Page last updated: 2024-10-16

carnitine and Cognition Disorders

carnitine has been researched along with Cognition Disorders in 14 studies

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the putative neurotherapeutic effects of the mitochondrial cofactors, L-carnitine, acetyl-L-carnitine, and alpha-lipoic acid; and to provide a rationale for investigating their efficacy in the treatment of neurocognitive deficits associated with mood disorders."8.84Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? ( Chow, CS; Kennedy, SH; Konarski, JZ; McIntyre, RS; Soczynska, JK; Woldeyohannes, HO, 2008)
"Twenty-nine patients with probable Alzheimer's disease, 18 with mild cognitive impairment of the amnestic type, 24 with subjective memory complaint and 46 healthy subjects were enrolled in the study, and the levels of carnitine and acyl-carnitines were measured by tandem mass spectrometry."5.43Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia. ( Angiolillo, A; Corbi, G; Corso, G; Cristofano, A; Di Costanzo, A; Intrieri, M; La Marca, G; Russo, C; Sapere, N; Scapagnini, G; Vitale, M, 2016)
"To evaluate the putative neurotherapeutic effects of the mitochondrial cofactors, L-carnitine, acetyl-L-carnitine, and alpha-lipoic acid; and to provide a rationale for investigating their efficacy in the treatment of neurocognitive deficits associated with mood disorders."4.84Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? ( Chow, CS; Kennedy, SH; Konarski, JZ; McIntyre, RS; Soczynska, JK; Woldeyohannes, HO, 2008)
"Minimal hepatic encephalopathy (mHE) is common among patients with cirrhotic liver disease and causes significant morbidity and mortality."2.52Diagnosis and Treatment of Low-Grade Hepatic Encephalopathy. ( Direkze, S; Jalan, R, 2015)
"Twenty-nine patients with probable Alzheimer's disease, 18 with mild cognitive impairment of the amnestic type, 24 with subjective memory complaint and 46 healthy subjects were enrolled in the study, and the levels of carnitine and acyl-carnitines were measured by tandem mass spectrometry."1.43Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia. ( Angiolillo, A; Corbi, G; Corso, G; Cristofano, A; Di Costanzo, A; Intrieri, M; La Marca, G; Russo, C; Sapere, N; Scapagnini, G; Vitale, M, 2016)
"Increasing evidence suggest that Alzheimer's disease (AD) is a heterogeneous disorder that includes several subtypes with different etiology and progression."1.40Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease. ( Cedazo-Mínguez, Á; Cifuentes, A; Ibáñez, C; Lodeiro, M; Simó, C, 2014)
" Our findings also suggest that ethnic traits may affect carnitine bioavailability as well as cognitive outcomes in this clinical context."1.36Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review. ( Abramson, RK; Cuturic, M; Hardin, JW; Moran, RR, 2010)
" Chronic administration of carnitine over time pre- and post-lesions seemed to partially ameliorate the cognitive deficits caused by the synaptic lesion."1.31Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine. ( Ando, S; Fukui, F; Iwamoto, M; Izumiyama, N; Kobayashi, S; Kon, K; Nakamura, H; Tadenuma, T; Takeda, Y; Waki, H; Watanabe, K, 2002)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's2 (14.29)18.2507
2000's3 (21.43)29.6817
2010's8 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lodeiro, M1
Ibáñez, C1
Cifuentes, A1
Simó, C1
Cedazo-Mínguez, Á1
Yan, J1
Huang, Y1
Lu, Y1
Chen, J1
Jiang, H1
Direkze, S1
Jalan, R1
Cristofano, A1
Sapere, N1
La Marca, G1
Angiolillo, A1
Vitale, M1
Corbi, G1
Scapagnini, G1
Intrieri, M1
Russo, C1
Corso, G1
Di Costanzo, A1
Cuturic, M1
Abramson, RK1
Moran, RR1
Hardin, JW1
Owen, L1
Sunram-Lea, SI1
Malaguarnera, M1
Listernick, R1
Ando, S1
Kobayashi, S1
Waki, H1
Kon, K1
Fukui, F1
Tadenuma, T1
Iwamoto, M1
Takeda, Y1
Izumiyama, N1
Watanabe, K1
Nakamura, H1
Külkens, S1
Harting, I1
Sauer, S1
Zschocke, J1
Hoffmann, GF1
Gruber, S1
Bodamer, OA1
Kölker, S1
Soczynska, JK1
Kennedy, SH1
Chow, CS1
Woldeyohannes, HO1
Konarski, JZ1
McIntyre, RS1
Vanhooren, GT1
Tempesta, E1
Troncon, R1
Janiri, L1
Colusso, L1
Riscica, P1
Saraceni, G1
Gesmundo, E1
Calvani, M1
Benedetti, N1
Pola, P1
Bonavita, E1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of PeakATP (Adenosine 5' - Triphosphate Disodium) Supplementation vs. Placebo on Measures of Mood, Reaction Time and Cognitive Performance[NCT05100589]35 participants (Actual)Interventional2021-10-06Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for carnitine and Cognition Disorders

ArticleYear
Diagnosis and Treatment of Low-Grade Hepatic Encephalopathy.
    Digestive diseases (Basel, Switzerland), 2015, Volume: 33, Issue:4

    Topics: Accidental Falls; Ammonia; Carnitine; Cognition Disorders; Electroencephalography; Gastrointestinal

2015
Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine.
    Nutrients, 2011, Volume: 3, Issue:8

    Topics: Adenosine Triphosphate; Aging; Brain; Carnitine; Cognition; Cognition Disorders; Creatine; Energy Me

2011
Carnitine derivatives: clinical usefulness.
    Current opinion in gastroenterology, 2012, Volume: 28, Issue:2

    Topics: Acetylcarnitine; Cardiotonic Agents; Cardiovascular Diseases; Carnitine; Cognition Disorders; Depres

2012
Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders?
    Expert opinion on investigational drugs, 2008, Volume: 17, Issue:6

    Topics: Acetylcarnitine; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carnitine; Cl

2008

Trials

2 trials available for carnitine and Cognition Disorders

ArticleYear
Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism.
    International journal of clinical pharmacology research, 1990, Volume: 10, Issue:1-2

    Topics: Acetylcarnitine; Adult; Alcoholism; Carnitine; Clinical Trials as Topic; Cognition Disorders; Double

1990
Study of the efficacy and tolerability of L-acetylcarnitine therapy in the senile brain.
    International journal of clinical pharmacology, therapy, and toxicology, 1986, Volume: 24, Issue:9

    Topics: Acetylcarnitine; Aged; Aged, 80 and over; Anxiety Disorders; Carnitine; Cognition Disorders; Depress

1986

Other Studies

8 other studies available for carnitine and Cognition Disorders

ArticleYear
Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 41, Issue:1

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Arginine; Biomarkers; Carnitine;

2014
Repeated administration of ketamine can induce hippocampal neurodegeneration and long-term cognitive impairment via the ROS/HIF-1α pathway in developing rats.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2014, Volume: 33, Issue:6

    Topics: Analgesics; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcium Channel Blockers; Carni

2014
Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia.
    PloS one, 2016, Volume: 11, Issue:5

    Topics: Aged; Alzheimer Disease; Analysis of Variance; Biomarkers; Body Mass Index; Calibration; Carnitine;

2016
Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review.
    Journal of psychiatric practice, 2010, Volume: 16, Issue:1

    Topics: Adult; Aged; Antimanic Agents; Black or African American; Brain Diseases, Metabolic; Carnitine; Cogn

2010
A 14-year-old boy with vomiting.
    Pediatric annals, 2012, Volume: 41, Issue:5

    Topics: Abdominal Pain; Adolescent; Brain Ischemia; Carnitine; Cognition Disorders; Diagnosis, Differential;

2012
Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine.
    Journal of neuroscience research, 2002, Nov-01, Volume: 70, Issue:3

    Topics: Aging; Alzheimer Disease; Animals; Botulinum Toxins, Type A; Brain-Derived Neurotrophic Factor; Carn

2002
Late-onset neurologic disease in glutaryl-CoA dehydrogenase deficiency.
    Neurology, 2005, Jun-28, Volume: 64, Issue:12

    Topics: Age of Onset; Aged; Atrophy; Brain Diseases, Metabolic, Inborn; Carnitine; Cerebral Cortex; Cognitio

2005
[Valproic acid and stupor].
    Nederlands tijdschrift voor geneeskunde, 1991, Feb-02, Volume: 135, Issue:5

    Topics: Carnitine; Cognition Disorders; Humans; Male; Middle Aged; Valproic Acid

1991