carnitine has been researched along with Glucose Intolerance in 18 studies
Glucose Intolerance: A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present review provides an overview about data from both animal and human studies reporting effects of either carnitine supplementation or carnitine deficiency on parameters of glucose homeostasis and insulin sensitivity in order to establish the less well-recognized role of carnitine in regulating glucose homeostasis." | 8.88 | Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency. ( Eder, K; Keller, J; Ringseis, R, 2012) |
| "Carnitine deficiency and impaired glucose tolerance (IGT) exacerbate liver steatosis." | 8.12 | High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models. ( Matsuura, T; Mekada, K; Nakamura, SI; Ozaki, K; Terayama, Y, 2022) |
| "In this study the correlations between the concentration of carnitine and an increasing glucose intolerance in women with untreated, non insulin dependent gestational diabetes (GDM) were examined." | 7.71 | [The concentration of carnitine in the last trimester of pregnancy subject to glucose tolerance]. ( Günter, HH; Oehler, K; Peulecke, W; Scharf, A; Schumann, G; Sohn, C, 2002) |
| "Obesity is associated with insulin resistance and impaired glucose tolerance, which represent characteristic features of the metabolic syndrome." | 5.43 | Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice. ( Bardova, K; Gardlo, A; Hansikova, J; Horakova, O; Kopecky, J; Kuda, O; Rombaldova, M; Rossmeisl, M, 2016) |
| "Offspring of type 2 diabetes (T2D) patients have increased risk to develop diabetes, due to inherited genetic susceptibility that directly interferes with the individual adaption to environmental conditions." | 5.43 | Untargeted mass spectrometric approach in metabolic healthy offspring of patients with type 2 diabetes reveals medium-chain acylcarnitine as potential biomarker for lipid induced glucose intolerance (LGIT). ( Barsch, A; Fuchser, J; Haas, J; Knebel, B; Kotzka, J; Lange, S; Lehr, S; Mack, S; Müller-Wieland, D; Schiller, M; Zurek, G, 2016) |
| "The present review provides an overview about data from both animal and human studies reporting effects of either carnitine supplementation or carnitine deficiency on parameters of glucose homeostasis and insulin sensitivity in order to establish the less well-recognized role of carnitine in regulating glucose homeostasis." | 4.88 | Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency. ( Eder, K; Keller, J; Ringseis, R, 2012) |
| "Carnitine deficiency and impaired glucose tolerance (IGT) exacerbate liver steatosis." | 4.12 | High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models. ( Matsuura, T; Mekada, K; Nakamura, SI; Ozaki, K; Terayama, Y, 2022) |
| "We conclude that the removal of dysfunctional mitochondria by induction of autophagy through PPARγ may be a novel mechanism by which carnitine improves insulin resistance and mitochondrial dysfunction in obesity." | 3.88 | Carnitine induces autophagy and restores high-fat diet-induced mitochondrial dysfunction. ( Choi, JW; Chung, SS; Jang, HC; Jung, HS; Ohn, JH; Park, KS; Park, YJ, 2018) |
| " We hypothesized that increasing free carnitine levels by administration of the carnitine precursor γ-butyrobetaine (γBB) could facilitate FAO, thereby improving insulin sensitivity." | 3.83 | The impact of altered carnitine availability on acylcarnitine metabolism, energy expenditure and glucose tolerance in diet-induced obese mice. ( Hollak, CE; Houten, SM; Houtkooper, RH; Schooneman, MG; Soeters, MR; Vaz, FM; Wanders, RJ, 2016) |
| "Alterations in serum concentrations of several acylcarnitines, in particular tetradecenoylcarnitine (C14:1), tetradecadienylcarnitine (C14:2), octadecenoylcarnitine (C18:1) and malonylcarnitine/hydroxybutyrylcarnitine (C3DC+C4OH) are associated not only with T2D but also with prediabetic states." | 3.79 | Serum levels of acylcarnitines are altered in prediabetic conditions. ( Fiedler, GM; Kovacs, P; Leichtle, AB; Mai, M; Stumvoll, M; Tönjes, A, 2013) |
| "Accumulation of triacylglycerols (TAGs) and acylcarnitines in skeletal muscle upon high-fat (HF) feeding is the resultant of fatty acid uptake and oxidation and is associated with insulin resistance." | 3.77 | The effects of long- or medium-chain fat diets on glucose tolerance and myocellular content of lipid intermediates in rats. ( Boon, W; De Vogel-van den Bosch, J; Hesselink, MK; Hoeks, J; Houten, SM; Kersten, S; Schaart, G; Schrauwen, P; Timmers, S; Van Beurden, D; van Dijk, PJ; Voshol, PJ; Wanders, RJ, 2011) |
| "In this study the correlations between the concentration of carnitine and an increasing glucose intolerance in women with untreated, non insulin dependent gestational diabetes (GDM) were examined." | 3.71 | [The concentration of carnitine in the last trimester of pregnancy subject to glucose tolerance]. ( Günter, HH; Oehler, K; Peulecke, W; Scharf, A; Schumann, G; Sohn, C, 2002) |
| "To elucidate the relationship between carnitine metabolism and plasma ketone body concentrations in moderately obese patients with mild glucose intolerance, the ketone body and carnitine levels in the basal state were determined in 72 obese patients: 20 with normal glucose tolerance (NGT), 29 with impaired glucose tolerance (IGT), and 23 with non-insulin-dependent diabetes mellitus (NIDDM) having a fasting plasma glucose (FPG) level of less than 200 mg/dl." | 3.69 | Changes in carnitine metabolism with ketone body production in obese glucose-intolerant patients. ( Imamura, K; Inokuchi, T; Isogai, S; Nomoto, K; Nomura, K, 1995) |
| "Obesity is associated with insulin resistance and impaired glucose tolerance, which represent characteristic features of the metabolic syndrome." | 1.43 | Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice. ( Bardova, K; Gardlo, A; Hansikova, J; Horakova, O; Kopecky, J; Kuda, O; Rombaldova, M; Rossmeisl, M, 2016) |
| "Offspring of type 2 diabetes (T2D) patients have increased risk to develop diabetes, due to inherited genetic susceptibility that directly interferes with the individual adaption to environmental conditions." | 1.43 | Untargeted mass spectrometric approach in metabolic healthy offspring of patients with type 2 diabetes reveals medium-chain acylcarnitine as potential biomarker for lipid induced glucose intolerance (LGIT). ( Barsch, A; Fuchser, J; Haas, J; Knebel, B; Kotzka, J; Lange, S; Lehr, S; Mack, S; Müller-Wieland, D; Schiller, M; Zurek, G, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 13 (72.22) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Terayama, Y | 1 |
| Nakamura, SI | 1 |
| Mekada, K | 1 |
| Matsuura, T | 1 |
| Ozaki, K | 1 |
| Owei, I | 1 |
| Umekwe, N | 1 |
| Stentz, F | 1 |
| Wan, J | 1 |
| Dagogo-Jack, S | 1 |
| Choi, JW | 1 |
| Ohn, JH | 1 |
| Jung, HS | 1 |
| Park, YJ | 1 |
| Jang, HC | 1 |
| Chung, SS | 1 |
| Park, KS | 1 |
| Batchuluun, B | 1 |
| Al Rijjal, D | 1 |
| Prentice, KJ | 1 |
| Eversley, JA | 1 |
| Burdett, E | 1 |
| Mohan, H | 1 |
| Bhattacharjee, A | 1 |
| Gunderson, EP | 1 |
| Liu, Y | 1 |
| Wheeler, MB | 1 |
| Mai, M | 1 |
| Tönjes, A | 1 |
| Kovacs, P | 1 |
| Stumvoll, M | 1 |
| Fiedler, GM | 1 |
| Leichtle, AB | 1 |
| Zhang, X | 1 |
| Zhang, C | 1 |
| Chen, L | 1 |
| Han, X | 1 |
| Ji, L | 1 |
| Fiamoncini, J | 1 |
| Lima, TM | 1 |
| Hirabara, SM | 1 |
| Ecker, J | 1 |
| Gorjão, R | 1 |
| Romanatto, T | 1 |
| ELolimy, A | 1 |
| Worsch, S | 1 |
| Laumen, H | 1 |
| Bader, B | 1 |
| Daniel, H | 1 |
| Curi, R | 1 |
| Schooneman, MG | 1 |
| Houtkooper, RH | 1 |
| Hollak, CE | 1 |
| Wanders, RJ | 2 |
| Vaz, FM | 1 |
| Soeters, MR | 1 |
| Houten, SM | 2 |
| Horakova, O | 1 |
| Hansikova, J | 1 |
| Bardova, K | 1 |
| Gardlo, A | 1 |
| Rombaldova, M | 1 |
| Kuda, O | 1 |
| Rossmeisl, M | 1 |
| Kopecky, J | 1 |
| Knebel, B | 1 |
| Mack, S | 1 |
| Lehr, S | 1 |
| Barsch, A | 1 |
| Schiller, M | 1 |
| Haas, J | 1 |
| Lange, S | 1 |
| Fuchser, J | 1 |
| Zurek, G | 1 |
| Müller-Wieland, D | 1 |
| Kotzka, J | 1 |
| Noland, RC | 1 |
| Koves, TR | 1 |
| Seiler, SE | 1 |
| Lum, H | 1 |
| Lust, RM | 1 |
| Ilkayeva, O | 1 |
| Stevens, RD | 2 |
| Hegardt, FG | 1 |
| Muoio, DM | 1 |
| Mihalik, SJ | 1 |
| Goodpaster, BH | 1 |
| Kelley, DE | 1 |
| Chace, DH | 1 |
| Vockley, J | 1 |
| Toledo, FG | 1 |
| DeLany, JP | 1 |
| De Vogel-van den Bosch, J | 1 |
| Hoeks, J | 1 |
| Timmers, S | 1 |
| van Dijk, PJ | 1 |
| Boon, W | 1 |
| Van Beurden, D | 1 |
| Schaart, G | 1 |
| Kersten, S | 1 |
| Voshol, PJ | 1 |
| Hesselink, MK | 1 |
| Schrauwen, P | 1 |
| Ringseis, R | 2 |
| Mooren, FC | 1 |
| Keller, J | 2 |
| Couturier, A | 1 |
| Wen, G | 1 |
| Hirche, F | 1 |
| Stangl, GI | 1 |
| Eder, K | 2 |
| Krüger, K | 1 |
| Anderson, KA | 1 |
| Lin, F | 1 |
| Ribar, TJ | 1 |
| Muehlbauer, MJ | 1 |
| Newgard, CB | 1 |
| Means, AR | 1 |
| Günter, HH | 1 |
| Peulecke, W | 1 |
| Oehler, K | 1 |
| Scharf, A | 1 |
| Schumann, G | 1 |
| Sohn, C | 1 |
| Inokuchi, T | 1 |
| Imamura, K | 1 |
| Nomura, K | 1 |
| Nomoto, K | 1 |
| Isogai, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| SWIFT: Study of Women, Infant Feeding and Type 2 Diabetes After GDM Pregnancy[NCT01967030] | 1,035 participants (Actual) | Observational | 2008-05-31 | Active, not recruiting | |||
| Evaluation of a Bakery Product Enriched With Fibre and L-carnitine on Cardiovascular Risk Parameters in Patients With Metabolic Syndrome: a Randomized, Double-blind, Placebo-controlled Study[NCT02281253] | 54 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for carnitine and Glucose Intolerance
| Article | Year |
|---|---|
Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency.
Topics: Acetyl Coenzyme A; Animals; Blood Glucose; Carnitine; Diabetes Mellitus, Type 2; Dietary Supplements | 2012 |
17 other studies available for carnitine and Glucose Intolerance
| Article | Year |
|---|---|
High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models.
Topics: Alloxan; Animals; Carcinogenesis; Carnitine; Diet, High-Fat; Disease Models, Animal; Glucose Intoler | 2022 |
Association of plasma acylcarnitines with insulin sensitivity, insulin secretion, and prediabetes in a biracial cohort.
Topics: Adult; Blood Glucose; Carnitine; Cross-Sectional Studies; Glucose Intolerance; Humans; Insulin Resis | 2021 |
Carnitine induces autophagy and restores high-fat diet-induced mitochondrial dysfunction.
Topics: Animals; Autophagosomes; Autophagy; Carnitine; Diet, High-Fat; Glucose Intolerance; Insulin; Insulin | 2018 |
Elevated Medium-Chain Acylcarnitines Are Associated With Gestational Diabetes Mellitus and Early Progression to Type 2 Diabetes and Induce Pancreatic β-Cell Dysfunction.
Topics: Adult; Animals; Carnitine; Case-Control Studies; Cell Respiration; Diabetes Mellitus, Type 2; Diabet | 2018 |
Serum levels of acylcarnitines are altered in prediabetic conditions.
Topics: Adult; Aged; Blood Glucose; Body Composition; Carnitine; Diabetes Mellitus, Type 2; Female; Glucose | 2013 |
Human serum acylcarnitine profiles in different glucose tolerance states.
Topics: Biomarkers; Blood Glucose; Carnitine; Chromatography, Liquid; Diabetes Mellitus, Type 2; Fasting; Fe | 2014 |
Medium-chain dicarboxylic acylcarnitines as markers of n-3 PUFA-induced peroxisomal oxidation of fatty acids.
Topics: Animals; Biomarkers; Carnitine; Diet, High-Fat; Dietary Fats; Dietary Fats, Unsaturated; Fatty Acids | 2015 |
The impact of altered carnitine availability on acylcarnitine metabolism, energy expenditure and glucose tolerance in diet-induced obese mice.
Topics: Animals; Betaine; Carnitine; Dietary Fats; Energy Metabolism; Glucose Intolerance; Insulin Resistanc | 2016 |
Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice.
Topics: Amino Acids; Analysis of Variance; Animals; Biomarkers; Blood Glucose; Carnitine; Cluster Analysis; | 2016 |
Untargeted mass spectrometric approach in metabolic healthy offspring of patients with type 2 diabetes reveals medium-chain acylcarnitine as potential biomarker for lipid induced glucose intolerance (LGIT).
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Glucose; Carnitine; Case-Control Studies; Chromatography, | 2016 |
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.
Topics: Aging; Animals; Biological Transport; Blotting, Western; Carnitine; Carnitine O-Acetyltransferase; C | 2009 |
Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity.
Topics: Adult; Biomarkers; Body Mass Index; Carnitine; Diabetes Mellitus, Type 2; Fasting; Glucose Clamp Tec | 2010 |
The effects of long- or medium-chain fat diets on glucose tolerance and myocellular content of lipid intermediates in rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Blotting, Western; Body Weight; Carnitine; Dietary Fat | 2011 |
Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet.
Topics: Acetylcarnitine; Animals; Body Weight; Carnitine; Diet, High-Fat; Fatty Acids; Gene Expression Regul | 2011 |
Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
Topics: Adenylate Kinase; Animals; Antigens, Neoplasm; Blood Glucose; Calcium-Calmodulin-Dependent Protein K | 2012 |
[The concentration of carnitine in the last trimester of pregnancy subject to glucose tolerance].
Topics: Adult; Biomarkers; Blood Glucose; Carnitine; Diabetes, Gestational; Female; Glucose Intolerance; Glu | 2002 |
Changes in carnitine metabolism with ketone body production in obese glucose-intolerant patients.
Topics: Acylation; Adult; Blood Glucose; Carnitine; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucose In | 1995 |