Page last updated: 2024-10-16

carnitine and Autoimmune Diabetes

carnitine has been researched along with Autoimmune Diabetes in 27 studies

Research Excerpts

ExcerptRelevanceReference
"The aim of this study is to determine the plasma free carnitine and acyl-carnitine levels at the time of diabetic ketoacidosis (DKA) diagnosis, and at the end of DKA treatment and to investigate their association with the duration of DKA treatment in children with DKA."8.12The association between plasma carnitines and duration of diabetic ketoacidosis treatment in children with type 1 diabetes. ( Acikgozoglu, A; Akgun, A; Esen, I; Okdemir, D, 2022)
"In type 1 diabetes (T1D), type 2 diabetes (T2D) and metabolic syndrome (MetS), the associated complex metabolomic changes in the involvement of carnitine metabolism in total carnitine ester level has already been documented; here we extended the investigations to the individual acylcarnitines."7.79Similarities in serum acylcarnitine patterns in type 1 and type 2 diabetes mellitus and in metabolic syndrome. ( Bagosi, Z; Bene, J; Bujtor, Z; Gasztonyi, B; Márton, M; Melegh, B; Mohás, M; Oroszlán, T; Wittmann, I, 2013)
"The aim of this study is to determine the plasma free carnitine and acyl-carnitine levels at the time of diabetic ketoacidosis (DKA) diagnosis, and at the end of DKA treatment and to investigate their association with the duration of DKA treatment in children with DKA."4.12The association between plasma carnitines and duration of diabetic ketoacidosis treatment in children with type 1 diabetes. ( Acikgozoglu, A; Akgun, A; Esen, I; Okdemir, D, 2022)
"In type 1 diabetes (T1D), type 2 diabetes (T2D) and metabolic syndrome (MetS), the associated complex metabolomic changes in the involvement of carnitine metabolism in total carnitine ester level has already been documented; here we extended the investigations to the individual acylcarnitines."3.79Similarities in serum acylcarnitine patterns in type 1 and type 2 diabetes mellitus and in metabolic syndrome. ( Bagosi, Z; Bene, J; Bujtor, Z; Gasztonyi, B; Márton, M; Melegh, B; Mohás, M; Oroszlán, T; Wittmann, I, 2013)
"A total of 1,035 patients with NIDDM and IDDM were included."2.69Multicenter study of the incidence of and predictive risk factors for diabetic neuropathic foot ulceration. ( Abbott, CA; Boulton, AJ; Carrington, AL; Vileikyte, L; Williamson, S, 1998)
"Carnitine insufficiency is reported in type 1 diabetes mellitus."1.62The Effects of Streptozotocin-Induced Diabetes and Insulin Treatment on Carnitine Biosynthesis and Renal Excretion. ( Boyle, KE; Broderick, TL; Upadhyay, A, 2021)
"In participants with type 2 diabetes, after Bonferroni correction and rigorous adjustment, SDNN was inversely associated with higher levels of diacyl-phosphatidylcholine (PCaa) C32:0, PCaa C34:1, acyl-alkyl-phosphatidylcholine (PCae) C36:0, SM C16:0 and SM C16:1."1.62Association of cardiac autonomic dysfunction with higher levels of plasma lipid metabolites in recent-onset type 2 diabetes. ( Bönhof, GJ; Knebel, B; Kotzka, J; Roden, M; Straßburger, K; Strom, A; Szendroedi, J; Ziegler, D, 2021)
"Betaine levels were found to be increased in the majority of diabetic mice but decreased in a few animals with severe loss of body weight and physical condition."1.35Metabolic profile changes in the testes of mice with streptozotocin-induced type 1 diabetes mellitus. ( Agbaje, IM; Amigues, E; Browne, RA; Green, BD; Hollis, J; Mallidis, C; McClure, N; Migaud, M; Rogers, D, 2009)
"Recognizing the similarity of type I diabetes mellitus to inborn errors of metabolism that have responded to carnitine therapy, we initiated a study of 54 children with type I diabetes mellitus."1.28Relative carnitine insufficiency in children with type I diabetes mellitus. ( Higashi, L; O'Hara, T; Simon, M; Szabo-Aczel, S; Vance, WH; Winter, SC; Zorn, EM, 1989)
"Free carnitine was significantly (p less than 0."1.27The relationship between carnitine and ketone body levels in diabetic children. ( Melegh, B; Sándor, A; Soltész, G, 1983)
"The overall frequency of ketonuria at (re)admission was 45% together with moderately elevated or high 3-hydroxybutyrate serum concentrations."1.27Ketosis, serum carnitine and its precursor amino acids in normal and diabetic ethiopians. ( Kohnert, KD; Löster, H; Lubs, H; Peters, WH; Seim, H; Strack, E, 1987)
"Acylcarnitine was significantly higher in the diabetic patients than in the controls in the two younger age groups."1.26Plasma and urine carnitine in children with diabetes mellitus. ( Cederblad, G; Hermansson, G; Ludvigsson, J, 1982)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19904 (14.81)18.7374
1990's6 (22.22)18.2507
2000's6 (22.22)29.6817
2010's5 (18.52)24.3611
2020's6 (22.22)2.80

Authors

AuthorsStudies
Upadhyay, A1
Boyle, KE1
Broderick, TL2
Okdemir, D1
Acikgozoglu, A1
Akgun, A1
Esen, I1
Rahmani, P1
Abolhasani, R1
Heidari, G1
Mohebbi, A1
Sayarifard, F1
Rabbani, A1
Vafaei, N1
Lotfi, J1
Ziegler, D1
Strom, A1
Straßburger, K1
Knebel, B1
Bönhof, GJ1
Kotzka, J1
Szendroedi, J1
Roden, M1
Badreldeen, A1
El Razaky, O1
Erfan, A1
El-Bendary, A1
El Amrousy, D1
Jahoor, F1
Hsu, JW1
Mehta, PB1
Keene, KR1
Gaba, R1
Mulukutla, SN1
Caducoy, E1
Peacock, WF1
Patel, SG1
Bennet, R1
Lernmark, A1
Balasubramanyam, A1
Porksen, NK1
Linnebjerg, H1
Lam, ECQ1
Garhyan, P1
Pachori, A1
Pratley, RE1
Smith, SR1
Imbe, A1
Tanimoto, K1
Inaba, Y1
Sakai, S1
Shishikura, K1
Imbe, H1
Tanimoto, Y1
Terasaki, J1
Imagawa, A1
Hanafusa, T1
Johnson, DT1
Harris, RA1
French, S1
Aponte, A1
Balaban, RS1
Gentile, V1
Antonini, G1
Antonella Bertozzi, M1
Dinelli, N1
Rizzo, C1
Ashraf Virmani, M1
Koverech, A1
Evangeliou, A1
Gourgiotis, D1
Karagianni, C1
Markouri, M1
Anogianaki, N1
Mamoulakis, D1
Maropoulos, G1
Tsakalidis, C1
Frentzayias, A1
Nicolaidou, P1
Liepinsh, E1
Skapare, E1
Vavers, E1
Konrade, I1
Strele, I1
Grinberga, S1
Pugovics, O1
Dambrova, M1
Bene, J1
Márton, M1
Mohás, M1
Bagosi, Z1
Bujtor, Z1
Oroszlán, T1
Gasztonyi, B1
Wittmann, I1
Melegh, B2
Michno, A1
Raszeja-Specht, A1
Jankowska-Kulawy, A1
Pawelczyk, T1
Szutowicz, A1
Adal, E1
Koyuncu, G1
Aydin, A1
Celebi, A1
Kavunoğlu, G1
Cam, H1
Mallidis, C1
Green, BD1
Rogers, D1
Agbaje, IM1
Hollis, J1
Migaud, M1
Amigues, E1
McClure, N1
Browne, RA1
Soltész, G1
Sándor, A1
Cederblad, G1
Hermansson, G1
Ludvigsson, J1
Averbuch-Heller, L1
Ben-Hur, T1
Reches, A1
Yajnik, CS1
Sardesai, BS1
Bhat, DS1
Naik, SS1
Raut, KN1
Shelgikar, KM1
Orskov, H1
Alberti, KG1
Hockaday, TD1
Abbott, CA1
Vileikyte, L1
Williamson, S1
Carrington, AL1
Boulton, AJ1
Dellow, WJ1
Chambers, ST1
Lever, M1
Lunt, H1
Robson, RA1
Coker, M1
Coker, C1
Darcan, S1
Can, S1
Orbak, Z1
Gökşen, D1
Pregant, P1
Schernthaner, G1
Legenstein, E1
Lienhart, L1
Bruck, S1
Schnack, C1
Kaiser, E1
Pinsard, D1
Tancrède, G1
Catellier, C1
Tremblay, A1
Nadeau, A1
Winter, SC1
Simon, M1
Zorn, EM1
Szabo-Aczel, S1
Vance, WH1
O'Hara, T1
Higashi, L1
Peters, WH1
Seim, H1
Löster, H1
Strack, E1
Lubs, H1
Kohnert, KD1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prediction and Prevention of Asymptomatic Cardiovascular Insult in Type 1 Diabetic Children: Comparative Effectiveness of Cardio-protective Drugs[NCT03660293]150 participants (Actual)Interventional2017-04-01Completed
Correlation Between Carnitine Deficiency and Hypoglycemic Events in Type I Diabetes; Effects of Carnitine Supplementation on Hypoglycemic Events in Type I Diabetes[NCT00351234]200 participants (Actual)Observational2004-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

6 trials available for carnitine and Autoimmune Diabetes

ArticleYear
Comparative study of the efficacy of captopril, simvastatin, and L-carnitine as cardioprotective drugs in children with type 1 diabetes mellitus: a randomised controlled trial.
    Cardiology in the young, 2021, Volume: 31, Issue:8

    Topics: Captopril; Carnitine; Carotid Intima-Media Thickness; Child; Diabetes Mellitus, Type 1; Humans; Phar

2021
Basal insulin peglispro increases lipid oxidation, metabolic flexibility, thermogenesis and ketone bodies compared to insulin glargine in subjects with type 1 diabetes mellitus.
    Diabetes, obesity & metabolism, 2018, Volume: 20, Issue:5

    Topics: Adult; Basal Metabolism; Biomarkers; Breakfast; Carnitine; Cross-Over Studies; Diabetes Mellitus, Ty

2018
Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes.
    Current medical research and opinion, 2009, Volume: 25, Issue:9

    Topics: Arginine; Carnitine; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Erectile Dysfunction; Hum

2009
Ketosis resistance in fibrocalculous pancreatic diabetes: II. Hepatic ketogenesis after oral medium-chain triglycerides.
    Metabolism: clinical and experimental, 1997, Volume: 46, Issue:1

    Topics: Adipose Tissue; Administration, Oral; Adult; Blood Glucose; C-Peptide; Carnitine; Diabetes Complicat

1997
Multicenter study of the incidence of and predictive risk factors for diabetic neuropathic foot ulceration.
    Diabetes care, 1998, Volume: 21, Issue:7

    Topics: Adult; Aged; Canada; Carnitine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Foot;

1998
Carnitine metabolism in diabetes mellitus.
    Journal of pediatric endocrinology & metabolism : JPEM, 2002, Volume: 15, Issue:6

    Topics: Adolescent; Adult; Carnitine; Child; Child, Preschool; Diabetes Mellitus, Type 1; Diabetic Angiopath

2002

Other Studies

21 other studies available for carnitine and Autoimmune Diabetes

ArticleYear
The Effects of Streptozotocin-Induced Diabetes and Insulin Treatment on Carnitine Biosynthesis and Renal Excretion.
    Molecules (Basel, Switzerland), 2021, Nov-15, Volume: 26, Issue:22

    Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hypoglycemic Agents;

2021
The association between plasma carnitines and duration of diabetic ketoacidosis treatment in children with type 1 diabetes.
    Journal of pediatric endocrinology & metabolism : JPEM, 2022, Dec-16, Volume: 35, Issue:12

    Topics: Carnitine; Child; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Female; Humans; Insulin; Male

2022
Determination of carnitine ester profile in the children with type 1 diabetes: a valuable step towards a better management.
    Archives of physiology and biochemistry, 2022, Volume: 128, Issue:5

    Topics: Amino Acids; Carnitine; Child; Coenzyme A; Diabetes Mellitus, Type 1; Esters; Fatty Acids; Female; G

2022
Association of cardiac autonomic dysfunction with higher levels of plasma lipid metabolites in recent-onset type 2 diabetes.
    Diabetologia, 2021, Volume: 64, Issue:2

    Topics: Adult; Autonomic Nervous System Diseases; Carnitine; Diabetes Mellitus, Type 1; Diabetes Mellitus, T

2021
Metabolomics Profiling of Patients With A-β+ Ketosis-Prone Diabetes During Diabetic Ketoacidosis.
    Diabetes, 2021, Volume: 70, Issue:8

    Topics: Adult; Amino Acids, Branched-Chain; Autoantibodies; Carnitine; Diabetes Mellitus, Type 1; Diabetes M

2021
Effects of L-carnitine supplementation on the quality of life in diabetic patients with muscle cramps.
    Endocrine journal, 2018, May-28, Volume: 65, Issue:5

    Topics: Adult; Aged; Carnitine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hypogl

2018
Proteomic changes associated with diabetes in the BB-DP rat.
    American journal of physiology. Endocrinology and metabolism, 2009, Volume: 296, Issue:3

    Topics: Animals; Carnitine; Citrate (si)-Synthase; Diabetes Mellitus, Type 1; Disease Models, Animal; Electr

2009
Carnitine status and lactate increase in patients with type I juvenile diabetes.
    Minerva pediatrica, 2010, Volume: 62, Issue:6

    Topics: Adolescent; Carnitine; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Humans; Lactic Ac

2010
High L-carnitine concentrations do not prevent late diabetic complications in type 1 and 2 diabetic patients.
    Nutrition research (New York, N.Y.), 2012, Volume: 32, Issue:5

    Topics: Adult; Aged; Carnitine; Diabetes Complications; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2

2012
Similarities in serum acylcarnitine patterns in type 1 and type 2 diabetes mellitus and in metabolic syndrome.
    Annals of nutrition & metabolism, 2013, Volume: 62, Issue:1

    Topics: Adult; Aged; Body Mass Index; Carnitine; Case-Control Studies; Diabetes Mellitus, Type 1; Diabetes M

2013
Effect of L-carnitine on acetyl-CoA content and activity of blood platelets in healthy and diabetic persons.
    Clinical chemistry, 2005, Volume: 51, Issue:9

    Topics: Acetyl Coenzyme A; Adult; Blood Platelets; Carnitine; Diabetes Mellitus, Type 1; Diabetes Mellitus,

2005
Asymptomatic cardiomyopathy in children and adolescents with type 1 diabetes mellitus: association of echocardiographic indicators with duration of diabetes mellitus and metabolic parameters.
    Journal of pediatric endocrinology & metabolism : JPEM, 2006, Volume: 19, Issue:5

    Topics: Adolescent; Adult; Blood Glucose; Cardiomyopathies; Carnitine; Child; Child, Preschool; Cholesterol;

2006
Metabolic profile changes in the testes of mice with streptozotocin-induced type 1 diabetes mellitus.
    International journal of andrology, 2009, Volume: 32, Issue:2

    Topics: Animals; Betaine; Carnitine; Choline; Creatine; Diabetes Mellitus, Experimental; Diabetes Mellitus,

2009
The relationship between carnitine and ketone body levels in diabetic children.
    Acta paediatrica Scandinavica, 1983, Volume: 72, Issue:4

    Topics: Adolescent; Bicarbonates; Blood Glucose; Carnitine; Child; Diabetes Mellitus, Type 1; Humans; Insuli

1983
Plasma and urine carnitine in children with diabetes mellitus.
    Clinica chimica acta; international journal of clinical chemistry, 1982, Oct-27, Volume: 125, Issue:2

    Topics: Adolescent; Adult; Aging; Carnitine; Child; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin;

1982
Valproate encephalopathy and hypocarnitinaemia in diabetic patients.
    Journal of neurology, 1994, Volume: 241, Issue:9

    Topics: Adolescent; Adult; Brain Diseases; Carnitine; Diabetes Mellitus, Type 1; Electroencephalography; Epi

1994
Elevated glycine betaine excretion in diabetes mellitus patients is associated with proximal tubular dysfunction and hyperglycemia.
    Diabetes research and clinical practice, 1999, Volume: 43, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Alkaloids; Betaine; Biomarkers; Carnitine; Creatinine; Diabetes Mell

1999
[Decreased plasma carnitine in Type I diabetes mellitus].
    Klinische Wochenschrift, 1991, Aug-16, Volume: 69, Issue:12

    Topics: Adult; Blood Glucose; Carnitine; Circadian Rhythm; Diabetes Mellitus, Type 1; Diabetes Mellitus, Typ

1991
Altered plasma free carnitine response to exercise in type 1 diabetic subjects.
    Diabetes research (Edinburgh, Scotland), 1990, Volume: 13, Issue:4

    Topics: Adult; Blood Glucose; Calorimetry; Carnitine; Diabetes Mellitus, Type 1; Heart Rate; Humans; Insulin

1990
Relative carnitine insufficiency in children with type I diabetes mellitus.
    American journal of diseases of children (1960), 1989, Volume: 143, Issue:11

    Topics: Adolescent; Blood Glucose; Carnitine; Chi-Square Distribution; Child; Diabetes Mellitus, Type 1; Fem

1989
Ketosis, serum carnitine and its precursor amino acids in normal and diabetic ethiopians.
    Experimental and clinical endocrinology, 1987, Volume: 90, Issue:1

    Topics: Acidosis; Adolescent; Adult; Amino Acids; Carnitine; Diabetes Mellitus, Type 1; Diabetic Ketoacidosi

1987