carmustine has been researched along with Leukoencephalopathy, Progressive Multifocal in 3 studies
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Leukoencephalopathy, Progressive Multifocal: An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventy-nine patients with malignant gliomas (19 anaplastic astrocytomas and 60 glioblastoma multiforme) received 4 cycles of infra-ophthalmic carotid injection of 160 mg carmustine, 2 mg vincristine IV and procarbazine orally 50 mg 3 times daily for 1 week, followed by whole-brain irradiation, with a midpoint dose of 54 Gy/6 weeks." | 5.07 | Combined intra-arterial chemotherapy and irradiation of malignant gliomas. ( Hager, B; Hirschberg, H; Nome, O; Watne, K, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Re, D | 1 |
| Bamborschke, S | 1 |
| Feiden, W | 1 |
| Schröder, R | 1 |
| Lehrke, R | 1 |
| Diehl, V | 1 |
| Tesch, H | 1 |
| Watne, K | 1 |
| Nome, O | 1 |
| Hager, B | 1 |
| Hirschberg, H | 1 |
| Kleinschmidt-DeMasters, BK | 1 |
1 review available for carmustine and Leukoencephalopathy, Progressive Multifocal
| Article | Year |
|---|---|
Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Combined Mo | 1999 |
1 trial available for carmustine and Leukoencephalopathy, Progressive Multifocal
| Article | Year |
|---|---|
Combined intra-arterial chemotherapy and irradiation of malignant gliomas.
Topics: Adolescent; Adult; Astrocytoma; Brain Neoplasms; Carmustine; Combined Modality Therapy; Eye Diseases | 1991 |
1 other study available for carmustine and Leukoencephalopathy, Progressive Multifocal
| Article | Year |
|---|---|
Intracarotid BCNU leukoencephalopathy.
Topics: Astrocytoma; Autopsy; Brain; Brain Neoplasms; Carmustine; Carotid Artery, Internal; Humans; Infusion | 1986 |