Page last updated: 2024-10-24

carmustine and Graft vs Host Disease

carmustine has been researched along with Graft vs Host Disease in 25 studies

Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.

Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.

Research Excerpts

ExcerptRelevanceReference
" In this retrospective study, we reviewed outcomes of 22 patients with recurrent and refractory NHL who underwent alloHCT with myeloablative BEAM conditioning and received tacrolimus/sirolimus as graft-versus-host disease (GVHD) prophylaxis at City of Hope between 2005 and 2018."9.30Outcomes of Patients with Recurrent and Refractory Lymphoma Undergoing Allogeneic Hematopoietic Cell Transplantation with BEAM Conditioning and Sirolimus- and Tacrolimus-Based GVHD Prophylaxis. ( Ali, H; Budde, E; Chen, R; Forman, SJ; Herrera, AF; Mei, M; Mokhtari, S; Nademanee, A; Nakamura, R; Popplewell, L; Salhotra, A; Sandhu, K; Stiller, T; Zain, J, 2019)
"Allogeneic stem cell transplant (SCT) after high-dose conditioning with BEAM/fludarabine/total body irradiation (TBI) in patients with relapsed or refractory lymphoma has shown promising results in a pilot study."9.17Allogeneic stem cell transplantation for relapsed or refractory lymphoma after conditioning with BEAM/fludarabine/TBI. ( Bucher, C; Buser, A; Gerull, S; Halter, J; Heim, D; O'Meara, A; Passweg, J; Stern, M, 2013)
"The combination of carmustine, etoposide, cytarabine and melphalan (BEAM) is an effective autologous transplantation preparative regimen for lymphoma and has little toxicity, but the feasibility and tolerance of BEAM as a preparative regimen for allogeneic transplantation has not been established."7.70Carmustine, etoposide, cytarabine and melphalan as a preparative regimen for allogeneic transplantation for high-risk malignant lymphoma. ( Anderlini, P; Andersson, B; Braunschweig, I; Champlin, R; Claxton, D; Cleary, K; Donato, M; Folloder, J; Gajewski, J; Giralt, S; Hagemeister, F; Khouri, I; Körbling, M; Mehra, R; Molldrem, J; Przepiorka, D; Samuels, B; Ueno, NT; van Besien, K, 1999)
" In this retrospective study, we reviewed outcomes of 22 patients with recurrent and refractory NHL who underwent alloHCT with myeloablative BEAM conditioning and received tacrolimus/sirolimus as graft-versus-host disease (GVHD) prophylaxis at City of Hope between 2005 and 2018."5.30Outcomes of Patients with Recurrent and Refractory Lymphoma Undergoing Allogeneic Hematopoietic Cell Transplantation with BEAM Conditioning and Sirolimus- and Tacrolimus-Based GVHD Prophylaxis. ( Ali, H; Budde, E; Chen, R; Forman, SJ; Herrera, AF; Mei, M; Mokhtari, S; Nademanee, A; Nakamura, R; Popplewell, L; Salhotra, A; Sandhu, K; Stiller, T; Zain, J, 2019)
"Allogeneic stem cell transplant (SCT) after high-dose conditioning with BEAM/fludarabine/total body irradiation (TBI) in patients with relapsed or refractory lymphoma has shown promising results in a pilot study."5.17Allogeneic stem cell transplantation for relapsed or refractory lymphoma after conditioning with BEAM/fludarabine/TBI. ( Bucher, C; Buser, A; Gerull, S; Halter, J; Heim, D; O'Meara, A; Passweg, J; Stern, M, 2013)
" Between March 1993 and June 2002, we treated 33 relapsed acute myelogenous leukemia (AML) patients with busulfan-based preparative regimens and selective TCD."5.11CD8+ T-cell-depleted, matched unrelated donor, allogeneic bone marrow transplantation for advanced AML using busulfan-based preparative regimens. ( Andresen, S; Ball, E; Bolwell, B; Cook, D; Kalaycio, M; Kuczkowski, E; Pohlman, B; Rybicki, L; Sobecks, R, 2005)
" Graft-versus-host disease prophylaxis consisted of cyclosporine A and alemtuzumab (10-20 mg)."3.78Radiation-free allogeneic conditioning with fludarabine, carmustine, and thiotepa for acute lymphoblastic leukemia and other hematologic malignancies necessitating enhanced central nervous system activity. ( Bertz, H; Christopoulos, P; Finke, J; Ihorst, G; Marks, R; Wäsch, R, 2012)
"The combination of carmustine, etoposide, cytarabine and melphalan (BEAM) is an effective autologous transplantation preparative regimen for lymphoma and has little toxicity, but the feasibility and tolerance of BEAM as a preparative regimen for allogeneic transplantation has not been established."3.70Carmustine, etoposide, cytarabine and melphalan as a preparative regimen for allogeneic transplantation for high-risk malignant lymphoma. ( Anderlini, P; Andersson, B; Braunschweig, I; Champlin, R; Claxton, D; Cleary, K; Donato, M; Folloder, J; Gajewski, J; Giralt, S; Hagemeister, F; Khouri, I; Körbling, M; Mehra, R; Molldrem, J; Przepiorka, D; Samuels, B; Ueno, NT; van Besien, K, 1999)
" In an attempt to reduce the high procedure-related mortality reported with allografting in lymphoma, we have used BEAM (BCNU, etoposide, cytarabine and melphalan), a standard conditioning regimen for autologous transplantation."3.70Preliminary experience of allogeneic stem cell transplantation for lymphoproliferative disorders using BEAM-CAMPATH conditioning: an effective regimen with low procedure-related toxicity. ( Byrne, JL; Carter, GI; Cull, GM; Hale, G; Haynes, AP; Miflin, G; Rebello, P; Russell, NH; Waldmann, H, 2000)
"Mini-BEAM/HSC is an effective treatment for lymphoma relapses after allogeneic HSCT, but optimal strategies of remission consolidation and prevention of treatment-related complications are needed to improve outcome."1.32Treatment of lymphoma relapses after allogeneic hematopoietic stem cell transplantation with intensive chemotherapy followed by infusion of hematopoietic stem cell from the original donor. ( Au, WY; Chan, EC; Kwong, YL; Leung, AY; Liang, R; Lie, AK; Ooi, GC; Siu, LL, 2003)
"The probability of disease progression at 1 year for patients with chemoresistant and chemosensitive disease were 75% and 25%, respectively (P =."1.31Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation: an analysis from the Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation. ( Carella, A; de Elvira, CR; Goldstone, AH; Mackinnon, S; Robinson, SP; Russell, N; Schmitz, N; Taghipour, G, 2002)
"Eleven patients with acute myeloblastic leukemia (AML) beyond the first complete remission or chronic myelogenous leukemia (CML) not in first chronic phase received an association of 13."1.29Total body irradiation and high-dose cyclophosphamide, BCNU and VP-16 (CBV) as a new preparatory regimen for allogeneic bone marrow transplantation in patients with advanced hematologic malignancies. ( Bourdin, S; Harousseau, JL; Le Tortorec, S; Mahe, B; Mahe, JM; Mechinaud-Lacroix, F; Milpied, N; Moreau, P; Rapp, MJ; Wu, DP, 1994)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.00)18.7374
1990's4 (16.00)18.2507
2000's13 (52.00)29.6817
2010's7 (28.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jain, T1
Kunze, KL1
Temkit, M1
Partain, DK1
Patnaik, MS1
Slack, JL1
Khera, N1
Hogan, WJ1
Roy, V1
Noel, P1
Leis, JF1
Sproat, LZ1
Fauble, V1
Mesa, RA1
Palmer, J1
Salhotra, A1
Mei, M1
Stiller, T1
Mokhtari, S1
Herrera, AF1
Chen, R1
Popplewell, L1
Zain, J1
Ali, H1
Sandhu, K1
Budde, E1
Nademanee, A1
Forman, SJ1
Nakamura, R1
Garfin, PM1
Link, MP1
Donaldson, SS1
Advani, RH1
Luna-Fineman, S1
Kharbanda, S1
Porteus, M1
Weinberg, KI1
Agarwal-Hashmi, R1
Hu, M1
Kramer, B1
Zhang, GY1
Wang, YM1
Watson, D1
Howden, B1
McCowage, G1
Alexander, IE1
Gunning, P1
Alexander, SI1
Rabitsch, W1
Bojic, M1
Wohlfarth, P1
Leiner, M1
Schörgenhofer, C1
Kalhs, P1
Schulenburg, A1
Sillaber, C1
Mitterbauer, M1
Sperr, WR1
Jäger, U1
Skrabs, K1
Greinix, H1
Hermann, A1
Lamm, W1
Christopoulos, P1
Bertz, H2
Ihorst, G1
Marks, R1
Wäsch, R2
Finke, J2
O'Meara, A1
Halter, J2
Heim, D2
Gerull, S1
Bucher, C2
Passweg, J1
Buser, A1
Stern, M2
Lush, RJ1
Haynes, AP3
Byrne, J1
Cull, GM2
Carter, GI2
Pagliuca, A2
Parker, JE1
Mufti, G1
Mahendra, P1
Craddock, CF1
Lui Yin, JA1
Garg, M1
Prentice, HG1
Potter, MN1
Russell, NH3
Marks, DI1
Lush, R1
Cavenagh, J1
Milligan, DW1
Schey, S1
Parker, A1
Clark, FJ1
Hunt, L1
Yin, J1
Fuller, S1
Vandenberghe, E1
Marsh, J1
Littlewood, T1
Smith, GM1
Culligan, D1
Hunter, A1
Chopra, R1
Davies, A1
Towlson, K1
Williams, CD1
Robinson, SP1
Goldstone, AH2
Mackinnon, S1
Carella, A1
Russell, N1
de Elvira, CR1
Taghipour, G1
Schmitz, N1
Rossi, HA1
Becker, PS1
Emmons, RV1
Westervelt, P1
Levy, W1
Liu, Q1
Clark, Y1
Ballen, K1
Au, WY1
Lie, AK1
Siu, LL1
Chan, EC1
Ooi, GC1
Leung, AY1
Liang, R1
Kwong, YL1
Kalaycio, M1
Rybicki, L1
Pohlman, B1
Sobecks, R1
Ball, E1
Cook, D1
Andresen, S1
Kuczkowski, E1
Bolwell, B1
Rao, PS1
Law, LY1
Horning, SJ1
Wong, RM1
Johnston, LJ1
Laport, GG1
Lowsky, R1
Shizuru, JA1
Blume, KG1
Negrin, RS1
Stockerl-Goldstein, KE1
Buser, AS1
Arber, C1
Meyer-Monard, S1
Stussi, G1
Lohri, A1
Ghielmini, M1
Tichelli, A1
Passweg, JR1
Gratwohl, A1
Vigouroux, S1
Michallet, M1
Porcher, R1
Attal, M1
Ades, L1
Bernard, M1
Blaise, D1
Tabrizi, R1
Garban, F1
Cassuto, JP1
Chevalier, P1
Facon, T1
Ifrah, N1
Renaud, M1
Tilly, H1
Vernant, JP1
Kuentz, M1
Bourhis, JH1
Bordigoni, P1
Deconinck, E1
Lioure, B1
Socié, G1
Milpied, N2
Ingram, W1
Devereux, S1
Das-Gupta, EP1
Byrne, JL2
Shaw, BE1
McMillan, A1
Gonzalez, J1
Ho, A1
Mufti, GJ1
Castenskiold, EC1
Kelsey, SM1
Collins, PW1
Coldwell, RD1
Allen, PD1
Side, LE1
Makin, HL1
Newland, AC1
Wu, DP1
Moreau, P1
Mechinaud-Lacroix, F1
Mahe, B1
Le Tortorec, S1
Rapp, MJ1
Bourdin, S1
Mahe, JM1
Harousseau, JL1
Barta, A1
Batai, A1
Torbagyi, E1
Sipos, A1
Lengyel, L1
Petranyi, GG1
Paloczi, K1
Kelemen, E1
Przepiorka, D1
van Besien, K1
Khouri, I1
Hagemeister, F1
Samuels, B1
Folloder, J1
Ueno, NT1
Molldrem, J1
Mehra, R1
Körbling, M1
Giralt, S1
Gajewski, J1
Donato, M1
Cleary, K1
Claxton, D1
Braunschweig, I1
Andersson, B1
Anderlini, P1
Champlin, R1
Miflin, G1
Rebello, P1
Hale, G1
Waldmann, H1
Reisser, S1
Hahn, J1
Engelhardt, M1
Kunzmann, R1
Veelken, H1
Holler, E2
Kolb, HJ1
Bender-Götze, C1
Haas, RJ1
Thierfelder, S1
Wilmanns, W1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase I/II Trial of Donor Derived Cytokine Induced Killer (CIK) Cells Infusion for Relapsed Hematologic Malignancy After Haploidentical Stem Cell Transplantation[NCT03821519]Phase 1/Phase 220 participants (Anticipated)Interventional2019-01-13Recruiting
Safety and Efficacy of a Strategy of Allogeneic Hematopoietic Stem Cell Transplantation After Reduced-intensity Conditioning for Chemosensitive Relapsed Follicular Lymphoma[NCT01208896]Phase 232 participants (Actual)Interventional2011-02-03Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

8 trials available for carmustine and Graft vs Host Disease

ArticleYear
Outcomes of Patients with Recurrent and Refractory Lymphoma Undergoing Allogeneic Hematopoietic Cell Transplantation with BEAM Conditioning and Sirolimus- and Tacrolimus-Based GVHD Prophylaxis.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2019, Volume: 25, Issue:2

    Topics: Adolescent; Adult; Allografts; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabin

2019
Allogeneic stem cell transplantation for relapsed or refractory lymphoma after conditioning with BEAM/fludarabine/TBI.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2013, Volume: 19, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Disease-Free Survival

2013
Allogeneic stem-cell transplantation for lymphoproliferative disorders using BEAM-CAMPATH (+/- fludarabine) conditioning combined with post-transplant donor-lymphocyte infusion.
    Cytotherapy, 2001, Volume: 3, Issue:3

    Topics: Adolescent; Adult; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodie

2001
High-dose cyclophosphamide, BCNU, and VP-16 (CBV) conditioning before allogeneic stem cell transplantation for patients with non-Hodgkin's lymphoma.
    Bone marrow transplantation, 2003, Volume: 31, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Blood Plate

2003
CD8+ T-cell-depleted, matched unrelated donor, allogeneic bone marrow transplantation for advanced AML using busulfan-based preparative regimens.
    Bone marrow transplantation, 2005, Volume: 35, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; Carmus

2005
High-dose chemotherapy using BEAM without autologous rescue followed by reduced-intensity conditioning allogeneic stem-cell transplantation for refractory or relapsing lymphomas: a comparison of delayed versus immediate transplantation.
    Bone marrow transplantation, 2007, Volume: 39, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Etoposide; Female; Graft vs

2007
Rapid achievement of complete donor chimerism and low regimen-related toxicity after reduced conditioning with fludarabine, carmustine, melphalan and allogeneic transplantation.
    Bone marrow transplantation, 2000, Volume: 26, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclosporine; Female; Follow-Up S

2000
Bone marrow transplantation for the treatment of leukaemia-results of the Munich Cooperative Group.
    Folia haematologica (Leipzig, Germany : 1928), 1989, Volume: 116, Issue:3-4

    Topics: Adolescent; Adult; Bone Marrow Transplantation; Carmustine; Child; Child, Preschool; Cyclophosphamid

1989

Other Studies

17 other studies available for carmustine and Graft vs Host Disease

ArticleYear
Comparison of reduced intensity conditioning regimens used in patients undergoing hematopoietic stem cell transplantation for myelofibrosis.
    Bone marrow transplantation, 2019, Volume: 54, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Busulfan; Carmustine; Chimerism; Female; Graft vs Host Disease;

2019
Improved outcomes after autologous bone marrow transplantation for children with relapsed or refractory Hodgkin lymphoma: twenty years experience at a single institution.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2015, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Bone Marrow Transplantation; Carmustine; Child; Cyclophosphamide; Etoposide; Fema

2015
Methyl-Guanine-Methyl-Transferase Transgenic Bone Marrow Transplantation Allows N,N-bis(2-chloroethyl)-Nitrosourea Driven Donor Mixed-Chimerism Without Graft-Versus-Host Disease, and With Donor-Specific Allograft Tolerance.
    Transplantation, 2015, Volume: 99, Issue:12

    Topics: Animals; Antineoplastic Agents, Alkylating; Bone Marrow Transplantation; Carmustine; Disease Models,

2015
Alemtuzumab-BEAM as conditioning for allogeneic hematopoietic stem cell transplantation in relapsed/refractory Hodgkin lymphoma: a single-center analysis.
    Journal of cancer research and clinical oncology, 2016, Volume: 142, Issue:6

    Topics: Adult; Alemtuzumab; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocol

2016
Radiation-free allogeneic conditioning with fludarabine, carmustine, and thiotepa for acute lymphoblastic leukemia and other hematologic malignancies necessitating enhanced central nervous system activity.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2012, Volume: 18, Issue:9

    Topics: Adult; Aged; Alemtuzumab; Antibodies, Monoclonal, Humanized; Carmustine; Central Nervous System; Cyc

2012
The toxicity and efficacy of donor lymphocyte infusions given after reduced-intensity conditioning allogeneic stem cell transplantation.
    Blood, 2002, Nov-01, Volume: 100, Issue:9

    Topics: Adult; Aged; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neo

2002
Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation: an analysis from the Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation.
    Blood, 2002, Dec-15, Volume: 100, Issue:13

    Topics: Adult; Aged; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neo

2002
Treatment of lymphoma relapses after allogeneic hematopoietic stem cell transplantation with intensive chemotherapy followed by infusion of hematopoietic stem cell from the original donor.
    Annals of hematology, 2003, Volume: 82, Issue:9

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Etoposide; Female; Gr

2003
Nephrotic syndrome in patients with peripheral blood stem cell transplant.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:4

    Topics: Acute Kidney Injury; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineop

2005
High-dose carmustine, etoposide, and cyclophosphamide followed by allogeneic hematopoietic cell transplantation for non-Hodgkin lymphoma.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2006, Volume: 12, Issue:7

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cause of Death; Combined Modality

2006
Long-term outcomes after reduced-intensity conditioning allogeneic stem cell transplantation for low-grade lymphoma: a survey by the French Society of Bone Marrow Graft Transplantation and Cellular Therapy (SFGM-TC).
    Haematologica, 2007, Volume: 92, Issue:5

    Topics: Adult; Aged; Antibodies, Monoclonal; Antilymphocyte Serum; Antineoplastic Combined Chemotherapy Prot

2007
Outcome of BEAM-autologous and BEAM-alemtuzumab allogeneic transplantation in relapsed advanced stage follicular lymphoma.
    British journal of haematology, 2008, Volume: 141, Issue:2

    Topics: Acute Disease; Adult; Aged; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized;

2008
Functional hyperactivity of monocytes after bone marrow transplantation: possible relevance for the development of post-transplant complications or relapse.
    Bone marrow transplantation, 1995, Volume: 15, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Biopterins; Bone Marr

1995
Total body irradiation and high-dose cyclophosphamide, BCNU and VP-16 (CBV) as a new preparatory regimen for allogeneic bone marrow transplantation in patients with advanced hematologic malignancies.
    Bone marrow transplantation, 1994, Volume: 14, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carm

1994
Haemopoietic cell transplantation activity and results: a single institution experience.
    Bone marrow transplantation, 1998, Volume: 22 Suppl 4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Graft vs Host Disease; Hemat

1998
Carmustine, etoposide, cytarabine and melphalan as a preparative regimen for allogeneic transplantation for high-risk malignant lymphoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:5

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Female; Graft vs Host

1999
Preliminary experience of allogeneic stem cell transplantation for lymphoproliferative disorders using BEAM-CAMPATH conditioning: an effective regimen with low procedure-related toxicity.
    British journal of haematology, 2000, Volume: 108, Issue:4

    Topics: Adult; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm;

2000