carnitine has been researched along with Disease Models, Animal in 248 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propionyl-L-carnitine (PLC) is a naturally occurring compound that has been considered for the treatment of congestive heart failure (CHF)." | 8.79 | The propionyl-L-carnitine hypothesis: an alternative approach to treating heart failure. ( De Giuli, F; Ferrari, R, 1997) |
| "Carnitine deficiency and impaired glucose tolerance (IGT) exacerbate liver steatosis." | 8.12 | High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models. ( Matsuura, T; Mekada, K; Nakamura, SI; Ozaki, K; Terayama, Y, 2022) |
| "L-carnitine (LC) is considered to have good therapeutic potential for myocardial infarction (MI), but its mechanism has not been clarified." | 8.12 | L-Carnitine Alleviates the Myocardial Infarction and Left Ventricular Remodeling through Bax/Bcl-2 Signal Pathway. ( Kou, JJ; Li, HR; Liu, Y; Pang, XB; Shi, JZ; Tian, JH; Xie, XM; Yan, Y; Zheng, XM, 2022) |
| "To prepare the levocarnitine thermosensitive in situ gel (LCTG) and evaluate its effect on dry eye disease (DED)." | 8.02 | Topical Delivery of Levocarnitine to the Cornea and Anterior Eye by Thermosensitive in-situ Gel for Dry Eye Disease. ( Bai, J; Cai, M; Huang, P; Ma, B; Ni, J; Pang, L; Qu, C; Wu, H; Xu, Y; Yang, J; Yin, X; Zhang, Z, 2021) |
| "Polycystic ovary syndrome (PCOS) is related to low levels of serum l-carnitine, which has antioxidant, anti-inflammatory and antiapoptotic properties." | 7.91 | L-Carnitine improves endocrine function and folliculogenesis by reducing inflammation, oxidative stress and apoptosis in mice following induction of polycystic ovary syndrome. ( Azadbakht, M; Kalhori, Z; Mehranjani, MS; Shariatzadeh, MA, 2019) |
| " Here, we extend our findings and provide evidence of epithelial-mesenchymal transition (EMT)-associated renal fibrosis caused by PFOS and the protection by l-carnitine." | 7.85 | From the Cover: l-Carnitine via PPARγ- and Sirt1-Dependent Mechanisms Attenuates Epithelial-Mesenchymal Transition and Renal Fibrosis Caused by Perfluorooctanesulfonate. ( Chang, CC; Chou, HC; Jin, L; Juan, SH; Lin, CY; Wen, LL, 2017) |
| "The important pathological consequences of insulin resistance arise from the detrimental effects of accumulated long-chain fatty acids and their respective acylcarnitines." | 7.83 | Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance. ( Dambrova, M; Grinberga, S; Kuka, J; Liepinsh, E; Makarova, E; Makrecka-Kuka, M; Sevostjanovs, E; Svalbe, B; Volska, K, 2016) |
| "L-Carnitine supplementation has been used to reduce obesity caused by high-fat diet, which is beneficial for lowering blood and hepatic lipid levels, and for ameliorating fatty liver." | 7.81 | L-Carnitine intake prevents irregular feeding-induced obesity and lipid metabolism disorder. ( Fu, Z; Guo, A; Kong, Y; Qi, Y; Shu, Q; Sun, S; Sun, Z; Wu, T, 2015) |
| "This study aimed to investigate the effects of L-carnitine, with its known antioxidant properties and positive effects on wound healing, on the healing of colon anastomosis in a cecal ligation and puncture sepsis model in rats." | 7.81 | The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model. ( Çikman, Ö; Ercan, U; Karaayvaz, M; Kilinç, N; Kiraz, A; Kiraz, HA; Otkun, MT; Özkan, ÖF; Türkön, H, 2015) |
| "Cilostazol and L-carnitine have been used as a first-line drug and supplement, respectively, in patients with peripheral arterial disease with intermittent claudication." | 7.81 | Combination of Cilostazol and L-Carnitine Improves Walking Performance in Peripheral Arterial Disease Model Rats. ( Orito, K; Sahara, H; Shiga, T, 2015) |
| " Simultaneous treatment with L-carnitine attenuated the renal fibrosis (which correlated with a reduction of plasma TGF-β1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR-γ." | 7.80 | L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ. ( Arévalo, M; Blanca, AJ; Mate, A; Miguel-Carrasco, JL; Ruiz-Armenta, MV; Vázquez, CM; Zambrano, S, 2014) |
| "To investigate the beneficial effect of the combination of butyrate, Lactobacillus casei, and L-carnitine in a rat colitis model." | 7.80 | Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis. ( Abdolghaffari, AH; Abdollahi, M; Baeeri, M; Ghasemi-Niri, SF; Moeinian, M; Mozaffari, S; Navaea-Nigjeh, M, 2014) |
| "In conclusion, our data supports a protective effect of L-carnitine against oxidative damage in hepatic ischemia-reperfusion injury in rats." | 7.79 | The protective effect of L-carnitine on hepatic ischemia-reperfusion injury in rats. ( Aldemır, D; Boyacioğlu, S; Çekın, AH; Gür, G; Gürsoy, M; Taşkoparan, M; Türkoğlu, S; Yilmaz, U, 2013) |
| "We recently showed that L-carnitine reduced oxidative stress and suppressed energy metabolism, while α-tocopherol only prevented redox imbalance, in the obstructed kidney of rats subjected to 24-hr of unilateral ureteral obstruction (UUO)." | 7.77 | L-carnitine improves oxidative stress and suppressed energy metabolism but not renal dysfunction following release of acute unilateral ureteral obstruction in rat. ( Ashtiyani, SC; Hosseinkhani, S; Moosavi, SM, 2011) |
| " The effects of the Zn(ii) complex with ascorbic acid (Vitamin C; VC), methylmethionine sulfonium chloride (Vitamin U; VU) and l-carnitine were assessed in diet-induced metabolic syndrome model rats." | 7.77 | Effects of Zn(II) complex with vitamins C and U, and carnitine on metabolic syndrome model rats. ( Fujii, T; Kajiwara, N; Matsumoto, K; Motoyasu, N; Sera, K; Taniguchi, H; Yasui, H; Yoshikawa, Y, 2011) |
| "The objective was to determine the antioxidant role of L-carnitine (LC) against ionizing radiation-induced cataracts in lens after total cranium irradiation of rats with a single dose of 5 Gy." | 7.74 | The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model. ( Ertekin, MV; Gepdiremen, A; Karslioglu, I; Kocer, I; Serifoglu, K; Sezen, O; Taysi, S, 2007) |
| " Secondary carnitine deficiency, which is frequently observed in hemodialysis patients, has been associated with cardiac hypertrophy and heart failure and may impair myocardial fatty acid oxidation." | 7.74 | Myocardial function, energy provision, and carnitine deficiency in experimental uremia. ( Bhandari, S; Reddy, V; Seymour, AM, 2007) |
| "Animals with heart failure exhibited depressions in ventricular function, positive inotropic response to isoproterenol, beta-AR receptor density and basal AC activity; these changes were also attenuated by PLC treatment." | 7.72 | Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction. ( Dhalla, NS; Ferrari, R; Sethi, R; Wang, X, 2004) |
| " In the present investigation, we examined the protective actions of L-arginine, a nitric oxide synthase substrate, and L-carnitine against hypoxia-reoxygenation (H/R) induced NEC in young mice." | 7.71 | Protective effect of dietary supplementation with L-arginine and L-carnitine on hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice. ( Akisu, M; Arslanoglu, S; Baka, M; Bayindir, O; Habif, S; Kultursay, N; Ozmen, D; Yalaz, M, 2002) |
| "The long-term administration of L-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue." | 7.70 | Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. ( Harashima, H; Hayashi, M; Horiuchi, M; Kamido, H; Kudo, T; Kuwajima, M; Lu, K; Ono, A; Ozaki, K; Saheki, T; Sei, M; Shima, K, 1999) |
| "To clarify the mechanism of cardiac hypertrophy in carnitine-deficient JVS mice, we studied the possible role of catecholamine metabolism." | 7.70 | Catecholamine metabolism inhibitors and receptor blockades only partially suppress cardiac hypertrophy of juvenile visceral steatosis mice with systemic carnitine deficiency. ( Horiuchi, M; Jalil, A; Kobayashi, K; Nomoto, M; Saheki, T, 1999) |
| "The effects of carnitine and cobamamide were studied at the unspecific stage of anorexia nervosa treatment." | 7.67 | [Clinico-experimental substantiation of the use of carnitine and cobalamin in the treatment of anorexia nervosa]. ( Korchak, GM; Korkina, MB; Medvedev, DI, 1989) |
| "Psoriasis is an immune-mediated chronic inflammatory disease." | 5.62 | Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis. ( Chen, C; Chen, X; Hou, G; Peng, C; Ren, Y; Zeng, C, 2021) |
| "Both treatments reduced cortical contusion at 24 h and 6 weeks, however neither affected gliosis and inflammatory cell activation." | 5.48 | L-Carnitine and extendin-4 improve outcomes following moderate brain contusion injury. ( Annissa, TF; Anwer, AG; Chan, YL; Chen, H; Gorrie, CA; Herok, G; Linnane, C; Mao, Y; Oliver, BG; Saad, S; Sapkota, A; Vissel, B, 2018) |
| "L-carnitine was shown to be potentially beneficial on the resolution of cerebral vasospasm following SAH." | 5.46 | The Effect of Intravenous L-Carnitine on the Vasospasm Process in the Experimental Subarachnoid Hemorrhage Model. ( Gokten, M; Oge, K; Soyer, A; Soylemezoglu, F, 2017) |
| "L-carnitine is a compound known to transport fatty acids into the mitochondria to enhance β-oxidation-mediated metabolism of fats." | 5.46 | Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver. ( Fujisawa, K; Matsumoto, T; Matsuzaki, A; Sakaida, I; Takami, T; Terai, S; Yamamoto, N, 2017) |
| "Obesity is associated with insulin resistance and impaired glucose tolerance, which represent characteristic features of the metabolic syndrome." | 5.43 | Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice. ( Bardova, K; Gardlo, A; Hansikova, J; Horakova, O; Kopecky, J; Kuda, O; Rombaldova, M; Rossmeisl, M, 2016) |
| "Cimetidine treatment significantly decreased creatinine, BUN, K, Na, SBP and creatine kinase and increased GFR and urine volume compared to group II." | 5.42 | A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats. ( Eissa, H; Elattar, S; Estaphan, S; Farouk, M; Rashed, L, 2015) |
| "l-Carnitine pretreatment significantly increased tetanic contraction amplitude in the SOL muscles following I/R (P < ." | 5.39 | L-carnitine pretreatment protects slow-twitch skeletal muscles in a rat model of ischemia-reperfusion injury. ( Cerkez, C; Demirel, M; Ertunc, M; Kaya, B; Sara, Y, 2013) |
| "Treatment of L-carnitine 30 min prior to reperfusion significantly relieved I/R-induced metabolomic changes." | 5.38 | Metabolomic changes and protective effect of (L)-carnitine in rat kidney ischemia/reperfusion injury. ( Dai, W; Hu, W; Ji, C; Liu, Y; Mei, C; Yan, S; Zhang, W, 2012) |
| "Skeletal muscle in congestive heart failure is responsible for increased fatigability and decreased exercise capacity." | 5.31 | L-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure. ( Angelini, A; Calvani, M; Dalla Libera, L; Della Barbera, M; Dona, M; Gobbo, V; Mosconi, L; Peluso, G; Ravara, B; Sandri, M; Vescovo, G, 2002) |
| "L-carnitine has been reported to influence respiratory functions." | 5.31 | The role of L-carnitine in treatment of a murine model of asthma. ( Işlekel, H; Karaman, O; Kargi, A; Kavukçu, S; Ozkal, S; Soylu, A; Uzuner, N; Yilmaz, O, 2002) |
| "Systemic carnitine-deficient juvenile visceral steatosis (JVS) mice exhibit decreased expression of some liver-selective genes including those for the urea cycle enzymes during the infantile period." | 5.30 | Suppressed expression of the urea cycle enzyme genes in the liver of carnitine-deficient juvenile visceral steatosis (JVS) mice in infancy and during starvation in adulthood. ( Horiuchi, M; Mori, M; Musa, DA; Saheki, T; Takiguchi, M; Tomomura, A; Tomomura, M, 1997) |
| "Propionyl-L-carnitine (PLC) is a naturally occurring compound that has been considered for the treatment of congestive heart failure (CHF)." | 4.79 | The propionyl-L-carnitine hypothesis: an alternative approach to treating heart failure. ( De Giuli, F; Ferrari, R, 1997) |
| "Carnitine deficiency and impaired glucose tolerance (IGT) exacerbate liver steatosis." | 4.12 | High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models. ( Matsuura, T; Mekada, K; Nakamura, SI; Ozaki, K; Terayama, Y, 2022) |
| "L-carnitine (LC) is considered to have good therapeutic potential for myocardial infarction (MI), but its mechanism has not been clarified." | 4.12 | L-Carnitine Alleviates the Myocardial Infarction and Left Ventricular Remodeling through Bax/Bcl-2 Signal Pathway. ( Kou, JJ; Li, HR; Liu, Y; Pang, XB; Shi, JZ; Tian, JH; Xie, XM; Yan, Y; Zheng, XM, 2022) |
| "CS could alleviate IMQ-induced psoriasis-like dermatitis by reducing the expression of cytokines and chemokines mediated by the MAPK pathway, and improved amino acid and carnitine metabolism in vivo." | 4.12 | Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma - Smilax glabra Roxb herb pair for the treatment of psoriasis. ( Di, T; Feng, F; Hu, X; Li, P; Meng, Y; Qi, C; Wang, Y; Zhang, X; Zhao, J; Zhao, N, 2022) |
| "To prepare the levocarnitine thermosensitive in situ gel (LCTG) and evaluate its effect on dry eye disease (DED)." | 4.02 | Topical Delivery of Levocarnitine to the Cornea and Anterior Eye by Thermosensitive in-situ Gel for Dry Eye Disease. ( Bai, J; Cai, M; Huang, P; Ma, B; Ni, J; Pang, L; Qu, C; Wu, H; Xu, Y; Yang, J; Yin, X; Zhang, Z, 2021) |
| "Polycystic ovary syndrome (PCOS) is related to low levels of serum l-carnitine, which has antioxidant, anti-inflammatory and antiapoptotic properties." | 3.91 | L-Carnitine improves endocrine function and folliculogenesis by reducing inflammation, oxidative stress and apoptosis in mice following induction of polycystic ovary syndrome. ( Azadbakht, M; Kalhori, Z; Mehranjani, MS; Shariatzadeh, MA, 2019) |
| " Furthermore, unlike chronic dietary choline, TML supplementation in mice failed to elevate plasma TMAO or heighten thrombosis potential in vivo." | 3.88 | Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. ( Allayee, H; Buffa, JA; Cajka, T; DiDonato, JA; Fiehn, O; Gu, X; Han, Y; Hartiala, JA; Hazen, SL; Hurd, AG; Kerby, RL; Li, L; Li, XS; Lüscher, TF; Nemet, I; Obeid, S; Rey, FE; Roberts, AB; Romano, KA; Shahen, CJ; Skye, SM; Tang, WHW; Wagner, MA; Wang, Z; Wu, Y, 2018) |
| " Here, we extend our findings and provide evidence of epithelial-mesenchymal transition (EMT)-associated renal fibrosis caused by PFOS and the protection by l-carnitine." | 3.85 | From the Cover: l-Carnitine via PPARγ- and Sirt1-Dependent Mechanisms Attenuates Epithelial-Mesenchymal Transition and Renal Fibrosis Caused by Perfluorooctanesulfonate. ( Chang, CC; Chou, HC; Jin, L; Juan, SH; Lin, CY; Wen, LL, 2017) |
| " The aim of the study was to investigate the role of MMPs and their inhibitors (TIMPs), in the pathogenesis of choline deficiency-induced cardiomyopathy, and the way they are affected by carnitine supplementation." | 3.83 | Immunohistochemical determination of the extracellular matrix modulation in a rat model of choline-deprived myocardium: the effects of carnitine. ( Giannopoulou, I; Karkalousos, P; Kriebardis, A; Lazaris, A; Liapi, C; Panayiotides, I; Papavdi, A; Perelas, A; Strilakou, A, 2016) |
| "The important pathological consequences of insulin resistance arise from the detrimental effects of accumulated long-chain fatty acids and their respective acylcarnitines." | 3.83 | Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance. ( Dambrova, M; Grinberga, S; Kuka, J; Liepinsh, E; Makarova, E; Makrecka-Kuka, M; Sevostjanovs, E; Svalbe, B; Volska, K, 2016) |
| "L-Carnitine supplementation has been used to reduce obesity caused by high-fat diet, which is beneficial for lowering blood and hepatic lipid levels, and for ameliorating fatty liver." | 3.81 | L-Carnitine intake prevents irregular feeding-induced obesity and lipid metabolism disorder. ( Fu, Z; Guo, A; Kong, Y; Qi, Y; Shu, Q; Sun, S; Sun, Z; Wu, T, 2015) |
| "The aim of this study was to examine the effects of carnitine on bone healing in ovariectomy (OVX) and inflammation (INF)-induced osteoporotic rats." | 3.81 | Treatment with Carnitine Enhances Bone Fracture Healing under Osteoporotic and/or Inflammatory Conditions. ( Aksakal, AM; Albayrak, A; Ayan, AK; Aydin, A; Bayir, Y; Cadirci, E; Halici, Z; Karakus, E; Polat, B; Yildirim, OS, 2015) |
| "This study aimed to investigate the effects of L-carnitine, with its known antioxidant properties and positive effects on wound healing, on the healing of colon anastomosis in a cecal ligation and puncture sepsis model in rats." | 3.81 | The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model. ( Çikman, Ö; Ercan, U; Karaayvaz, M; Kilinç, N; Kiraz, A; Kiraz, HA; Otkun, MT; Özkan, ÖF; Türkön, H, 2015) |
| "Cilostazol and L-carnitine have been used as a first-line drug and supplement, respectively, in patients with peripheral arterial disease with intermittent claudication." | 3.81 | Combination of Cilostazol and L-Carnitine Improves Walking Performance in Peripheral Arterial Disease Model Rats. ( Orito, K; Sahara, H; Shiga, T, 2015) |
| " Simultaneous treatment with L-carnitine attenuated the renal fibrosis (which correlated with a reduction of plasma TGF-β1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR-γ." | 3.80 | L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ. ( Arévalo, M; Blanca, AJ; Mate, A; Miguel-Carrasco, JL; Ruiz-Armenta, MV; Vázquez, CM; Zambrano, S, 2014) |
| "This study investigated whether cyclophosphamide (CP) and ifosfamide (IFO) therapy alters the expression of the key genes engaged in long-chain fatty acid (LCFA) oxidation outside rat heart mitochondria, and if so, whether these alterations should be viewed as a mechanism during CP- and IFO-induced cardiotoxicity." | 3.80 | Inhibition of gene expression of carnitine palmitoyltransferase I and heart fatty acid binding protein in cyclophosphamide and ifosfamide-induced acute cardiotoxic rat models. ( Al-Harbi, MM; Al-Harbi, NO; Al-Hosaini, KA; Al-Shabanah, OA; Al-Sharary, SD; Aldelemy, ML; Hafez, MM; Sayed-Ahmed, MM, 2014) |
| "To investigate the beneficial effect of the combination of butyrate, Lactobacillus casei, and L-carnitine in a rat colitis model." | 3.80 | Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis. ( Abdolghaffari, AH; Abdollahi, M; Baeeri, M; Ghasemi-Niri, SF; Moeinian, M; Mozaffari, S; Navaea-Nigjeh, M, 2014) |
| "To evaluate whether PDSC, an L-carnitine ester derivative of prednisolone and OCTN2 substrate, could provide a targeted delivery of the corticosteroid into the lung tissues of an asthmatic guinea pig model." | 3.80 | L-Carnitine ester of prednisolone: pharmacokinetic and pharmacodynamic evaluation of a type I prodrug. ( Lim, LY; Mo, J; Zhang, ZR, 2014) |
| "In conclusion, our data supports a protective effect of L-carnitine against oxidative damage in hepatic ischemia-reperfusion injury in rats." | 3.79 | The protective effect of L-carnitine on hepatic ischemia-reperfusion injury in rats. ( Aldemır, D; Boyacioğlu, S; Çekın, AH; Gür, G; Gürsoy, M; Taşkoparan, M; Türkoğlu, S; Yilmaz, U, 2013) |
| "Topical application of betaine, L-carnitine, or erythritol systematically limited progression of environmentally induced dry eye." | 3.79 | Efficacy of osmoprotectants on prevention and treatment of murine dry eye. ( Chen, Q; Chen, W; Garrett, Q; Hou, C; Li, J; Wang, Y; Zhang, X, 2013) |
| "In this study, we evaluated the effect of an analogue of l-carnitine on parameters involved with Metabolic Syndrome in obese Zucker rats." | 3.79 | Pharmacological evaluation of a β-hydroxyphosphonate analogue of l-carnitine in obese Zucker fa/fa rats. ( De la Cruz-Cordero, R; Duarte-Vázquez, MÁ; Mendoza-Rivera, B; Reyes-Esparza, J; Rodríguez-Fragoso, L; Rosado, JL; Solis, MG; Vite-Vallejo, O, 2013) |
| "We recently showed that L-carnitine reduced oxidative stress and suppressed energy metabolism, while α-tocopherol only prevented redox imbalance, in the obstructed kidney of rats subjected to 24-hr of unilateral ureteral obstruction (UUO)." | 3.77 | L-carnitine improves oxidative stress and suppressed energy metabolism but not renal dysfunction following release of acute unilateral ureteral obstruction in rat. ( Ashtiyani, SC; Hosseinkhani, S; Moosavi, SM, 2011) |
| " The effects of the Zn(ii) complex with ascorbic acid (Vitamin C; VC), methylmethionine sulfonium chloride (Vitamin U; VU) and l-carnitine were assessed in diet-induced metabolic syndrome model rats." | 3.77 | Effects of Zn(II) complex with vitamins C and U, and carnitine on metabolic syndrome model rats. ( Fujii, T; Kajiwara, N; Matsumoto, K; Motoyasu, N; Sera, K; Taniguchi, H; Yasui, H; Yoshikawa, Y, 2011) |
| "These data suggest that alcohol could promote cardiac myocyte apoptosis, reduce cardiac function and aggravate myocardial remodeling which valsartan and carnitine could reduce alcoholic cardiomyopathy by downregulating Calpain-1 and Bad protein expression and upregulating expression of Bcl-xl protein." | 3.77 | [Effect of valsartan and carnitine on cardiomyocyte Calpain-1 and Bcl-xl expressions of dogs with chronic alcohol intake-induced cardiomyopathy]. ( Jing, L; Lu, LX; Sang, Y; Yuan, L; Zhang, QH; Zhou, LJ, 2011) |
| "The effects of chronic hypoxia on cardiac membrane fatty acids and on lipid peroxidation were examined, as well as the effect of l-carnitine (LCAR), which suppresses lipid peroxidation, on this process." | 3.74 | Change in the membranous lipid composition accelerates lipid peroxidation in young rat hearts subjected to 2 weeks of hypoxia followed by hyperoxia. ( Hamaoka, K; Itoi, T; Nakanishi, H; Oka, T; Taguchi, R; Terada, N, 2008) |
| "The objective was to determine the antioxidant role of L-carnitine (LC) against ionizing radiation-induced cataracts in lens after total cranium irradiation of rats with a single dose of 5 Gy." | 3.74 | The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model. ( Ertekin, MV; Gepdiremen, A; Karslioglu, I; Kocer, I; Serifoglu, K; Sezen, O; Taysi, S, 2007) |
| " Secondary carnitine deficiency, which is frequently observed in hemodialysis patients, has been associated with cardiac hypertrophy and heart failure and may impair myocardial fatty acid oxidation." | 3.74 | Myocardial function, energy provision, and carnitine deficiency in experimental uremia. ( Bhandari, S; Reddy, V; Seymour, AM, 2007) |
| "Recently we showed that the administration of intraperitoneal L-carnitine (CA) has insulin-sensitizing effects in the high fructose-fed Wistar rat, a widely used model of metabolic syndrome." | 3.74 | Increase in nitric oxide and reductions in blood pressure, protein kinase C beta II and oxidative stress by L-carnitine: a study in the fructose-fed hypertensive rat. ( Anuradha, CV; Palanisamy, N; Rajasekar, P, 2007) |
| " L-carnitine significantly prevented gastric ulcerogenesis induced by indomethacin and decreased the ulcer index macroscopically and histopathologically." | 3.73 | Gastroprotective effect of L-carnitine on indomethacin-induced gastric mucosal injury in rats: a preliminary study. ( Altaner, S; Dokmeci, D; Erkin, B; Turan, FN, 2006) |
| "Animals with heart failure exhibited depressions in ventricular function, positive inotropic response to isoproterenol, beta-AR receptor density and basal AC activity; these changes were also attenuated by PLC treatment." | 3.72 | Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction. ( Dhalla, NS; Ferrari, R; Sethi, R; Wang, X, 2004) |
| " In the present investigation, we examined the protective actions of L-arginine, a nitric oxide synthase substrate, and L-carnitine against hypoxia-reoxygenation (H/R) induced NEC in young mice." | 3.71 | Protective effect of dietary supplementation with L-arginine and L-carnitine on hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice. ( Akisu, M; Arslanoglu, S; Baka, M; Bayindir, O; Habif, S; Kultursay, N; Ozmen, D; Yalaz, M, 2002) |
| "The long-term administration of L-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue." | 3.70 | Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. ( Harashima, H; Hayashi, M; Horiuchi, M; Kamido, H; Kudo, T; Kuwajima, M; Lu, K; Ono, A; Ozaki, K; Saheki, T; Sei, M; Shima, K, 1999) |
| "To clarify the mechanism of cardiac hypertrophy in carnitine-deficient JVS mice, we studied the possible role of catecholamine metabolism." | 3.70 | Catecholamine metabolism inhibitors and receptor blockades only partially suppress cardiac hypertrophy of juvenile visceral steatosis mice with systemic carnitine deficiency. ( Horiuchi, M; Jalil, A; Kobayashi, K; Nomoto, M; Saheki, T, 1999) |
| "Alterations in energy metabolism, reduced fatty acid oxidation, and cardiac carnitine content have been implicated in the evolution from compensated to decompensated cardiac hypertrophy." | 3.69 | Alterations in energy metabolism of hypertrophied rat cardiomyocytes: influence of propionyl-L-carnitine. ( Anversa, P; Bianchi, G; Ceppi, E; Cinato, E; Conti, F; Ferrari, P; Torielli, L, 1995) |
| "To characterize cardiac hypertrophy in juvenile visceral steatosis (JVS) mice with systemic carnitine deficiency, we investigated how the hypertrophy develops and whether it is associated with altered expression of any specific genes, especially atrial natriuretic peptide (ANP) and contractile protein genes, in the hypertrophied ventricle." | 3.69 | Altered expression of atrial natriuretic peptide and contractile protein genes in hypertrophied ventricle of JVS mice with systemic carnitine deficiency. ( Abdul, JM; Horiuchi, M; Itoh, H; Kobayashi, K; Masuda, M; Nakao, K; Ogawa, Y; Osame, M; Saheki, T; Suzuki, S; Tomomura, M; Yoshimine, K, 1997) |
| "In order to clarify the pathogenesis and pathophysiology of cardiac hypertrophy in carnitine-deficient juvenile visceral steatosis (JVS) mice, we performed mRNA differential display analysis with total RNA extracted from the ventricles of control and JVS mice at 14 days of age." | 3.69 | A novel gene suppressed in the ventricle of carnitine-deficient juvenile visceral steatosis mice. ( Horiuchi, M; Kobayashi, K; Masuda, M; Saheki, T; Terazono, H; Yoshimura, N, 1997) |
| "We analyzed carnitine profiles in C3H-H-2 degrees strain of mouse associated with fatty liver, hyperammonemia and hypoglycemia (Koizumi et al." | 3.68 | Animal model of systemic carnitine deficiency: analysis in C3H-H-2 degrees strain of mouse associated with juvenile visceral steatosis. ( Hayakawa, J; Horiuchi, M; Imamura, Y; Inui, Y; Kawata, S; Koizumi, T; Kono, N; Kuwajima, M; Ono, A; Saheki, T, 1991) |
| "The effects of carnitine and cobamamide were studied at the unspecific stage of anorexia nervosa treatment." | 3.67 | [Clinico-experimental substantiation of the use of carnitine and cobalamin in the treatment of anorexia nervosa]. ( Korchak, GM; Korkina, MB; Medvedev, DI, 1989) |
| "Phenylacetylglutamine, for example, was recently shown to promote adverse cardiovascular phenotypes in the host via interaction with multiple ARs (adrenergic receptors)-a class of key receptors that regulate cardiovascular homeostasis." | 2.66 | Gut Microbiota and Cardiovascular Disease. ( Hazen, SL; Weeks, TL; Witkowski, M, 2020) |
| " Fatigue is the most common side effect of radiotherapy, while others include nausea, hair loss, skin irritation, anemia, infertility, cardiovascular disease, cognitive impairment and even the development of second cancers." | 2.47 | A review of the logistic role of L-carnitine in the management of radiation toxicity and radiotherapy side effects. ( Alhomida, AS; Khan, HA, 2011) |
| "The etiology and pathology of autism spectrum disorders (ASDs) are still poorly understood, which largely limit the treatment and diagnosis of ASDs." | 1.91 | Untargeted Metabolomic Analysis Reveals the Metabolic Disturbances and Exacerbation of Oxidative Stress in the Cerebral Cortex of a BTBR Mouse Model of Autism. ( Cao, C; Chen, Y; Li, Q; Li, X; Sun, C; Wu, L; Zou, M, 2023) |
| "Post-traumatic stress disorder (PTSD) is a genuine obstructing mental disorder." | 1.72 | L-Carnitine prevents memory impairment induced by post-traumatic stress disorder. ( Al-Dekah, AM; Alrabadi, N; Alzoubi, KH; Jaradat, S, 2022) |
| "The carnitine shuttle is a complex consisting of three enzymes whose function is to transport the long-chain fatty acids into the mitochondria." | 1.72 | The Reversible Carnitine Palmitoyltransferase 1 Inhibitor (Teglicar) Ameliorates the Neurodegenerative Phenotype in a Drosophila Huntington's Disease Model by Acting on the Expression of Carnitine-Related Genes. ( Bertapelle, C; Cacciola, NA; Carillo, MR; Digilio, FA; Peluso, G; Shidlovskii, YV, 2022) |
| "Psoriasis is an immune-mediated chronic inflammatory disease." | 1.62 | Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis. ( Chen, C; Chen, X; Hou, G; Peng, C; Ren, Y; Zeng, C, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disorder." | 1.56 | L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet. ( Codella, R; Luzi, L; Mollica, G; Montesano, A; Senesi, P; Terruzzi, I; Vacante, F, 2020) |
| "Nicotinamide treatment reversed fetal growth restriction, placental development, and altered metabolic flow in the early stage in PE." | 1.56 | Metabolomics of a mouse model of preeclampsia induced by overexpressing soluble fms-like tyrosine kinase 1. ( Ito, S; Kaneko, M; Kawana, Y; Oe, Y; Saigusa, D; Saito, R; Sato, E; Sato, H; Sekimoto, A; Shimma, S; Takahashi, N; Tsunokuni, Y, 2020) |
| "Both treatments reduced cortical contusion at 24 h and 6 weeks, however neither affected gliosis and inflammatory cell activation." | 1.48 | L-Carnitine and extendin-4 improve outcomes following moderate brain contusion injury. ( Annissa, TF; Anwer, AG; Chan, YL; Chen, H; Gorrie, CA; Herok, G; Linnane, C; Mao, Y; Oliver, BG; Saad, S; Sapkota, A; Vissel, B, 2018) |
| "L-carnitine was shown to be potentially beneficial on the resolution of cerebral vasospasm following SAH." | 1.46 | The Effect of Intravenous L-Carnitine on the Vasospasm Process in the Experimental Subarachnoid Hemorrhage Model. ( Gokten, M; Oge, K; Soyer, A; Soylemezoglu, F, 2017) |
| "L-carnitine is a compound known to transport fatty acids into the mitochondria to enhance β-oxidation-mediated metabolism of fats." | 1.46 | Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver. ( Fujisawa, K; Matsumoto, T; Matsuzaki, A; Sakaida, I; Takami, T; Terai, S; Yamamoto, N, 2017) |
| " There were also increases in plasma 2HG in CER-treated rats on Days 8 and 11 and in TMPD-treated rats at 24 hr after dosing and increases in plasma hexanoylcarnitine in CER-treated rats on Day 11 and in TMPD-treated rats at 6 and 24 hr after dosing." | 1.46 | Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats. ( Asai, F; Kobayashi, N; Nezu, Y; Obayashi, H; Shirai, M; Yamoto, T, 2017) |
| "The pathogenesis of Alzheimer's disease (AD) is complex involving multiple contributing factors." | 1.43 | Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome. ( Elliott, CT; Graham, SF; Green, BD; Hölscher, C; Kehoe, PG; McClean, PL; McGuinness, B; Nasaruddin, MB; Pan, X; Passmore, AP, 2016) |
| "Obesity is associated with insulin resistance and impaired glucose tolerance, which represent characteristic features of the metabolic syndrome." | 1.43 | Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice. ( Bardova, K; Gardlo, A; Hansikova, J; Horakova, O; Kopecky, J; Kuda, O; Rombaldova, M; Rossmeisl, M, 2016) |
| "l-Carnitine treatment of CKD rats significantly reduced serum creatinine and BUN, attenuated renal hypertrophy and decreased renal tissue damage." | 1.43 | l-Carnitine improves cognitive and renal functions in a rat model of chronic kidney disease. ( Abu Ahmad, N; Aga-Mizrachi, S; Armaly, Z; Avital, A; Berman, S; Jabour, A; Mosenego-Ornan, E, 2016) |
| "L-carnitine-treated rats exhibited significantly reduced escape latency in the Morris water maze task at 28 days after chronic hypoperfusion." | 1.42 | L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain. ( Hattori, N; Hira, K; Koike, M; Shimada, Y; Shimura, H; Tanaka, R; Uchiyama, Y; Ueno, Y; Urabe, T, 2015) |
| "Cimetidine treatment significantly decreased creatinine, BUN, K, Na, SBP and creatine kinase and increased GFR and urine volume compared to group II." | 1.42 | A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats. ( Eissa, H; Elattar, S; Estaphan, S; Farouk, M; Rashed, L, 2015) |
| "Carnitine depletion was associated with a 30% decrease soleus muscle weight, whereas contractile function (expressed per gram of muscle), free coenzyme A, and water content remained unaltered from CON." | 1.42 | Contractile function and energy metabolism of skeletal muscle in rats with secondary carnitine deficiency. ( Bonifacio, A; Bouitbir, J; Kaufmann, P; Krähenbühl, S; Roberts, PA; Singh, F; Urwyler, A, 2015) |
| "Liver fibrosis is a reversible wound-healing response that occurs following liver injury." | 1.40 | Protective effects of L-carnitine, N-acetylcysteine and genistein in an experimental model of liver fibrosis. ( Bahcecioglu, IH; Demiroren, K; Dogan, Y; Ilhan, S; Kocamaz, H; Ozercan, IH; Ustundag, B, 2014) |
| "Pretreatment with coenzyme Q10 (10 mg/kg/day, oral) and L-Carnitine (350 mg/kg/day, oral) were conducted for 5 consecutive weeks." | 1.40 | CoQ10 and L-carnitine attenuate the effect of high LDL and oxidized LDL on spermatogenesis in male rats. ( Garjani, A; Ghanbarzadeh, S; Khorrami, A; Ziaee, M, 2014) |
| "Carnitine was supplemented orally for 4 weeks starting at 5 weeks of age." | 1.39 | Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice. ( Bakermans, AJ; Denis, S; Houten, SM; Nicolay, K; Prompers, JJ; van Weeghel, M, 2013) |
| "l-Carnitine pretreatment significantly increased tetanic contraction amplitude in the SOL muscles following I/R (P < ." | 1.39 | L-carnitine pretreatment protects slow-twitch skeletal muscles in a rat model of ischemia-reperfusion injury. ( Cerkez, C; Demirel, M; Ertunc, M; Kaya, B; Sara, Y, 2013) |
| "Biotinidase has a key role in the reutilization of the biotin, catalyzing the hydrolysis of biocytin (ε-N-biotinyl-l-lysine) and biocytin-containing peptides derived from carboxylase turnover, thus contributing substantially to the bioavailability of this vitamin." | 1.39 | Biotinidase knockout mice show cellular energy deficit and altered carbon metabolism gene expression similar to that of nutritional biotin deprivation: clues for the pathogenesis in the human inherited disorder. ( Heredia-Antúnez, A; Hernández-González, R; Hernández-Vázquez, A; Ibarra-González, I; Ortega-Cuellar, D; Pindolia, K; Velázquez-Arellano, A; Wolf, B, 2013) |
| "Treatment of L-carnitine 30 min prior to reperfusion significantly relieved I/R-induced metabolomic changes." | 1.38 | Metabolomic changes and protective effect of (L)-carnitine in rat kidney ischemia/reperfusion injury. ( Dai, W; Hu, W; Ji, C; Liu, Y; Mei, C; Yan, S; Zhang, W, 2012) |
| "L-carnitine is an essential compound involved in cellular energy production through free fatty acid metabolism." | 1.37 | L-carnitine increases survival in a murine model of severe verapamil toxicity. ( Bania, T; Chu, J; Medlej, K; Perez, E, 2011) |
| "Carnitine treatment increased the mRNA expression of carnitine palmitoyltransferase 1A and peroxisome proliferator-activated receptor-γ, and carnitine-lipoic acid further augmented the mRNA expression." | 1.37 | Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction. ( Cho, WK; Choi, HS; Hahm, JS; Jang, KS; Jeon, HJ; Jun, DW; Jun, JH; Kim, HJ; Kwon, HJ; Lee, HL; Lee, KN; Lee, MH; Lee, OY; Yoon, BC, 2011) |
| "L-carnitine plays a role in facilitating the mitochondrial transport of fatty acids, but it also protects the cells from oxidative damage." | 1.36 | Neuroprotective effects of L-carnitine in a transgenic animal model of Huntington's disease. ( Klivenyi, P; Vamos, E; Vecsei, L; Voros, K, 2010) |
| "(1) Carnitine deficiency is a risk factor which is involved in CP-related cardiomyopathy; (2) serum and urinary carnitine levels should be monitored and viewed as indices of CP-induced multiple organ toxicity, and (3) carnitine supplementation, using PLC, prevents the development of CP-induced cardiotoxicity." | 1.36 | Carnitine deficiency aggravates cyclophosphamide-induced cardiotoxicity in rats. ( Al-Shabanah, OA; Aleisa, AM; Darweesh, AQ; Fatani, AG; Rizwan, L; Sayed-Ahmed, MM, 2010) |
| "As L-carnitine plays a pivotal role in the balanced metabolism of fatty acids and carbohydrates, this study was carried out to investigate whether long-term mildronate treatment could influence glucose levels and prevent diabetic complications in an experimental model of type 2 diabetes in Goto-Kakizaki (GK) rats." | 1.35 | Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats. ( Cirule, H; Dambrova, M; Grinberga, S; Kalvinsh, I; Kuka, J; Liepinsh, E; Skapare, E; Svalbe, B; Vilskersts, R; Zvejniece, L, 2009) |
| "Carnitine-deficient juvenile visceral steatosis (JVS) mice, suffering from fatty acid metabolism abnormalities, have reduced locomotor activity after fasting." | 1.35 | Failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis (JVS) mice: involvement of defective acyl-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus. ( Asakawa, A; Fujimiya, M; Horiuchi, M; Inui, A; Kato, I; Nakazato, M; Saheki, T; Sakoguchi, T; Takeuchi, T; Ushikai, M; Yoshida, G, 2009) |
| "Carnitine-treated HD's HO-1 significantly correlated with haemoglobin." | 1.35 | Carnitine-mediated improved response to erythropoietin involves induction of haem oxygenase-1: studies in humans and in an animal model. ( Bertipaglia, L; Calò, LA; Corradini, R; Dalla Libera, L; Davis, PA; Naso, A; Pagnin, E; Piccoli, A; Savica, V; Spinello, M, 2008) |
| "Heart failure is associated with decreased myocardial fatty acid oxidation capacity and has been likened to energy starvation." | 1.35 | Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure. ( Chandler, MP; Foster, AB; Fujioka, H; Hoit, BD; Hoppel, CL; McElfresh, TA; Minkler, PE; Okere, IC; Patel, HV; Patel, KK; Rennison, JH; Stoll, MS; Young, ME, 2008) |
| "L-carnitine is a cofactor in the transfer of long-chain fatty acid allowing the beta-oxidation of fatty acid in the mitochondria." | 1.34 | Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice. ( Atakisi, O; Citil, M; Erginsoy, S; Karapehlivan, M; Kart, A; Tunca, R; Yapar, K, 2007) |
| "L-carnitine pretreatment had no significant effect on superoxide dismutase and catalase activity in the RL group." | 1.33 | Changes in visual evoked potentials, lipid peroxidation and antioxidant enzymes in rats exposed to restraint stress: effect of L-carnitine. ( Agar, A; Aydin, S; Derin, N; Yargiçoglu, P, 2006) |
| "Irradiation significantly increased oral mucositis, and decreased thrombocyte and White Blood Cell counts." | 1.33 | Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced oral mucositis and myelosuppression: a controlled study in a rat model. ( Erdoğan, F; Ertekin, MV; Gündoğdu, C; Kiziltunç, A; Ozkan, A; Sezen, O; Uçüncü, H; Yörük, O, 2006) |
| "Mechanisms underlying dilated cardiomyopathy (DCM) are poorly understood and effective therapy is still unavailable." | 1.33 | A metabolic approach to the treatment of dilated cardiomyopathy in BIO T0-2 cardiomyopathic Syrian hamsters. ( Cappai, A; Faa, G; Floris, G; Fraschini, M; Mancinelli, R; Vargiu, R, 2005) |
| "Carnitine is an essential cofactor for the oxidation of fatty acid in the mitochondria and an efficient therapeutics for primary carnitine deficiency." | 1.33 | Prolonged effect of single carnitine administration on fasted carnitine-deficient JVS mice regarding their locomotor activity and energy expenditure. ( Horiuchi, M; Kobayashi, K; Li, MX; Saheki, T; Yoshida, G, 2006) |
| "L-carnitine has a major role in glycolysis-based energy supply of blood trypanosomes for it stimulates constant ATP production." | 1.32 | Activity of D-carnitine and its derivatives on Trypanosoma infections in rats and mice. ( Gradoni, L; Manganaro, M; Mascellino, MT, 2003) |
| "L-Carnitine is a cofactor required for transport of long-chain fatty acids into the mitochondrial matrix." | 1.32 | L-carnitine ameliorates oxidative damage due to chronic renal failure in rats. ( Alican, I; Kaçmaz, A; Paskaloğlu, K; Sakarcan, A; Satiroglu, H; Sener, G, 2004) |
| "Skeletal muscle in congestive heart failure is responsible for increased fatigability and decreased exercise capacity." | 1.31 | L-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure. ( Angelini, A; Calvani, M; Dalla Libera, L; Della Barbera, M; Dona, M; Gobbo, V; Mosconi, L; Peluso, G; Ravara, B; Sandri, M; Vescovo, G, 2002) |
| " Chronic administration of carnitine over time pre- and post-lesions seemed to partially ameliorate the cognitive deficits caused by the synaptic lesion." | 1.31 | Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine. ( Ando, S; Fukui, F; Iwamoto, M; Izumiyama, N; Kobayashi, S; Kon, K; Nakamura, H; Tadenuma, T; Takeda, Y; Waki, H; Watanabe, K, 2002) |
| "L-carnitine treatment increased the mitochondrial enzyme activities in cortical regions towards control value and was effective in enhancing QO2 and decreasing TBARS levels in the spinal cord of mndT." | 1.31 | Mitochondrial oxidative metabolism in motor neuron degeneration (mnd) mouse central nervous system. ( Bertamini, M; Bigini, P; Curti, D; Guarneri, P; Guarneri, R; Marzani, B; Mennini, T, 2002) |
| "L-carnitine has been reported to influence respiratory functions." | 1.31 | The role of L-carnitine in treatment of a murine model of asthma. ( Işlekel, H; Karaman, O; Kargi, A; Kavukçu, S; Ozkal, S; Soylu, A; Uzuner, N; Yilmaz, O, 2002) |
| "Carnitine biosynthesis was blocked in THP-treated rats (-0." | 1.31 | Development and characterization of an animal model of carnitine deficiency. ( Auer, L; Brooks, H; Krähenbühl, S; Solioz, M; Spaniol, M; Stieger, B; Zimmermann, A, 2001) |
| "L-Carnitine treatment of diabetic rats had no effect on the levels of IGF-II in serum, liver, and kidney." | 1.31 | L-Carnitine changes the levels of insulin-like growth factors (IGFs) and IGF binding proteins in streptozotocin-induced diabetic rat. ( Cha, YS; Heo, YR; Kang, CW, 2001) |
| "Systemic carnitine-deficient juvenile visceral steatosis (JVS) mice exhibit decreased expression of some liver-selective genes including those for the urea cycle enzymes during the infantile period." | 1.30 | Suppressed expression of the urea cycle enzyme genes in the liver of carnitine-deficient juvenile visceral steatosis (JVS) mice in infancy and during starvation in adulthood. ( Horiuchi, M; Mori, M; Musa, DA; Saheki, T; Takiguchi, M; Tomomura, A; Tomomura, M, 1997) |
| "Juvenile visceral steatosis (JVS) mice have been reported to have systemic carnitine deficiency, and the carnitine concentration in the liver of JVS mice was markedly lower than that of controls (11." | 1.30 | The effect of carnitine on ketogenesis in perfused livers from juvenile visceral steatosis mice with systemic carnitine deficiency. ( Horiuchi, M; Inoue, F; Kinugasa, A; Kizaki, Z; Kodo, N; Nakajima, T; Saheki, T; Sawada, T; Yamanaka, H, 1997) |
| "The nephrotic syndrome is associated with disturbances in plasma lipid pattern and metabolism." | 1.30 | On the interrelationship between hepatic carnitine, fatty acid oxidation, and triglyceride biosynthesis in nephrosis. ( al-Shurbaji, A; Berge, RK; Berglund, L; Cederblad, G; Humble, E, 1997) |
| " Long-term administration of L-carnitine increases the cardiac L-carnitine content in mice and has been shown to improve surrogate markers of coronary heart disease such as arrhythmias, nitrate consumption, and left ventricular dilatation and infarct size in patients after myocardial infarction." | 1.30 | [Physiologic bases for the use of L-carnitine in cardiology]. ( Krähenbühl, S, 1998) |
| "L-Carnitine has been shown to improve the post-ischemic recovery of myocardial function and metabolic measurements that are reduced in the course of ischemia and reperfusion of the heart." | 1.30 | The dose-dependent effects of L-carnitine in myocardial protection in normothermic ischemia. ( Ersöz, A; Gökgöz, L; Kalaycioğlu, S; Oktar, L; Oz, E; Sinci, V; Soncul, H; Tatlican, O; Türközkan, N; Yener, A, 1998) |
| "Carnitine is an essential cofactor for the mitochondrial beta-oxidation of long-chain fatty acids." | 1.30 | A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, in the juvenile visceral steatosis mouse. ( Kuwajima, M; Lu, Km; Nakamura, Y; Nishimori, H; Shima, K, 1998) |
| " Long-term administration (4 weeks) of PLC (60 and 250 mg/kg os) caused a significant improvement of walking capacity throughout the entire period." | 1.29 | Effect of propionyl-L-carnitine in a rat model of peripheral arteriopathy: a functional, histologic, and NMR spectroscopic study. ( Arrigoni Martelli, E; Aureli, T; Conti, F; Corsico, N; Di Cocco, ME; Lucreziotti, MR; Miccheli, A; Nardone, A; Pesce, D; Spagnoli, LG, 1993) |
| "Carnitine has been hypothesized to be a semi-essential nutrient in the nutrition of critically ill patients." | 1.28 | Increased acylcarnitine clearance and excretion in septic rats. ( Albrecht, RM; Crady, SK; Davis, AT; Scholten, DJ; Strong, SA, 1991) |
| "Because of the paucity of causes of Reye's syndrome seen at any one centre, the clinical variability of the disease, and limited knowledge of definite aetiologic factors, controlled clinical trials are not easy to carry out or to interpret in human cases." | 1.28 | Evaluation of the possible role of glucose, carnitine, coenzyme Q10 and steroids in the treatment of Reye's syndrome using the margosa oil animal model. ( Baskaran, G; Pathmanathan, R; Sinniah, D; Sinniah, R; Yamashita, F; Yoshino, M, 1990) |
| "Third, epidemiologic experience with Reye's syndrome suggests that clusters of cases may occur more frequently when new influenza A or B viruses become epidemic." | 1.27 | From the National Institute of Allergy and Infectious Diseases: Summary of a workshop on disease mechanisms and prospects for prevention of Reye's syndrome. ( La Montagne, JR, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (3.63) | 18.7374 |
| 1990's | 36 (14.52) | 18.2507 |
| 2000's | 69 (27.82) | 29.6817 |
| 2010's | 102 (41.13) | 24.3611 |
| 2020's | 32 (12.90) | 2.80 |
| Authors | Studies |
|---|---|
| Emran, T | 1 |
| Chowdhury, NI | 1 |
| Sarker, M | 1 |
| Bepari, AK | 1 |
| Hossain, M | 1 |
| Rahman, GMS | 1 |
| Reza, HM | 1 |
| Zhang, X | 4 |
| Shi, L | 1 |
| Chen, R | 1 |
| Zhao, Y | 1 |
| Ren, D | 1 |
| Yang, X | 2 |
| Ikuno, M | 1 |
| Yamakado, H | 1 |
| Amano, I | 1 |
| Hatanaka, Y | 1 |
| Uemura, N | 1 |
| Matsuzawa, SI | 1 |
| Takahashi, R | 1 |
| Dunlop, K | 1 |
| Sarr, O | 1 |
| Stachura, N | 1 |
| Zhao, L | 1 |
| Nygard, K | 1 |
| Thompson, JA | 1 |
| Hadway, J | 1 |
| Richardson, BS | 1 |
| Bureau, Y | 1 |
| Borradaile, N | 1 |
| Lee, TY | 1 |
| Regnault, TRH | 1 |
| Alzoubi, KH | 1 |
| Al-Dekah, AM | 1 |
| Jaradat, S | 1 |
| Alrabadi, N | 1 |
| Terayama, Y | 1 |
| Nakamura, SI | 1 |
| Mekada, K | 1 |
| Matsuura, T | 2 |
| Ozaki, K | 4 |
| Bertapelle, C | 1 |
| Carillo, MR | 1 |
| Cacciola, NA | 1 |
| Shidlovskii, YV | 1 |
| Peluso, G | 3 |
| Digilio, FA | 2 |
| Li, HR | 1 |
| Zheng, XM | 1 |
| Liu, Y | 3 |
| Tian, JH | 1 |
| Kou, JJ | 1 |
| Shi, JZ | 1 |
| Pang, XB | 1 |
| Xie, XM | 1 |
| Yan, Y | 2 |
| Hu, X | 1 |
| Qi, C | 1 |
| Feng, F | 1 |
| Wang, Y | 5 |
| Di, T | 1 |
| Meng, Y | 1 |
| Zhao, N | 1 |
| Li, P | 3 |
| Zhao, J | 4 |
| Sánchez-Quevedo, J | 1 |
| Ocampo-Rodríguez, E | 1 |
| Alvarez-Ayala, E | 1 |
| Rodríguez-López, A | 1 |
| Duarte-Vázquez, MA | 3 |
| Rosado, JL | 2 |
| Rodríguez-Fragoso, L | 3 |
| Subramanian, C | 1 |
| Frank, MW | 1 |
| Tangallapally, R | 1 |
| Yun, MK | 1 |
| White, SW | 1 |
| Lee, RE | 1 |
| Rock, CO | 1 |
| Jackowski, S | 1 |
| Qutob, HMH | 1 |
| Saad, RA | 1 |
| Bali, H | 1 |
| Osailan, A | 1 |
| Jaber, J | 1 |
| Alzahrani, E | 1 |
| Alyami, J | 1 |
| Elsayed, H | 1 |
| Alserihi, R | 1 |
| Shaikhomar, OA | 1 |
| Divya, KM | 1 |
| Savitha, DP | 1 |
| Krishna, GA | 1 |
| Dhanya, TM | 1 |
| Mohanan, PV | 1 |
| Shah, SF | 1 |
| Jafry, AT | 1 |
| Hussain, G | 1 |
| Kazim, AH | 1 |
| Ali, M | 1 |
| Rivani, E | 1 |
| Endraswari, PD | 1 |
| Widodo, ADW | 1 |
| Khalil, MR | 1 |
| Guldberg, R | 1 |
| Nørgård, BM | 1 |
| Uldbjerg, N | 1 |
| Wehberg, S | 1 |
| Fowobaje, KR | 1 |
| Mashood, LO | 1 |
| Ekholuenetale, M | 1 |
| Ibidoja, OJ | 1 |
| Romagnoli, A | 1 |
| D'Agostino, M | 1 |
| Pavoni, E | 1 |
| Ardiccioni, C | 1 |
| Motta, S | 1 |
| Crippa, P | 1 |
| Biagetti, G | 1 |
| Notarstefano, V | 1 |
| Rexha, J | 1 |
| Perta, N | 1 |
| Barocci, S | 1 |
| Costabile, BK | 1 |
| Colasurdo, G | 1 |
| Caucci, S | 1 |
| Mencarelli, D | 1 |
| Turchetti, C | 1 |
| Farina, M | 1 |
| Pierantoni, L | 1 |
| La Teana, A | 1 |
| Al Hadi, R | 1 |
| Cicconardi, F | 1 |
| Chinappi, M | 1 |
| Trucchi, E | 1 |
| Mancia, F | 1 |
| Menzo, S | 1 |
| Morozzo Della Rocca, B | 1 |
| D'Annessa, I | 1 |
| Di Marino, D | 1 |
| Choya, A | 1 |
| de Rivas, B | 1 |
| Gutiérrez-Ortiz, JI | 1 |
| López-Fonseca, R | 1 |
| Xu, S | 1 |
| Cheng, B | 1 |
| Huang, Z | 1 |
| Liu, T | 1 |
| Li, Y | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy of L-Carnitine in the Management of Acute Clozapine Intoxication[NCT05632094] | Phase 2 | 40 participants (Anticipated) | Interventional | 2023-06-30 | Not yet recruiting | ||
| Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease[NCT05719714] | Phase 1/Phase 2 | 60 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
| Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow[NCT01825369] | Phase 1 | 0 participants (Actual) | Interventional | 2014-12-31 | Withdrawn (stopped due to Changes to cardiac surgery program) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 reviews available for carnitine and Disease Models, Animal
| Article | Year |
|---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Trimethylamine N-Oxide in Relation to Cardiometabolic Health-Cause or Effect?
Topics: Age Factors; Amines; Animals; Cardiometabolic Risk Factors; Cardiovascular Diseases; Carnitine; Dige | 2020 |
Gut Microbiota and Cardiovascular Disease.
Topics: Animals; Atherosclerosis; Bile Acids and Salts; Cardiovascular Diseases; Carnitine; Choline; Disease | 2020 |
Gut Microbiota and Atherosclerosis.
Topics: Animals; Atherosclerosis; Bile Acids and Salts; Carnitine; Diet; Disease Models, Animal; Gastrointes | 2017 |
Molecular mechanisms of nickel induced neurotoxicity and chemoprevention.
Topics: Animals; Carnitine; Cell Line; Chemoprevention; Disease Models, Animal; DNA Damage; DNA, Mitochondri | 2017 |
Mechanisms underlying the anti-wasting effect of L-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies.
Topics: Animals; Carnitine; Dietary Supplements; Disease Models, Animal; Humans; Muscle, Skeletal; Muscular | 2013 |
Carnitine therapy for the treatment of metabolic syndrome and cardiovascular disease: evidence and controversies.
Topics: Administration, Oral; Animals; Athletes; Blood Pressure; Cardiovascular Diseases; Carnitine; Cholest | 2014 |
[Experimental Approach to Analysis of the Relationship between Food Environments and Lifestyle-Related Diseases, Including Cardiac Hypertrophy, Fatty Liver, and Fatigue Symptoms].
Topics: Animals; Beriberi; Cardiomegaly; Carnitine; Disease Models, Animal; Fatigue Syndrome, Chronic; Fatty | 2015 |
Potential protective effects of l-carnitine against neuromuscular ischemia-reperfusion injury: From experimental data to potential clinical applications.
Topics: Animals; Carnitine; Central Nervous System; Disease Models, Animal; Humans; Muscle, Skeletal; Reperf | 2016 |
Trimethylamine N-Oxide From Gut Microbiota in Chronic Kidney Disease Patients: Focus on Diet.
Topics: Animals; Cardiovascular Diseases; Carnitine; Choline; Diet, Protein-Restricted; Disease Models, Anim | 2015 |
Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?
Topics: Animals; Carnitine; Disease Models, Animal; Exercise; Humans; Insulin Resistance; Lipid Metabolism; | 2010 |
A review of the logistic role of L-carnitine in the management of radiation toxicity and radiotherapy side effects.
Topics: Animals; Biomarkers; Carnitine; Disease Management; Disease Models, Animal; Homeostasis; Humans; Neo | 2011 |
Carnitine transport: pathophysiology and metabolism of known molecular defects.
Topics: Animals; Biological Transport; Carnitine; Carrier Proteins; Chemical and Drug Induced Liver Injury; | 2003 |
The propionyl-L-carnitine hypothesis: an alternative approach to treating heart failure.
Topics: Animals; Cardiotonic Agents; Carnitine; Chronic Disease; Disease Models, Animal; Heart; Heart Failur | 1997 |
Carnitine deficiency-induced cardiomyopathy.
Topics: Animals; Cardiomyopathies; Carnitine; Disease Models, Animal; Humans; Kinetics; Models, Biological; | 1998 |
Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: a common denominator in the pathophysiology of diseases of oxidative phosphorylation and beta-oxidation.
Topics: Animals; Carnitine; Disease Models, Animal; Docosahexaenoic Acids; Humans; Metabolism, Inborn Errors | 2000 |
Carnitine transport by organic cation transporters and systemic carnitine deficiency.
Topics: Animals; Biological Transport; Carnitine; Carrier Proteins; Cations; Disease Models, Animal; Humans; | 2001 |
3 trials available for carnitine and Disease Models, Animal
| Article | Year |
|---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Nutritional Interventions that Slow the Age-Associated Decline in Renal Function in a Canine Geriatric Model for Elderly Humans.
Topics: Absorptiometry, Photon; Aged; Aging; Animals; Arginine; Biomarkers; Body Weight; Carnitine; Cross-Se | 2016 |
L-carnitine influence on oxidative stress induced by hind limb unloading in adult rats.
Topics: Animals; Carnitine; Disease Models, Animal; Hindlimb Suspension; Lipid Peroxidation; Male; Malondial | 2007 |
229 other studies available for carnitine and Disease Models, Animal
| Article | Year |
|---|---|
L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carnitine; Disease Models, Animal; Fibrosis; Inflam | 2021 |
Chlorogenic acid inhibits trimethylamine-
Topics: Animal Feed; Animals; Carnitine; Chlorogenic Acid; Disease Models, Animal; Gastrointestinal Microbio | 2021 |
Mitochondrial dysfunction in a mouse model of prodromal Parkinson's disease: A metabolomic analysis.
Topics: Animals; Biomarkers; Carnitine; Disease Models, Animal; Metabolomics; Mice; Mitochondria; Parkinsoni | 2021 |
Differential and Synergistic Effects of Low Birth Weight and Western Diet on Skeletal Muscle Vasculature, Mitochondrial Lipid Metabolism and Insulin Signaling in Male Guinea Pigs.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Birth Weight; Blood Glucose; | 2021 |
L-Carnitine prevents memory impairment induced by post-traumatic stress disorder.
Topics: Animals; Antioxidants; Carnitine; Disease Models, Animal; Glutathione; Glutathione Disulfide; Hippoc | 2022 |
High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models.
Topics: Alloxan; Animals; Carcinogenesis; Carnitine; Diet, High-Fat; Disease Models, Animal; Glucose Intoler | 2022 |
The Reversible Carnitine Palmitoyltransferase 1 Inhibitor (Teglicar) Ameliorates the Neurodegenerative Phenotype in a Drosophila Huntington's Disease Model by Acting on the Expression of Carnitine-Related Genes.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Disease Models, Animal; Drosophila; Huntington | 2022 |
L-Carnitine Alleviates the Myocardial Infarction and Left Ventricular Remodeling through Bax/Bcl-2 Signal Pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carnitine; Disease Models, Animal; Mice; Mice, Inbre | 2022 |
Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma - Smilax glabra Roxb herb pair for the treatment of psoriasis.
Topics: Amino Acids; Animals; Carnitine; Cimicifuga; Cytokines; Disease Models, Animal; Imiquimod; Interleuk | 2022 |
β-Hydroxyphosphocarnitine modifies fibrosis, steatosis and improves liver function in non-alcoholic steatohepatitis induced in rats.
Topics: Animals; Carnitine; Cholesterol; Diet, High-Fat; Disease Models, Animal; Fructose; Glucose; Glycogen | 2022 |
Relief of CoA sequestration and restoration of mitochondrial function in a mouse model of propionic acidemia.
Topics: Animals; Carnitine; Disease Models, Animal; Methylmalonyl-CoA Decarboxylase; Mice; Mitochondria; Pro | 2023 |
Untargeted Metabolomic Analysis Reveals the Metabolic Disturbances and Exacerbation of Oxidative Stress in the Cerebral Cortex of a BTBR Mouse Model of Autism.
Topics: Animals; Autistic Disorder; Carnitine; Cerebral Cortex; Disease Models, Animal; Mice; Mice, Inbred C | 2023 |
OCTN2 enhances PGC-1α-mediated fatty acid oxidation and OXPHOS to support stemness in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Carnitine; Cell Line, Tumor; Disease Models, Animal; Fatty Acids | 2023 |
Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Lipids in Experimental Model of Traumatic Brain Injury Detecting Acylcarnitines as Injury Related Markers.
Topics: Animals; Biomarkers; Brain; Brain Injuries, Traumatic; Carnitine; Disease Models, Animal; Image Proc | 2019 |
L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet.
Topics: Animals; Carnitine; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal; Disease P | 2020 |
Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Cardiomyopathies; Carnitine; Disease Models, Animal; Fa | 2020 |
Potential osteomyelitis biomarkers identified by plasma metabolome analysis in mice.
Topics: Animals; Biomarkers; Carnitine; Citric Acid Cycle; Disease Models, Animal; Fatty Acids; Ketoglutaric | 2020 |
Metabolomic Analysis of the Liver of a Dextran Sodium Sulfate-Induced Acute Colitis Mouse Model: Implications of the Gut-Liver Connection.
Topics: Acute Disease; Animals; Body Weight; Carnitine; Colitis; Colon; Discriminant Analysis; Disease Model | 2020 |
Metabolomics of a mouse model of preeclampsia induced by overexpressing soluble fms-like tyrosine kinase 1.
Topics: Animals; Carnitine; Cell Line; Disease Models, Animal; Fatty Acids; Female; Fetal Growth Retardation | 2020 |
Targeted Metabolomic Analysis of a Mucopolysaccharidosis IIIB Mouse Model Reveals an Imbalance of Branched-Chain Amino Acid and Fatty Acid Metabolism.
Topics: Amino Acids, Aromatic; Amino Acids, Branched-Chain; Animals; Carnitine; Disease Models, Animal; Huma | 2020 |
Downregulation of OCTN2 by cytokines plays an important role in the progression of inflammatory bowel disease.
Topics: Adult; Animals; Anti-Inflammatory Agents; Carnitine; Cell Line; Colitis, Ulcerative; Crohn Disease; | 2020 |
Uncovering the mechanism of Astragali Radix against nephrotic syndrome by intergrating lipidomics and network pharmacology.
Topics: Animals; Astragalus propinquus; Carnitine; Disease Models, Animal; Doxorubicin; Drugs, Chinese Herba | 2020 |
The Discovery of Highly Potent THP Derivatives as OCTN2 Inhibitors: From Structure-Based Virtual Screening to In Vivo Biological Activity.
Topics: Animals; Carnitine; Cell Line; Cell Survival; Disease Models, Animal; Drosophila melanogaster; Drug | 2020 |
Combined protective effects of oligo-fucoidan, fucoxanthin, and L-carnitine on the kidneys of chronic kidney disease mice.
Topics: Animals; Apoptosis; Biomarkers; Carnitine; Cell Line; Disease Models, Animal; Drug Therapy, Combinat | 2021 |
Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations.
Topics: Animals; Biomarkers; Cardiopulmonary Resuscitation; Carnitine; Disease Models, Animal; Fatty Acids; | 2020 |
Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis.
Topics: Adult; Amino Acids; Animals; Biomarkers; Carnitine; Case-Control Studies; Disease Models, Animal; Fe | 2021 |
Increasing fatty acid oxidation elicits a sex-dependent response in failing mouse hearts.
Topics: Acetyl-CoA Carboxylase; Animals; Carnitine; Disease Models, Animal; Energy Metabolism; Fatty Acids; | 2021 |
Topical Delivery of Levocarnitine to the Cornea and Anterior Eye by Thermosensitive in-situ Gel for Dry Eye Disease.
Topics: Administration, Ophthalmic; Animals; Carnitine; Cornea; Disease Models, Animal; Drug Delivery System | 2021 |
Er-Xian decoction exhibits protective activity in a rat model of asthenospermia through a mechanism associated with DJ-1 protein upregulation.
Topics: Animals; Antioxidants; Asthenozoospermia; Carnitine; Disease Models, Animal; Dose-Response Relations | 2021 |
Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP Production Leading to Cardiac Dysfunction in Zebrafish.
Topics: Adenosine Triphosphate; Animals; Carnitine; Disease Models, Animal; Fatty Acids; Heart; Heart Diseas | 2021 |
Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.
Topics: Adipogenesis; Animals; Body Weight; Carnitine; Chronic Disease; Disease Models, Animal; Gene Express | 2017 |
The Effect of Intravenous L-Carnitine on the Vasospasm Process in the Experimental Subarachnoid Hemorrhage Model.
Topics: Animals; Basilar Artery; Carnitine; Disease Models, Animal; Male; Rabbits; Subarachnoid Hemorrhage; | 2017 |
Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver.
Topics: Animals; Biomarkers; Body Weight; Carnitine; Diet, High-Fat; Disease Models, Animal; Fatty Acids; Fa | 2017 |
Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats.
Topics: Aniline Compounds; Animals; Biomarkers; Carnitine; Creatine Kinase; Disease Models, Animal; Glutarat | 2017 |
From the Cover: l-Carnitine via PPARγ- and Sirt1-Dependent Mechanisms Attenuates Epithelial-Mesenchymal Transition and Renal Fibrosis Caused by Perfluorooctanesulfonate.
Topics: Acetylation; Alkanesulfonic Acids; Animals; Carnitine; Cell Line; Cell Movement; Cytoprotection; Dis | 2017 |
L-Carnitine Attenuates Cardiac Dysfunction by Ischemic Insults Through Akt Signaling Pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Carnitine; Cell Hypoxia; Cell | 2017 |
Therapeutic Potential of Novel Twin Compounds Containing Tetramethylpyrazine and Carnitine Substructures in Experimental Ischemic Stroke.
Topics: Animals; Brain Ischemia; Carnitine; Disease Models, Animal; Male; NADPH Oxidase 2; Neuroprotective A | 2017 |
CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Carnitine; Carnitine O-Palmitoyltransferase; Case-C | 2018 |
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.
Topics: Aged; Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Cholesterol; Choline; Disease Mo | 2018 |
Tissue acylcarnitine status in a mouse model of mitochondrial β-oxidation deficiency during metabolic decompensation due to influenza virus infection.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Cardiomyopathies; Carnitine; Congenital Bone Marrow Fai | 2018 |
L-Carnitine and extendin-4 improve outcomes following moderate brain contusion injury.
Topics: Animals; Antioxidants; Brain; Brain Contusion; Brain Injuries, Traumatic; Carnitine; Disease Models, | 2018 |
Clozapine-induced reduction of l-carnitine reabsorption via inhibition/down-regulation of renal carnitine/organic cation transporter 2 contributes to liver lipid metabolic disorder in mice.
Topics: Animals; Antipsychotic Agents; Carnitine; Cell Line; Chemical and Drug Induced Liver Injury; Clozapi | 2019 |
Sheathless CE-MS based metabolic profiling of kidney tissue section samples from a mouse model of Polycystic Kidney Disease.
Topics: Animals; Betaine; Carnitine; Creatine; Creatinine; Disease Models, Animal; Electrophoresis, Capillar | 2019 |
L-carnitine does not ameliorate asparaginase-associated hepatotoxicity in a C57BL6 mouse model.
Topics: Animals; Antineoplastic Agents; Asparaginase; Carnitine; Chemical and Drug Induced Liver Injury; Dis | 2019 |
Metabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for Yersinia pestis.
Topics: Animals; Betaine; Carnitine; Chlorocebus aethiops; Disease Models, Animal; Gas Chromatography-Mass S | 2018 |
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan.
Topics: Acetylcarnitine; Animals; Canavanine; Carnitine; Case-Control Studies; Disease Models, Animal; Disea | 2019 |
L-Carnitine improves endocrine function and folliculogenesis by reducing inflammation, oxidative stress and apoptosis in mice following induction of polycystic ovary syndrome.
Topics: Animals; Apoptosis; Carnitine; Disease Models, Animal; Female; Follicle Stimulating Hormone; Inflamm | 2019 |
l-Carnitine prevents oxidative stress in striatum of glutaryl-CoA dehydrogenase deficient mice submitted to lysine overload.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic; Carnitine; Corpus Striatum | 2019 |
Lipidomics unveils lipid dyshomeostasis and low circulating plasmalogens as biomarkers in a monogenic mitochondrial disorder.
Topics: Adolescent; Animals; Bile Acids and Salts; Biomarkers; Carnitine; Case-Control Studies; Disease Mode | 2019 |
Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine; Dietary Supplements; Disease Models, Animal; | 2013 |
Carnitine or dimethyl sulfoxide, or both, for the treatment of anthracycline extravasation in rats.
Topics: Administration, Topical; Animals; Anthracyclines; Carnitine; Dimethyl Sulfoxide; Disease Models, Ani | 2013 |
The protective effect of L-carnitine on hepatic ischemia-reperfusion injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carnitine; Disease Models, Animal; Gluta | 2013 |
L-carnitine pretreatment protects slow-twitch skeletal muscles in a rat model of ischemia-reperfusion injury.
Topics: Animals; Carnitine; Cytoprotection; Disease Models, Animal; Electric Stimulation; Male; Muscle Contr | 2013 |
Efficacy of osmoprotectants on prevention and treatment of murine dry eye.
Topics: Animals; Apoptosis; Betaine; Carnitine; Cornea; Disease Models, Animal; Disease Progression; Dry Eye | 2013 |
Biotinidase knockout mice show cellular energy deficit and altered carbon metabolism gene expression similar to that of nutritional biotin deprivation: clues for the pathogenesis in the human inherited disorder.
Topics: Animals; Biotin; Biotinidase Deficiency; Blood Glucose; Body Weight; Carbon; Carnitine; Diet; Diseas | 2013 |
L-carnitine ameliorates L-asparaginase-induced acute liver toxicity in steatotic rat livers.
Topics: Animals; Asparaginase; Aspartate Aminotransferases; Blood Pressure; Carnitine; Cell Line, Tumor; Che | 2013 |
Protective effects of L-carnitine, N-acetylcysteine and genistein in an experimental model of liver fibrosis.
Topics: Acetylcysteine; Animals; Carnitine; Disease Models, Animal; Genistein; Liver Cirrhosis; Male; Rats; | 2014 |
The protective effect of L-carnitine against hippocampal damage due to experimental formaldehyde intoxication in rats.
Topics: Animals; Carnitine; Disease Models, Animal; Formaldehyde; Hippocampus; Immunohistochemistry; Male; O | 2014 |
Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/mass spectrometry.
Topics: Allium; Animals; Antidepressive Agents; Carnitine; Chromatography, High Pressure Liquid; Depression; | 2014 |
CoQ10 and L-carnitine attenuate the effect of high LDL and oxidized LDL on spermatogenesis in male rats.
Topics: Animals; Antioxidants; Carnitine; Cell Survival; Cholesterol, Dietary; Cytoprotection; Disease Model | 2014 |
The effects of L-carnitine and N-acetylcysteine on carbontetrachloride induced acute liver damage in rats.
Topics: Acetylcysteine; Animals; Carbon Tetrachloride; Carnitine; Chemical and Drug Induced Liver Injury; Di | 2013 |
L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ.
Topics: Animals; Carnitine; Cells, Cultured; Collagen; Connective Tissue Growth Factor; Cytoprotection; Dise | 2014 |
Inhibition of gene expression of carnitine palmitoyltransferase I and heart fatty acid binding protein in cyclophosphamide and ifosfamide-induced acute cardiotoxic rat models.
Topics: Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Cardiomyopathies; Cardiotoxicity; Car | 2014 |
L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with upregulation of mitochondrial pathway.
Topics: Animals; Carnitine; Dietary Fats; Disease Models, Animal; Male; Mice; Mitochondria, Liver; Non-alcoh | 2014 |
Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Butyric Acid; Carnitine; Colitis; Colon | 2014 |
L-Carnitine ester of prednisolone: pharmacokinetic and pharmacodynamic evaluation of a type I prodrug.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Carn | 2014 |
L-Carnitine intake prevents irregular feeding-induced obesity and lipid metabolism disorder.
Topics: Abdominal Fat; Animals; Body Weight; Carnitine; Disease Models, Animal; Feeding Behavior; Gene Expre | 2015 |
L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain.
Topics: Animals; Axons; Blotting, Western; Brain Ischemia; Carnitine; Disease Models, Animal; Immunohistoche | 2015 |
Investigation of protective effect of L-carnitine on L-asparaginase-induced acute pancreatic injury in male Balb/c mice.
Topics: Acute Disease; Amylases; Animals; Antioxidants; Asparaginase; Biomarkers; Blood Glucose; Carnitine; | 2015 |
Protective effect of L-carnitine in a rat model of retinopathy of prematurity.
Topics: Animals; Animals, Newborn; Carnitine; Disease Models, Animal; Malondialdehyde; Oxidative Stress; Oxy | 2014 |
Treatment with Carnitine Enhances Bone Fracture Healing under Osteoporotic and/or Inflammatory Conditions.
Topics: Absorptiometry, Photon; Animals; Bone Density; Carnitine; Disease Models, Animal; Female; Fracture H | 2015 |
A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats.
Topics: Acute Kidney Injury; Animals; Carnitine; Cimetidine; Creatine Kinase; Creatinine; Disease Models, An | 2015 |
Contractile function and energy metabolism of skeletal muscle in rats with secondary carnitine deficiency.
Topics: Animals; Apoptosis; Biomarkers; Carnitine; Deficiency Diseases; Disease Models, Animal; Energy Metab | 2015 |
The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model.
Topics: Anastomosis, Surgical; Animals; Antioxidants; Carnitine; Colon; Disease Models, Animal; Hydroxyproli | 2015 |
Combination of Cilostazol and L-Carnitine Improves Walking Performance in Peripheral Arterial Disease Model Rats.
Topics: Angiogenic Proteins; Animals; Carnitine; Cilostazol; Disease Models, Animal; Drug Therapy, Combinati | 2015 |
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; | 2016 |
Immunohistochemical determination of the extracellular matrix modulation in a rat model of choline-deprived myocardium: the effects of carnitine.
Topics: Administration, Oral; Animals; Cardiomyopathies; Carnitine; Choline Deficiency; Disease Models, Anim | 2016 |
L-carnitine Prevents Oxidative Stress in the Brains of Rats Subjected to a Chemically Induced Chronic Model of MSUD.
Topics: Amino Acids, Branched-Chain; Animals; Brain; Carnitine; Catalase; Disease Models, Animal; Glutathion | 2016 |
Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema.
Topics: Animals; Apoptosis; Biomarkers; Bronchoalveolar Lavage Fluid; Carnitine; Cell Line; Disease Models, | 2016 |
L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE(-/-) transgenic mice expressing CETP.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Carnitine; Cells, Cultured; Cholesterol Ester Transfer | 2016 |
Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance.
Topics: Animals; Blood Glucose; Carnitine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diet, High-Fa | 2016 |
Protective effect of R. glutinosa oligosaccharides against high L-carnitine diet-induced endothelial dysfunction and hepatic injury in mice.
Topics: Animals; Bacillus; Biomarkers; Body Weight; Carnitine; Diet; Disease Models, Animal; Endothelium; Li | 2016 |
Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.
Topics: Animals; Carbon Isotopes; Carnitine; Ceramides; Chromatography, Liquid; Citric Acid Cycle; Dietary F | 2016 |
Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome.
Topics: Aging; Alzheimer Disease; Amino Acids, Branched-Chain; Amino Acids, Essential; Animals; Biogenic Pol | 2016 |
Longitudinal metabolic imaging of hepatocellular carcinoma in transgenic mouse models identifies acylcarnitine as a potential biomarker for early detection.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Carnitine; Diffusion Magnetic Resonance Imaging; Dis | 2016 |
Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.
Topics: Animals; Blood Pressure; Carnitine; Disease Models, Animal; Disease Progression; Glutathione; Humans | 2016 |
[Antioxidating and energy metabolism improving effects of Qiangjing Decoction on oligospermia and asthenospermia: An experimental study].
Topics: alpha-Glucosidases; Animals; Antioxidants; Asthenozoospermia; Carnitine; Disease Models, Animal; Dru | 2016 |
Oxidative stress balance is dysregulated and represents an additional target for treating cholangiocarcinoma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antioxidants; Carnitine; Cholangiocarcinoma; Disease Models | 2016 |
Oxidative stress controlling agents are effective for small intestinal injuries induced by non-steroidal anti-inflammatory drugs.
Topics: Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Capsule End | 2017 |
Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels.
Topics: Age Factors; Aged; Animals; Body Mass Index; Cardiovascular Diseases; Carnitine; Diabetes Mellitus; | 2016 |
Influence of moderate maternal nutrition restriction on the fetal baboon metabolome at 0.5 and 0.9 gestation.
Topics: Adaptation, Physiological; Animals; Biomarkers; Caloric Restriction; Carnitine; Chromatography, Liqu | 2016 |
Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice.
Topics: Amino Acids; Analysis of Variance; Animals; Biomarkers; Blood Glucose; Carnitine; Cluster Analysis; | 2016 |
Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats.
Topics: Animals; Caloric Restriction; Carnitine; Diet, High-Fat; Disease Models, Animal; Fatty Acid Desatura | 2016 |
l-Carnitine improves cognitive and renal functions in a rat model of chronic kidney disease.
Topics: Animals; Avoidance Learning; Blood Urea Nitrogen; Carnitine; Cognition; Creatinine; Disease Models, | 2016 |
Novel Mouse Models of Methylmalonic Aciduria Recapitulate Phenotypic Traits with a Genetic Dosage Effect.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Biomarkers; Brain; Carnitine; Dietary Protei | 2016 |
L-carnitine has a protective effect on the colonic mucosa during abdominopelvic radiotherapy in rats.
Topics: Animals; Carnitine; Colitis; Colon; Disease Models, Animal; Female; Intestinal Mucosa; Radiation Inj | 2016 |
Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects.
Topics: Amino Acids; Animals; Carnitine; Dietary Supplements; Disease Models, Animal; Embryo, Mammalian; Fem | 2017 |
Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders.
Topics: Acyl-CoA Dehydrogenase; Animals; Carnitine; Computational Biology; Computer Simulation; Disease Mode | 2016 |
Change in the membranous lipid composition accelerates lipid peroxidation in young rat hearts subjected to 2 weeks of hypoxia followed by hyperoxia.
Topics: Acetylcarnitine; Age Factors; Animals; Antioxidants; Carnitine; Catalase; Cell Membrane; Chronic Dis | 2008 |
The role of inflammatory markers in the cardioprotective effect of L-carnitine in L-NAME-induced hypertension.
Topics: Animals; Biomarkers; Blood Pressure; Body Weight; Cardiotonic Agents; Carnitine; Disease Models, Ani | 2008 |
Proteomic changes associated with diabetes in the BB-DP rat.
Topics: Animals; Carnitine; Citrate (si)-Synthase; Diabetes Mellitus, Type 1; Disease Models, Animal; Electr | 2009 |
L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation.
Topics: Animals; Carnitine; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Cytokines; Dendritic Cells | 2009 |
Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats.
Topics: Animals; Carnitine; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2009 |
Early nerve ending rescue from oxidative damage and energy failure by L: -carnitine as post-treatment in two neurotoxic models in rat: recovery of antioxidant and reductive capacities.
Topics: Animals; Antioxidants; Brain; Carnitine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2009 |
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.
Topics: 3-Hydroxybutyric Acid; Administration, Oral; Animals; Blood Glucose; Cardiovascular Agents; Carnitin | 2009 |
Increased urinary losses of carnitine and decreased intramitochondrial coenzyme A in gentamicin-induced acute renal failure in rats.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Blood Urea Nitrogen; Carnitine; Coenzyme A; Cr | 2010 |
Failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis (JVS) mice: involvement of defective acyl-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus.
Topics: Animals; Carnitine; Corticotropin-Releasing Hormone; Disease Models, Animal; Fasting; Fatty Acids; F | 2009 |
Neuroprotective effects of L-carnitine in a transgenic animal model of Huntington's disease.
Topics: Animals; Behavior, Animal; Carnitine; Disease Models, Animal; Huntington Disease; Injections, Intrap | 2010 |
Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide production.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Carnitine; Cell Proliferation; Chic | 2010 |
Carnitine deficiency aggravates cyclophosphamide-induced cardiotoxicity in rats.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Animals; Antineoplastic Agents, Alkylating; Cardiomyopath | 2010 |
Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders.
Topics: Animals; Behavior, Animal; Brain; Carnitine; Child; Child Development Disorders, Pervasive; Chromato | 2010 |
Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.
Topics: Alzheimer Disease; Animals; Antioxidants; Biomarkers; Brain; Carnitine; Cholinesterase Inhibitors; D | 2012 |
Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart.
Topics: Animals; Cardiomyopathies; Carnitine; Disease Models, Animal; Female; Glucose; Hyperammonemia; Male; | 2011 |
L-carnitine improves oxidative stress and suppressed energy metabolism but not renal dysfunction following release of acute unilateral ureteral obstruction in rat.
Topics: alpha-Tocopherol; Analysis of Variance; Animals; Antioxidants; Carnitine; Disease Models, Animal; En | 2011 |
In vivo neuroprotective effect of L-carnitine against oxidative stress in maple syrup urine disease.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Animals; Antioxidants; Carnitine; Catalase; Cereb | 2011 |
Effects of Zn(II) complex with vitamins C and U, and carnitine on metabolic syndrome model rats.
Topics: Adipocytes; Adipose Tissue; Animals; Ascorbic Acid; Body Weight; Carnitine; Cell Separation; Diet; D | 2011 |
Efficacy and safety of two analogs of L-carnitine on rats made insulin resistant by a high-fructose diet.
Topics: Animals; Blood Glucose; Body Weight; Carnitine; Chick Embryo; Cholesterol; Diet; Disease Models, Ani | 2011 |
[Effect of valsartan and carnitine on cardiomyocyte Calpain-1 and Bcl-xl expressions of dogs with chronic alcohol intake-induced cardiomyopathy].
Topics: Animals; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Calpain; Cardiomyopathy, Alcoholic; | 2011 |
Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b(-/-) mice as a model for Wilson disease.
Topics: Aconitate Hydratase; Adenosine Triphosphatases; Alanine; Animals; Brain; Carnitine; Cation Transport | 2011 |
L-carnitine increases survival in a murine model of severe verapamil toxicity.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Carnitine; Disease Models, Animal; Infusions, Int | 2011 |
Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Carnitine; Carnitine O-Palmitoyltransferase; Choline Def | 2011 |
Metabolomic changes and protective effect of (L)-carnitine in rat kidney ischemia/reperfusion injury.
Topics: Acute Kidney Injury; Animals; Carnitine; Disease Models, Animal; Energy Metabolism; Male; Malondiald | 2012 |
[A primary study of L-carnitine protective effect on corneal and conjunctival epithelium of mouse dry eye model induced by hyperosmolar saline].
Topics: Animals; Carnitine; Conjunctiva; Cornea; Disease Models, Animal; Epithelium; Female; Mice; Mice, Inb | 2012 |
Pharmacological evaluation of a β-hydroxyphosphonate analogue of l-carnitine in obese Zucker fa/fa rats.
Topics: Animals; Carnitine; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; | 2013 |
The mdx mouse as a model for carnitine deficiency in the pathogenesis of Duchenne muscular dystrophy.
Topics: Animals; Carnitine; Disease Models, Animal; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, | 2012 |
Studies on the chemopreventive effect of carnitine on tumorigenesis in vivo, using two experimental murine models of colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carnitine; Carnitine O-Acetyltransferase; Cell Trans | 2012 |
Downregulation of oxidative and nitrosative apoptotic signaling by L-carnitine in Ifosfamide-induced Fanconi syndrome rat model.
Topics: Animals; Apoptosis; Blood Urea Nitrogen; Carnitine; Caspases; Catalase; Creatinine; Disease Models, | 2012 |
Consumption of a high β-glucan barley flour improves glucose control and fatty liver and increases muscle acylcarnitines in the Zucker diabetic fatty rat.
Topics: Adiponectin; Animals; beta-Glucans; Blood Glucose; Body Weight; Carnitine; Cholesterol; Diabetes Mel | 2013 |
Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.
Topics: Adenosine Triphosphate; Animals; Arginine; Carnitine; Disease Models, Animal; Endothelial Cells; Hea | 2013 |
Protective effects of carnitine in an experimental ischemia-reperfusion injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carnitine; Disease Models, Animal; Femal | 2002 |
Effects of L-carnitine and ginkgo biloba extract (EG b 761) in experimental bleomycin-induced lung fibrosis.
Topics: Animals; Bleomycin; Carnitine; Collagen; Disease Models, Animal; Ginkgo biloba; Lipid Peroxides; Lun | 2002 |
A heterozygote phenotype is present in the jvs +/- mutant mouse livers.
Topics: Animals; Body Weight; Carnitine; Carrier Proteins; Cholesterol; Disease Models, Animal; Heterozygote | 2002 |
L-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure.
Topics: Angiotensin II; Animals; Apoptosis; Carnitine; Caspase 3; Caspase 9; Caspases; Cell Nucleus; Cells, | 2002 |
Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine.
Topics: Aging; Alzheimer Disease; Animals; Botulinum Toxins, Type A; Brain-Derived Neurotrophic Factor; Carn | 2002 |
Relative importance of enhanced glucose uptake versus attenuation of long-chain acyl carnitines in protecting ischemic myocardium.
Topics: Animals; Carnitine; Creatine Kinase; Cytochalasin B; Disease Models, Animal; Glucose; Models, Cardio | 2002 |
Mitochondrial oxidative metabolism in motor neuron degeneration (mnd) mouse central nervous system.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Carnitine; Central Nervous System; Cerebral Cor | 2002 |
The role of L-carnitine in treatment of a murine model of asthma.
Topics: Animals; Asthma; Carnitine; Disease Models, Animal; Leukotriene E4; Lung; Methacholine Chloride; Mic | 2002 |
Exercise intolerance during post-MI heart failure in rats: prevention with supplemental dietary propionyl-L-carnitine.
Topics: Animals; Carnitine; Diet; Disease Models, Animal; Exercise Tolerance; Heart Failure; In Vitro Techni | 2003 |
Activity of D-carnitine and its derivatives on Trypanosoma infections in rats and mice.
Topics: Adenosine Triphosphate; Animals; Brain; Carnitine; Disease Models, Animal; Dose-Response Relationshi | 2003 |
Betaine and carnitine uptake systems in Listeria monocytogenes affect growth and survival in foods and during infection.
Topics: Animals; Betaine; Carnitine; Cryoprotective Agents; Disease Models, Animal; Food Microbiology; Human | 2003 |
Identification of the up- and down-regulated genes in the heart of juvenile visceral steatosis mice.
Topics: Animals; Cardiomegaly; Carnitine; Disease Models, Animal; Down-Regulation; Gene Expression Profiling | 2004 |
L-carnitine ameliorates oxidative damage due to chronic renal failure in rats.
Topics: Animals; Antioxidants; Aorta; Blood Urea Nitrogen; Carnitine; Creatinine; Disease Models, Animal; Er | 2004 |
Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agent | 2004 |
Progression of cisplatin-induced nephrotoxicity in a carnitine-depleted rat model.
Topics: Animals; Antineoplastic Agents; Carnitine; Cisplatin; Disease Models, Animal; Kidney; Kidney Disease | 2004 |
Prevention of postischemic spinal cord injury by means of regional infusion of adenosine and L-carnitine dissolved in normothermic saline.
Topics: Adenosine; Animals; Axons; Blood Pressure; Carnitine; Disease Models, Animal; Female; Infusions, Int | 2004 |
Tissue carnitine homeostasis in very-long-chain acyl-CoA dehydrogenase-deficient mice.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Bile; Carnitine; Disease Models, Animal; Homeostasis; H | 2005 |
The additive effects of carnitine and ascorbic acid on distally burned dorsal skin flap in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Burns; Carnitine; Disease Models, Animal; Rats; Rats, Sprague- | 2005 |
L-carnitine and neuroprotection in the animal model of mitochondrial dysfunction.
Topics: Animals; Body Temperature; Carnitine; Disease Models, Animal; Electroencephalography; Male; Mitochon | 2005 |
Cardio-protective effects of carnitine in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Animals; Cardiotonic Agents; Carnitine; Diabetes Mellitus, Experimental; Disea | 2006 |
Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration.
Topics: Acetylcysteine; Adenosine Triphosphate; Animal Feed; Animals; Ascorbic Acid; Carnitine; Cloning, Mol | 2005 |
Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model.
Topics: Adenosine Triphosphate; Animals; Cardiomyopathies; Carnitine; Cisplatin; Disease Models, Animal; Glu | 2006 |
Attenuation of cardiac hypertrophy in carnitine-deficient juvenile visceral steatosis (JVS) mice achieved by lowering dietary lipid.
Topics: Animals; Aspirin; Carnitine; Diet; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Dr | 2006 |
Changes in visual evoked potentials, lipid peroxidation and antioxidant enzymes in rats exposed to restraint stress: effect of L-carnitine.
Topics: Analysis of Variance; Animals; Carnitine; Catalase; Disease Models, Animal; Enzyme Activation; Evoke | 2006 |
Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced oral mucositis and myelosuppression: a controlled study in a rat model.
Topics: Administration, Oral; Animals; Carnitine; Dietary Supplements; Disease Models, Animal; Drug Combinat | 2006 |
Intracerebral accumulation of glutaric and 3-hydroxyglutaric acids secondary to limited flux across the blood-brain barrier constitute a biochemical risk factor for neurodegeneration in glutaryl-CoA dehydrogenase deficiency.
Topics: Amino Acids; Animals; Biological Transport; Blood-Brain Barrier; Blotting, Western; Brain; Carnitine | 2006 |
Effects of L-carnitine on oxidant/antioxidant status in acetic acid-induced colitis.
Topics: Acetic Acid; Animals; Carnitine; Colitis, Ulcerative; Disease Models, Animal; Inflammation Mediators | 2006 |
A metabolic approach to the treatment of dilated cardiomyopathy in BIO T0-2 cardiomyopathic Syrian hamsters.
Topics: Animals; Cardiomyopathy, Dilated; Carnitine; Cricetinae; Disease Models, Animal; Electric Stimulatio | 2005 |
Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus.
Topics: Acetylcarnitine; Adenosine Triphosphate; Animals; Carnitine; Disease Models, Animal; Energy Metaboli | 2006 |
The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model.
Topics: Animals; Carnitine; Cataract; Cranial Irradiation; Disease Models, Animal; Female; Free Radical Scav | 2007 |
Prolonged effect of single carnitine administration on fasted carnitine-deficient JVS mice regarding their locomotor activity and energy expenditure.
Topics: Animals; Carnitine; Disease Models, Animal; Energy Metabolism; Fasting; Fatty Acids; Lipid Metabolis | 2006 |
Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitine.
Topics: Animals; Body Temperature; Carnitine; Disease Models, Animal; Drug Interactions; Gene Expression Reg | 2006 |
Myocardial function, energy provision, and carnitine deficiency in experimental uremia.
Topics: Animals; Cardiomegaly; Cardiovascular Diseases; Carnitine; Creatinine; Disease Models, Animal; Energ | 2007 |
Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats.
Topics: Adenosine Triphosphate; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2007 |
Carnitine, acylcarnitine and amino acid profiles analyzed by tandem mass spectrometry in a surfactant/virus mouse model of acute hepatic encephalopathy.
Topics: Amino Acids; Animals; Carnitine; Disease Models, Animal; Hepatic Encephalopathy; Influenza B virus; | 2007 |
Gastroprotective effect of L-carnitine on indomethacin-induced gastric mucosal injury in rats: a preliminary study.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carnitine; Chemoprevention; | 2006 |
Propionyl-L-carnitine prevents age-related myocardial remodeling in the rabbit.
Topics: Aging; Animals; Cardiotonic Agents; Carnitine; Collagen; Collagen Type I; Disease Models, Animal; En | 2007 |
Beneficial impact of L-carnitine in liver: a study in a rat model of syndrome X.
Topics: Administration, Oral; Animals; Carnitine; Disease Models, Animal; Fructose; Injections, Intraperiton | 2008 |
Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Ami | 2007 |
Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice.
Topics: Amino Acid Transport Systems; Animals; Atrophy; Carnitine; Colon; Crohn Disease; Disease Models, Ani | 2007 |
Changes in redox ratio and protein glycation in precataractous lens from fructose-fed rats: effects of exogenous L-carnitine.
Topics: Animals; Antioxidants; Blood Glucose; Carnitine; Catalase; Cataract; Dietary Carbohydrates; Disease | 2008 |
Carnitine-mediated improved response to erythropoietin involves induction of haem oxygenase-1: studies in humans and in an animal model.
Topics: Animals; Apoptosis; Carnitine; Disease Models, Animal; Erythropoiesis; Erythropoietin; Heart Failure | 2008 |
Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension.
Topics: Animals; Animals, Newborn; Carnitine; Carnitine O-Acetyltransferase; Carnitine O-Palmitoyltransferas | 2008 |
Increase in nitric oxide and reductions in blood pressure, protein kinase C beta II and oxidative stress by L-carnitine: a study in the fructose-fed hypertensive rat.
Topics: Animals; Blood Pressure; Carnitine; Disease Models, Animal; Hypertension; Male; Metabolic Syndrome; | 2007 |
Comparison of the effects of sodium nitroprusside and L-carnitine in experimental ischemia-reperfusion injury in rats.
Topics: Animals; Carnitine; Disease Models, Animal; Male; Mesenteric Arteries; Nitroprusside; Rats; Rats, Wi | 2007 |
Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine.
Topics: Animals; Antioxidants; Brain; Carnitine; Convulsants; Disease Models, Animal; Dose-Response Relation | 2008 |
L: -carnitine fumarate and isovaleryl-L: -carnitine fumarate accelerate the recovery of bone volume/total volume ratio after experimetally induced osteoporosis in pregnant mice.
Topics: Animals; Calcification, Physiologic; Calcium; Calcium, Dietary; Carnitine; Cell Count; Cell Prolifer | 2008 |
Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure.
Topics: Acyl-CoA Dehydrogenase; Adiponectin; Animals; Blood Glucose; Carnitine; Dietary Fats; Disease Models | 2008 |
Tissue damage in rat ovaries subjected to torsion and detorsion: effects of L-carnitine and N-acetyl cysteine.
Topics: Acetylcysteine; Animals; Carnitine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Femal | 2008 |
From the National Institute of Allergy and Infectious Diseases: Summary of a workshop on disease mechanisms and prospects for prevention of Reye's syndrome.
Topics: Adolescent; Adult; Animals; Biological Transport; Calcium; Carnitine; Child; Child, Preschool; Disea | 1983 |
Cardiac carnitine deficiency and altered carnitine transport in cardiomyopathic hamsters.
Topics: Animals; Biological Transport; Cardiomyopathies; Carnitine; Cricetinae; Disease Models, Animal; Meso | 1983 |
[Myocardial disease caused by adriamycin. Experimental animal models and possible pharmacologic prevention].
Topics: Animals; Cardiomyopathies; Carnitine; Disease Models, Animal; Doxorubicin; Mice; Rabbits; Rats; Razo | 1982 |
Fatty acid metabolism in skeletal muscle mitochondria from two strains of dystrophic mice.
Topics: Acetylcarnitine; Animals; Carnitine; Carnitine O-Acetyltransferase; Carnitine O-Palmitoyltransferase | 1980 |
Reye syndrome model in rats: protection against liver abnormalities by L-carnitine and acetyl-L-carnitine.
Topics: Acetylcarnitine; Acyl Coenzyme A; Animals; Aspirin; Carnitine; Coenzyme A; Disease Models, Animal; K | 1995 |
Propionyl-L-carnitine prevents the progression of atherosclerotic lesions in aged hyperlipemic rabbits.
Topics: Aging; Animals; Arteriosclerosis; Carnitine; Cell Division; Diet; Disease Models, Animal; Female; Fo | 1995 |
Effect of propionyl-L-carnitine in a rat model of peripheral arteriopathy: a functional, histologic, and NMR spectroscopic study.
Topics: Animals; Cardiotonic Agents; Carnitine; Disease Models, Animal; Energy Metabolism; Femoral Artery; H | 1993 |
In vivo 31P spectroscopy study of treated and untreated recovery of rat partial brain ischemia.
Topics: Adenosine Triphosphate; Animals; Basilar Artery; Carnitine; Carotid Arteries; Disease Models, Animal | 1995 |
Alterations in energy metabolism of hypertrophied rat cardiomyocytes: influence of propionyl-L-carnitine.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiomegaly; Cardiotonic Agents; Carnitine; | 1995 |
Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cardiomyopathies; Carnitine; Carnitine O-Palmito | 1996 |
Disordered expression of glycolytic and gluconeogenic liver enzymes of juvenile visceral steatosis mice with systemic carnitine deficiency.
Topics: Age Factors; Animals; Blotting, Northern; Carnitine; Disease Models, Animal; Fatty Liver; Fructose-B | 1996 |
Long-term 1-carnitine treatment prolongs the survival in rats with adriamycin-induced heart failure.
Topics: Acyl Coenzyme A; Adenosine Triphosphate; Administration, Oral; Analysis of Variance; Animals; Carnit | 1996 |
Positive action of propionyl-L-carnitine on mechanical performance of papillary muscle from Syrian hamsters with hereditary dilated cardiomyopathy.
Topics: Administration, Oral; Analysis of Variance; Animals; Biomechanical Phenomena; Cardiomyopathy, Dilate | 1995 |
Suppressed expression of the urea cycle enzyme genes in the liver of carnitine-deficient juvenile visceral steatosis (JVS) mice in infancy and during starvation in adulthood.
Topics: Age Factors; Animals; Argininosuccinate Synthase; Basic Helix-Loop-Helix Leucine Zipper Transcriptio | 1997 |
Altered expression of atrial natriuretic peptide and contractile protein genes in hypertrophied ventricle of JVS mice with systemic carnitine deficiency.
Topics: Actins; Animals; Atrial Natriuretic Factor; Body Weight; Cardiomegaly; Carnitine; Disease Models, An | 1997 |
A novel gene suppressed in the ventricle of carnitine-deficient juvenile visceral steatosis mice.
Topics: Amino Acid Sequence; Animals; Blotting, Northern; Brain; Cardiomegaly; Carnitine; Carnitine O-Palmit | 1997 |
The effect of carnitine on ketogenesis in perfused livers from juvenile visceral steatosis mice with systemic carnitine deficiency.
Topics: Animals; Butyrates; Butyric Acid; Caprylates; Carnitine; Disease Models, Animal; Fatty Liver; In Vit | 1997 |
Neonatal nutritional carnitine deficiency: a piglet model.
Topics: Animals; Animals, Newborn; Carnitine; Diet; Disease Models, Animal; Fatty Acids; In Vitro Techniques | 1997 |
On the interrelationship between hepatic carnitine, fatty acid oxidation, and triglyceride biosynthesis in nephrosis.
Topics: Acetyl Coenzyme A; Animals; Carnitine; Cholesterol; Cytosol; Disease Models, Animal; Fatty Acids; Li | 1997 |
Dietary carnitine supplements slow disease progression in a putative mouse model for hereditary ceroid-lipofuscinosis.
Topics: Animals; Brain Chemistry; Carnitine; Cerebral Cortex; Disease Models, Animal; Lysosomes; Male; Mice; | 1997 |
Mitochondrial abnormalities in a murine model of primary carnitine deficiency. Systemic pathology and trial of replacement therapy.
Topics: Animals; Brain; Carnitine; Disease Models, Animal; Drug Evaluation, Preclinical; Electron Transport; | 1997 |
[Physiologic bases for the use of L-carnitine in cardiology].
Topics: Animals; Arrhythmias, Cardiac; Carnitine; Coronary Disease; Disease Models, Animal; Fatty Acids; Glu | 1998 |
Markers of cellular dysoxia during orthotopic liver transplantation in pigs.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Biomarkers; Carnitine; Cell Hypoxia; Cytosol; Disease | 1998 |
The dose-dependent effects of L-carnitine in myocardial protection in normothermic ischemia.
Topics: Adenosine Deaminase; Analysis of Variance; Animals; Carnitine; Chick Embryo; Disease Models, Animal; | 1998 |
Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency.
Topics: Animals; Biological Transport; Carnitine; Carrier Proteins; Disease Models, Animal; Embryo, Mammalia | 1998 |
A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, in the juvenile visceral steatosis mouse.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carnitine; Carrier Proteins; Disease Models, Animal; DN | 1998 |
Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection.
Topics: Aging; Animals; Body Weight; Cardiomegaly; Carnitine; Disease Models, Animal; Half-Life; Injections, | 1999 |
Dysfunctions of the epididymis as a result of primary carnitine deficiency in juvenile visceral steatosis mice.
Topics: Abnormalities, Multiple; Animals; Carnitine; Disease Models, Animal; Epididymis; Fertility; Male; Mi | 1999 |
Catecholamine metabolism inhibitors and receptor blockades only partially suppress cardiac hypertrophy of juvenile visceral steatosis mice with systemic carnitine deficiency.
Topics: Adrenergic Antagonists; Animals; Atrial Natriuretic Factor; Body Weight; Cardiomegaly; Carnitine; Cy | 1999 |
Involvement of a cis-acting element in the suppression of carbamoyl phosphate synthetase I gene expression in the liver of carnitine-deficient mice.
Topics: Animals; Binding Sites; Carbamoyl-Phosphate Synthase (Ammonia); Carnitine; Chloramphenicol O-Acetylt | 1999 |
Development and characterization of an animal model of carnitine deficiency.
Topics: Animals; Base Sequence; Biological Transport; Carnitine; Carrier Proteins; Disease Models, Animal; D | 2001 |
Comparison of histopathologic effects of carnitine and ascorbic acid on reperfusion injury.
Topics: Animals; Antioxidants; Ascorbic Acid; Carnitine; Disease Models, Animal; Female; Muscle Fibers, Skel | 2001 |
Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice.
Topics: Animals; Betaine; Carnitine; Carrier Proteins; Disease Models, Animal; Fatty Acids; Infusions, Intra | 2001 |
Assessment of dietary therapies in a canine model of Batten disease.
Topics: Animals; Carnitine; Cerebral Ventricles; Corn Oil; Disease Models, Animal; Dogs; Fish Oils; Glucose; | 2001 |
L-Carnitine transport in mouse renal and intestinal brush-border and basolateral membrane vesicles.
Topics: Animals; Biological Transport; Blotting, Western; Carnitine; Carrier Proteins; Disease Models, Anima | 2002 |
Propionyl-L-carnitine reduces intimal hyperplasia after injury in normocholesterolemic rabbit carotid artery by modulating proliferation and caspase 3-dependent apoptosis of vascular smooth muscle cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Biomarkers; Carnitine; Carotid Arteries | 2002 |
L-Carnitine changes the levels of insulin-like growth factors (IGFs) and IGF binding proteins in streptozotocin-induced diabetic rat.
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relations | 2001 |
Protective effect of dietary supplementation with L-arginine and L-carnitine on hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice.
Topics: Animals; Arginine; Carnitine; Dietary Supplements; Disease Models, Animal; Enterocolitis, Necrotizin | 2002 |
Control of carnitine-related metabolism during myocardial ischemia.
Topics: Aerobiosis; Animals; Biological Transport; Carnitine; Carnitine O-Acetyltransferase; Cell Membrane P | 1979 |
Accumulation and excretion of long-chain acylcarnitine by rat hearts; studies with aminocarnitine.
Topics: Animals; Betaine; Carnitine; Carnitine O-Palmitoyltransferase; Coronary Disease; Disease Models, Ani | 1991 |
Increased acylcarnitine clearance and excretion in septic rats.
Topics: Animals; Bacterial Infections; Carnitine; Disease Models, Animal; Kidney; Liver; Male; Muscles; Myoc | 1991 |
Animal model of systemic carnitine deficiency: analysis in C3H-H-2 degrees strain of mouse associated with juvenile visceral steatosis.
Topics: Aging; Animals; Carnitine; Disease Models, Animal; Fatty Liver; Lipid Metabolism; Liver; Mice; Mice, | 1991 |
Protective effects of D,L-carnitine against arrhythmias induced by lysophosphatidylcholine or reperfusion.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Carnitine; Disease Models, Animal; Guinea Pigs; | 1991 |
The effect of L-carnitine supplementation in 4 pentenoic acid treated rats.
Topics: Ammonia; Animals; Blood Glucose; Carnitine; Disease Models, Animal; Fatty Acids, Monounsaturated; Fa | 1990 |
[Limitation of experimental infarct size by levo-carnitine chloride (LC-80), a new mitochondrial function-reactivating agent].
Topics: Animals; Carnitine; Disease Models, Animal; Dogs; Hemodynamics; Male; Microscopy, Electron; Mitochon | 1990 |
Evaluation of the possible role of glucose, carnitine, coenzyme Q10 and steroids in the treatment of Reye's syndrome using the margosa oil animal model.
Topics: Animals; Carnitine; Coenzymes; Dexamethasone; Disease Models, Animal; Female; Glucose; Glycerides; M | 1990 |
A murine model for short-chain acyl-CoA dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Animals; Blotting, Western; Carnitine; Disease Mode | 1990 |
[Clinico-experimental substantiation of the use of carnitine and cobalamin in the treatment of anorexia nervosa].
Topics: Animals; Anorexia Nervosa; Body Weight; Carnitine; Cerebral Cortex; Disease Models, Animal; Drug Eva | 1989 |
Short-chain acyl-coenzyme A dehydrogenase deficiency in mice.
Topics: Acyl-CoA Dehydrogenase; Animals; Carnitine; Disease Models, Animal; Fatty Acid Desaturases; Fatty Ac | 1989 |
The carnitine-deprived newborn rabbit: a potential model to study carnitine deficiency.
Topics: Adipose Tissue, Brown; Animals; Animals, Newborn; Carnitine; Deficiency Diseases; Diet; Disease Mode | 1988 |
Acute diabetes mellitus does not impair survival rate in rats submitted to left coronary artery ligation.
Topics: Acute Disease; Animals; Blood Glucose; Carnitine; Coronary Disease; Coronary Vessels; Creatine Kinas | 1987 |