Cells, Cultured; Gene Expression; Humans; Infertility, Male; Male; Reverse T | 2010 |
Role of L-carnitine in male infertility.
Topics: Adult; Carnitine; Case-Control Studies; Chromatography, High Pressure Liquid; Fertility; Humans; Inf | 2011 |
Reduction in sperm aneuploidy levels in severe oligoasthenoteratospermic patients after medical therapy: a preliminary report.
Topics: Adult; Aneuploidy; Asthenozoospermia; Carnitine; Chi-Square Distribution; Cyclooxygenase Inhibitors; | 2012 |
[Current approach to therapy for male infertility in patients with varicocele].
Topics: Adult; Carnitine; Clomiphene; Drug Therapy, Combination; Estrogen Antagonists; Follow-Up Studies; Hu | 2012 |
Relationship between semen quality and seminal plasma total carnitine in infertile men.
Topics: Biomarkers; Carnitine; Case-Control Studies; Humans; Infertility, Male; Male; Predictive Value of Te | 2003 |
Effect of L-carnitine administration on the seminal characteristics of oligoasthenospermic stallions.
Topics: Acetylcarnitine; Animals; Breeding; Carnitine; Carnitine O-Acetyltransferase; Horse Diseases; Horses | 2004 |
The level of adrenomedullin immunoreactivity in seminal fluid is higher in oligozoospermic subjects and correlates with semen biochemical parameters.
Topics: Adrenomedullin; Adult; Azoospermia; Carnitine; Follicle Stimulating Hormone; Fructose; Humans; Infer | 2007 |
Determination of free L-carnitine in human seminal plasma by high performance liquid chromatography with pre-column ultraviolet derivatization and its clinical application in male infertility.
Topics: Adult; Carnitine; Chromatography, High Pressure Liquid; Humans; Infertility, Male; Male; Reproducibi | 2007 |
[Level of free L-carnitine in human seminal plasma and its correlation with semen quality].
Topics: Adult; Carnitine; Case-Control Studies; Chromatography, High Pressure Liquid; Humans; Infertility, M | 2007 |
[Correlation of free L-carnitine level with accessory gland markers and its clinical significance].
Topics: Acid Phosphatase; Adult; alpha-Glucosidases; Carnitine; Case-Control Studies; Fructose; Humans; Infe | 2007 |
Paradoxical increase of sperm motility and seminal carnitine associated with moderate leukocytospermia in infertile patients.
Topics: Acid Phosphatase; Adult; Biomarkers; Carnitine; Humans; Infertility, Male; Leukocyte Count; Leukocyt | 2008 |
Levels of seminal free L(-) carnitine in fertile and infertile men.
Topics: Carnitine; Epididymis; Humans; Infertility, Male; Male; Reference Values; Semen; Sexual Abstinence; | 1984 |
Diamine oxidase activity and biochemical markers in human seminal plasma.
Topics: Acid Phosphatase; Adult; Biomarkers; Carnitine; Citrates; Citric Acid; Fructose; Genitalia, Male; Hu | 1995 |
Biochemical parameters in evaluation of oligospermia.
Topics: Adult; Carnitine; Follicle Stimulating Hormone; Fructose; Humans; Infertility, Male; Luteinizing Hor | 1994 |
Lactic dehydrogenase-C4 activity in seminal plasma and male infertility.
Topics: Carnitine; Humans; Infertility, Male; Isoenzymes; L-Lactate Dehydrogenase; Male; Models, Biological; | 1993 |
CA 125 in seminal plasma: correlation with semen parameters.
Topics: Adult; Age Factors; Biomarkers; CA-125 Antigen; Carnitine; Female; Fertility; Fructose; Humans; Infe | 1996 |
[Intra-spermatic L-carnitine and survival of sperm motility].
Topics: Animals; Carnitine; Cattle; Cervix Mucus; Culture Media; Female; Humans; In Vitro Techniques; Infert | 1999 |
Relationship between semen quality and the seminal plasma components carnitine, alpha-glucosidase, fructose, citrate and granulocyte elastase in infertile men compared with a normal population.
Topics: Adolescent; Adult; alpha-Glucosidases; Biomarkers; Carnitine; Citric Acid; Fructose; Humans; Inferti | 2000 |
Effects of treatment with carnitines in infertile patients with prostato-vesiculo-epididymitis.
Topics: Acetylcarnitine; Adult; Antioxidants; Carnitine; Epididymitis; Female; Genital Diseases, Male; Human | 2001 |
[Andrologic aspects of hypogonadism].
Topics: Acrosin; Adult; Biopsy; Carnitine; Fructose; Humans; Hypogonadism; Infertility, Male; Male; Middle A | 1979 |
Levels of L-carnitine and L-O-acetylcarnitine in normal and infertile human semen: a lower level of L-O-acetycarnitine in infertile semen.
Topics: Acetylcarnitine; Carnitine; Humans; Infertility, Male; Male; Oligospermia; Semen | 1977 |
The management of azoospermia.
Topics: Carnitine; Epididymis; Glycerylphosphorylcholine; Humans; Infertility, Male; Male; Oligospermia; Sem | 1978 |
Epididymis and seminal vesicle as sources of carnitine in human seminal fluid: the clinical significance of the carnitine concentration in human seminal fluid.
Topics: Acid Phosphatase; Carnitine; Epididymis; Epididymitis; Fructose; Humans; Infertility, Male; Inositol | 1976 |
Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats.
Topics: Animals; Carnitine; Epididymis; Fertility; Gossypol; Infertility, Male; L-Lactate Dehydrogenase; Mal | 1987 |
Recommended biochemical parameters for routine semen analysis.
Topics: Acid Phosphatase; Carnitine; Citrates; Citric Acid; Fructose; Humans; Infertility, Male; Male; Semen | 1986 |
Free l-carnitine in human semen.
Topics: Carnitine; Humans; Infertility, Male; Male; Semen; Spectrophotometry | 1985 |
The epididymal factor--a diagnostic approach.
Topics: Carnitine; Epididymis; Humans; Infertility, Male; Male; Semen; Sperm Maturation | 1985 |
[Azoospermia, asthenozoospermia and seminal biochemistry].
Topics: Acid Phosphatase; Carnitine; Citrates; Citric Acid; Epididymis; Fructose; Humans; Infertility, Male; | 1985 |
Carnitine acetyltransferase and spermatozoan development in Drosophila melanogaster.
Topics: Acyltransferases; Animals; Carbon Isotopes; Carnitine; Choline; Diet; Drosophila; Female; Genes; Inf | 1970 |