carmustine has been researched along with Leukemia L 1210 in 122 studies
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic usefulness of chlorpromazine (CPZ) and caffeine (CAF) in combination with selected nitrosoureas was investigated in mice bearing L1210 leukemia, Lewis lung carcinoma, and B16 melanoma." | 3.66 | Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors. ( Dykes, DJ; Laster, WR; Rose, WC; Schabel, FM; Trader, MW, 1978) |
| " The half-life of BCNU in cells was approximately 40 min." | 1.31 | In vitro pharmacokinetics and pharmacodynamics of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). ( Gwilt, PR; Lawson, TA; Ueda-Kawamitsu, H, 2002) |
| " Pharmacokinetic studies indicated a rapid clearance of L-histidinol following a bolus dose (250 mg/kg i." | 1.28 | L-histidinol: preclinical therapeutic studies in combination with antitumor agents and pharmacokinetic studies in mice. ( Dykes, D; Malspeis, L; Plowman, J; Waud, W; Zaharko, D, 1992) |
| "Carmethizole activity was similar to that of melphalan across the murine solid tumor panel, which consisted of B16 melanoma; colon adenocarcinomas 11a, 26, and 36; and the KHT sarcoma." | 1.28 | In vivo and in vitro evaluation of the alkylating agent carmethizole. ( Anderson, WK; Elliott, WL; Fry, DW; Hawkins, PA; Hook, KE; Leopold, WR; Nelson, JM, 1991) |
| " At an optimum dosage level of 40 mg/kg, 7 and 8 produced 90% and 60% "cures" (greater than 60-day survivors), respectively." | 1.27 | Antineoplastic activity of 3'-(chloroethyl)nitrosourea analogues of 2'-deoxyuridine and 2'-deoxy-5-fluorouridine. ( Brubaker, WF; Lin, TS; Park, S; Prusoff, WH; Wang, ZH, 1986) |
| "The methylnitrosoureas 3a and 3b were not significantly cytotoxic to H." | 1.27 | Nitrosoureido nucleosides as potential inhibitors of nucleotide biosynthesis. ( Adamson, DJ; Brockman, RW; Elliott, RD; Montgomery, JA; Riordan, JM; Shaddix, SC; Thomas, HJ, 1988) |
| "Vitamin A, whether combined with various cytotoxic drugs or not, did not show, when different experimental schedules were used, an anti-tumour effect on various murine tumours." | 1.27 | Vitamin A: failure to demonstrate in mice an anti-tumour effect, whether combined with cytotoxic drugs or not. ( Bresson, ML; Cattan, A, 1986) |
| " This synergism produced an improved therapeutic index in a dose-response study and in a comparison between antileukemic effects and effects on white blood cell nadirs." | 1.26 | Synergistic antileukemic effect of theophylline and 1,3-bis(2-chloroethyl)-1-nitrosourea. ( Bathina, SH; DeWys, WD, 1980) |
| "This paper represents a method for determining optimal dose levels in a drug combination by analyzing the dose-response surfaces estimated from experimental data." | 1.26 | Combination chemotherapy: arriving at optimal treatment levels by incorporating side effect constraints. ( Carter, WH; Wampler, GL; Williams, VR, 1978) |
| "Certain psychotropic drugs when combined with caffeine significantly enhanced the antitumor effect of 1,3-bis(2-chloroethyl)-1-nitrosourea in murine leukemia L1210." | 1.25 | Enhancement of the antitumor effect of 1,3-bis(2-chloroethyl)-1-nitrosourea by various psychotropic drugs in combination with caffeine. ( Cohen, MH, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 102 (83.61) | 18.7374 |
| 1990's | 14 (11.48) | 18.2507 |
| 2000's | 6 (4.92) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Suami, T | 1 |
| Tadano, K | 1 |
| Bradner, WT | 1 |
| Lin, TS | 3 |
| Fischer, PH | 1 |
| Shiau, GT | 1 |
| Prusoff, WH | 5 |
| Johnston, TP | 3 |
| McCaleb, GS | 2 |
| Clayton, SD | 1 |
| Frye, JL | 1 |
| Krauth, CA | 1 |
| Montgomery, JA | 4 |
| Mayo, JG | 1 |
| Laster, WR | 5 |
| Roger, P | 1 |
| Monneret, C | 2 |
| Fournier, JP | 1 |
| Choay, P | 1 |
| Gagnet, R | 1 |
| Gosse, C | 1 |
| Letourneux, Y | 1 |
| Atassi, G | 4 |
| Gouyette, A | 3 |
| Brubaker, WF | 1 |
| Wang, ZH | 1 |
| Park, S | 1 |
| Weinkam, RJ | 1 |
| Dolan, ME | 1 |
| Crider, AM | 1 |
| Kolczynski, TM | 1 |
| Yates, KM | 1 |
| Hansch, C | 1 |
| Leo, A | 1 |
| Schmidt, C | 1 |
| Jow, PY | 1 |
| Rice, KP | 1 |
| Penketh, PG | 2 |
| Shyam, K | 2 |
| Sartorelli, AC | 2 |
| Maurer, HR | 1 |
| Meckert, C | 1 |
| Ali-Osman, F | 1 |
| Musil, J | 1 |
| Berger, NA | 1 |
| Catino, DM | 1 |
| Vietti, TJ | 1 |
| DeWys, WD | 1 |
| Bathina, SH | 1 |
| Cohen, MH | 6 |
| Matthews, MJ | 1 |
| Cavanaugh, PF | 1 |
| Pavelic, ZP | 1 |
| Porter, CW | 1 |
| Kann, HE | 4 |
| Schott, MA | 1 |
| Petkas, A | 1 |
| Macdonald, JS | 1 |
| Hoth, D | 1 |
| Schein, PS | 6 |
| Wheeler, GP | 2 |
| Alexander, JA | 1 |
| Adamson, DJ | 2 |
| Kukushkina, GV | 5 |
| Peretolchina, NM | 1 |
| Minenkova, EA | 1 |
| Verovskiĭ, VN | 1 |
| Sof'ina, ZP | 1 |
| Guadagni, F | 1 |
| Roselli, M | 1 |
| Fuggetta, MP | 1 |
| Perno, CF | 1 |
| Goldin, A | 10 |
| Giuliani, A | 1 |
| Umeda, Y | 1 |
| Sakamoto, A | 1 |
| Nakamura, J | 1 |
| Ishitsuka, H | 1 |
| Yagi, Y | 1 |
| Oguro, M | 1 |
| Yanagawa, T | 1 |
| Takenaga, K | 1 |
| Verloes, R | 2 |
| Mulcahy, RT | 1 |
| Siemann, DW | 1 |
| Dumont, P | 2 |
| Tagnon, HJ | 1 |
| Nicolin, A | 4 |
| Canti, G | 1 |
| Marelli, O | 1 |
| Veronese, F | 1 |
| Contessa, AR | 1 |
| Bonmassar, A | 1 |
| Giampietri, A | 1 |
| Circolo, A | 1 |
| Fioretti, MC | 3 |
| Brandt, AE | 1 |
| Martin, AD | 1 |
| Beer, RW | 1 |
| Bosanquet, AG | 1 |
| Gilby, ED | 1 |
| Gibson, NW | 1 |
| Hickman, JA | 1 |
| Ritter, C | 2 |
| Iyengar, CL | 1 |
| Rutman, RJ | 3 |
| Roberts, D | 1 |
| Peck, C | 1 |
| Hilliard, S | 1 |
| Karas, JG | 1 |
| Riccardi, C | 1 |
| Bartocci, A | 1 |
| Puccetti, P | 2 |
| Spreafico, F | 1 |
| Bonmassar, E | 3 |
| Kanarek, L | 1 |
| Ribrag, V | 1 |
| Massaad, L | 1 |
| Janot, F | 1 |
| Bissery, MC | 1 |
| Parise, O | 1 |
| Chabot, GG | 1 |
| Takenaga, M | 1 |
| Igarashi, R | 1 |
| Tsuji, H | 1 |
| Mizushima, Y | 1 |
| Institoris, E | 2 |
| Tretter, L | 1 |
| Gaál, D | 1 |
| Lawson, T | 1 |
| Gwilt, PR | 2 |
| Chen, FX | 1 |
| Zhang, Y | 1 |
| Church, KM | 1 |
| Bodell, WJ | 1 |
| Gold, B | 1 |
| Steele, TA | 2 |
| Cox, DC | 5 |
| Barret, JM | 1 |
| Etiévant, C | 1 |
| Fahy, J | 1 |
| Lhomme, J | 2 |
| Hill, BT | 1 |
| Rissé, S | 1 |
| Ardouin, P | 1 |
| Williams, DA | 1 |
| Maze, R | 1 |
| Kurpad, C | 1 |
| Pegg, A | 1 |
| Erickson, LC | 1 |
| Finch, RA | 1 |
| Alarcon, K | 1 |
| Demeunynck, M | 1 |
| Carrez, D | 1 |
| Croisy, A | 1 |
| Ueda-Kawamitsu, H | 1 |
| Lawson, TA | 1 |
| Anderson, T | 3 |
| McMenamin, MG | 2 |
| Panasci, L | 1 |
| Woolley, PV | 1 |
| Fox, PA | 1 |
| Panasci, LC | 2 |
| Bhuyan, BK | 1 |
| Fraser, TJ | 1 |
| Day, KJ | 1 |
| Green, D | 1 |
| Nagourney, R | 1 |
| Fox, P | 1 |
| Ewig, RA | 2 |
| Kohn, KW | 4 |
| Miyahara, M | 2 |
| Nakadate, M | 1 |
| Suzuki, I | 1 |
| Ishidate, M | 1 |
| Odashima, S | 1 |
| Schabel, FM | 6 |
| Trader, MW | 4 |
| Witt, MH | 1 |
| Tashima, M | 1 |
| Sawada, H | 1 |
| Tatsumi, K | 1 |
| Nakamura, T | 1 |
| Uchino, H | 1 |
| McConnell, WR | 1 |
| Kari, P | 1 |
| Hill, DL | 1 |
| Wampler, GL | 1 |
| Carter, WH | 1 |
| Williams, VR | 1 |
| Rose, WC | 1 |
| Dykes, DJ | 1 |
| Schepartz, SA | 1 |
| Cantrell, JL | 2 |
| Killion, JJ | 2 |
| Kollmorgen, GM | 2 |
| Dombernowsky, P | 1 |
| Nissen, NI | 1 |
| Colvin, M | 1 |
| Brundrett, RB | 1 |
| Cowens, W | 1 |
| Jardine, I | 1 |
| Ludlum, DB | 1 |
| Ritter, CA | 1 |
| Avadhani, NG | 1 |
| Hansel, J | 1 |
| Zucker, RM | 1 |
| Helfman, D | 1 |
| Shaddix, SC | 2 |
| Brockman, RW | 2 |
| Sansing, WA | 1 |
| Bundren, JC | 1 |
| LeFever, AV | 1 |
| Houchens, DP | 1 |
| Bremerskov, V | 1 |
| Clemmesen, J | 1 |
| Kristensen, P | 1 |
| Sebolt-Leopold, JS | 1 |
| Scavone, SV | 1 |
| Farone, AL | 1 |
| Zaharko, D | 1 |
| Plowman, J | 2 |
| Waud, W | 1 |
| Dykes, D | 1 |
| Malspeis, L | 1 |
| Elliott, WL | 1 |
| Fry, DW | 1 |
| Anderson, WK | 1 |
| Nelson, JM | 1 |
| Hook, KE | 1 |
| Hawkins, PA | 1 |
| Leopold, WR | 1 |
| August, EM | 2 |
| Cooper, DL | 1 |
| Gorbacheva, LB | 3 |
| Elksne, SJ | 1 |
| Miniker, TD | 1 |
| Preobrazhenskaya, MN | 1 |
| Driscoll, JS | 1 |
| Johns, DG | 1 |
| Allegrucci, M | 1 |
| Borri Voltattorni, C | 1 |
| Romani, L | 1 |
| Dominici, P | 1 |
| Szikla, K | 1 |
| Otvös, L | 1 |
| Gál, F | 1 |
| Williams, ME | 1 |
| Stevenson, JR | 1 |
| Eder, JP | 1 |
| Teicher, BA | 1 |
| Holden, SA | 1 |
| Cathcart, KN | 1 |
| Schnipper, LE | 1 |
| Durdeva, AD | 1 |
| Ponomarenko, NA | 2 |
| Elliott, RD | 1 |
| Thomas, HJ | 1 |
| Riordan, JM | 1 |
| Bryson, JS | 1 |
| Cohen, MB | 1 |
| Duvel, DL | 1 |
| Griswold, DP | 1 |
| Frei, E | 2 |
| Peters, WP | 1 |
| Wolpert, MK | 1 |
| Duc, HN | 1 |
| Nickolls, PM | 1 |
| Catapano, CV | 1 |
| Broggini, M | 1 |
| Erba, E | 1 |
| Ponti, M | 1 |
| Mariani, L | 1 |
| Citti, L | 1 |
| D'Incalci, M | 1 |
| Durdyeva, ED | 2 |
| Cattan, A | 1 |
| Bresson, ML | 1 |
| Gorbacheva, KB | 1 |
| Jeney, A | 1 |
| Kopper, L | 1 |
| Nagy, P | 1 |
| Lapis, K | 1 |
| Süli-Vargha, H | 1 |
| Medzihradszky, K | 1 |
| Ducore, JM | 1 |
| Rosenstein, BS | 1 |
| Valeriote, F | 1 |
| Vietti, T | 1 |
| Carter, SK | 2 |
| Woodman, RJ | 1 |
| Sirica, AE | 1 |
| Gang, M | 1 |
| Kline, I | 1 |
| Venditti, JM | 1 |
| Davignon, JP | 1 |
| Yang, KW | 1 |
| Wood, HB | 1 |
| Cradock, JC | 1 |
| Rosenoff, SH | 1 |
| Bostick, F | 1 |
| Young, RC | 1 |
| Pouillart, R | 1 |
| Huong, TH | 1 |
| Brugerie, E | 1 |
| Lheritier, J | 1 |
| Broder, LE | 1 |
| Schmidt, V | 1 |
| Zapol, W | 1 |
| Prensky, W | 1 |
| Wonders, T | 1 |
| Wodinsky, I | 1 |
| Kitz, R | 1 |
| Straus, MJ | 1 |
| Choi, SC | 1 |
| Ullman, NS | 1 |
| Jacquez, JA | 1 |
| Lyles, JM | 1 |
| Widerlite, L | 1 |
| Gullion, D | 1 |
| Waalkes, TP | 1 |
| Adamson, RH | 1 |
| Riddick, D | 1 |
| Gallo, RC | 1 |
| Vadlamudi, S | 1 |
| Carbone, PP | 1 |
5 reviews available for carmustine and Leukemia L 1210
| Article | Year |
|---|---|
Patterns of resistance and therapeutic synergism among alkylating agents.
Topics: Alkylating Agents; Animals; Carmustine; Cell Survival; Cyclophosphamide; Drug Resistance; Drug Syner | 1978 |
Experimental chemoimmunotherapy of cancer.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Immunotherapy; Leukemia L1210; Male; N | 1978 |
Nitrosoureas: a review of experimental antitumor activity.
Topics: Animals; Carmustine; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, | 1976 |
Current status of new agents.
Topics: Alopecia; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Azacitidine; Azaguanine; Carm | 1972 |
1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) and other nitrosoureas in cancer treatment: a review.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma; Carmustine; Cell Line; Cell-Free System; | 1972 |
1 trial available for carmustine and Leukemia L 1210
| Article | Year |
|---|---|
1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) and other nitrosoureas in cancer treatment: a review.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma; Carmustine; Cell Line; Cell-Free System; | 1972 |
117 other studies available for carmustine and Leukemia L 1210
| Article | Year |
|---|---|
Synthesis and antitumor activity of water-soluble (2-chloroethyl)nitrosoureas.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Nitrosourea Com | 1979 |
Antineoplastic agents. 1. Synthesis and antineoplastic activities of chloroethyl- and methylnitrosourea analogues of thymidine.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carbamates; Cell Division; Cells, Cultured; Chemi | 1978 |
Synthesis of analogues of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Isomerism; Leukemia L1210; Mice; Mice | 1977 |
Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma.
Topics: Animals; Carcinoma; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimen | 1977 |
Rationale for the synthesis and preliminary biological evaluation of highly active new antitumor nitrosoureido sugars.
Topics: Amino Sugars; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Drug Evaluation, Precli | 1989 |
Antineoplastic activity of 3'-(chloroethyl)nitrosourea analogues of 2'-deoxyuridine and 2'-deoxy-5-fluorouridine.
Topics: Alkylation; Animals; Antineoplastic Agents; Deoxyuridine; Dideoxynucleosides; Female; Floxuridine; L | 1986 |
An analysis of 1-(2-chloroethyl)-1-nitrosourea activity at the cellular level.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Drug Evaluation, Preclinical; Ethylnitros | 1983 |
Synthesis and anticancer activity of nitrosourea derivatives of phensuximide.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Ependymoma; Leukemia L1210; Mice; Neoplasms, Experi | 1980 |
Antitumor structure-activity relations. Nitrosoureas vs. L-1210 leukemia.
Topics: Animals; Antineoplastic Agents; Leukemia L1210; Mice; Models, Theoretical; Nitrosourea Compounds; So | 1980 |
Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU.
Topics: Animals; Antineoplastic Agents; Carmustine; Enzyme Inhibitors; Glutathione; Glutathione Reductase; H | 2005 |
Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU).
Topics: Acetylcysteine; Animals; Carmustine; Cell Survival; Cells, Cultured; Clone Cells; Granulocytes; Leuk | 1984 |
Synergistic antileukemic effect of 6-aminonicotinamide and 1,3-bis(2-chloroethyl)-1-nitrosourea on L1210 cells in vitro and in vivo.
Topics: 6-Aminonicotinamide; Animals; Carmustine; Drug Therapy, Combination; Leukemia L1210; Mice; Mice, Inb | 1982 |
Synergistic antileukemic effect of theophylline and 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Animals; Carmustine; Cell Count; Cell Survival; Cyclic AMP; Drug Evaluation, Preclinical; Drug Syner | 1980 |
Chemotherapy-induced pulmonary toxicity in mice bearing L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Doxorubicin; Leukemia L1210; Lung Dise | 1983 |
Enhancement of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced cytotoxicity and DNA damage by alpha-difluoromethylornithine in L1210 leukemia cells.
Topics: Animals; Carmustine; Cell Survival; DNA, Neoplasm; Drug Synergism; Eflornithine; Kinetics; Leukemia | 1984 |
Effects of structure and chemical activity on the ability of nitrosoureas to inhibit DNA repair.
Topics: Animals; Carmustine; Cells, Cultured; DNA Repair; Leukemia L1210; Lomustine; Mice; Nitrosourea Compo | 1980 |
Preclinical and clinical studies on chlorozotocin, a new nitrosourea with decreased bone marrow toxicity.
Topics: Animals; Bone Marrow; Carmustine; Drug Evaluation; Drug Evaluation, Preclinical; Female; Humans; Leu | 1980 |
Effects of N,N'-bis(2-chloroethyl)-N-nitrosourea and 2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy-D-glucopyranose upon the proliferation, DNA synthesis, and viability of cultured sensitive and resistant L1210 cells.
Topics: Animals; Carmustine; Cell Division; Cell Line; Cyclophosphamide; DNA; Drug Resistance; Leukemia L121 | 1980 |
[Disruption of DNA synthesis and structure of mouse L1210 leukemia cells, sensitive and resistant to 1-methyl-1 nitrosourea and 1,3-bis(2-chloroethyl)-1-nitrosourea in vivo].
Topics: Animals; Carmustine; Centrifugation, Density Gradient; Chromosome Aberrations; DNA, Neoplasm; DNA, S | 1984 |
Increased immunogenicity of murine lymphoma cells following exposure to gamma rays in vivo.
Topics: Animals; Carmustine; Dacarbazine; Gamma Rays; Histocompatibility Antigens; Immune Tolerance; Immunit | 1984 |
Thymosin alpha 1 restores NK-cell activity and prevents tumor progression in mice immunosuppressed by cytostatics or X-rays.
Topics: Animals; Carmustine; Fluorouracil; Immunosuppression Therapy; Killer Cells, Natural; Leukemia L1210; | 1983 |
[Antitumor activity of a new nitrosourea, MCNU, on a cellular morphological basis evaluated by a new in vitro antitumor sensitivity assay].
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Re | 1984 |
Superiority of Micrococcus lysodeikticus to BCG in chemo-immunotherapy of advanced L1210 leukaemia.
Topics: Animals; Antineoplastic Agents; Bacillus subtilis; Bacterial Vaccines; BCG Vaccine; Carmustine; Fema | 1981 |
In vivo chemosensitization by misonidazole in sensitive and resistant tumor lines.
Topics: Animals; Carmustine; Cell Line; Drug Resistance; Drug Synergism; Humans; Leukemia L1210; Lomustine; | 1983 |
Combination chemotherapy with AMSA on L1210 leukaemia and B16 melanoma.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Carmustine; Dacarbazine; Drug Therapy, Co | 1981 |
Chemotherapy and immunotherapy of L1210 leukemic mice with antigenic tumor sublines.
Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Carmustine; Cell Line; Cyclophosphamide; Dacarba | 1981 |
In vitro generation of a highly immunogenic subline of L1210 leukemia following exposure to 5-(3,3'-dimethyl-1-triazeno)imidazole-4-carboxamide.
Topics: Animals; Antigens, Neoplasm; Carmustine; Cell Line; Cytological Techniques; Dacarbazine; Leukemia L1 | 1981 |
Correspondence re: J. H. Pincus, A. K. Jameson, and A. E. Brandt. Immunotherapy of L1210 leukemia using neuraminidase-modified plasma membranes combined with chemotherapy. Cancer Res., 41: 3082-3086, 1981.
Topics: Animals; Carmustine; Cell Membrane; Immunotherapy; Leukemia L1210; Mice; Neuraminidase; Semustine | 1982 |
The effect of alkylating agents and other drugs on the accumulation of melphalan by murine L1210 leukaemia cells in vitro.
Topics: Alkylating Agents; Animals; Carmustine; Cells, Cultured; Leukemia L1210; Melphalan; Mice; Time Facto | 1982 |
The role of isocyanates in the toxicity of antitumour haloalkylnitrosoureas.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyanates; Female; Leukemia L1210; Lomustine; Lymphoma; M | 1982 |
Differential enhancement of antitumor effectiveness by phospholipid vesicles (liposomes).
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Carmustine; Cell Line; Cell Membran | 1981 |
Response of L1210 leukemia to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea plus 4'-demethylepipodophyllotoxin-9-(4,6-O-2-thenylidene-beta-D-glucopyranoside).
Topics: Animals; Carmustine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Et | 1981 |
Cure of advanced L1210 leukemia after correction of abnormal red blood cell deformability.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Erythrocytes; Inosine; Leukemia L1210; | 1981 |
Combined effects of antineoplastic agents and anti-lymphoma allograft reactions.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Dacarbazine; Female; Histocompatibilit | 1980 |
Relative enhancement by various liposomes of BCNU effectiveness against L-1210 leukemia in vivo.
Topics: Animals; Carmustine; Leukemia L1210; Liposomes; Mice | 1980 |
Successful immunotherapy with micrococcus, BCG or related polysaccharides on L1210 leukaemia after BCNU chemotherapy.
Topics: Animals; Antibodies, Neoplasm; BCG Vaccine; Carmustine; Dose-Response Relationship, Radiation; Femal | 1981 |
Principal drug-metabolizing enzyme systems in L1210 leukemia sensitive or resistant to BCNU in vivo.
Topics: Animals; Carmustine; Cytochrome P-450 Enzyme System; Drug Resistance; Epoxide Hydrolases; Female; Gl | 1994 |
Enhanced antitumor activity and reduced toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea administered in lipid microspheres to tumor-bearing mice.
Topics: Animals; Body Weight; Carmustine; Drug Delivery Systems; Leukemia L1210; Lipids; Male; Mice; Microsp | 1993 |
Severe depletion of cellular thiols and glutathione-related enzymes of a carmustine-resistant L1210 strain associates with collateral sensitivity to cyclophosphamide.
Topics: Animals; Carmustine; Cyclophosphamide; Drug Resistance; Drug Screening Assays, Antitumor; Glutathion | 1993 |
Clofibrate enhances the DNA damaging action and cytotoxicity of nitrosoureas.
Topics: Animals; Carmustine; Cell Survival; Clofibrate; DNA Damage; DNA, Neoplasm; Drug Synergism; Ethylnitr | 1993 |
DNA crosslinking, sister chromatid exchange and cytotoxicity of N-2-chloroethylnitrosoureas tethered to minor groove binding peptides.
Topics: Alkylation; Animals; Base Sequence; Carcinogens; Carmustine; Cell Survival; Dipeptides; DNA; Ethylni | 1993 |
Reovirus type 3 chemoimmunotherapy of murine lymphoma is abrogated by cyclosporine.
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Combined Modality Therapy; Cyclosporine; Imm | 1995 |
Elimination of EL-4 and L1210 murine tumors by 1,3-bis (2-chloroethyl)-1-nitrosourea requires an intact immune response.
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Cyclosporine; Immunosuppressive Agents; Leuk | 1996 |
Novel artificial endonucleases inhibit base excision repair and potentiate the cytotoxicity of DNA-damaging agents on L1210 cells.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Base Pairing; Carmustine; D | 1999 |
Synthesis and antitumour activity of a new series of nitrosoureido sugars.
Topics: Animals; Antineoplastic Agents; Carmustine; Glucosides; Leukemia L1210; Melanoma, Experimental; Mice | 2000 |
Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase.
Topics: Animals; Antineoplastic Agents; Carmustine; DNA Repair; Drug Resistance; Gene Expression; Genetic Th | 2000 |
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): a novel sulfonylhydrazine prodrug with broad-spectrum antineoplastic activity.
Topics: Animals; Antineoplastic Agents; Carmustine; Drug Screening Assays, Antitumor; Female; Humans; Hydraz | 2001 |
Potentiation of BCNU cytotoxicity by molecules targeting abasic lesions in DNA.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Alkylating; Carmustine; Cattle; DNA; Humans; Leukemi | 2001 |
In vitro pharmacokinetics and pharmacodynamics of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Cycle; Cell Death; Cell Survival; DNA, | 2002 |
Chlorozotocin, 2-(3-(2-chloroethyl)-3-nitrosoureido)-D-glucopyranose, an antitumor agent with modified bone marrow toxicity.
Topics: Animals; Antineoplastic Agents; Blood Cell Count; Bone Marrow; Carmustine; DNA, Neoplasm; Ethyl Chlo | 1975 |
Pharmacology of chlorozotocin Nsc-178248), a new nitrosourea antitumor agent.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Carmustine; DNA, Neoplasm; Ethyl Chloride; Leukemia L12 | 1976 |
Biological and biochemical properties of 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea (NSC D 254157), a nitrosourea with reduced bone marrow toxicity.
Topics: Animals; Bone Marrow; Carmustine; DNA, Neoplasm; Ethyl Chloride; In Vitro Techniques; Leukemia L1210 | 1977 |
Cell proliferation kinetics and drug sensitivity of exponential and stationary populations of cultured L1210 cells.
Topics: Amino Acids; Animals; Antineoplastic Agents; Carmustine; Cell Division; Cell Survival; Cells, Cultur | 1977 |
A structure-activity analysis of chemical and biological parameters of chloroethylnitrosoureas in mice.
Topics: Alkylation; Animals; Bone Marrow; Carmustine; Ethyl Chloride; Ethylnitrosourea; Half-Life; Leukemia | 1977 |
Comparison of biochemical and biological effects of four nitrosoureas with differing carbamoylating activities.
Topics: Animals; Carmustine; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; DNA, Neoplasm; E | 1978 |
DNA-protein cross-linking and DNA interstrand cross-linking by haloethylnitrosoureas in L1210 cells.
Topics: Animals; Carmustine; Cells, Cultured; Chemical Phenomena; Chemistry; DNA, Neoplasm; Endopeptidases; | 1978 |
Antitumor effect of 1,1'-polymethylene-bis (1-nitrosourea) and related compounds.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Carmustine; Drug Evaluation, Preclinical; | 1977 |
Enhancement of the antitumor effect of 1,3-bis(2-chloroethyl)-1-nitrosourea by various psychotropic drugs in combination with caffeine.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Caffeine; Carmustine; Dose-Resp | 1975 |
Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea on newly synthesized DNA in L-1210 cells.
Topics: Animals; Carmustine; Cells, Cultured; DNA Replication; DNA, Neoplasm; Kinetics; Leukemia L1210; Mice | 1979 |
Reduction of glutathione levels in livers of mice treated with N,N'-bis (2-chloroethyl)-N-nitrosourea.
Topics: Animals; Carmustine; Glutathione; Glutathione Reductase; Leukemia L1210; Liver; Male; Mice | 1979 |
DNA damage and repair in mouse leukemia L1210 cells treated with nitrogen mustard, 1,3-bis(2-chloroethyl)-1-nitrosourea, and other nitrosoureas.
Topics: Animals; Carmustine; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; DNA Repair; DNA, | 1977 |
Combination chemotherapy: arriving at optimal treatment levels by incorporating side effect constraints.
Topics: Animals; Carmustine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combination; Fema | 1978 |
Rationale of chemotherapeutic adjuvant treatment.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Admi | 1978 |
Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors.
Topics: Animals; Caffeine; Carmustine; Chlorpromazine; Drug Synergism; Drug Therapy, Combination; Female; Le | 1978 |
Interrelationship between chemotherapy and immunotherapy in the treatment of disseminated disease.
Topics: Animals; Carmustine; Dacarbazine; Humans; Immunity; Immunotherapy; Leukemia L1210; Methotrexate; Mic | 1978 |
Early history and development of the nitrosoureas.
Topics: Animals; Carmustine; History, 20th Century; Leukemia L1210; Methylnitronitrosoguanidine; Methylnitro | 1976 |
Correlations between humoral immunity and successful chemotherapy-immunotherapy.
Topics: Animals; Antibodies, Neoplasm; Antibody Formation; Antigens, Neoplasm; BCG Vaccine; Carmustine; Fluo | 1976 |
Combination chemotherapy with 4'Demethylepipodophyllotoxin 9-(4,6-0-ethylidene-beta-D-glucopyranoside), VP 16-213 (NSC 141540) in L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin | 1976 |
A chemical basis for the antitumor activity of chloroethylnitrosoureas.
Topics: Animals; Antineoplastic Agents; Buffers; Carmustine; Chemical Phenomena; Chemistry; Ethylnitrosourea | 1976 |
Liposomal potentiation of the antitumor activity of alkylating drugs.
Topics: Alkylating Agents; Animals; Carcinoma, Ehrlich Tumor; Carmustine; Drug Synergism; Leukemia L1210; Li | 1976 |
Electronic volume analysis of L1210 chemotherapy.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Count; Cell Division; Cell Survival; Cyclophosphami | 1976 |
Studies with 2,5-piperazinedione, 3,6-bis(5-chloro-2-piperidyl)-,dihydrochloride. III. Biochemical and therapeutic effects in L1210 leukemias sensitive and resistant to alkylating agents: comparison with melphalan, cyclophosphamide, and BCNU.
Topics: Animals; Antibiotics, Antineoplastic; Carmustine; Cells, Cultured; Cyclophosphamide; DNA, Neoplasm; | 1976 |
Immunotherapy with neuraminidase-treated cells and bacillus Calmette-Guerin.
Topics: Animals; BCG Vaccine; Carmustine; Cells, Cultured; Immunotherapy; Injections, Intraperitoneal; Leuke | 1976 |
Uptake of 5-iododeoxyuridine as a measure of tumor growth and tumor inhibition.
Topics: Animals; Carmustine; Cell Transformation, Neoplastic; Cyclophosphamide; DNA, Neoplasm; Female; Idoxu | 1975 |
Leukocidin--new antimetabolite: effects on L 1210: preliminary report.
Topics: Animals; Antimetabolites, Antineoplastic; Carmustine; Cytarabine; Leukemia L1210; Leukocidins; Mice | 1975 |
Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly(ADP-ribose) synthetase inhibitor.
Topics: Alkylating Agents; Animals; Carmustine; Drug Synergism; In Vitro Techniques; Isoquinolines; Leukemia | 1992 |
1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU)/interleukin-2 chemoimmunotherapy of murine L1210 leukemia.
Topics: Animals; Carmustine; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Immunity; | 1992 |
L-histidinol: preclinical therapeutic studies in combination with antitumor agents and pharmacokinetic studies in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cisplatin; Cyclophosphamide; Hi | 1992 |
In vivo and in vitro evaluation of the alkylating agent carmethizole.
Topics: Animals; Antineoplastic Agents; Carmustine; DNA Repair; DNA, Neoplasm; Drug Screening Assays, Antitu | 1991 |
Inhibition of poly(adenosine diphosphate-ribose) polymerase by thymidine and thymidine analogues in L1210 cells and its relationship to the potentiation of the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea but not of 3'-[3-(2-chloroethyl)-3-n
Topics: Animals; Antineoplastic Agents; Carmustine; Dideoxynucleosides; DNA; DNA Damage; Drug Synergism; Enz | 1991 |
O6-methylguanine as a modulator of antitumor activity of N-alkyl-N-nitrosoureas in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA Damage; DNA, Neoplasm; Drug | 1991 |
Comparison of the activity of arabinosyl-5-azacytosine, arabinosyl cytosine, and 5-azacytidine against intracerebrally implanted L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Azacitidine; Brain Neoplasms; Carmustine; Cytarabine; Leukemia L1210 | 1985 |
DNA methylating activity in murine lymphoma cells treated with xenogenizing chemicals.
Topics: Animals; Azacitidine; Carmustine; DNA, Neoplasm; Leukemia L1210; Male; Methylation; Mice; Mice, Inbr | 1987 |
Absence of cross-resistance between two alkylating agents: BCNU vs bifunctional galactitol.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carmustine; Cross-Linking Reagents; Dianhydrogala | 1989 |
Rejection of reovirus-treated L1210 leukemia cells by mice.
Topics: Animals; Carmustine; Cell Division; Cell Survival; Leukemia L1210; Male; Mice; Mice, Inbred Strains; | 1986 |
Novobiocin enhances alkylating agent cytotoxicity and DNA interstrand crosslinks in a murine model.
Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cell Surviva | 1987 |
In vivo DNA damage and resistance to 1-methyl-1-nitrosourea and 1,3-bis(2-chloroethyl)-1-nitrosourea in L1210 leukemia cells.
Topics: Animals; Carmustine; DNA Damage; DNA Repair; DNA-Directed DNA Polymerase; Drug Resistance; Ethidium; | 1988 |
Nitrosoureido nucleosides as potential inhibitors of nucleotide biosynthesis.
Topics: Animals; Carmustine; Cell Division; DNA Replication; Drug Stability; Indicators and Reagents; Leukem | 1988 |
Characteristics of reovirus-mediated chemoimmunotherapy of murine L1210 leukemia.
Topics: Animals; Antibodies, Viral; Carmustine; Cell Division; Drug Administration Schedule; Immunotherapy; | 1988 |
Effect of thymidine on uptake, DNA alkylation, and DNA repair in L1210 cells treated with 1,3-bis(2-chloroethyl)-1-nitrosourea or 3'-[3-(2-chloroethyl)-3-nitrosoureido]-3'-deoxythymidine.
Topics: Alkylation; Animals; Carmustine; Cell Line; Dideoxynucleosides; DNA; DNA Repair; Drug Synergism; Leu | 1988 |
Characterization of the inhibition of glutathione reductase and the recovery of enzyme activity in exponentially growing murine leukemia (L1210) cells treated with 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Animals; Carmustine; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Glutathione Red | 1988 |
Response of drug-sensitive and -resistant L1210 leukemias to high-dose chemotherapy.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cisplatin; Cyclopho | 1987 |
Multicompartment models of cancer chemotherapy incorporating resistant cell populations.
Topics: Animals; Antineoplastic Agents; Biological Availability; Carmustine; Cytarabine; Drug Resistance; Ki | 1987 |
In vitro and in vivo methazolastone-induced DNA damage and repair in L-1210 leukemia sensitive and resistant to chloroethylnitrosoureas.
Topics: Animals; Antineoplastic Agents; Carmustine; Dacarbazine; DNA Damage; DNA Repair; DNA, Neoplasm; Drug | 1987 |
[The role of N-nitrosourea-induced changes in the nucleoid structure and activity of repair enzymes in the development of drug resistance in mice with leukemia L1210].
Topics: Animals; Carmustine; Cell Nucleus; DNA Repair; DNA-Directed DNA Polymerase; DNA, Neoplasm; Drug Resi | 1987 |
Vitamin A: failure to demonstrate in mice an anti-tumour effect, whether combined with cytotoxic drugs or not.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cisplatin; Cyclophosphamide; Et | 1986 |
Enhancement of the anticancer activity of bis(2-chloroethyl)nitrosourea in mice by coadministration of 2'-deoxyuridine, 2'-deoxycytidine, or thymidine.
Topics: Animals; Carmustine; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; Drug Synergism; Leukemia L12 | 1987 |
[Relation between the changes in the structure and synthesis of DNA in the cells of mouse leukemia L1210 induced by 1-methyl-1-nitrosourea and 1,3-bis(2-chloroethyl)-1-nitrosourea].
Topics: Animals; Carmustine; DNA Repair; DNA Replication; DNA, Neoplasm; DNA, Single-Stranded; Kinetics; Leu | 1986 |
Antitumor action of N-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of biologically active polypeptide hormone fragments.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Drug Eva | 1986 |
Theophylline release of replicon initiation inhibition by nitrosoureas correlates with the synergistic killing in L1210 leukemia in vitro.
Topics: Animals; Carmustine; Cell Survival; Cells, Cultured; DNA, Neoplasm; Drug Synergism; Ethylnitrosourea | 1985 |
Comparison of cytotoxicity of single dose and infusion of alkylating agents.
Topics: Alkylating Agents; Animals; Carmustine; Cell Survival; Colony-Forming Units Assay; Infusions, Parent | 1985 |
The enhanced therapeutic effect of cis-platinum (II) diamminodichloride against L1210 leukemia when combined with cyclophosphamide or 1,2-bis(3,5-dioxopiperazine-1-yl)propane or several other antitumor agents.
Topics: Amines; Animals; Antineoplastic Agents; Azacitidine; Camptothecin; Carmustine; Chlorides; Cyclophosp | 1973 |
Formulation of three nitrosoureas for intravenous use.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclohexanes; Dogs; Emulsions; Ethanol; Fats; Haplorhini | 1973 |
3-(Tetraacetyl glucopyranos-2-yl)-1-(2-chloroethyl)-1-nitrosourea, an antitumor agent with modified bone marrow toxicity.
Topics: Animals; Antineoplastic Agents; Blood Glucose; Bone Marrow; Carmustine; Cyclohexanes; DNA, Neoplasm; | 1973 |
Alterations induced by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in deoxyribonucleic acid synthesis in normal and tumorous tissues. Implications for optimal chemotherapy.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Carmustine; DNA; DNA, Neoplasm; Dose-Response Relations | 1974 |
Sequential administration of two oncostatic drugs: study of modalities for pharmacodynamic potentiation.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Drug Synergi | 1974 |
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara | 1974 |
Continuous cancer chemotherapy: nitrosourea diffusion through implanted silicone rubber capsules.
Topics: Administration, Topical; Animals; Capsules; Carmustine; Cell Survival; Deoxyuridine; Dialysis; Diffu | 1972 |
Increased lifespan with altered sequence of administration of BCNU and cytoxan in L1210 leukemic mice.
Topics: Animals; Ascites; Carmustine; Cyclophosphamide; Disease Models, Animal; Leukemia L1210; Male; Mice; | 1973 |
Brief communication: Enhancement of the antitumor effect of 1,-3-bis(2-chloroethyl)-1-nitrosourea by chlorpromazine and caffeine.
Topics: Animals; Caffeine; Carmustine; Chlorpromazine; Dose-Response Relationship, Drug; Drug Therapy, Combi | 1973 |
Analysis of tests of chemotherapeutic agents involving repeated drug treatment.
Topics: Animals; Antineoplastic Agents; Carmustine; Drug Evaluation, Preclinical; Drug Resistance; Leukemia | 1973 |
Inhibition of DNA repair by the 1,3-bis(2-chloroethyl)-1-nitrosourea breakdown product, 2-chloroethyl isocyanate.
Topics: Animals; Carmustine; Cells, Cultured; Cyanates; Cycloheximide; Dactinomycin; Depression, Chemical; D | 1974 |
Effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds on nuclear RNA metabolism.
Topics: Animals; Carmustine; Cell Nucleolus; Cell Nucleus; Cells, Cultured; Depression, Chemical; Leukemia L | 1974 |
Evaluation of anti-tumor agents on tRNA methylase activity of leukemia L1210.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Carmustine; Cell Count; Cells, Cultured; Depression | 1972 |
Antigenicity of L1210 leukemic sublines induced by drugs.
Topics: Animals; Antigens; Antigens, Neoplasm; Antineoplastic Agents; Carmustine; Cell Line; Cyclophosphamid | 1972 |
Enhancement of the antitumor effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide by vitamin A.
Topics: Alkylating Agents; Animals; Carmustine; Cell Membrane; Cyclophosphamide; Drug Synergism; Hemolysis; | 1972 |
Enhancement of the antitumor effect of 1,3-bis(2-chloroethyl)-1-nitrosourea by vitamin A and caffeine.
Topics: Alkylating Agents; Animals; Caffeine; Carmustine; Cell Membrane; DNA Repair; Drug Combinations; Drug | 1972 |