Page last updated: 2024-10-16

carnitine and Hypothyroidism

carnitine has been researched along with Hypothyroidism in 15 studies

Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.

Research Excerpts

ExcerptRelevanceReference
"Weakness is common in both hyper- and hypothyroidism, and skeletal muscle L-carnitine may play a role in this regard, as suggested by studies indicating abnormal levels of carnitine in serum and urine of patients with thyroid dysfunction."7.73Muscle carnitine in hypo- and hyperthyroidism. ( Gilchrist, JM; Hennessey, JV; Kandula, M; Sinclair, C, 2005)
"Urinary excretion of carnitine and serum concentrations of carnitine, triglyceride, and free fatty acids were measured in 54 hyperthyroid and 13 hypothyroid patients, and the results were compared with those of normal subjects."7.65Urinary excretion of carnitine in patients with hyperthyroidism and hypothyroidism: augmentation by thyroid hormone. ( Imamura, A; Kawamura, N; Maebashi, M; Sato, M; Yoshinaga, K, 1977)
"Propylthiouracil (PTU; 0."5.27Effect of hypothyroidism during gestation and in the suckling period on cholesterol and carnitine metabolism in the rat. ( Hahn, P, 1986)
"To examine acylcarnitine profiles in individuals with hypo- or hyperthyroidism, and determine whether any atypical acylcarnitine species identified would normalize with correction of thyroid status."3.79Acylcarnitine profile in thyroid disease. ( Dahl, M; Hannah-Shmouni, F; Mattman, A; Sinclair, G; Sirrs, S; Wong, S, 2013)
" Chronic hypothyroidism was associated with substantial depletion in skeletal muscle free carnitine."3.75Longitudinal study of the effects of chronic hypothyroidism on skeletal muscle in dogs. ( Duncan, RB; Inzana, KD; Panciera, DL; Rossmeisl, JH; Shelton, GD, 2009)
"Weakness is common in both hyper- and hypothyroidism, and skeletal muscle L-carnitine may play a role in this regard, as suggested by studies indicating abnormal levels of carnitine in serum and urine of patients with thyroid dysfunction."3.73Muscle carnitine in hypo- and hyperthyroidism. ( Gilchrist, JM; Hennessey, JV; Kandula, M; Sinclair, C, 2005)
"Urinary excretion of carnitine and serum concentrations of carnitine, triglyceride, and free fatty acids were measured in 54 hyperthyroid and 13 hypothyroid patients, and the results were compared with those of normal subjects."3.65Urinary excretion of carnitine in patients with hyperthyroidism and hypothyroidism: augmentation by thyroid hormone. ( Imamura, A; Kawamura, N; Maebashi, M; Sato, M; Yoshinaga, K, 1977)
"Propylthiouracil (PTU; 0."1.27Effect of hypothyroidism during gestation and in the suckling period on cholesterol and carnitine metabolism in the rat. ( Hahn, P, 1986)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19907 (46.67)18.7374
1990's2 (13.33)18.2507
2000's2 (13.33)29.6817
2010's4 (26.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
An, JH2
Kim, YJ1
Kim, KJ1
Kim, SH1
Kim, NH2
Kim, HY1
Choi, KM1
Baik, SH1
Choi, DS1
Kim, SG2
Benvenga, S1
Sindoni, A1
Rossmeisl, JH1
Duncan, RB1
Inzana, KD1
Panciera, DL1
Shelton, GD1
Wong, S1
Hannah-Shmouni, F1
Sinclair, G1
Sirrs, S1
Dahl, M1
Mattman, A1
Sinclair, C1
Gilchrist, JM1
Hennessey, JV1
Kandula, M1
Eanes, RZ1
Biniek, RL1
Black, SC1
McNeill, JH1
Katz, S1
Maebaski, M1
Kawamura, N3
Sato, M2
Imamura, A2
Yoshinaga, K3
Maebashi, M1
Kaminsky, P1
Franck, P1
Jacob, JL1
Klein, M1
Nabet, P1
Duc, M1
Dillmann, WH1
Hahn, P1
Nolte, J1
Pette, D1
Bachmaier, B1
Kiefhaber, P1
Schneider, H1
Scriba, PC1
Maebashi, S1
Saito, S1
Sakurada, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Single-center, Randomized, Double-Blinded, Comparative Study of the Effectiveness of L-carnitine in Patients'Fatigue Degree Changing With Hypothyroidism Who Take Levothyroxine[NCT01769157]Phase 460 participants (Actual)Interventional2012-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for carnitine and Hypothyroidism

ArticleYear
Diabetes mellitus and hypothyroidism induce changes in myosin isoenzyme distribution in the rat heart--do alterations in fuel flux mediate these changes?
    Advances in experimental medicine and biology, 1986, Volume: 194

    Topics: Adenosine Triphosphatases; Animals; Carnitine; Diabetes Mellitus, Experimental; Energy Metabolism; H

1986

Trials

1 trial available for carnitine and Hypothyroidism

ArticleYear
L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial.
    Endocrine journal, 2016, Oct-29, Volume: 63, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Carnitine; Dietary Supplements; Double-Blind Method; Fatigue; Female

2016

Other Studies

13 other studies available for carnitine and Hypothyroidism

ArticleYear
L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment [Letter to the Editor].
    Endocrine journal, 2016, 10-29, Volume: 63, Issue:10

    Topics: Carnitine; Dietary Supplements; Fatigue; Humans; Hypothyroidism; Thyroxine

2016
L-carnitine supplementation in hypothyroidism [Letter to the Editor].
    Endocrine journal, 2016, 10-29, Volume: 63, Issue:10

    Topics: Carnitine; Dietary Supplements; Humans; Hypothyroidism

2016
Longitudinal study of the effects of chronic hypothyroidism on skeletal muscle in dogs.
    American journal of veterinary research, 2009, Volume: 70, Issue:7

    Topics: Animals; Carnitine; Chronic Disease; Dog Diseases; Dogs; Female; Hypothyroidism; Muscle, Skeletal; M

2009
Acylcarnitine profile in thyroid disease.
    Clinical biochemistry, 2013, Volume: 46, Issue:1-2

    Topics: Adult; Aged; Carnitine; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Referenc

2013
Muscle carnitine in hypo- and hyperthyroidism.
    Muscle & nerve, 2005, Volume: 32, Issue:3

    Topics: Adult; Biopsy; Carnitine; Down-Regulation; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Mi

2005
The twenty-four-hour urinary excretion of carnitine and creatinine in normal and hypothyroid children.
    Biochemical medicine, 1980, Volume: 24, Issue:2

    Topics: Adolescent; Aging; Carnitine; Child; Child, Preschool; Creatinine; Female; Humans; Hypothyroidism; M

1980
Cardiac sarcoplasmic reticulum calcium transport activity of thyroidectomized rats: the role of endogenous myocardial acylcarnitines and calcium pump protein.
    Pharmacology, 1993, Volume: 46, Issue:3

    Topics: Animals; Body Weight; Calcium; Calcium-Transporting ATPases; Carnitine; Electron Transport Complex I

1993
Urinary excretion of carnitine and serum concentrations of carnitine and lipids in patients with hypofunctional endocrine diseases: involvement of adrenocorticoid and thyroid hormones in ACTH-induced augmentation of carnitine and lipids metabolism.
    Metabolism: clinical and experimental, 1977, Volume: 26, Issue:4

    Topics: Addison Disease; Adrenalectomy; Adrenocorticotropic Hormone; Carnitine; Cosyntropin; Fatty Acids, No

1977
Urinary excretion of carnitine in patients with hyperthyroidism and hypothyroidism: augmentation by thyroid hormone.
    Metabolism: clinical and experimental, 1977, Volume: 26, Issue:4

    Topics: Adolescent; Adult; Carnitine; Fatty Acids, Nonesterified; Female; Humans; Hyperthyroidism; Hypothyro

1977
[Serum carnitine values in dysthyroidism].
    Presse medicale (Paris, France : 1983), 1992, Jan-18, Volume: 21, Issue:2

    Topics: Carnitine; Humans; Hyperthyroidism; Hypothyroidism; Reference Values

1992
Effect of hypothyroidism during gestation and in the suckling period on cholesterol and carnitine metabolism in the rat.
    Biology of the neonate, 1986, Volume: 50, Issue:5

    Topics: Aging; Animals; Carnitine; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Female; Fetus; Hydroxymethy

1986
Enzyme response to thyrotoxicosis and hypothyroidism in human liver and muscle: comparative aspects.
    European journal of clinical investigation, 1972, Volume: 2, Issue:3

    Topics: Acyltransferases; Alcohol Oxidoreductases; Animals; Biopsy; Carnitine; Enzymes; Fructose-Bisphosphat

1972
[Proceedings: Changes in the quantity of carnitine excreted in the urine in hyperthyroidism and hypothyroidism].
    Nihon Naibunpi Gakkai zasshi, 1974, Feb-20, Volume: 50, Issue:2

    Topics: Adolescent; Adult; Carnitine; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged

1974