Page last updated: 2024-10-16

carnitine and Diabetic Neuropathies

carnitine has been researched along with Diabetic Neuropathies in 17 studies

Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)

Research Excerpts

ExcerptRelevanceReference
"A total of 1,035 patients with NIDDM and IDDM were included."2.69Multicenter study of the incidence of and predictive risk factors for diabetic neuropathic foot ulceration. ( Abbott, CA; Boulton, AJ; Carrington, AL; Vileikyte, L; Williamson, S, 1998)
"In participants with type 2 diabetes, after Bonferroni correction and rigorous adjustment, SDNN was inversely associated with higher levels of diacyl-phosphatidylcholine (PCaa) C32:0, PCaa C34:1, acyl-alkyl-phosphatidylcholine (PCae) C36:0, SM C16:0 and SM C16:1."1.62Association of cardiac autonomic dysfunction with higher levels of plasma lipid metabolites in recent-onset type 2 diabetes. ( Bönhof, GJ; Knebel, B; Kotzka, J; Roden, M; Straßburger, K; Strom, A; Szendroedi, J; Ziegler, D, 2021)
"L‑carnitine (LC) was recently demonstrated to serve a positive role in ameliorating DPN."1.51L-carnitine ameliorates peripheral neuropathy in diabetic mice with a corresponding increase in insulin‑like growth factor‑1 level. ( Dong, J; Liu, Y; Ma, R; Song, L; Wang, L; Wang, R; Zhang, C; Zhang, Y, 2019)
"Alloxan treatment caused hyperglycemia and reduced boy growth."1.29Diabetic neuropathy in the rat: 1. Alcar augments the reduced levels and axoplasmic transport of substance P. ( Di Giulio, AM; Gorio, A; Lesma, E, 1995)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.88)18.7374
1990's11 (64.71)18.2507
2000's1 (5.88)29.6817
2010's2 (11.76)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Ziegler, D1
Strom, A1
Straßburger, K1
Knebel, B1
Bönhof, GJ1
Kotzka, J1
Szendroedi, J1
Roden, M1
Didangelos, T1
Karlafti, E1
Kotzakioulafi, E1
Kontoninas, Z1
Margaritidis, C1
Giannoulaki, P1
Kantartzis, K1
Wang, R1
Wang, L1
Zhang, C1
Zhang, Y1
Liu, Y1
Song, L1
Ma, R1
Dong, J1
Freeman, OJ1
Unwin, RD1
Dowsey, AW1
Begley, P1
Ali, S1
Hollywood, KA1
Rustogi, N1
Petersen, RS1
Dunn, WB1
Cooper, GJ1
Gardiner, NJ1
Poorabbas, A1
Fallah, F1
Bagdadchi, J1
Mahdavi, R1
Aliasgarzadeh, A1
Asadi, Y1
Koushavar, H1
Vahed Jabbari, M1
Di Giulio, AM1
Lesma, E1
Gorio, A1
Stevens, MJ1
Feldman, EL1
Greene, DA1
Ido, Y1
McHowat, J1
Chang, KC1
Arrigoni-Martelli, E1
Orfalian, Z1
Kilo, C1
Corr, PB1
Williamson, JR1
Hotta, N2
Koh, N2
Sakakibara, F2
Nakamura, J2
Hamada, Y2
Wakao, T1
Hara, T2
Mori, K1
Naruse, K2
Nakashima, E2
Sakamoto, N1
Arduini, A2
Chiodi, P2
Bellucci, A1
Calvani, M1
Yildiz, O2
Ozata, M2
Ozkardeş, A2
Deniz, G1
Yildirimkaya, M1
Corakçi, A2
Yardim, M1
Gündoğan, MA2
Gündoğan, N1
Cameron, NE1
Cotter, MA1
Abbott, CA1
Vileikyte, L1
Williamson, S1
Carrington, AL1
Boulton, AJ1
Sasaki, H1
Chaya, S1
Komori, T1
Kato, K1
Takeuchi, N1
Kasuya, Y1
Scarpini, E1
Doneda, P1
Pizzul, S1
Ramacci, MT1
Baron, P1
Conti, G1
Sacilotto, G1
Scarlato, G1
Tahiliani, AG1
McNeill, JH1

Reviews

2 reviews available for carnitine and Diabetic Neuropathies

ArticleYear
The aetiology of diabetic neuropathy: the combined roles of metabolic and vascular defects.
    Diabetic medicine : a journal of the British Diabetic Association, 1995, Volume: 12, Issue:7

    Topics: Aldehyde Reductase; Animals; Carnitine; Cells; Diabetes Mellitus; Diabetes Mellitus, Experimental; D

1995
Diabetes-induced abnormalities in the myocardium.
    Life sciences, 1986, Mar-17, Volume: 38, Issue:11

    Topics: Adenosine Triphosphatases; Animals; Blood Glucose; Calcium; Carbohydrate Metabolism; Cardiomyopathie

1986

Trials

2 trials available for carnitine and Diabetic Neuropathies

ArticleYear
Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B12, and Carnitine for 12 Months in Patients with Diabetic Neuropathy.
    Nutrients, 2020, Oct-23, Volume: 12, Issue:11

    Topics: Aged; Carnitine; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Drug Combina

2020
Multicenter study of the incidence of and predictive risk factors for diabetic neuropathic foot ulceration.
    Diabetes care, 1998, Volume: 21, Issue:7

    Topics: Adult; Aged; Canada; Carnitine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Foot;

1998

Other Studies

13 other studies available for carnitine and Diabetic Neuropathies

ArticleYear
Association of cardiac autonomic dysfunction with higher levels of plasma lipid metabolites in recent-onset type 2 diabetes.
    Diabetologia, 2021, Volume: 64, Issue:2

    Topics: Adult; Autonomic Nervous System Diseases; Carnitine; Diabetes Mellitus, Type 1; Diabetes Mellitus, T

2021
L-carnitine ameliorates peripheral neuropathy in diabetic mice with a corresponding increase in insulin‑like growth factor‑1 level.
    Molecular medicine reports, 2019, Volume: 19, Issue:1

    Topics: Animals; Blood Glucose; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Insulin-L

2019
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.
    Diabetes, 2016, Volume: 65, Issue:1

    Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal;

2016
Determination of free L-carnitine levels in type II diabetic women with and without complications.
    European journal of clinical nutrition, 2007, Volume: 61, Issue:7

    Topics: Blood Glucose; Blood Pressure; Body Mass Index; Carnitine; Case-Control Studies; Cross-Sectional Stu

2007
Diabetic neuropathy in the rat: 1. Alcar augments the reduced levels and axoplasmic transport of substance P.
    Journal of neuroscience research, 1995, Feb-15, Volume: 40, Issue:3

    Topics: Alloxan; Animals; Axons; Blood Glucose; Body Weight; Carnitine; Diabetic Neuropathies; Male; Rats; R

1995
Neural dysfunction and metabolic imbalances in diabetic rats. Prevention by acetyl-L-carnitine.
    Diabetes, 1994, Volume: 43, Issue:12

    Topics: Acetylcarnitine; Animals; Ca(2+) Mg(2+)-ATPase; Carnitine; Diabetes Mellitus, Experimental; Diabetic

1994
Effect of propionyl-L-carnitine on motor nerve conduction, autonomic cardiac function, and nerve blood flow in rats with streptozotocin-induced diabetes: comparison with an aldose reductase inhibitor.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:1

    Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism; Cardiotonic Agents

1996
Abnormality of nerve conduction in diabetic neuropathy: Is there a functional relationship with the carnitine system?
    Neurology, 1996, Volume: 46, Issue:3

    Topics: Animals; Carnitine; Diabetic Neuropathies; Male; Neural Conduction; Rats; Rats, Sprague-Dawley; Scia

1996
Comparison of the effects of aminoguanidine and L-carnitine treatments on somatosensorial evoked potentials in alloxan-diabetic rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 354, Issue:4

    Topics: Alloxan; Animals; Blood Glucose; Body Weight; Carnitine; Diabetes Mellitus, Experimental; Diabetic N

1996
L-carnitine treatment improves brain stem auditory evoked potentials in diabetic rats.
    Neuroreport, 1996, Nov-25, Volume: 7, Issue:18

    Topics: Animals; Blood Glucose; Body Weight; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathi

1996
Metabolic and vascular factors in the pathogenesis of diabetic neuropathy.
    Diabetes, 1997, Volume: 46 Suppl 2

    Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endothelium, Vascular; F

1997
Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:3

    Topics: Acetylcarnitine; Aldehyde Reductase; Animals; Body Weight; Carnitine; Diabetes Mellitus, Experimenta

1998
L-carnitine and acetyl-L-carnitine in human nerves from normal and diabetic subjects.
    Journal of the peripheral nervous system : JPNS, 1996, Volume: 1, Issue:2

    Topics: Acetylcarnitine; Adult; Aged; Aged, 80 and over; Carnitine; Diabetic Neuropathies; Female; Humans; I

1996