Page last updated: 2024-10-24

carmustine and Pulmonary Fibrosis

carmustine has been researched along with Pulmonary Fibrosis in 52 studies

Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.

Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.

Research Excerpts

ExcerptRelevanceReference
"Delayed pulmonary toxicity syndrome, characterized by interstitial pneumonia and pulmonary fibrosis, is common following high-dose bischloroethylnitrosourea (BCNU) (carmustine, [1,3-bis (2-chloroethyl)-1-nitrosourea]) containing chemotherapeutic regimens."3.72Interferon-gamma for delayed pulmonary toxicity syndrome resistant to steroids. ( Brown, KK; Cool, CD; Jones, RB; Lynch, DA; Suratt, BT, 2003)
"Previously, we have reported in 1990 that 35% of carmustine treated patients (6 of 17) who survived childhood brain tumors died of pulmonary fibrosis between 2 and 13 years after treatment."3.69Late carmustine lung fibrosis. Age at treatment may influence severity and survival. ( Gattamaneni, HR; Kalra, S; O'Driscoll, BR; Woodcock, AA, 1995)
"Carmustine (BCNU) is a cytotoxic drug which is a recognized cause of acute pulmonary fibrosis."3.68Chronic lung fibrosis following carmustine (BCNU) chemotherapy: radiological features. ( Gattamaneni, HR; O'Driscoll, BR; Taylor, PM; Woodcock, AA, 1991)
"We describe eight patients who developed interstitial pulmonary fibrosis following BCNU (carmustine) therapy for cerebral tumours."3.68Late BCNU lung: a light and ultrastructural study on the delayed effect of BCNU on the lung parenchyma. ( Gattamaneini, HR; Hasleton, PS; Kalra, SJ; Lynch, P; O'Driscoll, BR; Poulter, LW; Webster, A; Woodcock, AA, 1991)
"Carmustine (BCNU) is an anticancer drug known to produce pulmonary fibrosis as a side effect within three years of treatment."3.68Active lung fibrosis up to 17 years after chemotherapy with carmustine (BCNU) in childhood. ( Gattameneni, HR; Hasleton, PS; O'Driscoll, BR; Poulter, LW; Taylor, PM; Woodcock, AA, 1990)
"A patient who had a pneumonectomy for lung carcinoma was treated with carmustine when brain metastases developed."3.66Pulmonary toxicity from carmustine (BCNU): a case report. ( Shah, S; Shane, SR; Weiss, RB, 1979)
"A 43-year-old man with metastatic malignant melanoma was treated with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in combination with imidazole carboxamide and hydroxyurea."3.65Pulmonary fibrosis after prolonged therapy with 1,3-bis (2-chloroethyl)-1-nitrosourea. ( Crittenden, D; Haut, A; Tranum, BL, 1977)
"No fatal complications or chronic pulmonary fibrosis was seen."2.68Pulmonary toxicity of high-dose chemotherapy for breast cancer: a non-invasive approach to diagnosis and treatment. ( Chap, L; Glaspy, J; Levine, M; Lill, M; Norton, L; Shpiner, R, 1997)
"Pulmonary fibrosis is the end point of progressive functional disorder of respiratory mechanism and alveolo-capillary gas exchanges."2.66Nitrosourea derivatives-induced pulmonary toxicity in patients treated for malignant brain tumors. Early subclinical detection and its prevention. ( Butti, G; Gaetani, P; Knerich, R; Rossi, A; Silvani, V; Spanu, G, 1987)
"Diffuse pulmonary diseases seen in patients receiving chemotherapy have a wide variety of etiologies including infection, involvement with the underlying disease, injury from radiation or diagnostic agents, and toxicity from chemotherapeutic drugs."2.36Review: diagnosis of chemotherapy lung. ( Gamsu, G; Putman, CE; Sostman, HD, 1981)
" Additionally, medical records of 163 patients treated with BCNU for recurrent glioma WHO grade II to IV were retrospectively evaluated for BCNU-related side effects classified according to the National Cancer Institute Common Toxicity Criteria for Adverse Events (CTCAE) version 2."1.43Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients. ( Ahmadi, R; Bermejo, JL; Capper, D; Chatziaslanidou, D; Exner, J; Herold-Mende, C; Jungk, C; Unterberg, A; von Deimling, A, 2016)
"Bilateral upper lobe pulmonary fibrosis can be associated with chemotherapeutic drugs."1.32Upper lobe pulmonary fibrosis associated with high-dose chemotherapy containing BCNU for bone marrow transplantation. ( Leslie, KO; Muhm, JR; Parish, JM, 2003)
"In conclusion, pulmonary fibrosis can develop early and progress rapidly after the administration of high-dose BCNU."1.32Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2. ( Chen, CL; Chiu, CF; Chow, KC; Liaw, YC; Shen, YC; Yeh, SP, 2004)
" The side effect of pulmonary fibrosis occurs in 20 to 30 percent of patients receiving this drug."1.29Carmustine toxicity presenting as a lobar infiltrate. ( Byron, WA; Lee, TH; Patterson, DL; Wiemann, MC, 1993)
" The 30-day LD50 for BCNU in male and female BALB/c mice was 52 and 46 mg/kg, respectively."1.27Enhanced oxygen toxicity following treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea. ( Kehrer, JP; Paraidathathu, T, 1984)
"She developed progressive, pulmonary fibrosis as a consequence of chemotherapy, which lead to her death."1.27Chemotherapy-induced fatal pulmonary fibrosis. ( Révész, T; Somló, P, 1984)
"Two patients treated for chronic myeloid leukemia with high doses of CCNU (1100 mg/m2 and 1240 mg/m2, respectively) developed a fatal pulmonary fibrosis."1.27Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia. ( Bernaudin, JF; Cordonnier, C; Lange, F; Mital, P; Rochant, H; Vernant, JP, 1983)
"The occurrence of pulmonary disease associated with long-term BCNU therapy is reported in two patients treated for astrocytoma grade II whose clinical presentations of pulmonary complications and corresponding tissue alterations showed striking differences."1.27BCNU (1,3-bis-(2-chloroethyl)-1-nitrosurea) lung. Drug-induced pulmonary changes. ( Banerji, B; Greenwald, ES; Koss, LG; Mitsudo, SM, 1984)
"All animals developed pulmonary fibrosis accompanied by formation of peribronchial and peribronchiolar foci of granulomatous tissue."1.27Sequential pathological changes induced in rats with the anti-cancer drug I, 3-bis (2-chloroethyl)-I-nitrosourea (BCNU). ( Boyd, MR; Gregg, M; Schuller, HM; Smith, AC, 1985)
"It is concluded that BCNU causes pulmonary fibrosis that is primarily but not necessarily dose-related and may not be reversible."1.261,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced pulmonary fibrosis. ( Bellot, P; Cohen, M; Fisher, ER; Jacobs, SA; Moore, PB; Selker, RG; Wald, M, 1980)
" The patient received a cumulative dosage of 1."1.26Pulmonary fibrosis: a complication of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy. ( Ryan, BR; Walters, TR, 1981)
"Both patients developed pulmonary fibrosis, which was visible in postmortem examination."1.26Pulmonary fibrosis following low-dose 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) therapy. ( Melato, M; Tuveri, G, 1980)
"Ten patients developed pulmonary fibrosis after bischloroethylnitrosourea (BCNU) therapy for malignancy."1.26Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU). ( Bartolucci, AA; Durant, JR; Langford, KH; Murad, TM; Norgard, MJ, 1979)
"A case of interstitial pulmonary fibrosis secondary to bischloronitrosourea (BCNU) in a 49-year-old man with carcinoma of the pancreas is reported."1.26Pulmonary toxicity of bischloronitrosourea: report of a case with transient response to corticosteroid therapy. ( Dalton, JF; Hastedt, R; Marshall, D; Raymond, LW; Richter, JE, 1979)
"A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy."1.26Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy. ( Bailey, CC; Jones, PH; Marsden, HB, 1978)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-199036 (69.23)18.7374
1990's10 (19.23)18.2507
2000's5 (9.62)29.6817
2010's1 (1.92)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jungk, C1
Chatziaslanidou, D1
Ahmadi, R1
Capper, D1
Bermejo, JL1
Exner, J1
von Deimling, A1
Herold-Mende, C1
Unterberg, A1
Helal, GK1
Helal, OK1
Parish, JM1
Muhm, JR1
Leslie, KO1
Suratt, BT1
Lynch, DA1
Cool, CD1
Jones, RB1
Brown, KK1
Shen, YC1
Chiu, CF1
Chow, KC1
Chen, CL1
Liaw, YC1
Yeh, SP1
Lohani, S1
O'Driscoll, BR5
Woodcock, AA5
Sostman, HD1
Putman, CE1
Gamsu, G1
Ginsberg, SJ1
Comis, RL1
Cohen, MH1
Matthews, MJ1
Weiss, RB3
Poster, DS1
Penta, JS1
Kehrer, JP2
Paraidathathu, T1
Somló, P2
Révész, T2
Cordonnier, C1
Vernant, JP1
Mital, P1
Lange, F1
Bernaudin, JF1
Rochant, H1
Mitsudo, SM1
Greenwald, ES1
Banerji, B1
Koss, LG1
Wilson, KS1
Brigden, ML1
Alexander, S1
Worth, A1
Selker, RG1
Jacobs, SA1
Moore, PB1
Wald, M1
Fisher, ER1
Cohen, M1
Bellot, P1
Klein, RC1
Paddison, RM1
Bardella, D1
Beccati, D1
Cruciani, G1
Ryan, BR1
Walters, TR1
Melato, M1
Tuveri, G1
Patten, GA1
Billi, JE1
Rotman, HH1
Kalra, S1
Gattamaneni, HR2
Patterson, DL1
Wiemann, MC1
Lee, TH1
Byron, WA1
Schmitz, N1
Diehl, V1
Chap, L1
Shpiner, R1
Levine, M1
Norton, L1
Lill, M1
Glaspy, J1
Bargon, G2
Anger, B2
Schreml, W2
Kubanek, W1
Heimpel, H2
Durant, JR1
Norgard, MJ1
Murad, TM1
Bartolucci, AA1
Langford, KH1
Richter, JE1
Hastedt, R1
Dalton, JF1
Marshall, D1
Raymond, LW1
Kaplan, RL1
Muggia, FM1
Stillerman, R1
Sweet, DL1
Shah, S1
Shane, SR1
Barker, M1
Deen, DF1
Baker, DG1
Kubanek, B1
Bailey, CC1
Marsden, HB1
Jones, PH1
Crittenden, D1
Tranum, BL1
Haut, A1
Holoye, PY1
Jenkins, DE1
Greenberg, SD1
Massin, F1
Coudert, B1
Foucher, P1
Lombard, JN1
Reybet-Degat, O1
Jeannin, L1
Camus, P1
Twohig, KJ1
Matthay, RA1
Taylor, PM2
Hasleton, PS2
Lynch, P1
Webster, A1
Kalra, SJ1
Gattamaneini, HR1
Poulter, LW2
Gattameneni, HR1
Limper, AH1
McDonald, JA1
White, JP1
Ward, MJ1
Gaetani, P1
Silvani, V1
Butti, G1
Spanu, G1
Rossi, A1
Knerich, R1
Phillips, GL1
Reece, DE1
Lee, YC1
Vetter, N1
Berger, E1
Otupal, I1
Jürgenssen, OA1
Schuller, HM1
Smith, AC1
Gregg, M1
Boyd, MR1

Reviews

5 reviews available for carmustine and Pulmonary Fibrosis

ArticleYear
Review: diagnosis of chemotherapy lung.
    AJR. American journal of roentgenology, 1981, Volume: 136, Issue:1

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Busulfan; Carmustine; Cy

1981
[Nitrosourea-induced lung diseases].
    Revue des maladies respiratoires, 1992, Volume: 9, Issue:6

    Topics: Adult; Brain Neoplasms; Carmustine; Child; Drug Therapy, Combination; Female; Humans; Iatrogenic Dis

1992
Pulmonary effects of cytotoxic agents other than bleomycin.
    Clinics in chest medicine, 1990, Volume: 11, Issue:1

    Topics: Antineoplastic Agents; Bleomycin; Busulfan; Carmustine; Cyclophosphamide; Humans; Lomustine; Methotr

1990
Drug-induced adverse pulmonary reactions.
    Adverse drug reactions and acute poisoning reviews, 1985,Winter, Volume: 4, Issue:4

    Topics: Amiodarone; Asthma; Bleomycin; Carmustine; Drug-Related Side Effects and Adverse Reactions; Gold; Hu

1985
Clinical studies of autologous bone marrow transplantation in Hodgkin's disease.
    Clinics in haematology, 1986, Volume: 15, Issue:1

    Topics: Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marro

1986

Trials

2 trials available for carmustine and Pulmonary Fibrosis

ArticleYear
Pulmonary toxicity of high-dose chemotherapy for breast cancer: a non-invasive approach to diagnosis and treatment.
    Bone marrow transplantation, 1997, Volume: 20, Issue:12

    Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; C

1997
Nitrosourea derivatives-induced pulmonary toxicity in patients treated for malignant brain tumors. Early subclinical detection and its prevention.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:3

    Topics: Adult; Aged; Ambroxol; Brain Neoplasms; Bromhexine; Carmustine; Clinical Trials as Topic; Double-Bli

1987

Other Studies

45 other studies available for carmustine and Pulmonary Fibrosis

ArticleYear
Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients.
    BMC cancer, 2016, Feb-10, Volume: 16

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carmustine; Combined Modality Therapy; Disease-Free Surv

2016
Metallothionein attenuates carmustine-induced oxidative stress and protects against pulmonary fibrosis in rats.
    Archives of toxicology, 2009, Volume: 83, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Collagen; Glutathione; Glutathione Reductase

2009
Upper lobe pulmonary fibrosis associated with high-dose chemotherapy containing BCNU for bone marrow transplantation.
    Mayo Clinic proceedings, 2003, Volume: 78, Issue:5

    Topics: Antineoplastic Agents, Alkylating; Bone Marrow Transplantation; Breast Neoplasms; Carmustine; Drug A

2003
Interferon-gamma for delayed pulmonary toxicity syndrome resistant to steroids.
    Bone marrow transplantation, 2003, Volume: 31, Issue:10

    Topics: Adrenal Cortex Hormones; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Pro

2003
Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2.
    Bone marrow transplantation, 2004, Volume: 34, Issue:7

    Topics: Adult; Antineoplastic Agents, Alkylating; Carmustine; Cyclooxygenase 2; Fatal Outcome; Female; Human

2004
25-year study of lung fibrosis following carmustine therapy for brain tumor in childhood.
    Chest, 2004, Volume: 126, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Child; Disease Pr

2004
The pulmonary toxicity of antineoplastic agents.
    Seminars in oncology, 1982, Volume: 9, Issue:1

    Topics: Age Factors; Aged; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bleomycin; Busul

1982
Chemotherapy-induced pulmonary toxicity in mice bearing L1210 leukemia.
    Oncology, 1983, Volume: 40, Issue:2

    Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Doxorubicin; Leukemia L1210; Lung Dise

1983
The nitrosoureas and pulmonary toxicity.
    Cancer treatment reviews, 1981, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Aged; Animals; Antineoplastic Agents; Carmustine; Child; Child, Preschool; Dogs;

1981
Enhanced oxygen toxicity following treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:5

    Topics: Animals; Carmustine; Glutathione; Glutathione Reductase; Lethal Dose 50; Lung; Mice; Mice, Inbred BA

1984
Chemotherapy-induced fatal pulmonary fibrosis.
    Neoplasma, 1984, Volume: 31, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Child, Preschool; Epend

1984
Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.
    Cancer, 1983, May-15, Volume: 51, Issue:10

    Topics: Adult; Carmustine; Female; Humans; Leukemia, Myeloid; Lomustine; Male; Nitrosourea Compounds; Pulmon

1983
[Fatal pulmonary fibrosis induced by cytotoxic therapy].
    Orvosi hetilap, 1984, May-06, Volume: 125, Issue:19

    Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Child; Child, Preschool; Ependymoma; Female; Hum

1984
BCNU (1,3-bis-(2-chloroethyl)-1-nitrosurea) lung. Drug-induced pulmonary changes.
    Cancer, 1984, Aug-15, Volume: 54, Issue:4

    Topics: Adult; Astrocytoma; Brain Neoplasms; Carmustine; Humans; Lung; Lung Diseases; Male; Pulmonary Fibros

1984
Fatal pneumothorax in "BCNU lung".
    Medical and pediatric oncology, 1982, Volume: 10, Issue:2

    Topics: Adult; Astrocytoma; Brain Neoplasms; Carmustine; Female; Frontal Lobe; Humans; Parietal Lobe; Pneumo

1982
1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced pulmonary fibrosis.
    Neurosurgery, 1980, Volume: 7, Issue:6

    Topics: Adolescent; Adult; Aged; Biopsy; Brain Neoplasms; Carmustine; Female; Glioma; Humans; Lung; Male; Mi

1980
Failure of corticosteroids to prevent carmustine-induced pulmonary fibrosis in a woman with astrocytoma.
    Archives of neurology, 1981, Volume: 38, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Astrocytoma; Brain Neoplasms; Carmustine; Female; Frontal Lobe; Huma

1981
[Interstitial pulmonary fibrosis following treatment with bis-chloronitrosourea].
    Tumori, 1981, Feb-28, Volume: 67, Issue:1

    Topics: Carmustine; Humans; Male; Middle Aged; Pulmonary Fibrosis

1981
Pulmonary fibrosis: a complication of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.
    Cancer, 1981, Aug-15, Volume: 48, Issue:4

    Topics: Brain Neoplasms; Carmustine; Child, Preschool; Humans; Medulloblastoma; Pulmonary Fibrosis; Risk

1981
Pulmonary fibrosis following low-dose 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) therapy.
    Cancer, 1980, Mar-15, Volume: 45, Issue:6

    Topics: Aged; Carmustine; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Melanoma; Middle Aged

1980
Rapidly progressive, fatal pulmonary fibrosis induced by carmustine.
    JAMA, 1980, Aug-15, Volume: 244, Issue:7

    Topics: Astrocytoma; Brain Neoplasms; Carmustine; Female; Humans; Lung; Middle Aged; Postoperative Care; Pul

1980
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 41-1980.
    The New England journal of medicine, 1980, Oct-16, Volume: 303, Issue:16

    Topics: Astrocytoma; Carmustine; Cerebellar Neoplasms; Child, Preschool; Diagnosis, Differential; Female; Hu

1980
Late carmustine lung fibrosis. Age at treatment may influence severity and survival.
    Chest, 1995, Volume: 107, Issue:5

    Topics: Adolescent; Age Factors; Brain Neoplasms; Carmustine; Child; Child, Preschool; Follow-Up Studies; Hu

1995
Carmustine toxicity presenting as a lobar infiltrate.
    Chest, 1993, Volume: 104, Issue:1

    Topics: Adult; Brain Neoplasms; Carmustine; Female; Glioma; Humans; Pulmonary Fibrosis; Vital Capacity

1993
Carmustine and the lungs .
    Lancet (London, England), 1997, Jun-14, Volume: 349, Issue:9067

    Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Child; Female; Hodgkin Disease; Huma

1997
[Progressive pulmonary fibrosis due to combined treatment with BCNU, cyclophosphospahmide and cytosin-arabinoside (author's transl)].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1978, Volume: 129, Issue:3

    Topics: Carmustine; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Female; Humans; Middle Aged; Pu

1978
Pulmonary toxicity associated with bischloroethylnitrosourea (BCNU).
    Annals of internal medicine, 1979, Volume: 90, Issue:2

    Topics: Adolescent; Adult; Aged; Carmustine; Cough; Dyspnea; Female; Humans; Hypoxia; Lymphoma; Male; Middle

1979
Pulmonary toxicity of bischloronitrosourea: report of a case with transient response to corticosteroid therapy.
    Cancer, 1979, Volume: 43, Issue:5

    Topics: Carmustine; Humans; Male; Middle Aged; Pancreatic Neoplasms; Prednisone; Pulmonary Fibrosis; Radiogr

1979
Pulmonary effects of carmustine (bischloroethylnitrosourea, BCNU)
    Annals of internal medicine, 1979, Volume: 91, Issue:1

    Topics: Carmustine; Humans; Pulmonary Fibrosis

1979
Pulmonary effects of carmustine (bischloroethylnitrosourea, BCNU)
    Annals of internal medicine, 1979, Volume: 91, Issue:1

    Topics: Carmustine; Humans; Pulmonary Fibrosis

1979
Pulmonary effects of carmustine (bischloroethylnitrosourea, BCNU)
    Annals of internal medicine, 1979, Volume: 91, Issue:1

    Topics: Antineoplastic Agents; Carmustine; Drug Therapy, Combination; Humans; Pulmonary Fibrosis

1979
Pulmonary effects of carmustine (bischloroethylnitrosourea, BCNU)
    Annals of internal medicine, 1979, Volume: 91, Issue:1

    Topics: Antineoplastic Agents; Carmustine; Drug Therapy, Combination; Humans; Pulmonary Fibrosis

1979
Pulmonary toxicity from carmustine (BCNU): a case report.
    Medical and pediatric oncology, 1979, Volume: 6, Issue:3

    Topics: Autopsy; Brain Neoplasms; Carmustine; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Neoplasm Meta

1979
BCNU and X-ray therapy of intracerebral 9L rat tumors.
    International journal of radiation oncology, biology, physics, 1979, Volume: 5, Issue:9

    Topics: Animals; Brain Neoplasms; Carmustine; Male; Neoplasms, Experimental; Pulmonary Fibrosis; Radiation I

1979
[Progressive pulmonary fibrosis during combination chemotherapy with BCNU (author's transl)].
    Blut, 1978, Jun-20, Volume: 36, Issue:6

    Topics: Acute Disease; Carmustine; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Female; Humans;

1978
Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.
    Cancer, 1978, Volume: 42, Issue:1

    Topics: Carmustine; Cerebellar Neoplasms; Female; Humans; Infant; Medulloblastoma; Pneumonia, Pneumococcal;

1978
Pulmonary fibrosis after prolonged therapy with 1,3-bis (2-chloroethyl)-1-nitrosourea.
    Chest, 1977, Volume: 72, Issue:3

    Topics: Adult; Carmustine; Drug Therapy, Combination; Humans; Hydroxyurea; Imidazoles; Male; Melanoma; Pulmo

1977
Pulmonary toxicity in long-term administration of BCNU.
    Cancer treatment reports, 1976, Volume: 60, Issue:11

    Topics: Adult; Brain Neoplasms; Carmustine; Humans; Male; Pulmonary Fibrosis

1976
Chronic lung fibrosis following carmustine (BCNU) chemotherapy: radiological features.
    Clinical radiology, 1991, Volume: 44, Issue:5

    Topics: Carmustine; Central Nervous System Neoplasms; Child; Humans; Pulmonary Fibrosis; Time Factors; Tomog

1991
Late BCNU lung: a light and ultrastructural study on the delayed effect of BCNU on the lung parenchyma.
    The Journal of pathology, 1991, Volume: 164, Issue:1

    Topics: Astrocytoma; Biopsy; Brain Neoplasms; Carmustine; Ependymoma; Humans; Lung; Medulloblastoma; Microsc

1991
Active lung fibrosis up to 17 years after chemotherapy with carmustine (BCNU) in childhood.
    The New England journal of medicine, 1990, Aug-09, Volume: 323, Issue:6

    Topics: Acute Disease; Adolescent; Brain Neoplasms; Carmustine; Child; Female; Humans; Lung; Male; Pulmonary

1990
Delayed pulmonary fibrosis after nitrosourea therapy.
    The New England journal of medicine, 1990, Aug-09, Volume: 323, Issue:6

    Topics: Carmustine; Humans; Pulmonary Fibrosis; Time Factors

1990
Pulmonary hydroxyproline content and production following treatment of mice with O,S,S-trimethyl phosphorodithioate.
    Toxicology letters, 1987, Volume: 38, Issue:3

    Topics: Animals; Carmustine; Hydroxyproline; Lung; Male; Mice; Mice, Inbred BALB C; Organothiophosphates; Or

1987
[Recurrent bilateral pneumothorax in progressive lung fibrosis following combination therapy with BCNU].
    Praxis und Klinik der Pneumologie, 1985, Volume: 39, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cerebellar Neoplasms; Humans; Mal

1985
Sequential pathological changes induced in rats with the anti-cancer drug I, 3-bis (2-chloroethyl)-I-nitrosourea (BCNU).
    Experimental lung research, 1985, Volume: 9, Issue:3-4

    Topics: Animals; Blood Vessels; Bronchi; Carmustine; Collagen; Cytoplasm; Endoplasmic Reticulum; Endothelium

1985