carmustine has been researched along with Pancreatic Neoplasms in 25 studies
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a prospective, multi-centre, randomized study of 109 patients with metastatic gastro-intestinal adenocarcinomas the response rate, survival time and side-effects of two drug combinations, carmustin +5-fluorouracil and carmustin + ftorafur, were compared (same carmustin dosage in both groups)." | 5.04 | [A prospective multi-centre study of the response of metastatic gastrointestinal tumours (author's transl)]. ( Arnold, H; Drings, P; Geldmacher, J; Hartwich, G; Kredel, L; Mayer, M; Neidhardt, B; Queisser, W; Rösch, W; Schaefer, J; von Oldershausen, HF; Wahrendorf, J, 1979) |
| "A case of interstitial pulmonary fibrosis secondary to bischloronitrosourea (BCNU) in a 49-year-old man with carcinoma of the pancreas is reported." | 1.26 | Pulmonary toxicity of bischloronitrosourea: report of a case with transient response to corticosteroid therapy. ( Dalton, JF; Hastedt, R; Marshall, D; Raymond, LW; Richter, JE, 1979) |
| "The therapy of cancer of the colon still remains unsatisfactory: the rate of remissions could be increased, but survival remains unaltered." | 1.26 | [Current state of therapy for gastrointestinal tumors]. ( Hartmann, D; Obrecht, JP, 1978) |
| "Although advanced gastrointestinal cancer is the most commonplace problem encountered by the medical oncologist, this group of diseases has proved exceedingly resistant to past chemotherapy efforts." | 1.25 | Clinical management of advanced gastrointestinal cancer. ( Moertel, CG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (92.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kokkinakis, DM | 2 |
| Ahmed, MM | 2 |
| Chendil, D | 1 |
| Moschel, RC | 1 |
| Pegg, AE | 1 |
| Hartwich, G | 2 |
| Klapdor, R | 1 |
| Andersen, JR | 1 |
| Friis-Möller, A | 1 |
| Hancke, S | 1 |
| Röder, O | 1 |
| Steen, J | 1 |
| Baden, H | 1 |
| Joss, R | 1 |
| Goldhirsch, A | 1 |
| Tschopp, L | 1 |
| Brunner, K | 1 |
| Delgado, R | 1 |
| Fruitwala, MM | 1 |
| Mohiuddin, M | 1 |
| Albores-Saavedra, J | 1 |
| Macdonald, JS | 1 |
| Widerlite, L | 1 |
| Schein, PS | 2 |
| Moertel, CG | 5 |
| Queisser, W | 1 |
| Schaefer, J | 1 |
| Arnold, H | 1 |
| Drings, P | 1 |
| Geldmacher, J | 1 |
| Kredel, L | 1 |
| Mayer, M | 1 |
| Neidhardt, B | 1 |
| von Oldershausen, HF | 1 |
| Rösch, W | 1 |
| Wahrendorf, J | 1 |
| Hall, SW | 1 |
| Benjamin, RS | 1 |
| Murphy, WK | 1 |
| Valdivieso, M | 1 |
| Bodey, GP | 1 |
| Richter, JE | 1 |
| Hastedt, R | 1 |
| Dalton, JF | 1 |
| Marshall, D | 1 |
| Raymond, LW | 1 |
| Stephens, RL | 1 |
| Hoogstraten, B | 1 |
| Haas, C | 1 |
| Clark, G | 1 |
| Hartmann, D | 1 |
| Obrecht, JP | 1 |
| Hill, GJ | 1 |
| Johnson, RO | 1 |
| Metter, G | 1 |
| Wilson, WL | 1 |
| Davis, HL | 1 |
| Grage, T | 1 |
| Fletcher, WS | 1 |
| Golomb, FM | 1 |
| Cruz, AB | 1 |
| Yunis, AA | 1 |
| Arimura, GK | 1 |
| Russin, DJ | 1 |
| Jochimsen, PR | 1 |
| Pearlman, NW | 1 |
| Lawton, RL | 1 |
| Carter, SK | 1 |
| Comis, RL | 1 |
| Lokich, JJ | 1 |
| Brooks, JR | 1 |
| O'Connell, MJ | 1 |
| Blom, J | 1 |
| Hubbard, S | 1 |
| Magrath, IT | 1 |
| Bergevin, P | 1 |
| Wiernik, PH | 1 |
| Ziegler, JL | 1 |
| DeVita, VT | 1 |
| Reitemeier, RJ | 2 |
| Schutt, AJ | 2 |
| Hahn, RG | 2 |
| Lewis, MB | 1 |
| Nunes, LB | 1 |
| Powell, DE | 1 |
| Shnider, BI | 1 |
| Kovach, JS | 1 |
| Lokich, J | 1 |
| Chawla, PL | 1 |
| Brooks, J | 1 |
| Frei, E | 1 |
2 reviews available for carmustine and Pancreatic Neoplasms
| Article | Year |
|---|---|
[Results of considerations on the chemotherapy of pancreatic neoplasms].
Topics: Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Humans | 1980 |
The integration of chemotherapy into a combined modality approach for cancer treatment. VI. Pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carmustine; Drug Therapy, Combination; Female; F | 1975 |
4 trials available for carmustine and Pancreatic Neoplasms
| Article | Year |
|---|---|
A controlled trial of combination chemotherapy with 5-FU and BCNU in pancreatic cancer.
Topics: Adult; Aged; Carmustine; Clinical Trials as Topic; Drug Combinations; Female; Fluorouracil; Humans; | 1981 |
[A prospective multi-centre study of the response of metastatic gastrointestinal tumours (author's transl)].
Topics: Adenocarcinoma; Carmustine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Intestinal Neoplasms; | 1979 |
Pancreatic cancer treated with carmustine, fluorouracil, and spironolactone: a randomized study.
Topics: Adult; Carmustine; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Neopl | 1978 |
Clinical antitumor activity and toxicity of streptozotocin (NSC-85998).
Topics: Adenoma, Islet Cell; Blood Cells; Burkitt Lymphoma; Carcinoid Tumor; Carmustine; Clinical Trials as | 1974 |
19 other studies available for carmustine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
Topics: Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Dacarba | 2003 |
[Chemotherapy of pancreatic cancer is not yet generally recommended].
Topics: Antineoplastic Agents; Carmustine; Cyclophosphamide; Doxorubicin; Drug Evaluation; Drug Therapy, Com | 1980 |
[Gastrointestinal tumors. Prognostic factors and chemotherapy of today].
Topics: Carmustine; Colonic Neoplasms; Doxorubicin; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans | 1981 |
Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents, Alkylating; Apoptosis; Carmustine; Cell Survival | 1997 |
Current diagnosis and management of pancreatic carcinoma.
Topics: alpha-Fetoproteins; Antigens, Neoplasm; Biopsy; Carmustine; Cholangiography; Drug Therapy, Combinati | 1976 |
Clinical management of advanced gastrointestinal cancer.
Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Carmustine; Colonic Neoplasms; Cytarabine; Drug Ther | 1975 |
Walter Hubert lecture Chemotherapy of upper gastrointestinal carcinoma.
Topics: Adenoma, Islet Cell; Antineoplastic Agents; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, S | 1976 |
Adriamycin, BCNU, ftorafur chemotherapy of pancreatic and biliary tract cancer.
Topics: Adult; Aged; Biliary Tract Neoplasms; Bone Marrow; Carmustine; Doxorubicin; Drug Therapy, Combinatio | 1979 |
Pulmonary toxicity of bischloronitrosourea: report of a case with transient response to corticosteroid therapy.
Topics: Carmustine; Humans; Male; Middle Aged; Pancreatic Neoplasms; Prednisone; Pulmonary Fibrosis; Radiogr | 1979 |
[Current state of therapy for gastrointestinal tumors].
Topics: Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Gastrointestinal Neoplasms; | 1978 |
Multimodal surgical adjuvant therapy for a broad spectrum of tumors in humans.?
Topics: Adult; Altretamine; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Carmustine; Colonic Neo | 1976 |
Human pancreatic carcinoma (MIA PaCa-2) in continuous culture: sensitivity to asparaginase.
Topics: Aged; Aneuploidy; Asparaginase; Carmustine; Cell Division; Cell Line; Cells, Cultured; Cytarabine; F | 1977 |
Gastrointestinal cancer. Treatment with fluorouracil-nitrosourea combinations.
Topics: Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neo | 1976 |
Pancreatic carcinoma as a sequel to therapy of lymphoma.
Topics: Adenocarcinoma; Adolescent; Adult; Antineoplastic Agents; Carmustine; Cyclophosphamide; Female; Hodg | 1976 |
Disappearance of disseminated pancreatic carcinoma with combined chemotherapy.
Topics: Adult; Carcinoma, Intraductal, Noninfiltrating; Carmustine; Duodenum; Fluorouracil; Gastrectomy; Hum | 1973 |
Treatment of the patient with adenocarcinoma of unknown origin.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Autopsy; Carmustine; Female; Fluorouracil; Human | 1972 |
Extra-axial spread of medulloblastoma.
Topics: Autopsy; Brain Neoplasms; Carmustine; Cranial Fossa, Posterior; Femoral Neoplasms; Humans; Liver Neo | 1973 |
Proceedings: A controlled study of combined 1,3-bis-(2-chloroethyl)-1-nitrosourea and 5-fluorouracil therapy for advanced gastric and pancreatic cancer.
Topics: Adenocarcinoma; Carmustine; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leukopenia; Mal | 1974 |
Chemotherapy in pancreatic carcinoma: 5 fluorouracil (5FU) and 1,3 bis-(2 chloretjyl)-1-nitrosourea (BCNU).
Topics: Adenocarcinoma; Adult; Aged; Biopsy; Carmustine; Drug Therapy, Combination; Evaluation Studies as To | 1974 |