Page last updated: 2024-10-24

carmustine and Epilepsy

carmustine has been researched along with Epilepsy in 7 studies

Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"Anticonvulsant therapy is usually recommended before surgery in all patients affected by high grade glioma who are planned to be treated with Carmustine 1,3-bis [2 chloroetyl]-1-nitrosurea, or BCNU) wafers."5.15Postoperative seizure in high grade glioma patients treated with BCNU wafers. A mono-institutional experience. ( Ciccarino, P; d'Avella, D; Del Moro, G; Della Puppa, A; Denaro, L; Lombardi, G; Manara, R; Rossetto, M; Rotilio, A; Scienza, R, 2011)
"Factors predicting adverse events following implantation with wafers containing 1,3-bis(2-chloroethyl)-1-nitrosourea (carmustine, BCNU), which is used in local chemotherapy for malignant gliomas (MGs), are unknown."4.12Cerebral Edema Due to Chemotherapeutic Wafer Implantation for Malignant Glioma: Registry Study of Correlation with Perioperative Epileptic Seizures. ( Fujii, Y; Goto, T; Hanaoka, Y; Hardian, RF; Hongo, K; Horiuchi, T; Kato, H; Ogiwara, T, 2022)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Fujii, Y1
Ogiwara, T1
Kato, H1
Hanaoka, Y1
Hardian, RF1
Goto, T1
Hongo, K1
Horiuchi, T1
Pennacchio, P1
NoƩ, F1
Gnatkovsky, V1
Moroni, RF3
Zucca, I1
Regondi, MC3
Inverardi, F3
de Curtis, M1
Frassoni, C3
Cipelletti, B1
Spreafico, R2
Della Puppa, A1
Denaro, L1
Rossetto, M1
Ciccarino, P1
Manara, R1
Lombardi, G1
Del Moro, G1
Rotilio, A1
d'Avella, D1
Scienza, R1
Benardete, EA1
Kriegstein, AR1
Panzica, F1
Yamamoto, YL1
Thompson, CJ1
Diksic, M1
Meyer, E1
Feindel, WH1

Reviews

1 review available for carmustine and Epilepsy

ArticleYear
Positron emission tomography.
    Neurosurgical review, 1984, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Brain; Brain Diseases; Brain Neoplasms; Carmustine; Cerebrovascular

1984

Trials

1 trial available for carmustine and Epilepsy

ArticleYear
Postoperative seizure in high grade glioma patients treated with BCNU wafers. A mono-institutional experience.
    Journal of neuro-oncology, 2011, Volume: 105, Issue:2

    Topics: Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Clinical Trials, Ph

2011

Other Studies

5 other studies available for carmustine and Epilepsy

ArticleYear
Cerebral Edema Due to Chemotherapeutic Wafer Implantation for Malignant Glioma: Registry Study of Correlation with Perioperative Epileptic Seizures.
    Neurologia medico-chirurgica, 2022, Jul-15, Volume: 62, Issue:7

    Topics: Adult; Antineoplastic Agents, Alkylating; Brain Edema; Brain Neoplasms; Carmustine; Combined Modalit

2022
Increased pCREB expression and the spontaneous epileptiform activity in a BCNU-treated rat model of cortical dysplasia.
    Epilepsia, 2015, Volume: 56, Issue:9

    Topics: Age Factors; Animals; Antineoplastic Agents, Alkylating; Brain; Calbindins; Carmustine; CREB-Binding

2015
Development of cortical malformations in BCNU-treated rat, model of cortical dysplasia.
    Neuroscience, 2011, Feb-23, Volume: 175

    Topics: Animals; Animals, Newborn; Carmustine; Cell Differentiation; Cell Movement; Disease Models, Animal;

2011
Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex.
    Epilepsia, 2002, Volume: 43, Issue:9

    Topics: Animals; Bicuculline; Carmustine; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Ele

2002
Altered spatial distribution of PV-cortical cells and dysmorphic neurons in the somatosensory cortex of BCNU-treated rat model of cortical dysplasia.
    Epilepsia, 2008, Volume: 49, Issue:5

    Topics: Animals; Animals, Newborn; Antibodies; Calbindins; Carmustine; Classical Lissencephalies and Subcort

2008