carmustine has been researched along with Leukemia, Myeloid in 23 studies
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 42-year-old male patient with a history of occupational exposure to benzene presented with pancytopenia." | 3.69 | t(9;13)(q34;q12) chromosomal translocation persisting 4 years post autologous bone marrow transplantation for secondary AML despite morphological remission. ( Mahendra, P; Marcus, RE; Nacheva, E; Richards, EM; Sinclair, P, 1996) |
| "At ABMT, 17 patients were in untreated relapse and one was in third complete remission (CR)." | 2.68 | Autologous bone marrow transplantation for patients with acute myeloblastic leukemia in relapse after autologous blood stem cell transplantation. ( Bonanad, S; Carral, A; de la Rubia, J; Jarque, I; Larrea, L; López, F; Martín, G; Martínez, J; Picón, I; Sanz, GF; Sanz, MA; Sempere, A; Soler, MA, 1996) |
| "Six patients, four with Hodgkin's disease and two with non-Hodgkin lymphomas, developed leukemic complications, myelodysplasia (MDS) in four cases and overt acute myeloid leukemia (AML) in two." | 2.68 | High risk of therapy-related leukemia after BEAM chemotherapy and autologous stem cell transplantation for previously treated lymphomas is mainly related to primary chemotherapy and not to the BEAM-transplantation procedure. ( Geisler, C; Myhre, J; Pedersen, M; Pedersen-Bjergaard, J, 1997) |
| "Hodgkin's disease is curable in the majority of patients, although a proportion of patients are resistant to or relapse after initial therapy." | 1.30 | High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML. ( Devereux, S; Goldstone, AH; Gregory, W; Hancock, B; Harrison, CN; Hoskin, P; Hudson, GV; Linch, DC; MacMillan, AK; Milligan, D; Newland, AC; Winfield, D, 1999) |
| "Two patients treated for chronic myeloid leukemia with high doses of CCNU (1100 mg/m2 and 1240 mg/m2, respectively) developed a fatal pulmonary fibrosis." | 1.27 | Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia. ( Bernaudin, JF; Cordonnier, C; Lange, F; Mital, P; Rochant, H; Vernant, JP, 1983) |
| "Chronic granulocytic leukemia (CGL) terminates in a disease similar to acute leukemia." | 1.26 | Blast crisis of chronic granulocytic leukemia. Morphologic variants and therapeutic implications. ( Canellos, GP; Gralnick, HR; Rosenthal, S; Whang-Peng, J, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 9 (39.13) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bertz, H | 1 |
| Potthoff, K | 1 |
| Finke, J | 1 |
| Kang, HJ | 1 |
| Shin, HY | 1 |
| Choi, HS | 1 |
| Han, KS | 1 |
| Ahn, HS | 1 |
| Fouillard, L | 1 |
| Labopin, M | 1 |
| Meloni, G | 3 |
| Polge, E | 1 |
| Gorin, NC | 1 |
| Frassoni, F | 1 |
| Thomas, X | 1 |
| Suciu, S | 1 |
| Rio, B | 1 |
| Leone, G | 1 |
| Broccia, G | 1 |
| Fillet, G | 1 |
| Jehn, U | 1 |
| Feremans, W | 1 |
| Vignetti, M | 1 |
| de Witte, T | 1 |
| Amadori, S | 1 |
| Cordonnier, C | 1 |
| Vernant, JP | 1 |
| Mital, P | 1 |
| Lange, F | 1 |
| Bernaudin, JF | 1 |
| Rochant, H | 1 |
| Klingemann, HG | 1 |
| Shepherd, JD | 1 |
| Reece, DE | 1 |
| Barnett, MJ | 1 |
| Nantel, SH | 1 |
| Sutherland, HJ | 1 |
| Spinelli, JJ | 1 |
| Phillips, GL | 1 |
| Salooja, N | 1 |
| Chatterjee, R | 1 |
| McMillan, AK | 1 |
| Kelsey, SM | 1 |
| Newland, AC | 2 |
| Milligan, DW | 1 |
| Franklin, IM | 1 |
| Hutchinson, RM | 1 |
| Linch, DC | 2 |
| Goldstone, AH | 2 |
| Müller, MR | 1 |
| Seiler, F | 1 |
| Thomale, J | 1 |
| Buschfort, C | 1 |
| Rajewsky, MF | 1 |
| Seeber, S | 1 |
| Mahendra, P | 1 |
| Richards, EM | 1 |
| Sinclair, P | 1 |
| Nacheva, E | 1 |
| Marcus, RE | 1 |
| de la Rubia, J | 1 |
| Sanz, GF | 1 |
| Martín, G | 1 |
| Sempere, A | 1 |
| Picón, I | 1 |
| Carral, A | 1 |
| Larrea, L | 1 |
| Martínez, J | 1 |
| Soler, MA | 1 |
| Bonanad, S | 1 |
| López, F | 1 |
| Jarque, I | 1 |
| Sanz, MA | 1 |
| Pedersen-Bjergaard, J | 1 |
| Pedersen, M | 1 |
| Myhre, J | 1 |
| Geisler, C | 1 |
| Harrison, CN | 1 |
| Gregory, W | 1 |
| Hudson, GV | 1 |
| Devereux, S | 1 |
| Hancock, B | 1 |
| Winfield, D | 1 |
| MacMillan, AK | 1 |
| Hoskin, P | 1 |
| Milligan, D | 1 |
| Proia, A | 1 |
| Guerrisi, V | 1 |
| Cordone, I | 1 |
| De Cuia, R | 1 |
| Fenu, S | 1 |
| Mauro, FR | 1 |
| Pescarmona, E | 1 |
| Reato, G | 1 |
| Mandelli, F | 1 |
| Potthoff, RF | 1 |
| Peterson, BL | 1 |
| George, SL | 1 |
| Garban, F | 1 |
| Gallagher, M | 1 |
| Jouvin-Marche, E | 1 |
| Jacob, MC | 1 |
| Moine, A | 1 |
| Marche, PN | 1 |
| Sotto, JJ | 1 |
| Rosenthal, S | 1 |
| Canellos, GP | 2 |
| Whang-Peng, J | 1 |
| Gralnick, HR | 1 |
| Chuang, RY | 1 |
| Laszlo, J | 1 |
| Keller, P | 1 |
| Harousseau, JL | 2 |
| Milpied, N | 2 |
| Briere, J | 2 |
| Desablens, B | 2 |
| Leprise, PY | 2 |
| Ifrah, N | 2 |
| Gandhour, B | 2 |
| Casassus, P | 2 |
| Karp, DD | 1 |
| Parker, LM | 1 |
| Binder, N | 1 |
| Tantravahi, R | 1 |
| Smith, BR | 1 |
| Ervin, TJ | 1 |
| Gerson, SL | 1 |
| Trey, JE | 1 |
| Burchenal, JH | 1 |
| Carter, SK | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| RANDOMIZED PHASE III STUDY TO EVALUATE THE VALUE OF rHuG-CSF IN INDUCTION AND OF AN ORAL SCHEDULE AS CONSOLIDATION TREATMENT IN ELDERLY PATIENTS WITH ACUTE MYELOGENOUS LEUMEKIA (AML-13 PROTOCOL)[NCT00002719] | Phase 3 | 500 participants (Anticipated) | Interventional | 1995-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for carmustine and Leukemia, Myeloid
| Article | Year |
|---|---|
Regimen-related acute toxicities: pathophysiology, risk factors, clinical evaluation and preventive strategies.
Topics: Acute Disease; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Tr | 1994 |
New cancer chemotherapeutic agents.
Topics: Aldehydes; Amides; Amines; Animals; Antineoplastic Agents; Asparaginase; Azacitidine; Azaguanine; Bl | 1972 |
An overview of the status of the nitrosoureas in other tumors.
Topics: Adenocarcinoma; Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Carcinoma, Br | 1973 |
7 trials available for carmustine and Leukemia, Myeloid
| Article | Year |
|---|---|
Allogeneic stem-cell transplantation from related and unrelated donors in older patients with myeloid leukemia.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chemotherapy, Adjuvant; Female; He | 2003 |
Autologous peripheral blood stem cell transplantation with BCVAC conditioning in childhood acute myeloid leukemia.
Topics: Acute Disease; Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Ant | 2004 |
Autologous stem cell transplantation after complete remission and first consolidation in acute myeloid leukemia patients aged 61-70 years: results of the prospective EORTC-GIMEMA AML-13 study.
Topics: Administration, Oral; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Proto | 2007 |
Autologous bone marrow transplantation for patients with acute myeloblastic leukemia in relapse after autologous blood stem cell transplantation.
Topics: Acute Disease; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transpl | 1996 |
High risk of therapy-related leukemia after BEAM chemotherapy and autologous stem cell transplantation for previously treated lymphomas is mainly related to primary chemotherapy and not to the BEAM-transplantation procedure.
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Combined Modality | 1997 |
Double intensive consolidation chemotherapy in adult acute myeloid leukemia.
Topics: Acute Disease; Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Carmust | 1991 |
Double intensive consolidation chemotherapy in adult acute myeloid leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Amsacrine; Analysis of Variance; Antibiotics, Antineoplastic | 1991 |
13 other studies available for carmustine and Leukemia, Myeloid
| Article | Year |
|---|---|
Comparison of BAVC to BuCy regimens in autologous stem cell transplantation for adult patients with acute myeloid leukemia.
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Carmus | 2004 |
Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.
Topics: Adult; Carmustine; Female; Humans; Leukemia, Myeloid; Lomustine; Male; Nitrosourea Compounds; Pulmon | 1983 |
Successful pregnancies in women following single autotransplant for acute myeloid leukemia with a chemotherapy ablation protocol.
Topics: Abortion, Induced; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantatio | 1994 |
Capacity of individual chronic lymphatic leukemia lymphocytes and leukemic blast cells for repair of O6-ethylguanine in DNA: relation to chemosensitivity in vitro and treatment outcome.
Topics: Acute Disease; Carmustine; Cyclophosphamide; Cytarabine; DNA Repair; Doxorubicin; Drug Resistance; E | 1994 |
t(9;13)(q34;q12) chromosomal translocation persisting 4 years post autologous bone marrow transplantation for secondary AML despite morphological remission.
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Benzene; Bone Marrow; Bone Mar | 1996 |
High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; | 1999 |
Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carm | 2000 |
Detecting treatment-by-centre interaction in multi-centre clinical trials.
Topics: Aged; Antineoplastic Agents, Alkylating; Aziridines; Benzoquinones; Brain Neoplasms; Carmustine; Com | 2001 |
Immunotherapy by non-myeloablative stem cell transplantation: study of the immune reconstitution. Arguments for distinct cell subsets in skin and blood.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Blood; Blood Cells; Carmustine; CD8-P | 2000 |
Blast crisis of chronic granulocytic leukemia. Morphologic variants and therapeutic implications.
Topics: Adult; Bone Marrow; Carmustine; Cytarabine; Diploidy; Drug Therapy, Combination; Female; Humans; Leu | 1977 |
Effects of nitrosoureas on human DNA polymerase activities from acute and chronic granulocytic leukemia cells.
Topics: Acute Disease; Carmustine; Chronic Disease; DNA Nucleotidyltransferases; Granulocytes; Humans; Kinet | 1976 |
Treatment of the blastic transformation of chronic granulocytic leukemia using high dose BCNU chemotherapy and cryopreserved autologous peripheral blood stem cells.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Preservation; Blood Transfu | 1985 |
Modulation of nitrosourea resistance in myeloid leukemias.
Topics: Carmustine; Cell Differentiation; Colony-Stimulating Factors; DNA Repair; Drug Resistance; Guanine; | 1988 |