carnitine has been researched along with Alzheimer Disease in 32 studies
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetyl-L-carnitine (ALCAR) is a drug currently under investigation for Alzheimer disease (AD) therapy." | 7.69 | Acetyl-L-carnitine in Alzheimer disease: a short-term study on CSF neurotransmitters and neuropeptides. ( Angelucci, L; Bonamini, M; Bruno, G; Cesarino, F; Grassini, P; Lenzi, GL; Patacchioli, FR; Scaccianoce, S; Sorrentino, E, 1995) |
| "The acute effects of intravenously administered L-acetylcarnitine (LAC) were evaluated with single-photon emission computed tomography (SPECT) and 99mTc-hexamethylpropyleneamine oxime in 30 demented patients (21 with a clinical diagnosis of Alzheimer's dementia and 9 with mixed-type dementia)." | 7.67 | Single-photon emission computed tomography studies with 99mTc-hexamethylpropyleneamine oxime in dementia: effects of acute administration of L-acetylcarnitine. ( Battistin, L; Borsato, N; Calvani, M; Da Col, C; Dam, M; Ferlin, G; Perlotto, N; Pizzolato, G; Saitta, B, 1989) |
| "Twenty-nine patients with probable Alzheimer's disease, 18 with mild cognitive impairment of the amnestic type, 24 with subjective memory complaint and 46 healthy subjects were enrolled in the study, and the levels of carnitine and acyl-carnitines were measured by tandem mass spectrometry." | 5.43 | Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia. ( Angiolillo, A; Corbi, G; Corso, G; Cristofano, A; Di Costanzo, A; Intrieri, M; La Marca, G; Russo, C; Sapere, N; Scapagnini, G; Vitale, M, 2016) |
| "Acetyl-L-carnitine (ALCAR) is a drug currently under investigation for Alzheimer disease (AD) therapy." | 3.69 | Acetyl-L-carnitine in Alzheimer disease: a short-term study on CSF neurotransmitters and neuropeptides. ( Angelucci, L; Bonamini, M; Bruno, G; Cesarino, F; Grassini, P; Lenzi, GL; Patacchioli, FR; Scaccianoce, S; Sorrentino, E, 1995) |
| "The acute effects of intravenously administered L-acetylcarnitine (LAC) were evaluated with single-photon emission computed tomography (SPECT) and 99mTc-hexamethylpropyleneamine oxime in 30 demented patients (21 with a clinical diagnosis of Alzheimer's dementia and 9 with mixed-type dementia)." | 3.67 | Single-photon emission computed tomography studies with 99mTc-hexamethylpropyleneamine oxime in dementia: effects of acute administration of L-acetylcarnitine. ( Battistin, L; Borsato, N; Calvani, M; Da Col, C; Dam, M; Ferlin, G; Perlotto, N; Pizzolato, G; Saitta, B, 1989) |
| "L-carnitine (LC) plays a crucial role in the energetic metabolism of the cell." | 2.66 | Preventive Role of L-Carnitine and Balanced Diet in Alzheimer's Disease. ( Borzym-Kluczyk, M; Chojnowska, S; Kepka, A; Ochocinska, A; Skorupa, E; Stasiewicz-Jarocka, B; Waszkiewicz, N, 2020) |
| "L-Carnitine is an essential co-factor in the metabolism of lipids and consequently in the production of cellular energy." | 2.44 | [Physiological functions of carnitine and carnitine transporters in the central nervous system]. ( Inazu, M; Matsumiya, T, 2008) |
| "The pathogenesis of Alzheimer's disease (AD) is complex involving multiple contributing factors." | 1.43 | Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome. ( Elliott, CT; Graham, SF; Green, BD; Hölscher, C; Kehoe, PG; McClean, PL; McGuinness, B; Nasaruddin, MB; Pan, X; Passmore, AP, 2016) |
| "Twenty-nine patients with probable Alzheimer's disease, 18 with mild cognitive impairment of the amnestic type, 24 with subjective memory complaint and 46 healthy subjects were enrolled in the study, and the levels of carnitine and acyl-carnitines were measured by tandem mass spectrometry." | 1.43 | Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia. ( Angiolillo, A; Corbi, G; Corso, G; Cristofano, A; Di Costanzo, A; Intrieri, M; La Marca, G; Russo, C; Sapere, N; Scapagnini, G; Vitale, M, 2016) |
| "Increasing evidence suggest that Alzheimer's disease (AD) is a heterogeneous disorder that includes several subtypes with different etiology and progression." | 1.40 | Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease. ( Cedazo-Mínguez, Á; Cifuentes, A; Ibáñez, C; Lodeiro, M; Simó, C, 2014) |
| " Chronic administration of carnitine over time pre- and post-lesions seemed to partially ameliorate the cognitive deficits caused by the synaptic lesion." | 1.31 | Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine. ( Ando, S; Fukui, F; Iwamoto, M; Izumiyama, N; Kobayashi, S; Kon, K; Nakamura, H; Tadenuma, T; Takeda, Y; Waki, H; Watanabe, K, 2002) |
| "L-Carnitine was tested as a potential therapeutic agent, since it has been used to treat a variety of experimental metabolic encephalopathies." | 1.28 | Cultured cells as a screen for novel treatments of Alzheimer's disease. ( Baker, AC; Blass, JP; Malow, BA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.63) | 18.7374 |
| 1990's | 5 (15.63) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 11 (34.38) | 24.3611 |
| 2020's | 8 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qutob, HMH | 1 |
| Saad, RA | 1 |
| Bali, H | 1 |
| Osailan, A | 1 |
| Jaber, J | 1 |
| Alzahrani, E | 1 |
| Alyami, J | 1 |
| Elsayed, H | 1 |
| Alserihi, R | 1 |
| Shaikhomar, OA | 1 |
| Divya, KM | 1 |
| Savitha, DP | 1 |
| Krishna, GA | 1 |
| Dhanya, TM | 1 |
| Mohanan, PV | 1 |
| Shah, SF | 1 |
| Jafry, AT | 1 |
| Hussain, G | 1 |
| Kazim, AH | 1 |
| Ali, M | 1 |
| Rivani, E | 1 |
| Endraswari, PD | 1 |
| Widodo, ADW | 1 |
| Khalil, MR | 1 |
| Guldberg, R | 1 |
| Nørgård, BM | 1 |
| Uldbjerg, N | 1 |
| Wehberg, S | 1 |
| Fowobaje, KR | 1 |
| Mashood, LO | 1 |
| Ekholuenetale, M | 1 |
| Ibidoja, OJ | 1 |
| Romagnoli, A | 1 |
| D'Agostino, M | 1 |
| Pavoni, E | 1 |
| Ardiccioni, C | 1 |
| Motta, S | 1 |
| Crippa, P | 1 |
| Biagetti, G | 1 |
| Notarstefano, V | 1 |
| Rexha, J | 1 |
| Perta, N | 1 |
| Barocci, S | 1 |
| Costabile, BK | 1 |
| Colasurdo, G | 1 |
| Caucci, S | 1 |
| Mencarelli, D | 1 |
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| D'Annessa, I | 1 |
| Di Marino, D | 1 |
| Choya, A | 1 |
| de Rivas, B | 1 |
| Gutiérrez-Ortiz, JI | 1 |
| López-Fonseca, R | 1 |
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| Cristofano, A | 1 |
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| Scaccianoce, S | 1 |
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| Patacchioli, FR | 1 |
| Cesarino, F | 1 |
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| Rubio, JC | 1 |
| de Bustos, F | 1 |
| Molina, JA | 1 |
| Jiménez-Jiménez, FJ | 1 |
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| Campos, Y | 1 |
| Ortí-Pareja, M | 1 |
| Cabrera-Valdivia, F | 1 |
| Arenas, J | 1 |
| Rai, G | 1 |
| Wright, G | 1 |
| Scott, L | 1 |
| Beston, B | 1 |
| Rest, J | 1 |
| Exton-Smith, AN | 1 |
| Malow, BA | 1 |
| Baker, AC | 1 |
| Gambi, D | 1 |
| Onofrj, M | 1 |
| Calvani, M | 2 |
| Faricelli, A | 1 |
| Del Re, ML | 1 |
| Bazzano, S | 1 |
| Cutarella, R | 1 |
| Fulgente, T | 1 |
| Colangelo, U | 1 |
| Lucca, U | 1 |
| Menasce, G | 1 |
| Comelli, M | 1 |
| Cizza, G | 1 |
| Bressi, S | 1 |
| Frattura, L | 1 |
| Tiraboschi, P | 1 |
| Spagnoli, A | 1 |
| Battistin, L | 1 |
| Pizzolato, G | 1 |
| Dam, M | 1 |
| Da Col, C | 1 |
| Perlotto, N | 1 |
| Saitta, B | 1 |
| Borsato, N | 1 |
| Ferlin, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Clinical Trial of a Vitamin/Nutriceutical Formulation for Alzheimer's Disease[NCT01320527] | Phase 2 | 135 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for carnitine and Alzheimer Disease
| Article | Year |
|---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Preventive Role of L-Carnitine and Balanced Diet in Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carnitine; Diet, Healthy; Diet, Mediterranean; Dietary A | 2020 |
OCTN cation transporters in health and disease: role as drug targets and assay development.
Topics: Acetylcholine; Alzheimer Disease; Amino Acid Sequence; Animals; Biological Transport; Carnitine; Hum | 2013 |
Brain metabolism and Alzheimer's disease: the prospect of a metabolite-based therapy.
Topics: Acetoacetates; Adenosine Triphosphate; Aluminum; Alzheimer Disease; Astrocytes; Brain; Carnitine; Hu | 2015 |
Epigenetic Treatment of Neurodegenerative Disorders: Alzheimer and Parkinson Diseases.
Topics: Alzheimer Disease; Antioxidants; Carnitine; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Hum | 2016 |
[Physiological functions of carnitine and carnitine transporters in the central nervous system].
Topics: Acetylcarnitine; Alzheimer Disease; Astrocytes; Brain; Carnitine; Choline; Energy Metabolism; Ketone | 2008 |
Delaying the mitochondrial decay of aging with acetylcarnitine.
Topics: Acetylcarnitine; Aging; Alzheimer Disease; Animals; Brain; Carnitine; Dose-Response Relationship, Dr | 2004 |
5 trials available for carnitine and Alzheimer Disease
| Article | Year |
|---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
[The use of 1-acetylcarnitine in (presenile and senile) Alzheimer's disease. Preliminary results].
Topics: Acetylcarnitine; Aged; Alzheimer Disease; Carnitine; Clinical Trials as Topic; Dementia; Double-Blin | 1983 |
Cerebrospinal fluid carnitine levels in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Carnitine; Female; Humans; Male; Psychiatric Status Rating Scales; Referenc | 1998 |
Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia.
Topics: Acetylcarnitine; Activities of Daily Living; Aged; Alzheimer Disease; Carnitine; Double-Blind Method | 1990 |
An example of a clinical trial in patients with Alzheimer's disease: some methodological issues.
Topics: Acetylcarnitine; Aged; Alzheimer Disease; Carnitine; Clinical Trials as Topic; Double-Blind Method; | 1989 |
21 other studies available for carnitine and Alzheimer Disease
| Article | Year |
|---|---|
Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer's and Parkinson's diseases.
Topics: Alzheimer Disease; Asian People; ATP-Binding Cassette Transporters; Carnitine; China; DNA-Binding Pr | 2020 |
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Calcium; Calcium Channel Blockers; Carnitine; Cell Line; Ch | 2019 |
Systemic and central nervous system metabolic alterations in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain; Carnitine; Cas | 2019 |
Brain and blood metabolome for Alzheimer's dementia: findings from a targeted metabolomics analysis.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Brain; Carnitine; Cognition; Cohort Studies; | 2020 |
Potential Therapeutic Role of Carnitine and Acetylcarnitine in Neurological Disorders.
Topics: Acetylcarnitine; Aged; Alzheimer Disease; Carnitine; Energy Metabolism; Humans; Oxidative Stress | 2020 |
Causal relationships between gut metabolites and Alzheimer's disease: a bidirectional Mendelian randomization study.
Topics: Alzheimer Disease; Betaine; Carnitine; Choline; Female; Gastrointestinal Microbiome; Genetic Predisp | 2021 |
Mechanistic perspectives on differential mitochondrial-based neuroprotective effects of several carnitine forms in Alzheimer's disease in vitro model.
Topics: Acetylcarnitine; Alzheimer Disease; Animals; Apoptosis; Carnitine; Cells, Cultured; Female; Hippocam | 2021 |
The Neuroprotective Effect of L-Carnitine against Glyceraldehyde-Induced Metabolic Impairment: Possible Implications in Alzheimer's Disease.
Topics: Adenosine Triphosphate; Alzheimer Disease; Animals; Carnitine; Cell Survival; Glyceraldehyde; Glycol | 2021 |
Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Arginine; Biomarkers; Carnitine; | 2014 |
Plasma phospholipids identify antecedent memory impairment in older adults.
Topics: Aged; Alzheimer Disease; Asparagine; Biomarkers; Carnitine; Cognitive Dysfunction; Cohort Studies; D | 2014 |
Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome.
Topics: Aging; Alzheimer Disease; Amino Acids, Branched-Chain; Amino Acids, Essential; Animals; Biogenic Pol | 2016 |
Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Biomarkers; Body Mass Index; Calibration; Carnitine; | 2016 |
Medium-chain plasma acylcarnitines, ketone levels, cognition, and gray matter volumes in healthy elderly, mildly cognitively impaired, or Alzheimer's disease subjects.
Topics: Aged; Aging; Alzheimer Disease; Carnitine; Cognition; Cognitive Dysfunction; Cohort Studies; Female; | 2016 |
Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.
Topics: Alzheimer Disease; Animals; Antioxidants; Biomarkers; Brain; Carnitine; Cholinesterase Inhibitors; D | 2012 |
Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine.
Topics: Aging; Alzheimer Disease; Animals; Botulinum Toxins, Type A; Brain-Derived Neurotrophic Factor; Carn | 2002 |
Carnitine, carnitine acetyltransferase, and glutathione in Alzheimer brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autopsy; Brain; Brain Chemistry; Carnitine; Carnitine O- | 1995 |
Acetylcarnitine increases membrane cytoskeletal protein-protein interactions.
Topics: Acetylcarnitine; Alzheimer Disease; Carnitine; Cytoskeletal Proteins; Electron Spin Resonance Spectr | 1993 |
Acetyl-L-carnitine in Alzheimer disease: a short-term study on CSF neurotransmitters and neuropeptides.
Topics: Aged; Alzheimer Disease; Carnitine; Dopamine; Female; Humans; Male; Middle Aged; Neurotransmitter Ag | 1995 |
Cultured cells as a screen for novel treatments of Alzheimer's disease.
Topics: Alzheimer Disease; Carnitine; Cells, Cultured; Cyclic AMP; Fibroblasts; Humans; Hydrogen-Ion Concent | 1989 |
Neurophysiological studies of L-acetylcarnitine administration in man.
Topics: Acetylcarnitine; Adult; Aged; Alcoholic Intoxication; Alzheimer Disease; Carnitine; Electroencephalo | 1989 |
Single-photon emission computed tomography studies with 99mTc-hexamethylpropyleneamine oxime in dementia: effects of acute administration of L-acetylcarnitine.
Topics: Acetylcarnitine; Aged; Alzheimer Disease; Carnitine; Dementia; Female; Humans; Injections, Intraveno | 1989 |