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carnitine and Coma

carnitine has been researched along with Coma in 16 studies

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
"We observed two patients who developed coma following administration of valproate in dosages of 32 to 40 mg/kg per day."5.28Valproate-induced coma with ketosis and carnitine insufficiency. ( Bohan, TP; Lin, SN; Triggs, WJ; Willmore, LJ, 1990)
", drowsiness, coma) were selected for treatment with l-arginine."3.85L-Arginine in the treatment of valproate overdose - five clinical cases. ( Eyer, F; Felgenhauer, N; Fernando, M; Rabe, C; Schrettl, V, 2017)
"Here, we report the case of a 17-year-old girl who presented in both ten months and five years of age a clinical picture characterized by lethargy leading to apnea and coma, hepatomegaly, hypoglycemia, metabolic acidosis, hyperammoniemia, elevated serum transaminases and absence of ketonuria."3.70[3-hydroxy-3-methylglutaric aciduria and recurrent Reye-like syndrome]. ( Castro-Gago, M; Eirís, J; Fernández-Prieto, R; Ribes, A; Rodríguez-García, J; Rodríguez-Segade, S, 1998)
"We describe a patient with carnitine-acylcarnitine translocase deficiency (MIM 212138), who presented with neonatal generalized seizures, heart failure, and coma."3.70Carnitine-acylcarnitine translocase deficiency: metabolic consequences of an impaired mitochondrial carnitine cycle. ( Dorland, L; Duran, M; IJlst, L; Muntau, AC; Roscher, AA; Röschinger, W; Wanders, RJ, 2000)
"N-carbamylglutamate is approved for the treatment of hyperammonemia in N-acetylglutamate synthetase deficiency and may have efficacy in other urea cycle disorders."1.39Successful early management of a female patient with a metabolic stroke due to ornithine transcarbamylase deficiency. ( Bellantuono, R; Bellino, V; De Palo, T; Favia, V; Morrone, A; Papadia, F; Ranieri, A; Tummolo, A, 2013)
"The onset of coma may have been related to inhibition of beta-oxidation in the mitochondria, which was reversible by elimination of plasma VPA by DHP."1.30Successful treatment by direct hemoperfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication. ( Kuhara, T; Maeyama, R; Matsumoto, I; Matsumoto, J; Ogawa, H; Okudaira, K; Shinka, T, 1997)
"We observed two patients who developed coma following administration of valproate in dosages of 32 to 40 mg/kg per day."1.28Valproate-induced coma with ketosis and carnitine insufficiency. ( Bohan, TP; Lin, SN; Triggs, WJ; Willmore, LJ, 1990)
"Thus, this disease is revealed by a coma due to hypoglycemia in a young child; the presence of dicarboxylic aciduria in such a situation is the main evidence for this diagnosis."1.27[Medium chain acyl-CoA dehydrogenase deficiency. Apropos of a case with demonstration of this enzyme deficiency]. ( Blanc, JF; Collet, JP; David, M; Divry, P; Guibaud, P; Hermier, M; Macabeo, V; Vibert, J, 1984)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's5 (31.25)18.2507
2000's4 (25.00)29.6817
2010's6 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Diaz-Rangel, M1
Grande-Martin, A1
Monsalve-Naharro, JA1
Domingo-Chiva, E1
Cuesta-Montero, P1
Lopez-Perez, A1
Tummolo, A1
Favia, V1
Bellantuono, R1
Bellino, V1
Ranieri, A1
Morrone, A1
De Palo, T1
Papadia, F1
Gautschi, M1
Weisstanner, C1
Slotboom, J1
Nava, E1
Zürcher, T1
Nuoffer, JM1
Schrettl, V1
Felgenhauer, N1
Rabe, C1
Fernando, M1
Eyer, F1
Scrace, B1
Wilson, P1
Pappachan, J1
Hoflack, M1
Caruba, C1
Pitelet, G1
Haas, H1
Mas, JC1
Paquis, V1
Berard, E1
Kimmoun, A1
Munagamage, G1
Dessalles, N1
Gerard, A1
Feillet, F2
Levy, B1
Steinmann, G1
Vianey-Saban, C1
de Chillou, C1
Sadoul, N1
Lefebvre, E1
Vidailhet, M1
Bollaert, PE1
Collet, JP1
Divry, P2
Blanc, JF1
Guibaud, P1
David, M1
Macabeo, V1
Vibert, J1
Hermier, M1
Murakami, K1
Sugimoto, T1
Woo, M1
Nishida, N1
Muro, H1
Matsumoto, J1
Ogawa, H1
Maeyama, R1
Okudaira, K1
Shinka, T1
Kuhara, T1
Matsumoto, I1
Eirís, J1
Ribes, A1
Fernández-Prieto, R1
Rodríguez-García, J1
Rodríguez-Segade, S1
Castro-Gago, M1
Röschinger, W1
Muntau, AC1
Duran, M1
Dorland, L1
IJlst, L1
Wanders, RJ1
Roscher, AA1
Nicolai, J1
Smith, SJ1
Keunen, RW1
Stanley, CA1
DeLeeuw, S1
Coates, PM1
Vianey-Liaud, C1
Bonnefont, JP1
Saudubray, JM1
Haymond, M1
Trefz, FK1
Breningstall, GN1
Triggs, WJ1
Bohan, TP1
Lin, SN1
Willmore, LJ1

Reviews

1 review available for carnitine and Coma

ArticleYear
Chronic cardiomyopathy and weakness or acute coma in children with a defect in carnitine uptake.
    Annals of neurology, 1991, Volume: 30, Issue:5

    Topics: Biological Transport; Cardiomyopathies; Carnitine; Cells, Cultured; Child; Child, Preschool; Coma; F

1991

Other Studies

15 other studies available for carnitine and Coma

ArticleYear
[Valproate-induced hyperammonemic encephalopathy].
    Revista de neurologia, 2017, Dec-16, Volume: 65, Issue:12

    Topics: Acetamides; Anticonvulsants; Brain Diseases, Metabolic; Carnitine; Coma; Drug Therapy, Combination;

2017
Successful early management of a female patient with a metabolic stroke due to ornithine transcarbamylase deficiency.
    Pediatric emergency care, 2013, Volume: 29, Issue:5

    Topics: Adolescent; Arginine; Brain; Carnitine; Case Management; Citrulline; Coma; Combined Modality Therapy

2013
Highly efficient ketone body treatment in multiple acyl-CoA dehydrogenase deficiency-related leukodystrophy.
    Pediatric research, 2015, Volume: 77, Issue:1-1

    Topics: Brain; Carnitine; Child, Preschool; Coma; Consanguinity; Dietary Fats; Hereditary Central Nervous Sy

2015
L-Arginine in the treatment of valproate overdose - five clinical cases.
    Clinical toxicology (Philadelphia, Pa.), 2017, Volume: 55, Issue:4

    Topics: Acyl Coenzyme A; Adult; Amino-Acid N-Acetyltransferase; Ammonia; Arginine; Carnitine; Coma; Drug Ove

2017
Medium chain acyl CoA dehydrogenase deficiency causes unexplained coma in a 10-year-old child.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:12

    Topics: Acyl-CoA Dehydrogenase; Ammonia; Carnitine; Child; Coma; Critical Care; Emergency Medical Services;

2008
[Infant coma in the emergency department: 2 cases of MCAD deficiency].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2010, Volume: 17, Issue:7

    Topics: Acyl-CoA Dehydrogenase; Carnitine; Coma; Emergency Service, Hospital; Female; Humans; Infant; Lipid

2010
Unexpected awakening from comatose thyroid storm after a single intravenous injection of L-carnitine.
    Intensive care medicine, 2011, Volume: 37, Issue:10

    Topics: Aged, 80 and over; Carnitine; Coma; Humans; Injections, Intravenous; Male; Thyroid Crisis

2011
Adult presentation of MCAD deficiency revealed by coma and severe arrythmias.
    Intensive care medicine, 2003, Volume: 29, Issue:9

    Topics: Acyl-CoA Dehydrogenase; Adult; Arrhythmias, Cardiac; Carnitine; Coma; Critical Care; Dicarboxylic Ac

2003
[Medium chain acyl-CoA dehydrogenase deficiency. Apropos of a case with demonstration of this enzyme deficiency].
    Pediatrie, 1984, Volume: 39, Issue:8

    Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Carnitine; Cells, Cultured; Coma; Diagnosis, Differ

1984
Effect of L-carnitine supplementation on acute valproate intoxication.
    Epilepsia, 1996, Volume: 37, Issue:7

    Topics: Ammonia; Carnitine; Coma; Drug Overdose; Epilepsy; Humans; Infant; Male; Oxidation-Reduction; Valpro

1996
Successful treatment by direct hemoperfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication.
    Epilepsia, 1997, Volume: 38, Issue:8

    Topics: Acute Disease; Adult; Carnitine; Charcoal; Coma; Drug Overdose; Female; Glasgow Coma Scale; Hemoperf

1997
[3-hydroxy-3-methylglutaric aciduria and recurrent Reye-like syndrome].
    Revista de neurologia, 1998, Volume: 26, Issue:154

    Topics: Acidosis; Adolescent; Apnea; Carnitine; Coma; Diagnosis, Differential; Fatty Liver; Female; Fibrobla

1998
Carnitine-acylcarnitine translocase deficiency: metabolic consequences of an impaired mitochondrial carnitine cycle.
    Clinica chimica acta; international journal of clinical chemistry, 2000, Volume: 298, Issue:1-2

    Topics: Ammonia; Cardiac Output, Low; Carnitine; Carnitine Acyltransferases; Cells, Cultured; Coma; Consangu

2000
Simultaneous side effects of both clozapine and valproate.
    Intensive care medicine, 2001, Volume: 27, Issue:5

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Carnitine; Clozapine; Coma; Diabetic Ketoacidosis; Dru

2001
Valproate-induced coma with ketosis and carnitine insufficiency.
    Archives of neurology, 1990, Volume: 47, Issue:10

    Topics: Acids; Adult; Carnitine; Coma; Epilepsies, Partial; Epilepsy, Temporal Lobe; Female; Humans; Ketosis

1990