carmustine has been researched along with Pregnancy in 33 studies
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebral metastases were the sole or major cause of death in 8/9 patients who relapsed following control with DTIC for nine months or longer, and one patient developed a carcinoma of the breast following therapy with DTIC and BCNU." | 2.64 | Chemotherapy of malignant melanoma with dimethyl traizeno imidazole carboxamide (DITC) and nitrosourea derivatives (BCNU, CCNU). ( Berris, R; Hill, GJ; Parkin, P; Philpott, GW; Ruess, R, 1974) |
| "It has been concluded that cortical dysplasia induced by intrauterine BCNU administration results in delayed hippocampal maturation, which is successfully restored by intrauterine melatonin treatment." | 1.36 | Investigation of maternal melatonin effect on the hippocampal formation of newborn rat model of intrauterine cortical dysplasia. ( Ateş, U; Baka, M; Kültürsay, N; Uyanikgil, Y, 2010) |
| "The experimental model of cortical dysplasia (CD) obtained by administering carmustine (1-3-bis-chloroethyl-nitrosurea [BCNU]) in pregnant rat uterus mimics the histopathological abnormalities observed in human CD patients: altered cortical layering, and presence of heterotopia and dysmorphic/heterotopic neurons." | 1.35 | Expression of layer-specific markers in the adult neocortex of BCNU-Treated rat, a model of cortical dysplasia. ( Frassoni, C; Inverardi, F; Moroni, RF; Regondi, MC; Spreafico, R; Watakabe, A; Yamamori, T, 2009) |
| "Cytogenetic analysis showed complex chromosomal abnormalities including 11q23 rearrangement, which is frequently found in topoisomerase II inhibitor-related hematologic malignancies." | 1.31 | A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma. ( Bahng, HS; Jang, GD; Jeong, YH; Ji, HS; Kim, EK; Kim, SH; Kim, SW; Kim, WK; Lee, JS; Park, CJ; Park, IG; Suh, CW; Suh, EJ, 2002) |
| "Procarbazine and BCNU were given for 5 months before conception and throughout the first and second trimesters, and streptozotocin was given throughout the third trimester." | 1.27 | Successful pregnancy following continuous treatment with combination chemotherapy before conception and throughout pregnancy. ( Chudley, AE; Schapira, DV, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (33.33) | 18.7374 |
| 1990's | 5 (15.15) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 7 (21.21) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moroni, RF | 5 |
| Inverardi, F | 5 |
| Regondi, MC | 5 |
| Pennacchio, P | 3 |
| Spreafico, R | 3 |
| Frassoni, C | 5 |
| Burnette, BL | 1 |
| Jentoft, MA | 1 |
| Porrata, LF | 1 |
| Boyce, TG | 1 |
| Witzig, TE | 1 |
| González-González, MA | 1 |
| Ostos-Valverde, A | 1 |
| Becerra-Hernández, A | 1 |
| Sánchez-Castillo, H | 1 |
| Martínez-Torres, A | 1 |
| Noé, F | 1 |
| Gnatkovsky, V | 1 |
| Zucca, I | 2 |
| de Curtis, M | 1 |
| Watakabe, A | 1 |
| Yamamori, T | 1 |
| Blumenfeld, Z | 2 |
| Zuckerman, T | 2 |
| Baka, M | 2 |
| Uyanikgil, Y | 2 |
| Ateş, U | 2 |
| Kültürsay, N | 1 |
| Chikhladze, M | 1 |
| Donzelli, A | 1 |
| Corradini, I | 1 |
| Braida, D | 1 |
| Sala, M | 1 |
| Franceschetti, S | 1 |
| Jang, GD | 1 |
| Kim, SW | 1 |
| Suh, CW | 1 |
| Kim, EK | 1 |
| Bahng, HS | 1 |
| Jeong, YH | 1 |
| Park, IG | 1 |
| Kim, WK | 1 |
| Kim, SH | 1 |
| Suh, EJ | 1 |
| Park, CJ | 1 |
| Ji, HS | 1 |
| Lee, JS | 1 |
| Benardete, EA | 1 |
| Kriegstein, AR | 1 |
| Haddad, JJ | 1 |
| Safieh-Garabedian, B | 1 |
| Saadé, NE | 1 |
| Lauterbach, R | 1 |
| Ducray, F | 1 |
| Colin, P | 1 |
| Cartalat-Carel, S | 1 |
| Pelissou-Guyotat, I | 1 |
| Mahla, K | 1 |
| Audra, P | 1 |
| Gaucherand, P | 1 |
| Honnorat, J | 1 |
| Trouillas, P | 1 |
| Benaroush, M | 1 |
| Turgut, M | 1 |
| Yavaşoğlu, A | 1 |
| Ulker, S | 1 |
| Sözmen, EY | 1 |
| Sezer, E | 1 |
| Elmas, C | 1 |
| Yurtseven, ME | 1 |
| Li, RH | 1 |
| Tam, WH | 1 |
| Ng, PC | 1 |
| Mok, TS | 1 |
| Tam, B | 1 |
| Lau, TK | 1 |
| Long, LL | 1 |
| Xiao, B | 1 |
| Song, YM | 1 |
| Wang, K | 1 |
| Panzica, F | 1 |
| Schapira, DV | 1 |
| Chudley, AE | 1 |
| Applebaum, FR | 1 |
| Meyers, JD | 1 |
| Fefer, A | 1 |
| Fluornoy, N | 1 |
| Cheever, MA | 1 |
| Greenberg, PD | 1 |
| Hackman, R | 1 |
| Thomas, ED | 1 |
| Sariban, E | 1 |
| Erickson, LC | 1 |
| Kohn, KW | 1 |
| Fiebig, HH | 1 |
| Strobel, H | 1 |
| Schmähl, D | 1 |
| Chatterjee, R | 2 |
| Mills, W | 1 |
| Katz, M | 1 |
| McGarrigle, HH | 1 |
| Goldstone, AH | 2 |
| Brice, P | 1 |
| Pautier, P | 1 |
| Marolleau, JP | 1 |
| Castaigne, S | 1 |
| Gisselbrecht, C | 1 |
| Salooja, N | 1 |
| McMillan, AK | 1 |
| Kelsey, SM | 1 |
| Newland, AC | 1 |
| Milligan, DW | 1 |
| Franklin, IM | 1 |
| Hutchinson, RM | 1 |
| Linch, DC | 1 |
| Bierman, PJ | 1 |
| Bagin, RG | 1 |
| Jagannath, S | 1 |
| Vose, JM | 1 |
| Spitzer, G | 1 |
| Kessinger, A | 1 |
| Dicke, KA | 1 |
| Armitage, JO | 1 |
| Ehling, UH | 1 |
| Adler, ID | 1 |
| Favor, J | 1 |
| Neuhäuser-Klaus, A | 1 |
| Wong, M | 1 |
| Wells, PG | 1 |
| Szczech, J | 2 |
| Godlewski, A | 2 |
| Thompson, DJ | 1 |
| Molello, JA | 1 |
| Strebing, RJ | 1 |
| Dyke, IL | 1 |
| Robinson, VB | 1 |
| Hill, GJ | 1 |
| Ruess, R | 1 |
| Berris, R | 1 |
| Philpott, GW | 1 |
| Parkin, P | 1 |
| Weiss, Ede C | 1 |
| Cravioto, H | 1 |
| Weiss, JF | 1 |
| Ransohoff, J | 1 |
1 trial available for carmustine and Pregnancy
| Article | Year |
|---|---|
Chemotherapy of malignant melanoma with dimethyl traizeno imidazole carboxamide (DITC) and nitrosourea derivatives (BCNU, CCNU).
Topics: Adult; Amides; Antineoplastic Agents; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Cyclohe | 1974 |
32 other studies available for carmustine and Pregnancy
| Article | Year |
|---|---|
Genesis of heterotopia in BCNU model of cortical dysplasia, detected by means of in utero electroporation.
Topics: Animals; Axons; Carmustine; Cell Differentiation; Cell Movement; Disease Models, Animal; Electropora | 2013 |
Single-agent rituximab for primary CNS lymphoma during pregnancy as a bridge to definitive management.
Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Biops | 2014 |
The effect of carmustine on Bergmann cells of the cerebellum.
Topics: Alkylating Agents; Animals; Carmustine; Cerebellum; Female; Malformations of Cortical Development; M | 2015 |
Increased pCREB expression and the spontaneous epileptiform activity in a BCNU-treated rat model of cortical dysplasia.
Topics: Age Factors; Animals; Antineoplastic Agents, Alkylating; Brain; Calbindins; Carmustine; CREB-Binding | 2015 |
Expression of layer-specific markers in the adult neocortex of BCNU-Treated rat, a model of cortical dysplasia.
Topics: Animals; Carmustine; Disease Models, Animal; DNA-Binding Proteins; Female; Gene Expression Regulatio | 2009 |
Repeated spontaneous pregnancies and successful deliveries after repeated autologous stem cell transplantation and GnRH-agonist treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Cyclophosph | 2010 |
Investigation of maternal melatonin effect on the hippocampal formation of newborn rat model of intrauterine cortical dysplasia.
Topics: Animals; Animals, Newborn; Antineoplastic Agents, Alkylating; Carmustine; Female; Glial Fibrillary A | 2010 |
Cytoarchitectural, behavioural and neurophysiological dysfunctions in the BCNU-treated rat model of cortical dysplasia.
Topics: Animals; Carmustine; Cognition; Disease Models, Animal; Entorhinal Cortex; Excitatory Postsynaptic P | 2013 |
A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma.
Topics: Adult; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocy | 2002 |
Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex.
Topics: Animals; Bicuculline; Carmustine; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Ele | 2002 |
Inhibition of glutathione-related enzymes augments LPS-mediated cytokine biosynthesis: involvement of an IkappaB/NF-kappaB-sensitive pathway in the alveolar epithelium.
Topics: Animals; Antimetabolites; Blotting, Western; Buthionine Sulfoximine; Carmustine; Cytokines; Electrop | 2002 |
[Management of malignant gliomas diagnosed during pregnancy].
Topics: Abortion, Therapeutic; Adrenal Cortex Hormones; Adult; Algorithms; Anesthesia, General; Antineoplast | 2006 |
Spontaneous pregnancy and normal delivery after repeated autologous bone marrow transplantation and GnRH agonist treatment.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carm | 2007 |
Neuroprotective effects of melatonin upon the offspring cerebellar cortex in the rat model of BCNU-induced cortical dysplasia.
Topics: Animals; Animals, Newborn; Brain Diseases; Bromodeoxyuridine; Carmustine; Cerebellar Cortex; Disease | 2007 |
Microphthalmos associated with Dartmouth combination chemotherapy in pregnancy: a case report.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cisplatin; Dacarbazine; Female; H | 2007 |
[Changes of expression of cation-chloride cotransporter genes in hippocampus of cortical dysplasia: experiment with rat].
Topics: Animals; Animals, Newborn; Carmustine; Chlorides; Female; Gene Expression; Hippocampus; Ion Transpor | 2007 |
Altered spatial distribution of PV-cortical cells and dysmorphic neurons in the somatosensory cortex of BCNU-treated rat model of cortical dysplasia.
Topics: Animals; Animals, Newborn; Antibodies; Calbindins; Carmustine; Classical Lissencephalies and Subcort | 2008 |
Successful pregnancy following continuous treatment with combination chemotherapy before conception and throughout pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Fema | 1984 |
Nonbacterial nonfungal pneumonia following marrow transplantation in 100 identical twins.
Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Transplantation; Carmustine; Child; Cyclophosphamide; Cy | 1982 |
Effects of carbamoylation on cell survival and DNA repair in normal human embryo cells (IMR-90) treated with various 1-(2-chloroethyl)-1-nitrosoureas.
Topics: Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; DNA Replication; Ethylnitrosourea; Female; Hu | 1984 |
Bischloroethyl nitrosourea (BCNU).
Topics: Abnormalities, Drug-Induced; Animals; Carcinogens; Carmustine; Chemical Phenomena; Chemistry; Drug I | 1981 |
Experimental chemotherapy with N'N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) in autochthonous neurogenic tumors of the rat transplacentally induced by ethylnitrosourea.
Topics: Animals; Carmustine; Disease Models, Animal; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchang | 1982 |
Induction of ovarian function by using short-term human menopausal gonadotrophin in patients with ovarian failure following cytotoxic chemotherapy for haematological malignancy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplantation; Carmu | 1993 |
Pregnancy after autologous bone marrow transplantation for malignant lymphomas.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Cyt | 1994 |
Successful pregnancies in women following single autotransplant for acute myeloid leukemia with a chemotherapy ablation protocol.
Topics: Abortion, Induced; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantatio | 1994 |
High dose chemotherapy followed by autologous hematopoietic rescue in Hodgkin's disease: long-term follow-up in 128 patients.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carm | 1993 |
Induction of specific-locus and dominant lethal mutations in male mice by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU).
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Female; Genes, Dominant; Genes, Lethal; Lomu | 1997 |
Modulation of embryonic glutathione reductase and phenytoin teratogenicity by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
Topics: Animals; Carmustine; Cleft Palate; Drug Interactions; Embryo, Mammalian; Female; Fetal Resorption; G | 1989 |
Effect of BCNU given to pregnant female rats on neuroglia morphology and histochemistry in the progeny.
Topics: Age Factors; Animals; Brain; Carmustine; Enzyme Activation; Female; Karyometry; Neuroglia; Pregnancy | 1985 |
Effect of BCNU, administered to pregnant female rats, on morphology and histochemistry of brain neurocytes in the progeny.
Topics: Animals; Brain; Carmustine; Cytophotometry; DNA; Female; Karyometry; Male; Maternal-Fetal Exchange; | 1985 |
Reproduction and teratology studies with oncolytic agents in the rat and rabbit. I. I,3-bis(2-chloroethyl)-i-nitrosourea (BCNU).
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Animals, Newborn; Birth Weight; Body Wei | 1974 |
Brief communication: Pathologic effects in rats surviving prenatal and neonatal administration of 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Animals; Animals, Newborn; Carcinogens; Carmustine; Female; Liver; Maternal-Fetal Exchange; Neoplasm | 1973 |