carnitine has been researched along with Fatigue Syndrome, Chronic in 22 studies
Fatigue Syndrome, Chronic: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The serum concentrations of total, free and acylcarnitine were compared in 25 patients with multiple sclerosis (MS) and among age- and sex-matched normal controls by the new enzymatic cycling method in order to clarify whether the fatigue in MS might be due to possible carnitine-related fatty acid metabolic abnormalities in the mitochondria of skeletal muscles." | 7.69 | Serum carnitine and disabling fatigue in multiple sclerosis. ( Fukazawa, T; Hamada, T; Kikuchi, S; Sasaki, H; Tashiro, K, 1996) |
| "Patients with chronic fatigue syndrome (CFS) complain of muscle pain and impaired exercise tolerance." | 5.31 | Normal carnitine levels in patients with chronic fatigue syndrome. ( Bleijenberg, G; Elving, LD; Janssen, AJ; Soetekouw, PM; van der Meer, JW; van der Veen, Y; Vreken, P; Wevers, RA, 2000) |
| "The serum concentrations of total, free and acylcarnitine were compared in 25 patients with multiple sclerosis (MS) and among age- and sex-matched normal controls by the new enzymatic cycling method in order to clarify whether the fatigue in MS might be due to possible carnitine-related fatty acid metabolic abnormalities in the mitochondria of skeletal muscles." | 3.69 | Serum carnitine and disabling fatigue in multiple sclerosis. ( Fukazawa, T; Hamada, T; Kikuchi, S; Sasaki, H; Tashiro, K, 1996) |
| "L-Carnitine is a safe and very well tolerated medicine which improves the clinical status of CFS patients." | 2.68 | Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. ( Plioplys, AV; Plioplys, S, 1997) |
| "Many patients with chronic fatigue syndrome(CFS) fulfill the criteria of FMS and represent one end of a spectrum of presentation." | 2.40 | [Fibromyalgia syndrome]. ( Matsumoto, Y, 1999) |
| "Myalgic encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) share many symptoms of fatigue, pain, and cognitive dysfunction that are not relieved by rest." | 1.62 | Exercise modifies glutamate and other metabolic biomarkers in cerebrospinal fluid from Gulf War Illness and Myalgic encephalomyelitis / Chronic Fatigue Syndrome. ( Baraniuk, JN; Cheema, A; Kern, G; Narayan, V, 2021) |
| "The underlying aetiology of chronic fatigue syndrome is currently unknown; however, in the light of carnitine's critical role in mitochondrial energy production, it has been suggested that chronic fatigue syndrome may be associated with altered carnitine homeostasis." | 1.37 | Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity. ( Evans, AM; Reuter, SE, 2011) |
| "Patients with chronic fatigue syndrome (CFS) complain of muscle pain and impaired exercise tolerance." | 1.31 | Normal carnitine levels in patients with chronic fatigue syndrome. ( Bleijenberg, G; Elving, LD; Janssen, AJ; Soetekouw, PM; van der Meer, JW; van der Veen, Y; Vreken, P; Wevers, RA, 2000) |
| "As carnitine has an important role in energy production and modulation of the intramitochondrial coenzyme A (CoA)/acyl-CoA ratio in the skeletal muscle, this deficiency might induce an energy deficit and/or abnormality of the intramitochondrial condition in the skeletal muscle, thus resulting in general fatigue, myalgia, muscle weakness, and postexertional malaise in patients with CFS." | 1.29 | Acylcarnitine deficiency in chronic fatigue syndrome. ( Kitani, T; Kuratsune, H; Misaki, H; Tagawa, S; Takahashi, M; Yamaguti, K, 1994) |
| "Patients with chronic fatigue syndrome (CFS) suffer from disabling physical and mental fatigue." | 1.29 | Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome. ( Plioplys, AV; Plioplys, S, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Baraniuk, JN | 1 |
| Kern, G | 1 |
| Narayan, V | 1 |
| Cheema, A | 1 |
| Nicolson, GL | 1 |
| Horiuchi, M | 1 |
| Nakakuma, M | 1 |
| Arimura, E | 1 |
| Ushikai, M | 1 |
| Yoshida, G | 1 |
| Reuter, SE | 1 |
| Evans, AM | 1 |
| Laffon-Pioger, M | 1 |
| Rocher, F | 1 |
| Caruba, C | 1 |
| Cohen, M | 1 |
| Thomas, P | 1 |
| Lebrun, C | 1 |
| Jones, MG | 1 |
| Goodwin, CS | 1 |
| Amjad, S | 1 |
| Chalmers, RA | 1 |
| Malaguarnera, M | 1 |
| Di Mauro, A | 1 |
| Gargante, PM | 1 |
| Rampello, L | 1 |
| Miwa, S | 1 |
| Takikawa, O | 1 |
| Famularo, G | 1 |
| De Simone, C | 1 |
| Kuratsune, H | 3 |
| Yamaguti, K | 2 |
| Takahashi, M | 2 |
| Misaki, H | 1 |
| Tagawa, S | 1 |
| Kitani, T | 3 |
| Plioplys, AV | 3 |
| Plioplys, S | 3 |
| Grant, JE | 1 |
| Veldee, MS | 1 |
| Buchwald, D | 1 |
| Fukazawa, T | 1 |
| Sasaki, H | 1 |
| Kikuchi, S | 1 |
| Hamada, T | 1 |
| Tashiro, K | 1 |
| Lindh, G | 1 |
| Evengard, B | 1 |
| Machii, T | 1 |
| Matsumura, K | 1 |
| Takaishi, J | 1 |
| Kawata, S | 1 |
| Långström, B | 1 |
| Kanakura, Y | 1 |
| Watanabe, Y | 1 |
| Matsumoto, Y | 1 |
| Soetekouw, PM | 1 |
| Wevers, RA | 1 |
| Vreken, P | 1 |
| Elving, LD | 1 |
| Janssen, AJ | 1 |
| van der Veen, Y | 1 |
| Bleijenberg, G | 1 |
| van der Meer, JW | 1 |
| Masuda, A | 1 |
| Nakayama, T | 1 |
| Yamanaka, T | 1 |
| Hatsutanmaru, K | 1 |
| Tei, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Double Blinded Cross-over Study Comparing the Efficacy of L-carnitine Versus Placebo in the Treatment of Fatigue in Multiple Sclerosis[NCT01149525] | Phase 3 | 59 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Estudio clínico Fase III Para Evaluar la Eficacia terapéutica en Pacientes Mexicanos Con Dislipidemia Mediante el Uso vía Oral de L-Carnitina + Atorvastatina Comparado Con Atorvastatina[NCT03696940] | Phase 3 | 120 participants (Actual) | Interventional | 2018-05-28 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for carnitine and Fatigue Syndrome, Chronic
| Article | Year |
|---|---|
[Experimental Approach to Analysis of the Relationship between Food Environments and Lifestyle-Related Diseases, Including Cardiac Hypertrophy, Fatty Liver, and Fatigue Symptoms].
Topics: Animals; Beriberi; Cardiomegaly; Carnitine; Disease Models, Animal; Fatigue Syndrome, Chronic; Fatty | 2015 |
[Chronic fatigue syndrome and neurotransmitters].
Topics: Animals; Carnitine; Fatigue Syndrome, Chronic; Glutamates; Humans; Membrane Proteins; Neurotransmitt | 2007 |
[Fibromyalgia syndrome].
Topics: Biomarkers; Carnitine; Diagnosis, Differential; Fatigue; Fatigue Syndrome, Chronic; Fibromyalgia; Hu | 1999 |
[Chronic fatigue syndrome].
Topics: Carnitine; Diagnosis, Differential; Endocrine System Diseases; Fatigue Syndrome, Chronic; Humans; Im | 2000 |
2 trials available for carnitine and Fatigue Syndrome, Chronic
| Article | Year |
|---|---|
Carnitine serum levels and levocarnitine administration in multiple sclerosis patients treated with natalizumab.
Topics: Antibodies, Monoclonal, Humanized; Carnitine; Cohort Studies; Fatigue Syndrome, Chronic; Female; Hum | 2011 |
Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome.
Topics: Amantadine; Antiviral Agents; Carnitine; Cross-Over Studies; Fatigue Syndrome, Chronic; Humans; Neur | 1997 |
Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome.
Topics: Amantadine; Antiviral Agents; Carnitine; Cross-Over Studies; Fatigue Syndrome, Chronic; Humans; Neur | 1997 |
Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome.
Topics: Amantadine; Antiviral Agents; Carnitine; Cross-Over Studies; Fatigue Syndrome, Chronic; Humans; Neur | 1997 |
Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome.
Topics: Amantadine; Antiviral Agents; Carnitine; Cross-Over Studies; Fatigue Syndrome, Chronic; Humans; Neur | 1997 |
16 other studies available for carnitine and Fatigue Syndrome, Chronic
| Article | Year |
|---|---|
Exercise modifies glutamate and other metabolic biomarkers in cerebrospinal fluid from Gulf War Illness and Myalgic encephalomyelitis / Chronic Fatigue Syndrome.
Topics: Adult; Biomarkers; Carnitine; Case-Control Studies; Exercise Test; Fatigue Syndrome, Chronic; Female | 2021 |
Mitochondrial dysfunction and chronic disease: treatment with natural supplements.
Topics: Carnitine; Dietary Supplements; Fatigue Syndrome, Chronic; Humans; Mitochondrial Diseases; NAD; Thio | 2014 |
Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity.
Topics: Adult; Aged; Carnitine; Carnitine O-Palmitoyltransferase; Epidemiologic Methods; Fatigue Syndrome, C | 2011 |
L-carnitine.
Topics: Carnitine; Controlled Clinical Trials as Topic; Deficiency Diseases; Dietary Supplements; Double-Bli | 2004 |
Plasma and urinary carnitine and acylcarnitines in chronic fatigue syndrome.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Carnitine; Case-Control Studies; Depression; | 2005 |
L-carnitine reduces severity of physical and mental fatigue and improves daily activities in the elderly.
Topics: Activities of Daily Living; Aged, 80 and over; Carnitine; Fatigue Syndrome, Chronic; Follow-Up Studi | 2006 |
A new era for carnitine?
Topics: Acquired Immunodeficiency Syndrome; Carnitine; Fatigue Syndrome, Chronic; Humans; Shock, Septic | 1995 |
Acylcarnitine deficiency in chronic fatigue syndrome.
Topics: Acyl Coenzyme A; Carnitine; Coenzyme A; Energy Metabolism; Fatigue Syndrome, Chronic; Female; Humans | 1994 |
[Chronic fatigue syndrome].
Topics: Ascorbic Acid; Carnitine; Endocrine System Diseases; Fatigue Syndrome, Chronic; Humans; Killer Cells | 1993 |
Serum levels of carnitine in chronic fatigue syndrome: clinical correlates.
Topics: Adolescent; Adult; Aged; Carnitine; Fatigue Syndrome, Chronic; Female; Humans; Male; Middle Aged; Mi | 1995 |
Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.
Topics: Adolescent; Adult; Carnitine; Fatigue Syndrome, Chronic; Female; Humans; Lipid Metabolism; Male; Mat | 1995 |
Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome.
Topics: Acylation; Ascorbic Acid; Carnitine; Diet; Erythrocytes; Fatigue Syndrome, Chronic; Female; Food, Fo | 1996 |
Serum carnitine and disabling fatigue in multiple sclerosis.
Topics: Adult; Carnitine; Fatigue; Fatigue Syndrome, Chronic; Female; Humans; Male; Mitochondria, Muscle; Mu | 1996 |
Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases.
Topics: Acute Disease; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Fatigu | 1998 |
Normal carnitine levels in patients with chronic fatigue syndrome.
Topics: Adult; Carnitine; Case-Control Studies; Fatigue; Fatigue Syndrome, Chronic; Female; Humans; Middle A | 2000 |
Cognitive behavioral therapy and fasting therapy for a patient with chronic fatigue syndrome.
Topics: Adult; Carnitine; Cognitive Behavioral Therapy; Fasting; Fatigue Syndrome, Chronic; Humans; Killer C | 2001 |