Page last updated: 2024-10-24

carmustine and Mucositis

carmustine has been researched along with Mucositis in 11 studies

Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.

Mucositis: An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).

Research Excerpts

ExcerptRelevanceReference
" The median VAS scores of all patients were above 4 (moderate to severe pain) before the administration of transdermal fentanyl."7.74[Transdermal fentanyl in treating severe painful mucositis caused by autologous hematopoietic stem cell transplantation]. ( Bu, Q; Cai, QQ; Gao, Y; Huang, HQ; Lin, XB; Peng, YL; Wang, BF, 2007)
"With the eventual goal of reducing relapse and thus improving overall survival in selected lymphoma patients, a Phase I study was performed using the cytoprotectant amifostine to permit safe dose-augmentation of melphalan in the carmustine (BCNU), etoposide, cytarabine (arabinosylcytosine), and melphalan (BEAM) regimen before autologous hematopoietic stem cell transplantation."5.15A Phase I trial: dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection. ( Abboud, CN; Becker, MW; Bernstein, SH; Constine, LS; Friedberg, JW; Ifthikharuddin, JJ; Liesveld, JL; Loughner, JE; Milner, LA; Phillips, GL; Vesole, DH, 2011)
" The median VAS scores of all patients were above 4 (moderate to severe pain) before the administration of transdermal fentanyl."3.74[Transdermal fentanyl in treating severe painful mucositis caused by autologous hematopoietic stem cell transplantation]. ( Bu, Q; Cai, QQ; Gao, Y; Huang, HQ; Lin, XB; Peng, YL; Wang, BF, 2007)
"Etoposide has also been tested in a wide range of combination regimens, but for many of these combinations, relatively few patients are included, and some combinations have only been tested in patients who have undergone autologous transplants."2.48High-dose etoposide in allogeneic stem cell transplantation. ( Ahmed, AB; Bruserud, O; Hatfield, KJ; Kittang, AO; Reikvam, H; Sjo, M; Tvedt, TH, 2012)
"Melphalan dose was used as surrogate for the entire regimen."1.35Effect of the dose per body weight of conditioning chemotherapy on severity of mucositis and risk of relapse after autologous haematopoietic stem cell transplantation in relapsed diffuse large B cell lymphoma. ( Ansell, SM; Costa, LJ; Inwards, DJ; Johnston, PB; Litzow, MR; Micallef, IN; Porrata, LF, 2008)
"Patients with hematologic or solid tumors who underwent conditioning regimen were asked to score mucositis severity daily from the first day to the tenth day of reinfusion."1.35Self-reported experience of mucositis in cancer patients who underwent conditioning regimen and stem cell transplantation. ( Arpaci, F; Ataergin, S; Kilic, S; Komurcu, S; Kuzhan, O; Ozet, A; Ozturk, B; Ozturk, M, 2009)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's4 (36.36)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
Ahern, K1
Pham, J1
Sanderson, R1
Correia De Farias, M1
Walsh, K1
AlJohani, NI1
Nasani, M1
Ahmed, HE1
Ur Rehman, J1
Nawaz, A1
Alzahrani, Z1
Albeirouti, B1
Mikesch, JH1
Kuhlmann, M1
Demant, A1
Krug, U1
Thoennissen, GB1
Schmidt, E1
Kessler, T1
Schliemann, C1
Pohlen, M1
Mohr, M1
Evers, G1
Köhler, G1
Wessling, J1
Mesters, R1
Müller-Tidow, C1
Berdel, WE1
Thoennissen, NH1
Herbers, AH1
van der Velden, WJ1
de Haan, AF1
Donnelly, JP1
Blijlevens, NM1
Tsirigotis, P1
Triantafyllou, K1
Girkas, K1
Giannopoulou, V1
Ioannidou, E1
Chondropoulos, S1
Kalli, T1
Papaxoinis, G1
Pappa, V1
Papageorgiou, E1
Economopoulos, T1
Ladas, SD1
Dervenoulas, J1
Costa, LJ1
Micallef, IN1
Inwards, DJ1
Johnston, PB1
Porrata, LF1
Litzow, MR1
Ansell, SM1
Ozturk, M1
Komurcu, S1
Kilic, S1
Ozet, A1
Arpaci, F1
Ozturk, B1
Kuzhan, O1
Ataergin, S1
Phillips, GL1
Bernstein, SH1
Liesveld, JL1
Abboud, CN1
Becker, MW1
Constine, LS1
Ifthikharuddin, JJ1
Loughner, JE1
Milner, LA1
Vesole, DH1
Friedberg, JW1
Bruserud, O1
Reikvam, H1
Kittang, AO1
Ahmed, AB1
Tvedt, TH1
Sjo, M1
Hatfield, KJ1
Su, L1
Xu, J1
Ji, BX1
Wan, SG1
Lu, CY1
Dong, HQ1
Yu, YY1
Lu, DP1
Huang, HQ1
Cai, QQ1
Lin, XB1
Wang, BF1
Bu, Q1
Gao, Y1
Peng, YL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intensive Conditioning Regimen With Thiotepa Combined With Busulfan, Fludarabine and Cytarabine for Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of Myeloid Malignancies With Extramedullary Involvement[NCT06111612]50 participants (Anticipated)Observational2024-01-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for carmustine and Mucositis

ArticleYear
High-dose etoposide in allogeneic stem cell transplantation.
    Cancer chemotherapy and pharmacology, 2012, Volume: 70, Issue:6

    Topics: Adenine Nucleotides; Anthracyclines; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chem

2012

Trials

1 trial available for carmustine and Mucositis

ArticleYear
A Phase I trial: dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2011, Volume: 17, Issue:7

    Topics: Adult; Aged; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Atrial Fibrillation; Carmus

2011

Other Studies

9 other studies available for carmustine and Mucositis

ArticleYear
The nutritional impact of CD19-targeted CAR-T therapy versus BEAM chemotherapy for adult patients with lymphoma.
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2023, Volume: 36, Issue:5

    Topics: Adult; Antigens, CD19; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Human

2023
Dose-adjusted bendamustine as a replacement for carmustine in autologous stem cell transplant conditioning for patients with relapsed lymphoma: A retrospective single-center study.
    Hematology/oncology and stem cell therapy, 2021, Volume: 14, Issue:4

    Topics: Bendamustine Hydrochloride; Cardiotoxicity; Carmustine; Hematopoietic Stem Cell Transplantation; Hum

2021
DexaBEAM versus ICE salvage regimen prior to autologous transplantation for relapsed or refractory aggressive peripheral T cell lymphoma: a retrospective evaluation of parallel patient cohorts of one center.
    Annals of hematology, 2013, Volume: 92, Issue:8

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carmustine; Co

2013
Impact of palifermin on intestinal mucositis of HSCT recipients after BEAM.
    Bone marrow transplantation, 2014, Volume: 49, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; C-Reactive Prot

2014
Keratinocyte growth factor is effective in the prevention of intestinal mucositis in patients with hematological malignancies treated with high-dose chemotherapy and autologous hematopoietic SCT: a video-capsule endoscopy study.
    Bone marrow transplantation, 2008, Volume: 42, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capsule Endoscopy; Carmustine; Cytarabi

2008
Effect of the dose per body weight of conditioning chemotherapy on severity of mucositis and risk of relapse after autologous haematopoietic stem cell transplantation in relapsed diffuse large B cell lymphoma.
    British journal of haematology, 2008, Volume: 143, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carmustine; Chi-Square Dis

2008
Self-reported experience of mucositis in cancer patients who underwent conditioning regimen and stem cell transplantation.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2009, Volume: 17, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carmustine; Cy

2009
Autologous peripheral blood stem cell transplantation for severe multiple sclerosis.
    International journal of hematology, 2006, Volume: 84, Issue:3

    Topics: Adult; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Diarr

2006
[Transdermal fentanyl in treating severe painful mucositis caused by autologous hematopoietic stem cell transplantation].
    Ai zheng = Aizheng = Chinese journal of cancer, 2007, Volume: 26, Issue:4

    Topics: Administration, Cutaneous; Adolescent; Adult; Analgesics, Opioid; Antineoplastic Combined Chemothera

2007