carnitine has been researched along with Drug Overdose in 14 studies
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is a short-chain fatty acid widely prescribed in the treatment of seizure disorders and epilepsy syndromes, although its therapeutic value may be undermined by its toxicity." | 5.91 | Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation. ( Fagiolino, P; Ibarra, M; Maldonado, C; Schiavo, A; Trocóniz, IF; Vázquez, M, 2023) |
| "We describe the case of a 56-year-old man who presented to the emergency department after an intentional VPA overdose, was found to have hyperammonemia, and was treated with L-carnitine exclusively." | 5.22 | Valproic Acid Overdose: Case Report and Literature Review. ( Berezowski, I; Frasure, SE; Mazer-Amirshahi, M; Patel, J; Pourmand, A; Tran, QK, 2022) |
| "L-Carnitine combined with HDI may have helped with the calcium channel blocker (CCB) poisoning by decreasing insulin resistance, promoting intracellular glucose transport, facilitating the metabolism of free fatty acids, and increasing calcium channel sensitivity." | 4.89 | L-Carnitine for the treatment of a calcium channel blocker and metformin poisoning. ( Ajmo, I; Laliberté, M; Poirier, D; St-Onge, M, 2013) |
| ", drowsiness, coma) were selected for treatment with l-arginine." | 3.85 | L-Arginine in the treatment of valproate overdose - five clinical cases. ( Eyer, F; Felgenhauer, N; Fernando, M; Rabe, C; Schrettl, V, 2017) |
| "Two cases of acute valproic acid poisoning with central nervous system depression and raised ammonia level without hepatotoxicity were reported." | 3.74 | Two cases of valproic acid poisoning treated with L-carnitine. ( Chan, YC; Lau, FL; Tse, ML, 2007) |
| "Valproic acid (VPA) is a broad-spectrum antiepileptic drug and is usually well tolerated, but rare serious complications may occur in some patients receiving VPA chronically, including haemorrhagic pancreatitis, bone marrow suppression, VPA-induced hepatotoxicity (VHT) and VPA-induced hyperammonaemic encephalopathy (VHE)." | 2.43 | Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence? ( Gris, M; Lheureux, PE; Penaloza, A; Zahir, S, 2005) |
| "Valproic acid (VPA) is a short-chain fatty acid widely prescribed in the treatment of seizure disorders and epilepsy syndromes, although its therapeutic value may be undermined by its toxicity." | 1.91 | Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation. ( Fagiolino, P; Ibarra, M; Maldonado, C; Schiavo, A; Trocóniz, IF; Vázquez, M, 2023) |
| "Levocarnitine is the treatment of choice in valproic acid toxicity-related hyperammonaemia." | 1.62 | Managing valproic acid toxicity-related hyperammonaemia: an unpredicted course. ( Edquist, C; O'Rourke, N; Pagali, S, 2021) |
| "Acetaminophen (APAP) is a widely used analgesic." | 1.40 | Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. ( Curry, SC; Jaeschke, H; Li, F; Ma, X; McGill, MR; Sharpe, MR; Williams, CD, 2014) |
| "The onset of coma may have been related to inhibition of beta-oxidation in the mitochondria, which was reversible by elimination of plasma VPA by DHP." | 1.30 | Successful treatment by direct hemoperfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication. ( Kuhara, T; Maeyama, R; Matsumoto, I; Matsumoto, J; Ogawa, H; Okudaira, K; Shinka, T, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, J | 1 |
| Berezowski, I | 1 |
| Mazer-Amirshahi, M | 1 |
| Frasure, SE | 1 |
| Tran, QK | 1 |
| Pourmand, A | 1 |
| Schiavo, A | 1 |
| Maldonado, C | 1 |
| Vázquez, M | 1 |
| Fagiolino, P | 1 |
| Trocóniz, IF | 1 |
| Ibarra, M | 1 |
| Pagali, S | 1 |
| Edquist, C | 1 |
| O'Rourke, N | 1 |
| St-Onge, M | 1 |
| Ajmo, I | 1 |
| Poirier, D | 1 |
| Laliberté, M | 1 |
| McGill, MR | 1 |
| Li, F | 1 |
| Sharpe, MR | 1 |
| Williams, CD | 1 |
| Curry, SC | 1 |
| Ma, X | 1 |
| Jaeschke, H | 1 |
| Schrettl, V | 1 |
| Felgenhauer, N | 2 |
| Rabe, C | 1 |
| Fernando, M | 1 |
| Eyer, F | 2 |
| Davison, AS | 1 |
| Milan, AM | 1 |
| Roberts, NB | 1 |
| Minville, V | 1 |
| Roche Tissot, C | 1 |
| Samii, K | 1 |
| Gempel, K | 1 |
| Steimer, W | 1 |
| Gerbitz, KD | 1 |
| Zilker, T | 1 |
| Lheureux, PE | 1 |
| Penaloza, A | 1 |
| Zahir, S | 1 |
| Gris, M | 1 |
| Jung, J | 1 |
| Eo, E | 1 |
| Ahn, KO | 1 |
| Chan, YC | 1 |
| Tse, ML | 1 |
| Lau, FL | 1 |
| Murakami, K | 1 |
| Sugimoto, T | 1 |
| Woo, M | 1 |
| Nishida, N | 1 |
| Muro, H | 1 |
| Matsumoto, J | 1 |
| Ogawa, H | 1 |
| Maeyama, R | 1 |
| Okudaira, K | 1 |
| Shinka, T | 1 |
| Kuhara, T | 1 |
| Matsumoto, I | 1 |
3 reviews available for carnitine and Drug Overdose
| Article | Year |
|---|---|
Valproic Acid Overdose: Case Report and Literature Review.
Topics: Anticonvulsants; Carnitine; Drug Overdose; Humans; Hyperammonemia; Male; Middle Aged; Valproic Acid | 2022 |
L-Carnitine for the treatment of a calcium channel blocker and metformin poisoning.
Topics: Aged; Antidotes; Antihypertensive Agents; Calcium Channel Blockers; Carnitine; Combined Modality The | 2013 |
Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence?
Topics: Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatic Encephalo | 2005 |
11 other studies available for carnitine and Drug Overdose
| Article | Year |
|---|---|
Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation.
Topics: Ammonia; Anticonvulsants; Carnitine; Dietary Supplements; Drug Overdose; Drug-Related Side Effects a | 2023 |
Managing valproic acid toxicity-related hyperammonaemia: an unpredicted course.
Topics: Adult; Brain Diseases; Carnitine; Drug Overdose; Female; Humans; Hyperammonemia; Valproic Acid; Youn | 2021 |
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Biomarkers; Carnitine; Chemical and Drug Induced | 2014 |
L-Arginine in the treatment of valproate overdose - five clinical cases.
Topics: Acyl Coenzyme A; Adult; Amino-Acid N-Acetyltransferase; Ammonia; Arginine; Carnitine; Coma; Drug Ove | 2017 |
The consequences of valproate overdose.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; Anticonvulsants; Carnitine; Drug Overdose; Epilepsy; | 2011 |
[Haemodialysis, L-carnitine therapy and valproic acid overdose].
Topics: Adult; Anticonvulsants; Antidotes; Brain Edema; Carnitine; Drug Overdose; Humans; Male; Renal Dialys | 2004 |
Acute valproate poisoning: pharmacokinetics, alteration in fatty acid metabolism, and changes during therapy.
Topics: Anticonvulsants; Brain Edema; Carnitine; Drug Overdose; Fatty Acids; Female; Humans; Hyperammonemia; | 2005 |
A case of hemoperfusion and L-carnitine management in valproic acid overdose.
Topics: Adult; Anticonvulsants; Carnitine; Charcoal; Drug Overdose; Female; Hemoperfusion; Humans; Suicide, | 2008 |
Two cases of valproic acid poisoning treated with L-carnitine.
Topics: Adolescent; Adult; Anticonvulsants; Antidotes; Carnitine; Depression; Drug Overdose; Female; Humans; | 2007 |
Effect of L-carnitine supplementation on acute valproate intoxication.
Topics: Ammonia; Carnitine; Coma; Drug Overdose; Epilepsy; Humans; Infant; Male; Oxidation-Reduction; Valpro | 1996 |
Successful treatment by direct hemoperfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication.
Topics: Acute Disease; Adult; Carnitine; Charcoal; Coma; Drug Overdose; Female; Glasgow Coma Scale; Hemoperf | 1997 |