carnitine has been researched along with Aging in 191 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study evaluated the efficacy of L-carnitine on physical and mental fatigue and on cognitive functions of centenarians." | 9.12 | L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. ( Cammalleri, L; Colonna, V; Gargante, MP; Malaguarnera, M; Motta, M; Vacante, M, 2007) |
| "Testosterone and carnitines significantly improved the peak systolic velocity, end-diastolic velocity, resistive index, nocturnal penile tumescence, International Index of Erectile Function score, Depression Melancholia Scale score, and fatigue scale score." | 9.11 | Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. ( Biagiotti, G; Caracciolo, S; Cavallini, G; Modenini, F; Vitali, G, 2004) |
| " To investigate associations between acyl-carnitines and cardiovascular function as indexed by imaging measurements." | 8.02 | Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines. ( Chew, H; Ching, J; Chow, VJ; Ewe, SH; Gao, F; Keng, BM; Koh, AS; Koh, WP; Kovalik, JP; Lee, LS; Leng, S; Tan, HC; Tan, RS; Tan, TY; Teo, LL; Zhao, X; Zhong, L, 2021) |
| "This study aimed to investigate the effects of trimetazidine and l‑carnitine on heart aging and cardiac metabolism in the natural aging rats and explore the possible mechanism regarding the regulation of cardiac metabolic substrates." | 7.91 | Trimetazidine and l‑carnitine prevent heart aging and cardiac metabolic impairment in rats via regulating cardiac metabolic substrates. ( Liu, C; Wang, Y; Xing, Y; Zhang, W; Zhang, X, 2019) |
| "The objective of this study was to determine whether dietary L-carnitine can influence the status of alpha-tocopherol, retinol and selected lipid parameters in aging ovariectomized rats, an animal model for the menopausal state." | 7.74 | L-carnitine increases liver alpha-tocopherol and lowers liver and plasma triglycerides in aging ovariectomized rats. ( Aggarwal, D; Balakrishnan, A; Clark, RM; Koo, SI; Owen, KQ; Waters, D, 2007) |
| "Co-supplementation of lipoic acid with carnitine has a beneficial effect in reversing the age-related abnormalities seen in aging." | 7.73 | Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine. ( Anusuyadevi, M; Panneerselvam, C; Savitha, S; Tamilselvan, J, 2005) |
| "Juvenile visceral steatosis (JVS) mouse is an animal model of human primary carnitine deficiency caused by a mutation of the gene encoding carnitine transporter, and suffers from various symptoms, such as fatty liver, growth retardation, hyperammonemia, hypoglycemia, and cardiac hypertrophy." | 7.71 | Hyperammonemia in carnitine-deficient adult JVS mice used by starvation. ( Horiuchi, M; Jalil, A; Kobayashi, K; Li, XX; Saheki, T; Yoshida, G, 2002) |
| "The long-term administration of L-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue." | 7.70 | Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. ( Harashima, H; Hayashi, M; Horiuchi, M; Kamido, H; Kudo, T; Kuwajima, M; Lu, K; Ono, A; Ozaki, K; Saheki, T; Sei, M; Shima, K, 1999) |
| "The free- and acylcarnitine concentrations in neonatal rat brain and heart were determined after a 72-hour starvation period from the 3rd to 6th postnatal day." | 7.69 | The effect of starvation on brain carnitine concentration in neonatal rats. ( Murakami, R; Nakamura, H; Tanaka, A, 1997) |
| "The effect of aging and treatment with acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes was studied." | 7.68 | Effect of aging and acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes. ( Cafagna, F; Gadaleta, MN; Quagliariello, E; Ruggiero, FM, 1990) |
| "The effect of aging and subchronic treatment with acetyl-L-carnitine (50 mg/kg per day) was studied on mitochondrial bioenergetics and cholinergic metabolism in non-synaptic mitochondria and synaptosomes isolated from cerebral cortex, hippocampus and striatum of rats aged 4, 11 and 18 months." | 7.67 | Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. ( Curti, D; Dagani, F; Galmozzi, MR; Marzatico, F, 1989) |
| "Aging is associated with decreases in myocardial fatty acid oxidation and carnitine concentration." | 7.66 | Effects of dietary carnitine on myocardial palmitate oxidation in the aging rat. ( Edington, DW; Traeger, L, 1983) |
| "L-carnitine has also demonstrated antioxidant properties in animal models of oxidative damage." | 6.44 | The aging eye and the role of L-carnitine and its derivatives. ( Imperatrice, B; Karavitis, P; Pescosolido, N, 2008) |
| "l-carnitine (LC) has been widely studied as a natural antioxidant molecule for treating low-fertility gametes." | 5.62 | Testicular transcriptome analysis under the dietary inclusion of l-carnitine reveals potential key genes associated with oxidative defense and the semen quality factor in aging roosters. ( Abouzaid, M; Elokil, AA; Li, S; Liu, H; Magdy, M; Xiao, T; Xu, R, 2021) |
| " The hormetic dose-response, challenging long-standing beliefs about the nature of the dose-response in a lowdose zone, has the potential to affect significantly the design of pre-clinical studies and clinical trials as well as strategies for optimal patient dosing in the treatment of numerous diseases." | 5.36 | Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes. ( Calabrese, EJ; Calabrese, V; Cornelius, C; Stella, AM, 2010) |
| "Propylthiouracil (PTU; 0." | 5.27 | Effect of hypothyroidism during gestation and in the suckling period on cholesterol and carnitine metabolism in the rat. ( Hahn, P, 1986) |
| "A previous study conducted in our laboratory showed that feeding 500 ppm of dietary L-carnitine to young and aging White Leghorns for 5 wk improved sperm concentration and reduced sperm lipid peroxidation during the last half of supplementation." | 5.12 | The effect of dietary L-carnitine on semen traits of White Leghorns. ( Hester, PY; Latour, MA; Neuman, SL; Zhai, W, 2007) |
| "This study evaluated the efficacy of L-carnitine on physical and mental fatigue and on cognitive functions of centenarians." | 5.12 | L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. ( Cammalleri, L; Colonna, V; Gargante, MP; Malaguarnera, M; Motta, M; Vacante, M, 2007) |
| "Testosterone and carnitines significantly improved the peak systolic velocity, end-diastolic velocity, resistive index, nocturnal penile tumescence, International Index of Erectile Function score, Depression Melancholia Scale score, and fatigue scale score." | 5.11 | Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. ( Biagiotti, G; Caracciolo, S; Cavallini, G; Modenini, F; Vitali, G, 2004) |
| " To investigate associations between acyl-carnitines and cardiovascular function as indexed by imaging measurements." | 4.02 | Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines. ( Chew, H; Ching, J; Chow, VJ; Ewe, SH; Gao, F; Keng, BM; Koh, AS; Koh, WP; Kovalik, JP; Lee, LS; Leng, S; Tan, HC; Tan, RS; Tan, TY; Teo, LL; Zhao, X; Zhong, L, 2021) |
| "This study tested the hypothesis that in human aging, a decreased intramuscular acylcarnitine status is associated with (pre-)frailty, reduced physical performance, and altered mitochondrial function." | 3.96 | Intramuscular short-chain acylcarnitines in elderly people are decreased in (pre-)frail females, but not in males. ( Bos, P; Keijer, J; Kleemann, R; Kuda, O; Nieuwenhuizen, AG; Paluchová, V; van den Hoek, AM; van der Hoek, MD; van der Leij, FR; Veeger, NJGM; Verschuren, L, 2020) |
| "The purpose of this study was to determine if plasma acylcarnitine (AC) profiling is altered under hyperinsulinemic conditions as part of the aging process." | 3.83 | Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction. ( Consitt, LA; Houmard, JA; Koves, TR; Muoio, DM; Nakazawa, M; Newton, CA, 2016) |
| " The purpose of this study was to determine whether dietary supplementation of l-carnitine can influence bone density and slow the rate of bone turnover in an aging ovariectomized rat model." | 3.74 | Dietary l-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats. ( Arjmandi, BH; Balakrishnan, A; Clark, RM; Hooshmand, S; Koo, SI; Owen, KQ, 2008) |
| " In parallel, we have also investigated the levels of carnitine and lipoic acid during aging." | 3.74 | Carnitine and lipoate ameliorates lipofuscin accumulation and monoamine oxidase activity in aged rat heart. ( Naveen, B; Panneerselvam, C; Savitha, S, 2007) |
| "The objective of this study was to determine whether dietary L-carnitine can influence the status of alpha-tocopherol, retinol and selected lipid parameters in aging ovariectomized rats, an animal model for the menopausal state." | 3.74 | L-carnitine increases liver alpha-tocopherol and lowers liver and plasma triglycerides in aging ovariectomized rats. ( Aggarwal, D; Balakrishnan, A; Clark, RM; Koo, SI; Owen, KQ; Waters, D, 2007) |
| "This study demonstrated that aging is associated with a decline in immune functions and supplementing L-carnitine had a positive effect in improving immune responses in aged animals." | 3.74 | Role of L-carnitine in the modulation of immune response in aged rats. ( Chinnakkanu, P; Jeyakumar, P; Joyee, AG; Mendoza, E; Sittadjody, S; Subathra, M; Thangasamy, T, 2008) |
| "Co-supplementation of lipoic acid with carnitine has a beneficial effect in reversing the age-related abnormalities seen in aging." | 3.73 | Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine. ( Anusuyadevi, M; Panneerselvam, C; Savitha, S; Tamilselvan, J, 2005) |
| "Juvenile visceral steatosis (JVS) mouse is an animal model of human primary carnitine deficiency caused by a mutation of the gene encoding carnitine transporter, and suffers from various symptoms, such as fatty liver, growth retardation, hyperammonemia, hypoglycemia, and cardiac hypertrophy." | 3.71 | Hyperammonemia in carnitine-deficient adult JVS mice used by starvation. ( Horiuchi, M; Jalil, A; Kobayashi, K; Li, XX; Saheki, T; Yoshida, G, 2002) |
| "The long-term administration of L-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue." | 3.70 | Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. ( Harashima, H; Hayashi, M; Horiuchi, M; Kamido, H; Kudo, T; Kuwajima, M; Lu, K; Ono, A; Ozaki, K; Saheki, T; Sei, M; Shima, K, 1999) |
| "The free- and acylcarnitine concentrations in neonatal rat brain and heart were determined after a 72-hour starvation period from the 3rd to 6th postnatal day." | 3.69 | The effect of starvation on brain carnitine concentration in neonatal rats. ( Murakami, R; Nakamura, H; Tanaka, A, 1997) |
| "We analyzed carnitine profiles in C3H-H-2 degrees strain of mouse associated with fatty liver, hyperammonemia and hypoglycemia (Koizumi et al." | 3.68 | Animal model of systemic carnitine deficiency: analysis in C3H-H-2 degrees strain of mouse associated with juvenile visceral steatosis. ( Hayakawa, J; Horiuchi, M; Imamura, Y; Inui, Y; Kawata, S; Koizumi, T; Kono, N; Kuwajima, M; Ono, A; Saheki, T, 1991) |
| " In agreement with prior studies with the Wistar rat model of aging, significant decrements in the rates of palmitoylcarnitine oxidation and carnitine exchange were apparent in the old Fischer animals." | 3.68 | Mitochondrial metabolism and substrate competition in the aging Fischer rat heart. ( Hudson, EK; McMillin, JB; Taegtmeyer, H; Taffet, GE; Tate, CA, 1993) |
| "The effect of aging and treatment with acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes was studied." | 3.68 | Effect of aging and acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes. ( Cafagna, F; Gadaleta, MN; Quagliariello, E; Ruggiero, FM, 1990) |
| "Acetyl-l-carnitine (ALCAR) exerts antiaging effects with study we evaluated the effect of a chronic treatment with ALCAR (6 weeks, 50 mg/kg/day) on the open field behavior of 5-month-old and 26-month-old male Wistar rats." | 3.68 | Differential effect of acetyl-l-carnitine on open field behavior in young and old rats. ( Blokland, A; Jolles, J; Raaijmakers, W; van der Staay, FJ, 1990) |
| "Carnitine deficiency associated with impairment of muscle function has been described in infants and young adults as a result of inherited or acquired disease but there are no reports on carnitine levels in healthy aging people." | 3.67 | Age-dependent decrease of carnitine content in muscle of mice and humans. ( Costell, M; Grisolía, S; O'Connor, JE, 1989) |
| "The effect of aging and subchronic treatment with acetyl-L-carnitine (50 mg/kg per day) was studied on mitochondrial bioenergetics and cholinergic metabolism in non-synaptic mitochondria and synaptosomes isolated from cerebral cortex, hippocampus and striatum of rats aged 4, 11 and 18 months." | 3.67 | Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. ( Curti, D; Dagani, F; Galmozzi, MR; Marzatico, F, 1989) |
| "Brain autoradiography in adrenalectomized rats injected with 3H-corticosterone 2 hr before sacrifice was used to study the effect of aging and long-term acetyl-l-carnitine treatment on the hippocampal glucocorticoid receptor." | 3.67 | Acetyl-L-carnitine reduces the age-dependent loss of glucocorticoid receptors in the rat hippocampus: an autoradiographic study. ( Amenta, F; Angelucci, L; Maccari, S; Patacchioli, FR; Ramacci, MT; Taglialatela, G, 1989) |
| "L-carnitine (LC) plays an important role in energy production from long-chain fatty acids in mitochondria, and its serum level is lower in prefrail and frail subjects." | 3.11 | Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial. ( Bertino, G; Bonfiglio, C; Castorina, M; Catania, VE; Cauli, O; Chisari, LM; Malaguarnera, G; Malaguarnera, M, 2022) |
| "Levocarnitine is an important contributor to cellular energy metabolism." | 2.71 | Levocarnitine administration in elderly subjects with rapid muscle fatigue: effect on body composition, lipid profile and fatigue. ( Dell'Arte, S; Finocchiaro, G; Leotta, C; Malaguarnera, M; Marino, A; Pistone, G, 2003) |
| "Older age and obesity are associated with metabolic dysregulation; the mechanism by which these factors impact metabolism across the lifespan is important, but relatively unknown." | 2.53 | Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations. ( Bain, JR; Cohen, HJ; Huffman, KM; Kraus, VB; Kraus, WE; Morey, MC; Newgard, CB; Pieper, CF; Ravussin, E; Redman, LM; Stevens, RD; Thompson, DK, 2016) |
| "L-carnitine has also demonstrated antioxidant properties in animal models of oxidative damage." | 2.44 | The aging eye and the role of L-carnitine and its derivatives. ( Imperatrice, B; Karavitis, P; Pescosolido, N, 2008) |
| "L-Carnitine has been described as a "conditionally essential" nutrient for humans." | 2.38 | Carnitine function and requirements during the life cycle. ( Rebouche, CJ, 1992) |
| "l-Carnitine has a potent cardioprotective effect and its synthesis decreases during ageing." | 1.72 | Effect of l-carnitine and mildronate on the mitochondrial metabolism of heart and bacterial composition of the gut microbiome in ageing mice. ( Gryaznova, MV; Gureev, AP; Ignatyeva, DA; Popov, VN; Shaforostova, EA; Volodina, DE, 2022) |
| "Metallothionein (MT) is a family of low molecular weight, cysteine-rich proteins that regulate zinc homeostasis and have potential protective effects against oxidative stress and toxic metals." | 1.62 | Metabolomic profiling of plasma from middle-aged and advanced-age male mice reveals the metabolic abnormalities of carnitine biosynthesis in metallothionein gene knockout mice. ( Kadota, Y; Kawakami, T; Sato, M; Suzuki, S; Yano, A, 2021) |
| "Carnitine has been used as an energy supplement but the roles in improving health and delaying aging remain unclear." | 1.56 | Carnitine promotes recovery from oxidative stress and extends lifespan in ( Li, L; Liu, D; Ou, ZL; Zeng, X, 2020) |
| "The pathogenesis of Alzheimer's disease (AD) is complex involving multiple contributing factors." | 1.43 | Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome. ( Elliott, CT; Graham, SF; Green, BD; Hölscher, C; Kehoe, PG; McClean, PL; McGuinness, B; Nasaruddin, MB; Pan, X; Passmore, AP, 2016) |
| "Endometrial cancer is associated with metabolic disturbances related to its underlying risk factors, including obesity and diabetes." | 1.38 | Analysis of serum metabolic profiles in women with endometrial cancer and controls in a population-based case-control study. ( Bain, JR; Brinton, LA; Falk, RT; Garcia-Closas, M; Gaudet, MM; Gunter, MJ; Lissowska, J; Newgard, CB; Peplonska, B; Pfeiffer, RM; Potischman, N; Sherman, ME; Stevens, RD, 2012) |
| " The hormetic dose-response, challenging long-standing beliefs about the nature of the dose-response in a lowdose zone, has the potential to affect significantly the design of pre-clinical studies and clinical trials as well as strategies for optimal patient dosing in the treatment of numerous diseases." | 1.36 | Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes. ( Calabrese, EJ; Calabrese, V; Cornelius, C; Stella, AM, 2010) |
| "Body weight was decreased on PNDs 8-18 in PCP-treated pups and PNDs 8-10 in KET-treated pups." | 1.35 | Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague-Dawley rats. ( Boctor, SY; Ferguson, SA; Wang, C, 2008) |
| "Carnitine is a vitamin-like compound that serves as a carrier to transport long-chain fatty acids into the mitochondria for beta-oxidation." | 1.35 | L-carnitine mediates protection against DNA damage in lymphocytes of aged rats. ( Chinnakannu, P; Jeyakumar, P; Joyee, AG; Sittadjody, S; Thangasamy, T, 2009) |
| "L-carnitine is a quaternary ammonium compound heterogeneously distributed in the brain." | 1.33 | Effect of L-carnitine on nucleic acid status of aged rat brain. ( Jayaraman, G; Joyee, AG; Juliet, PA; Mohankumar, MN; Panneerselvam, C, 2005) |
| "l-carnitine is an endogenous amine that has been shown to have an effect on the synthesis of reactive oxygen metabolites." | 1.32 | The effects of L-carnitine on presbyacusis in the rat model. ( Agirdir, B; Derin, A; Derin, N; Dinç, O; Güney, K; Kilinçarslan, S; Ozcaglar, H, 2004) |
| "Carnitine has antioxidant properties that protect sperm membranes against toxic reactive oxygen species." | 1.31 | The effect of dietary carnitine on semen traits of white Leghorn roosters. ( Heste, PY; Lin, TL; Neuman, SL, 2002) |
| " Chronic administration of carnitine over time pre- and post-lesions seemed to partially ameliorate the cognitive deficits caused by the synaptic lesion." | 1.31 | Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine. ( Ando, S; Fukui, F; Iwamoto, M; Izumiyama, N; Kobayashi, S; Kon, K; Nakamura, H; Tadenuma, T; Takeda, Y; Waki, H; Watanabe, K, 2002) |
| "L-carnitine was administered intraperitoneally 300 mg/kg/d using physiological saline as a vehicle for 7, 14, and 21 days." | 1.31 | Protective efficacy of L-carnitine on acetylcholinesterase activity in aged rat brain. ( Panneerselvam, C; Rani, PJ, 2001) |
| "Acyl-carnitines (C2-C16) were analysed as their p-bromophenacyl derivatives by reverse-phase high performance liquid chromatography using a ternary gradient of acetonitrile/water/triethylamine phosphate." | 1.28 | The measurement of carnitine and acyl-carnitines: application to the investigation of patients with suspected inherited disorders of mitochondrial fatty acid oxidation. ( Aynsley-Green, A; Bartlett, K; Bhuiyan, AK; Jackson, S; Leonard, JV; Turnbull, DM, 1992) |
| " This reduction is attenuated after long-term administration with L-acetylcarnitine (10 mg/Kg i." | 1.28 | L-acetylcarnitine attenuates the age-dependent decrease of NMDA-sensitive glutamate receptors in rat hippocampus. ( Fiore, L; Rampello, L, 1989) |
| "L-Carnitine plays a crucial role in the perinatal transition from carbohydrate to lipid-derived energy." | 1.28 | Enterohepatic distribution of carnitine in developing piglets: relation to glucagon and insulin. ( Heitlinger, LA; Hughes, AM; Li, BU; McClung, HJ; Murray, RD; O'Dorisio, TM, 1992) |
| "Carnitine biosynthesis was assessed in human infants by measuring changes in plasma carnitine concentration and rates of urinary carnitine excretion after infants were fed carnitine-free formulas with and without added epsilon-N-trimethyl-L-lysine or gamma-butyrobetaine." | 1.27 | gamma-Butyrobetaine hydroxylase activity is not rate limiting for carnitine biosynthesis in the human infant. ( Olson, AL; Rebouche, CJ, 1987) |
| "The effects of long-term dosing with acetyl-L-carnitine (ALC) were examined in aged rats, and they were compared with those in young rats." | 1.27 | Effects of acetyl-L-carnitine on the brain lipofuscin content and emotional behavior in aged rats. ( Anami, K; Fujii, T; Kohjimoto, Y; Kuwaki, T; Matsumoto, M; Ogawa, T; Ono, T; Satoh, H; Shirakawa, K; Yasuda, H, 1988) |
| "Propylthiouracil (PTU; 0." | 1.27 | Effect of hypothyroidism during gestation and in the suckling period on cholesterol and carnitine metabolism in the rat. ( Hahn, P, 1986) |
| "Carnitine content was decreased most in the soleus and the heart and to a lesser extent in the diaphragm." | 1.26 | Age-linked changes in the activity of enzymes of the tricarboxylate cycle and lipid oxidation, and of carnitine content, in muscles of the rat. ( Castro, F; Hansford, RG, 1982) |
| "Acylcarnitine was significantly higher in the diabetic patients than in the controls in the two younger age groups." | 1.26 | Plasma and urine carnitine in children with diabetes mellitus. ( Cederblad, G; Hermansson, G; Ludvigsson, J, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 57 (29.84) | 18.7374 |
| 1990's | 34 (17.80) | 18.2507 |
| 2000's | 57 (29.84) | 29.6817 |
| 2010's | 31 (16.23) | 24.3611 |
| 2020's | 12 (6.28) | 2.80 |
| Authors | Studies |
|---|---|
| Kadota, Y | 1 |
| Yano, A | 1 |
| Kawakami, T | 1 |
| Sato, M | 1 |
| Suzuki, S | 1 |
| Volodina, DE | 1 |
| Gureev, AP | 1 |
| Shaforostova, EA | 1 |
| Gryaznova, MV | 1 |
| Ignatyeva, DA | 1 |
| Popov, VN | 1 |
| Malaguarnera, G | 1 |
| Catania, VE | 1 |
| Bertino, G | 1 |
| Chisari, LM | 1 |
| Castorina, M | 1 |
| Bonfiglio, C | 1 |
| Cauli, O | 1 |
| Malaguarnera, M | 3 |
| Wang, L | 1 |
| Derous, D | 2 |
| Huang, X | 1 |
| Mitchell, SE | 2 |
| Douglas, A | 2 |
| Lusseau, D | 2 |
| Wang, Y | 3 |
| Speakman, JR | 2 |
| Rattray, NJW | 1 |
| Trivedi, DK | 1 |
| Xu, Y | 1 |
| Chandola, T | 1 |
| Johnson, CH | 1 |
| Marshall, AD | 1 |
| Mekli, K | 1 |
| Rattray, Z | 1 |
| Tampubolon, G | 1 |
| Vanhoutte, B | 1 |
| White, IR | 1 |
| Wu, FCW | 1 |
| Pendleton, N | 1 |
| Nazroo, J | 1 |
| Goodacre, R | 1 |
| Niska-Blakie, J | 1 |
| Gopinathan, L | 1 |
| Low, KN | 1 |
| Kien, YL | 1 |
| Goh, CMF | 1 |
| Caldez, MJ | 1 |
| Pfeiffenberger, E | 1 |
| Jones, OS | 1 |
| Ong, CB | 1 |
| Kurochkin, IV | 1 |
| Coppola, V | 1 |
| Tessarollo, L | 1 |
| Choi, H | 1 |
| Kanagasundaram, Y | 1 |
| Eisenhaber, F | 1 |
| Maurer-Stroh, S | 1 |
| Kaldis, P | 1 |
| Lin, X | 2 |
| Lyvers Peffer, PA | 1 |
| Woodworth, J | 2 |
| Odle, J | 2 |
| van der Hoek, MD | 1 |
| Nieuwenhuizen, AG | 1 |
| Kuda, O | 1 |
| Bos, P | 1 |
| Paluchová, V | 1 |
| Verschuren, L | 1 |
| van den Hoek, AM | 1 |
| Kleemann, R | 1 |
| Veeger, NJGM | 1 |
| van der Leij, FR | 2 |
| Keijer, J | 1 |
| Pagano, G | 1 |
| Pallardó, FV | 1 |
| Lyakhovich, A | 1 |
| Tiano, L | 1 |
| Fittipaldi, MR | 1 |
| Toscanesi, M | 1 |
| Trifuoggi, M | 1 |
| Elokil, AA | 2 |
| Abouzaid, M | 1 |
| Magdy, M | 1 |
| Xiao, T | 1 |
| Liu, H | 1 |
| Xu, R | 1 |
| Li, S | 2 |
| Ng, TKS | 1 |
| Kovalik, JP | 3 |
| Ching, J | 3 |
| Chan, AW | 1 |
| Matchar, DB | 1 |
| Liu, D | 1 |
| Zeng, X | 1 |
| Li, L | 1 |
| Ou, ZL | 1 |
| Gao, F | 2 |
| Zhao, X | 1 |
| Chow, VJ | 1 |
| Chew, H | 1 |
| Teo, LL | 1 |
| Tan, RS | 2 |
| Leng, S | 2 |
| Ewe, SH | 1 |
| Tan, HC | 1 |
| Tan, TY | 1 |
| Lee, LS | 1 |
| Keng, BM | 2 |
| Zhong, L | 2 |
| Koh, WP | 2 |
| Koh, AS | 2 |
| Barger, JL | 1 |
| Vann, JM | 1 |
| Cray, NL | 1 |
| Pugh, TD | 1 |
| Mastaloudis, A | 1 |
| Hester, SN | 1 |
| Wood, SM | 1 |
| Newton, MA | 1 |
| Weindruch, R | 1 |
| Prolla, TA | 1 |
| Zhang, N | 1 |
| Valentine, JM | 1 |
| Zhou, Y | 1 |
| Li, ME | 1 |
| Zhang, Y | 1 |
| Bhattacharya, A | 1 |
| Walsh, ME | 1 |
| Fischer, KE | 1 |
| Austad, SN | 1 |
| Osmulski, P | 1 |
| Gaczynska, M | 1 |
| Shoelson, SE | 1 |
| Van Remmen, H | 1 |
| Chen, HI | 1 |
| Chen, Y | 1 |
| Liang, H | 1 |
| Musi, N | 1 |
| Simcox, J | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tackling Disruptions to Frailty Interventions: Developing Personalized Interventions Targeted for Older Persons With Cardiac Frailty[NCT05946174] | 500 participants (Anticipated) | Interventional | 2023-07-12 | Recruiting | |||
| Effects of Triple Drug Cocktail Therapy on Metabolic, Endocrine Alterations and Perceived Stress Response in Patients With PCOS: A Double Blind Randomized Clinical Trial[NCT04113889] | Phase 2 | 147 participants (Actual) | Interventional | 2019-10-15 | Completed | ||
| Calorie Restriction Intervention Induces Enterotype-associated BMI Loss in Nonobese Individuals[NCT04044118] | 41 participants (Actual) | Interventional | 2017-04-01 | Completed | |||
| The Effects of PeakATP (Adenosine 5' - Triphosphate Disodium) Supplementation vs. Placebo on Measures of Mood, Reaction Time and Cognitive Performance[NCT05100589] | 35 participants (Actual) | Interventional | 2021-10-06 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for carnitine and Aging
| Article | Year |
|---|---|
Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures.
Topics: Aging; Animals; Antioxidants; Cardiovascular Diseases; Carnitine; Cell Line; Diabetes Mellitus, Type | 2020 |
Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.
Topics: Aged; Aging; Amino Acids; Body Mass Index; Carnitine; Female; Humans; Male; Metabolomics; Obesity; P | 2016 |
The aging eye and the role of L-carnitine and its derivatives.
Topics: Acetylcarnitine; Aged; Aging; Animals; Antioxidants; Carnitine; Eye; Eye Diseases; Humans; Vitamin B | 2008 |
Mechanistic contribution of carnitine deficiency to geriatric frailty.
Topics: Aged; Aged, 80 and over; Aging; Carnitine; Frail Elderly; Humans; Vitamin B Deficiency | 2010 |
Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine.
Topics: Adenosine Triphosphate; Aging; Brain; Carnitine; Cognition; Cognition Disorders; Creatine; Energy Me | 2011 |
Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis.
Topics: Aging; Animals; Carnitine; Female; Hypoxia; Lipid Peroxidation; Male; Rats; Rats, Wistar; Reactive O | 2012 |
Delaying the mitochondrial decay of aging with acetylcarnitine.
Topics: Acetylcarnitine; Aging; Alzheimer Disease; Animals; Brain; Carnitine; Dose-Response Relationship, Dr | 2004 |
Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes.
Topics: Acetylcarnitine; Aging; Animals; Caloric Restriction; Carnitine; Carnitine Acyltransferases; Cell Ph | 2006 |
Developmental aspects of lipid metabolism.
Topics: Adult; Aging; Animals; Carnitine; Humans; Lipid Metabolism; Rats | 1995 |
Carnitine metabolism in human subjects. II. Values of carnitine in biological fluids and tissues of "normal" subjects.
Topics: Adolescent; Adult; Aged; Aging; Carnitine; Child; Diet; Fasting; Female; Humans; Male; Menstruation; | 1978 |
Carnitine function and requirements during the life cycle.
Topics: Adolescent; Adult; Aged; Aging; Animals; Carnitine; Child; Child, Preschool; Female; Humans; Infant; | 1992 |
[Drug therapy possibilities for the senile heart].
Topics: Aged; Aging; Anti-Arrhythmia Agents; Antihypertensive Agents; Calcium Channel Blockers; Cardiotonic | 1986 |
Some aspects of fatty acid oxidation and ketone body formation and utilization during development of the rat.
Topics: Acetyltransferases; Acyltransferases; Aging; Alcohol Oxidoreductases; Animals; Animals, Newborn; Car | 1973 |
10 trials available for carnitine and Aging
| Article | Year |
|---|---|
Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial.
Topics: Acetylcarnitine; Aged; Aging; Carnitine; Double-Blind Method; Frailty; Humans | 2022 |
Nutritional Interventions that Slow the Age-Associated Decline in Renal Function in a Canine Geriatric Model for Elderly Humans.
Topics: Absorptiometry, Photon; Aged; Aging; Animals; Arginine; Biomarkers; Body Weight; Carnitine; Cross-Se | 2016 |
Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women.
Topics: Adiposity; Adult; Aging; Amino Acids; Body Composition; Caloric Restriction; Carnitine; Cross-Sectio | 2011 |
Levocarnitine administration in elderly subjects with rapid muscle fatigue: effect on body composition, lipid profile and fatigue.
Topics: Aged; Aging; Body Composition; Body Mass Index; Body Weight; Carnitine; Cholesterol; Female; Follow- | 2003 |
Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging.
Topics: Aged; Aging; Carnitine; Climacteric; Depression; Drug Therapy, Combination; Erectile Dysfunction; Fa | 2004 |
Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles.
Topics: Aging; Animals; Antioxidants; Carnitine; Diet; Discrimination Learning; Distance Perception; Dogs; T | 2004 |
Effects of breeder hen age and dietary L-carnitine on progeny embryogenesis.
Topics: Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Breeding; Carnitine; Chick | 2007 |
The effect of dietary L-carnitine on semen traits of White Leghorns.
Topics: Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Carnitine; Chickens; Diet; | 2007 |
L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial.
Topics: Adipose Tissue; Aged, 80 and over; Aging; Blood Pressure; Carnitine; Cholesterol; Cognition; Creatin | 2007 |
Screening for medium chain acyl-CoA dehydrogenase deficiency using electrospray ionisation tandem mass spectrometry.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Adolescent; Age Distribution; Aging; Carnitine; Chi | 1998 |
168 other studies available for carnitine and Aging
| Article | Year |
|---|---|
Metabolomic profiling of plasma from middle-aged and advanced-age male mice reveals the metabolic abnormalities of carnitine biosynthesis in metallothionein gene knockout mice.
Topics: Aging; Amino Acids; Animals; Bile Acids and Salts; Bilirubin; Carbohydrate Metabolism; Carnitine; Fa | 2021 |
Effect of l-carnitine and mildronate on the mitochondrial metabolism of heart and bacterial composition of the gut microbiome in ageing mice.
Topics: Aging; Animals; Bifidobacterium; Cardiovascular Agents; Carnitine; DNA, Mitochondrial; Female; Gastr | 2022 |
The Effects of Graded Levels of Calorie Restriction: XIX. Impact of Graded Calorie Restriction on Protein Expression in the Liver.
Topics: Aging; Animals; Caloric Restriction; Carnitine; Liver; Male; Mammals; Mice; Mice, Inbred C57BL | 2023 |
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty.
Topics: Aged; Aging; Carnitine; Confounding Factors, Epidemiologic; Discriminant Analysis; Energy Metabolism | 2019 |
Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.
Topics: Aging; Animals; Anti-Bacterial Agents; Bacteria; Carnitine; Coenzyme A-Transferases; Dietary Supplem | 2020 |
Ontogeny of carnitine biosynthesis in
Topics: Aging; Animals; Animals, Newborn; Body Weight; Carnitine; Enzyme Inhibitors; gamma-Butyrobetaine Dio | 2020 |
Intramuscular short-chain acylcarnitines in elderly people are decreased in (pre-)frail females, but not in males.
Topics: Aged; Aged, 80 and over; Aging; Carnitine; Cross-Sectional Studies; Female; Frail Elderly; Frailty; | 2020 |
Testicular transcriptome analysis under the dietary inclusion of l-carnitine reveals potential key genes associated with oxidative defense and the semen quality factor in aging roosters.
Topics: Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Carnitine; Chickens; Diet; | 2021 |
Novel metabolomics markers are associated with pre-clinical decline in hand grip strength in community-dwelling older adults.
Topics: Aged; Aging; Asymptomatic Diseases; Biomarkers; Carnitine; Energy Metabolism; Fatty Acids; Female; F | 2021 |
Carnitine promotes recovery from oxidative stress and extends lifespan in
Topics: Aging; Amyloid beta-Peptides; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carn | 2020 |
Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines.
Topics: Aged; Aging; Cardiovascular System; Carnitine; Diabetes Mellitus; Female; Humans; Male; Middle Aged | 2021 |
Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics.
Topics: 2,4-Dinitrophenol; Adipose Tissue, White; Aging; Animals; Bezafibrate; Caloric Restriction; Carnitin | 2017 |
Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health.
Topics: Aging; Animals; Blood Glucose; Carnitine; Cell Line; Ceramides; Female; Gene Expression Regulation; | 2017 |
Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.
Topics: Adipose Tissue, Brown; Aging; Animals; Body Temperature; Carnitine; Carnitine O-Palmitoyltransferase | 2017 |
Metabolomic profile of arterial stiffness in aged adults.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Amino Acids; Arterial Pressure; Biomarkers; Cardiovascu | 2018 |
L-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway.
Topics: Adipose Tissue; Aging; Animals; Carnitine; Cellular Senescence; Inflammation; MAP Kinase Signaling S | 2019 |
Trimetazidine and l‑carnitine prevent heart aging and cardiac metabolic impairment in rats via regulating cardiac metabolic substrates.
Topics: Aging; Animals; Carnitine; Carnitine O-Palmitoyltransferase; Echocardiography; Glucose Transporter T | 2019 |
The capability of L-carnitine-mediated antioxidant on cock during aging: evidence for the improved semen quality and enhanced testicular expressions of GnRH1, GnRHR, and melatonin receptors MT 1/2.
Topics: Aging; Animal Feed; Animals; Antioxidants; Avian Proteins; Carnitine; Chickens; Diet; Dietary Supple | 2019 |
Positive influence of L-carnitine on the different muscle fibres types of racing pigeons.
Topics: Aging; Animals; Carnitine; Columbidae; Gene Expression Regulation; Muscle Fibers, Skeletal; Muscle P | 2014 |
Metabolomics signature improves the prediction of cardiovascular events in elderly subjects.
Topics: Aged; Aged, 80 and over; Aging; Biomarkers; Cardiovascular Diseases; Carnitine; Cellular Senescence; | 2014 |
Age-related increase in alanine aminotransferase correlates with elevated levels of plasma amino acids, decanoylcarnitine, Lp-PLA2 Activity, oxidative stress, and arterial stiffness.
Topics: Adult; Aged; Aging; Alanine Transaminase; Amino Acids; Biomarkers; Carnitine; Case-Control Studies; | 2014 |
The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction.
Topics: Adipose Tissue; Aging; Animals; Arteries; Body Weight; Carnitine; Glutamic Acid; Malates; Male; Mice | 2014 |
Antioxidant effects of carnitine supplementation on 14-3-3 protein isoforms in the aged rat hippocampus detected using fully automated two-dimensional chip gel electrophoresis.
Topics: 14-3-3 Proteins; Aging; Animals; Antioxidants; Automation; Carnitine; Electrophoresis, Gel, Two-Dime | 2014 |
Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.
Topics: Acetylcholine; Aging; Animals; Antioxidants; Aspartic Acid; Brain; Carnitine; DNA Damage; DNA Polyme | 2015 |
Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome.
Topics: Aging; Alzheimer Disease; Amino Acids, Branched-Chain; Amino Acids, Essential; Animals; Biogenic Pol | 2016 |
Medium-chain plasma acylcarnitines, ketone levels, cognition, and gray matter volumes in healthy elderly, mildly cognitively impaired, or Alzheimer's disease subjects.
Topics: Aged; Aging; Alzheimer Disease; Carnitine; Cognition; Cognitive Dysfunction; Cohort Studies; Female; | 2016 |
Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction.
Topics: Acetyl-CoA Carboxylase; Adult; Aged; Aged, 80 and over; Aging; Amino Acids; Carnitine; Female; Gluco | 2016 |
The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice.
Topics: Aging; Animals; Bile Acids and Salts; Caloric Restriction; Carnitine; Catalase; Eating; Gene Express | 2017 |
Dietary l-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats.
Topics: Acid Phosphatase; Aging; Alkaline Phosphatase; Animals; Bone Density; Carnitine; Collagen Type I; Di | 2008 |
L-carnitine mediates protection against DNA damage in lymphocytes of aged rats.
Topics: Age Factors; Aging; Animals; Antioxidants; Apoptosis; Carnitine; Cell Movement; Cell Proliferation; | 2009 |
Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague-Dawley rats.
Topics: Aging; Animals; Animals, Newborn; Animals, Suckling; Behavior, Animal; Body Weight; Carnitine; Excit | 2008 |
L-carnitine supplementation and physical exercise restore age-associated decline in some mitochondrial functions in the rat.
Topics: Aging; Animals; Carnitine; Male; Mitochondria; Muscle, Skeletal; Physical Conditioning, Animal; Rand | 2008 |
Ontogeny of Na(+)/L-carnitine transporter and of gamma-trimethylaminobutyraldehyde dehydrogenase and gamma-butyrobetaine hydroxylase genes expression in rat kidney.
Topics: Aging; Aldehyde Oxidoreductases; Animals; Carnitine; gamma-Butyrobetaine Dioxygenase; Gene Expressio | 2009 |
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.
Topics: Aging; Animals; Biological Transport; Blotting, Western; Carnitine; Carnitine O-Acetyltransferase; C | 2009 |
Effect of L-carnitine on proliferative response and mRNA expression of some of its associated factors in splenic mononuclear cells of male broiler chicks.
Topics: Aging; Animal Feed; Animals; Carnitine; Cell Proliferation; Chickens; Concanavalin A; Immunoglobulin | 2010 |
Acetyl-L-carnitine improves aged brain function.
Topics: Acetylcarnitine; Aging; Animals; Brain; Carnitine; Hippocampus; Learning; Male; Maze Learning; Memor | 2010 |
Long-term effects of neonatal treatment with dexamethasone, L-carnitine, and combinations thereof in rats.
Topics: Aging; Animals; Animals, Newborn; Blood Glucose; Body Weight; Carnitine; Dexamethasone; Dose-Respons | 2011 |
Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes.
Topics: Adaptation, Physiological; Aging; Carnitine; Humans; Mitochondria; Neurodegenerative Diseases; Oxida | 2010 |
Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass.
Topics: Aging; Amino Acids; Animals; Animals, Genetically Modified; Biomarkers; Carnitine; Diglycerides; Dis | 2012 |
Analysis of serum metabolic profiles in women with endometrial cancer and controls in a population-based case-control study.
Topics: Adult; Aged; Aging; Algorithms; Amino Acids; Body Mass Index; Body Weight; Carnitine; Case-Control S | 2012 |
Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lamb.
Topics: Aging; Anilides; Animals; Carnitine; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Endothe | 2013 |
Gender and age differences in plasma carnitine, muscle strength, and exercise tolerance in haemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Carnitine; Female; Hand Strength; Humans; Kidney Failure, Chr | 2002 |
Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine.
Topics: Aging; Alzheimer Disease; Animals; Botulinum Toxins, Type A; Brain-Derived Neurotrophic Factor; Carn | 2002 |
Hyperammonemia in carnitine-deficient adult JVS mice used by starvation.
Topics: Aging; Amino Acids; Ammonia; Animals; Animals, Newborn; Carbamoyl-Phosphate Synthase (Ammonia); Carn | 2002 |
Effects of L-carnitine on neutrophil functions in aged rats.
Topics: Aging; Animals; Carnitine; Chemotaxis, Leukocyte; Indicators and Reagents; Male; Neutrophils; Phagoc | 2003 |
Effects of levocarnitine on mitochondrial antioxidant systems and oxidative stress in aged rats.
Topics: Aging; Animals; Antioxidants; Carnitine; Dose-Response Relationship, Drug; In Vitro Techniques; Lipi | 2003 |
Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes.
Topics: Adult; Aged; Aging; Apoptosis; Bone Marrow Cells; Carnitine; Carnitine Acyltransferases; Carnitine O | 2003 |
Effects of increasing dietary L-carnitine on growth performance of weanling pigs.
Topics: Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Carnitine | 2003 |
Carnitine: a neuromodulator in aged rats.
Topics: Aging; Animals; Brain; Carnitine; Dopamine; Epinephrine; Male; Neurotransmitter Agents; Rats; Seroto | 2003 |
Acetyl-L-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats.
Topics: Acetylcarnitine; Age Factors; Aging; Animals; Body Weight; Carnitine; Dietary Supplements; Drinking; | 2004 |
Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Carnitine; Diet; Discrimination Learn | 2004 |
The effects of L-carnitine on presbyacusis in the rat model.
Topics: Aging; Animals; Auditory Threshold; Carnitine; Evoked Potentials, Auditory, Brain Stem; Free Radical | 2004 |
Age-associated decreased activities of mitochondrial electron transport chain complexes in heart and skeletal muscle: role of L-carnitine.
Topics: Aging; Animals; Carnitine; Cattle; Dose-Response Relationship, Drug; Electron Transport Chain Comple | 2004 |
L-carnitine and DL-alpha-lipoic acid reverse the age-related deficit in glutathione redox state in skeletal muscle and heart tissues.
Topics: Aging; Animals; Carnitine; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glut | 2004 |
Age-dependent alterations in mitochondrial enzymes in cortex, striatum and hippocampus of rat brain -- potential role of L-Carnitine.
Topics: Aging; Animals; Carnitine; Cerebral Cortex; Corpus Striatum; Hippocampus; Male; Mitochondria; Rats; | 2004 |
Effect of L-carnitine on nucleic acid status of aged rat brain.
Topics: Aging; Animals; Brain; Carnitine; DNA; Male; Rats; Rats, Wistar; RNA | 2005 |
Peritoneal macrophages function modulation by L-carnitine in aging rats.
Topics: Aging; Animals; Carnitine; Chemotaxis; In Vitro Techniques; Macrophages, Peritoneal; Male; Phagocyto | 2004 |
Modulation of age-associated oxidative DNA damage in rat brain cerebral cortex, striatum and hippocampus by L-carnitine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Antioxidants; Brain; Carnitine; Cerebral Cortex; Corpus | 2005 |
Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine.
Topics: Aging; Animals; Antioxidants; Carnitine; Male; Mitochondria, Muscle; Oxidative Stress; Rats; Rats, W | 2005 |
Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging.
Topics: Age Factors; Aging; Animals; Carnitine; Citric Acid Cycle; Electron Transport Complex IV; Isocitrate | 2005 |
Age-associated deficit of mitochondrial oxidative phosphorylation in skeletal muscle: role of carnitine and lipoic acid.
Topics: Aging; Animals; Carnitine; Cell Respiration; Male; Mitochondria, Muscle; Mitochondrial Swelling; Oxi | 2005 |
Mitochondrial membrane damage during aging process in rat heart: potential efficacy of L-carnitine and DL alpha lipoic acid.
Topics: Aging; Animals; Antioxidants; Cardiolipins; Carnitine; Cytochromes c; Dose-Response Relationship, Dr | 2006 |
Developmental maturation and segmental distribution of rat small intestinal L-carnitine uptake.
Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Carnitine; Intestine, Small; Metabolic Clear | 2005 |
Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of L-carnitine and DL-alpha-lipoic acid.
Topics: Aging; Animals; Antioxidants; Brain; Carnitine; DNA-Binding Proteins; Lipid Peroxidation; Male; Oxid | 2006 |
Effects of resistance exercise and growth hormone administration at low doses on lipid metabolism in middle-aged female rats.
Topics: Aging; Animals; Body Composition; Carbon-Carbon Ligases; Carnitine; Carnitine O-Palmitoyltransferase | 2006 |
Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process.
Topics: Aging; Animals; Carnitine; Glutathione; Lipid Peroxidation; Male; Mitochondria; Myocardium; Oxidatio | 2006 |
Oxidative stress and DNA single strand breaks in skeletal muscle of aged rats: role of carnitine and lipoicacid.
Topics: Aging; Animals; Antioxidants; Carnitine; DNA Breaks, Single-Stranded; Lipid Peroxidation; Male; Musc | 2006 |
Dietary antioxidants and behavioral enrichment enhance neutrophil phagocytosis in geriatric Beagles.
Topics: Aging; alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Carnitine; CD4-Posi | 2006 |
L-carnitine and alpha-lipoic acid improve age-associated decline in mitochondrial respiratory chain activity of rat heart muscle.
Topics: Aging; Analysis of Variance; Animals; Carnitine; Cell Respiration; Glutamic Acid; Hydroxybutyrates; | 2006 |
Mitigation of age-dependent oxidative damage to DNA in rat heart by carnitine and lipoic acid.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Age Factors; Aging; Animals; Carnitine; Deoxyguanosine; DNA Breaks, Dou | 2007 |
L-carnitine increases liver alpha-tocopherol and lowers liver and plasma triglycerides in aging ovariectomized rats.
Topics: Aging; alpha-Tocopherol; Animals; Body Weight; Carnitine; Dietary Supplements; Female; Liver; Ovarie | 2007 |
Ontogeny of carnitine palmitoyltransferase I activity, carnitine-Km, and mRNA abundance in pigs throughout growth and development.
Topics: Aging; Animal Feed; Animals; Animals, Newborn; Animals, Suckling; Carnitine; Carnitine O-Palmitoyltr | 2007 |
Cytochrome c oxidase rather than cytochrome c is a major determinant of mitochondrial respiratory capacity in skeletal muscle of aged rats: role of carnitine and lipoic acid.
Topics: Administration, Oral; Aging; Animals; Carnitine; Caspases; Cell Nucleus; Cytochromes c; Electron Tra | 2007 |
Carnitine and lipoate ameliorates lipofuscin accumulation and monoamine oxidase activity in aged rat heart.
Topics: Aging; Animals; Antioxidants; Carnitine; Dietary Supplements; In Vitro Techniques; Lipofuscin; Male; | 2007 |
Propionyl-L-carnitine prevents age-related myocardial remodeling in the rabbit.
Topics: Aging; Animals; Cardiotonic Agents; Carnitine; Collagen; Collagen Type I; Disease Models, Animal; En | 2007 |
Age-dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: role of carnitine and lipoic acid.
Topics: Aging; Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Base Sequence; Carnitine; Caspase | 2007 |
Role of L-carnitine in the modulation of immune response in aged rats.
Topics: Aging; Animals; Antibody Formation; Carnitine; Immunity, Cellular; Rats; Rats, Wistar | 2008 |
Age-linked changes in the activity of enzymes of the tricarboxylate cycle and lipid oxidation, and of carnitine content, in muscles of the rat.
Topics: Aging; Animals; Carnitine; Citrate (si)-Synthase; Citric Acid Cycle; Electron Transport Complex IV; | 1982 |
Effect of aging on lipid and carnitine metabolism.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aging; Arteriosclerosis; Carnitine; Drug Synergism; Fatty | 1982 |
Tissue distribution of carnitine biosynthetic enzymes in man.
Topics: Adolescent; Adult; Aging; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Aldehyde-Lyases; Carniti | 1980 |
Effects of dietary carnitine on myocardial palmitate oxidation in the aging rat.
Topics: Aging; Animals; Carnitine; Diet; Myocardium; Oxidation-Reduction; Palmitates; Palmitic Acids; Rats | 1983 |
Postnastal changes in the concentration of carnitine and acylcarnitines in the rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Carnitine; Female; Rats; Rats, Inbred Strains | 1983 |
Plasma and urine carnitine in children with diabetes mellitus.
Topics: Adolescent; Adult; Aging; Carnitine; Child; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin; | 1982 |
Plasma and urine carnitine levels during development.
Topics: Adolescent; Adult; Aged; Aging; Carnitine; Child; Child, Preschool; Circadian Rhythm; Humans; Infant | 1980 |
Carnitine content of liver from genetically diabetic (db/db) and control mice.
Topics: Aging; Animals; Carnitine; Diabetes Mellitus; Fatty Acids, Nonesterified; Liver; Mice; Mice, Inbred | 1981 |
Antiketonemic and antiketogenic actions of carnitine in vivo and in vitro in rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Carnitine; Coenzyme A; Corn Oil; Dietary Fats; | 1981 |
The twenty-four-hour urinary excretion of carnitine and creatinine in normal and hypothyroid children.
Topics: Adolescent; Aging; Carnitine; Child; Child, Preschool; Creatinine; Female; Humans; Hypothyroidism; M | 1980 |
Weanling and adult rats differ in fatty acid and carnitine metabolism during sepsis.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Bacterial Infections; Blood Glucose; Carnitine; Fatty Acids; | 1995 |
Relationships between muscle carnitine, age and oxidative status.
Topics: Adult; Aging; Carnitine; Citrate (si)-Synthase; Humans; Male; Muscles; Oxidation-Reduction; Succinat | 1995 |
Propionyl-L-carnitine prevents the progression of atherosclerotic lesions in aged hyperlipemic rabbits.
Topics: Aging; Animals; Arteriosclerosis; Carnitine; Cell Division; Diet; Disease Models, Animal; Female; Fo | 1995 |
Carnitine palmitoyl transferase-I activity in the aging mouse heart.
Topics: Aging; Animals; Cardiotonic Agents; Carnitine; Carnitine O-Palmitoyltransferase; Male; Mice; Mice, I | 1995 |
Effect of externally added carnitine on the synthesis of acetylcholine in rat cerebral cortex cells.
Topics: Acetylcholine; Aging; Animals; Animals, Suckling; Carnitine; Carnitine O-Acetyltransferase; Cerebral | 1995 |
Control of the cardiac consequences of myocardial ischemia and reperfusion by L-propionylcarnitine: age-response and dose-response studies in the rat heart.
Topics: Aging; Animals; Animals, Newborn; Cardiotonic Agents; Carnitine; Coronary Circulation; Dose-Response | 1993 |
Mitochondrial metabolism and substrate competition in the aging Fischer rat heart.
Topics: Aging; Animals; Carnitine; Carnitine O-Palmitoyltransferase; Fatty Acids; Glucose; Male; Mitochondri | 1993 |
Purification of carnitine carrier from rat brain mitochondria.
Topics: Aging; Animals; Brain; Carnitine; Carnitine Acyltransferases; Male; Mitochondria; Molecular Weight; | 1993 |
Effect of carnitine feeding on the levels of heart and skeletal muscle carnitine of elderly mice.
Topics: Administration, Oral; Aging; Animals; Carnitine; Male; Mice; Muscles; Myocardium | 1993 |
Effect of L-carnitine and soybean oil on growth performance and body composition of early-weaned pigs.
Topics: Aging; Animals; Blood Urea Nitrogen; Body Composition; Carnitine; Diet; Fatty Acids, Nonesterified; | 1996 |
Cholinergic axonal dystrophy and mitochondrial pathology in prosimian primates.
Topics: Aging; Animals; Axons; Carnitine; Cheirogaleidae; Cholinergic Fibers; Choroid Plexus; Copper; Epithe | 1996 |
The effect of starvation on brain carnitine concentration in neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Brain; Brain Chemistry; Carnitine; Fatty Acids; Heart; Myocardium; | 1997 |
Age-and sex-related differences of serum carnitine in a Japanese population.
Topics: Absorption; Adolescent; Adult; Aging; Alcohol Oxidoreductases; Carnitine; Estradiol; Female; Humans; | 1998 |
Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection.
Topics: Aging; Animals; Body Weight; Cardiomegaly; Carnitine; Disease Models, Animal; Half-Life; Injections, | 1999 |
Correlation of serum L-carnitine and dehydro-epiandrosterone sulphate levels with age and sex in healthy adults.
Topics: Adult; Aged; Aged, 80 and over; Aging; Carnitine; Cross-Sectional Studies; Dehydroepiandrosterone Su | 1999 |
Muscle dysfunction in elderly individuals with hip fracture.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Carnitine; Electron Transport; Female; Hip Fractures; H | 1999 |
Protective efficacy of L-carnitine on acetylcholinesterase activity in aged rat brain.
Topics: Acetylcholinesterase; Aging; Animals; Brain; Carnitine; Male; Protective Agents; Rats; Rats, Wistar; | 2001 |
Carnitine as a free radical scavenger in aging.
Topics: Aging; Animals; Ascorbic Acid; Brain; Carnitine; Free Radical Scavengers; Glutathione; Lipofuscin; M | 2001 |
Dietary l-carnitine stimulates carnitine acyltransferases in the liver of aged rats.
Topics: Aging; Animals; Carnitine; Carnitine O-Acetyltransferase; Carnitine O-Palmitoyltransferase; Dietary | 2002 |
Effect of L-carnitine on brain lipid peroxidation and antioxidant enzymes in old rats.
Topics: Aging; Animals; Brain; Carnitine; Catalase; Glutathione Peroxidase; Lipid Peroxides; Male; Oxidoredu | 2002 |
The effect of dietary carnitine on semen traits of white Leghorn roosters.
Topics: Aging; Animals; Antioxidants; Carnitine; Chickens; Giant Cells; Lipid Peroxidation; Male; Malondiald | 2002 |
Age-associated cardiomyopathy in heterozygous carrier mice of a pathological mutation of carnitine transporter gene, OCTN2.
Topics: Adult; Aging; Animals; Cardiomyopathies; Carnitine; Carrier Proteins; Female; Glucose; Heterozygote; | 2002 |
Lipid oxidation by heart mitochondria from young adult and senescent rats.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Fatty Acids; In Vitro Techniques; Kinetics; Lipid Metabo | 1978 |
The effect of diet and development on blood levels of free and esterified carnitine in the rat.
Topics: Aging; Animals; Carnitine; Dietary Carbohydrates; Dietary Fats; Rats; Starvation; Triglycerides | 1978 |
Effect of age and dietary fat level on fatty acid oxidation in the neonatal pig.
Topics: Aging; Animals; Animals, Newborn; Butter; Carnitine; Cesarean Section; Dietary Fats; Fatty Acids; Fe | 1978 |
On the possibility of carnitine binding within the brown adipose tissue cell.
Topics: Adipose Tissue, Brown; Aging; Animals; Binding Sites; Carnitine; Chromatography, Thin Layer; Female; | 1978 |
The decreases with age in the activities of enzymes of human skeletal muscle. Some observations on palmityl-carnitine formation, hexokinase activity, and lactate dehydrogenase activity.
Topics: Adolescent; Adult; Aging; Carnitine; Diabetes Mellitus; Female; Hexokinase; Humans; L-Lactate Dehydr | 1978 |
Maternal-fetal carnitine relationship and neonatal ketosis in the rat.
Topics: Acidosis; Aging; Animals; Animals, Newborn; Body Weight; Carnitine; Fasting; Female; Fetus; Ketone B | 1976 |
[Relationship between the systems of activation of fatty acids and ademine nucleotide translocase in the mitochondria].
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aging; Animals; Biological Transport; Carnitine; Coen | 1976 |
Carnitine palymityltransferase in neonatal and adult heart and liver mitochondria. Effect of phospholipase C treatment.
Topics: Acyltransferases; Aging; Animals; Animals, Newborn; Carnitine; Cytochrome Reductases; Kinetics; Live | 1975 |
The role of carnitine in brown adipose tissue of suckling rats.
Topics: Adipose Tissue, Brown; Aging; Amniotic Fluid; Animals; Carnitine; Fatty Acids, Nonesterified; Female | 1975 |
The action of propionyl-L-carnitine on the vasal endothelium: increased t-PA synthesis and a decrease in the activity of PAI-1. A preliminary study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Cardiotonic Agents; Carnitine; Endothelium, Vascu | 1992 |
The measurement of carnitine and acyl-carnitines: application to the investigation of patients with suspected inherited disorders of mitochondrial fatty acid oxidation.
Topics: Aging; Carnitine; Child, Preschool; Fasting; Fatty Acids; Fatty Acids, Nonesterified; Genetic Diseas | 1992 |
Proto-oncogene c-jun and c-fos messenger RNAs increase in the liver of carnitine-deficient juvenile visceral steatosis (jvs) mice.
Topics: Aging; alpha-Fetoproteins; Animals; Animals, Newborn; Carnitine; Fructose-Bisphosphate Aldolase; Gen | 1992 |
Enterohepatic distribution of carnitine in developing piglets: relation to glucagon and insulin.
Topics: Aging; Animals; Animals, Newborn; Carnitine; Glucagon; Insulin; Jejunum; Liver; Milk; Radioimmunoass | 1992 |
Plasma carnitine in fasting neonatal and adult northern elephant seals.
Topics: Acylation; Aging; Analysis of Variance; Animals; Animals, Newborn; Animals, Suckling; Carnitine; Fas | 1992 |
Peroxidative stress effects on calpain activity in brain of young and adult rats.
Topics: Aging; Animals; Brain; Calpain; Carnitine; Cathepsin D; Cyclohexanones; Rats; Rats, Sprague-Dawley; | 1992 |
Carnitine administration to juvenile visceral steatosis mice corrects the suppressed expression of urea cycle enzymes by normalizing their transcription.
Topics: Aging; Animals; Argininosuccinate Synthase; Blotting, Northern; Body Weight; Carbamoyl-Phosphate Syn | 1992 |
Animal model of systemic carnitine deficiency: analysis in C3H-H-2 degrees strain of mouse associated with juvenile visceral steatosis.
Topics: Aging; Animals; Carnitine; Disease Models, Animal; Fatty Liver; Lipid Metabolism; Liver; Mice; Mice, | 1991 |
Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Blotting, Northern; Brain; Carnitine; DNA; Electron Transport Compl | 1990 |
Measurement of L-carnitine and acylcarnitines in body fluids and tissues in children and in adults.
Topics: Acetylcarnitine; Adult; Aging; Carnitine; Carnitine O-Acetyltransferase; Child; Female; Humans; Live | 1990 |
Age-dependent deficits in radial maze performance in the rat: effect of chronic treatment with acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Exploratory Behavior; Learning; Male; Rats; Rats, Inbred | 1990 |
Levels of carnitines in brain and other tissues of rats of different ages: effect of acetyl-L-carnitine administration.
Topics: Age Factors; Aging; Animals; Brain Chemistry; Carnitine; Liver; Male; Muscles; Myocardium; Rats; Rat | 1990 |
Effect of aging and acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Cholesterol; Erythrocytes; Lipids; Phospholipids; Plasma | 1990 |
Differential effect of acetyl-l-carnitine on open field behavior in young and old rats.
Topics: Acetylcarnitine; Aging; Animals; Arousal; Brain; Carnitine; Emotions; Male; Motor Activity; Rats; Ra | 1990 |
Immunological parameters in aging: studies on natural immunomodulatory and immunoprotective substances.
Topics: Acetylcarnitine; Adult; Aged; Aged, 80 and over; Aging; Carnitine; Female; Free Radicals; Hemaggluti | 1990 |
Plasma carnitine concentration and lipid metabolism in infants receiving parenteral nutrition.
Topics: Aging; Carnitine; Fatty Acids, Nonesterified; Humans; Infant; Infant, Newborn; Lipid Metabolism; Mal | 1989 |
Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions.
Topics: Acetylcarnitine; Acetylcholinesterase; Aging; Animals; Brain; Carnitine; Choline; Choline O-Acetyltr | 1989 |
L-acetylcarnitine attenuates the age-dependent decrease of NMDA-sensitive glutamate receptors in rat hippocampus.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors | 1989 |
Age-related changes of the mossy fibre system in rat hippocampus: effect of long term acetyl-L-carnitine treatment.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Hippocampus; Histocytochemistry; Male; Rats; Rats, Inbre | 1989 |
Age-dependent decrease of carnitine content in muscle of mice and humans.
Topics: Acetylcarnitine; Acylation; Adult; Aged; Aging; Animals; Brain; Carnitine; Carnitine O-Acetyltransfe | 1989 |
Long-term acetyl-L-carnitine preserves spatial learning in the senescent rat.
Topics: Acetylcarnitine; Aging; Animals; Avoidance Learning; Carnitine; Male; Rats; Rats, Inbred Strains; Sw | 1989 |
Acetyl-L-carnitine reduces the age-dependent loss of glucocorticoid receptors in the rat hippocampus: an autoradiographic study.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Corticosterone; Female; Hippocampus; Rats; Rats, Inbred | 1989 |
Nerve growth factor binding in aged rat central nervous system: effect of acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Brain; Carnitine; Male; Nerve Growth Factors; Rats; Rats, Inbred St | 1988 |
Metabolism of coronary vasculature in senescent rats--a histochemical study.
Topics: Adenosine Triphosphatases; Aging; Animals; Carnitine; Coronary Vessels; Female; Histocytochemistry; | 1987 |
Age-related change in ketone body metabolism: diminished glucagon effect on ketogenesis in adult rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aging; Animals; Carnitine; Cyclic AMP; Diabetes Mellitus, Expe | 1987 |
gamma-Butyrobetaine hydroxylase activity is not rate limiting for carnitine biosynthesis in the human infant.
Topics: Adolescent; Adult; Aged; Aging; Betaine; Carnitine; Child, Preschool; Female; gamma-Butyrobetaine Di | 1987 |
[Effect of vitamin B12 on carnitine synthesis in the body of rats].
Topics: Aging; Animals; Carnitine; Liver; Male; Methylation; Rats; Vitamin B 12 | 1988 |
Action of L-acetylcarnitine on age-dependent modifications of mitochondrial membrane proteins from rat cerebellum.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Cerebellum; Male; Membrane Proteins; Mitochondria; Rats; | 1988 |
Effects of acetyl-L-carnitine on the brain lipofuscin content and emotional behavior in aged rats.
Topics: Acetylcarnitine; Aging; Animals; Behavior, Animal; Body Weight; Brain; Carnitine; Histocytochemistry | 1988 |
Effect of long-term treatment with acetyl-L-carnitine on structural changes of ageing rat brain.
Topics: Acetylcarnitine; Aging; Animals; Brain; Carnitine; Cerebellar Cortex; Cerebral Cortex; Female; Hippo | 1988 |
Pathological brain ageing: evaluation of the efficacy of a pharmacological aid.
Topics: Acetylcarnitine; Aged; Aging; Carnitine; Female; Humans; Male; Middle Aged; Neurocognitive Disorders | 1988 |
Effect of acetyl-l-carnitine chronic treatment on discrimination models in aged rats.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Discrimination Learning; Female; Rats; Rats, Inbred Stra | 1988 |
Effects of L-acetylcarnitine treatment and its interruption on dentate gyrus synapses in ageing rat hippocampus.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Hippocampus; Microscopy, Electron; Rats; Synapses | 1988 |
Development of intestinal carnitine transport in rats.
Topics: Aging; Analysis of Variance; Animals; Animals, Suckling; Biological Transport; Carnitine; Humans; In | 1988 |
Ultrastructural aspects of ageing rat hippocampus and effects of L-acetyl-carnitine treatment.
Topics: Acetylcarnitine; Aging; Animals; Axons; Carnitine; Hippocampus; Microscopy, Electron; Rats; Synapses | 1987 |
Interaction of L-carnitine with DPN-diaphorase in the myocardium of the aged rat.
Topics: Aging; Animals; Carnitine; Electrocardiography; Heart; Male; Myocardium; NADH, NADPH Oxidoreductases | 1986 |
Impaired ketogenesis in iron-deficient rat pups.
Topics: Aging; Animals; Animals, Suckling; Carnitine; Female; Ferrous Compounds; Iron Deficiencies; Ketone B | 1986 |
Effect of hypothyroidism during gestation and in the suckling period on cholesterol and carnitine metabolism in the rat.
Topics: Aging; Animals; Carnitine; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Female; Fetus; Hydroxymethy | 1986 |
Action of L-acetylcarnitine on different cerebral mitochondrial populations from hippocampus.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Female; Hippocampus; In Vitro Techniques; Mitochondria; | 1986 |
Carnitine concentration of red blood cells.
Topics: Aging; Animals; Carnitine; Erythrocytes; Female; Humans; Male; Plasma; Rats; Rats, Inbred Strains; S | 1985 |
Studies on spermatogenesis in rats. II. Evidence that carnitine acetyltransferase is a marker enzyme for the investigation of germ cell differentiation.
Topics: Acyltransferases; Aging; Animals; Carnitine; Cell Differentiation; Cell Fractionation; Centrifugatio | 1971 |
Regulation of mitochondrial respiration in senescence.
Topics: Aging; Animals; Ascorbic Acid; Carnitine; Cell Fractionation; Coenzyme A; Cytochrome c Group; Glutam | 1972 |
Alterations of fatty acid metabolism in liver cells of hyperlipaemic old rats.
Topics: Acetates; Aging; Animals; Carbon Isotopes; Carnitine; Coenzyme A; Cytoplasm; Fatty Acids; Fatty Acid | 1972 |
In vitro fatty acid oxidation in liver and heart from neonatal swine (Sus domesticus).
Topics: Aging; Animals; Animals, Newborn; Carbon Dioxide; Carbon Isotopes; Carnitine; Fatty Acids; Female; H | 1973 |
Studies on the development of carnitine palmitoyltransferase and fatty acid oxidation in liver mitochondria of neonatal pigs.
Topics: Acyltransferases; Aging; Animals; Animals, Newborn; Carbon Radioisotopes; Carnitine; Coenzyme A; Fas | 1973 |
Carnitine (free carnitine).
Topics: Age Factors; Aging; Aorta; Arteries; Arteriosclerosis; Carnitine; Humans; Iliac Artery; Iliac Vein; | 1974 |
Concentration of carnitine in human muscle tissue.
Topics: Acetyltransferases; Age Factors; Aged; Aging; Carbon Radioisotopes; Carnitine; Child; Cholelithiasis | 1974 |
Fatty acid oxidation in embryonic chick tissues.
Topics: Acyltransferases; Adenosine Triphosphate; Age Factors; Aging; Alcohol Oxidoreductases; Animals; Capr | 1971 |
Cellular energy metabolism during fetal development. 3. Deficient acetyl-CoA synthetase, acetylcarnitine transferase and oxidation of acetate in the fetal bovine heart.
Topics: Acetates; Acyltransferases; Aging; Animals; Carnitine; Cattle; Coenzyme A | 1970 |
Hepatic ketogenesis during development.
Topics: Acetates; Acyltransferases; Aging; Animals; Animals, Newborn; Caprylates; Carnitine; Coenzyme A; Cyt | 1971 |