carnitine has been researched along with Dihydropyrimidine Dehydrogenase Deficiency in 2 studies
Dihydropyrimidine Dehydrogenase Deficiency: An autosomal recessive disorder affecting DIHYDROPYRIMIDINE DEHYDROGENASE and causing familial pyrimidinemia. It is characterized by thymine-uraciluria in homozygous deficient patients. Even a partial deficiency in the enzyme leaves individuals at risk for developing severe 5-FLUOROURACIL-associated toxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carnitine acts as a carrier of long chain fatty acid to mitochondria and to beta-oxidation, thus an important molecule for energy production by beta-oxidation and maintenance of mitochondrial function." | 2.45 | Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism. ( Ito, T, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Snyder, FF | 1 |
| Carter, RJ | 1 |
| Fung, E | 1 |
| Hodges, SD | 1 |
| Mantik, KB | 1 |
| Ito, T | 1 |
1 review available for carnitine and Dihydropyrimidine Dehydrogenase Deficiency
| Article | Year |
|---|---|
Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism.
Topics: Amidohydrolases; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carnitine; Cephalosporins; C | 2009 |
1 other study available for carnitine and Dihydropyrimidine Dehydrogenase Deficiency
| Article | Year |
|---|---|
Application of metabolomic principles to disorders of nucleotide metabolism reveals new metabolic perturbations.
Topics: Adenine Phosphoribosyltransferase; Adenosine Deaminase; Amino Acids; Carnitine; Dihydropyrimidine De | 2008 |