carmustine has been researched along with Carcinoma, Small Cell in 26 studies
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A selected case file of 32 patients with carcinoma of the lung which had passed the stage of surgical cure was randomized in 3 arms and treated with different schedules: regimen A, adriamycin plus cyclophosphamide; regimen B, the BACON combination, slightly modified; regimen CVP, cyclophosphamide plus vincristine plus prednisone." | 5.04 | Combined chemotherapy for unresectable carcinoma of the lung: a randomized trial. ( Arosio, A; Burdick, L; Cunietti, E; Eridani, S; Maggio, L; Periti, M; Perrone, G, 1978) |
| " The addition of a nitrosourea appears to be an improvement over cyclophosphamide used alone in oat cell carcinoma and over the two drug combination of cyclophosphamide and methotrexate in both adenocarcinoma of the lung and oat cell disease." | 5.04 | Nitrosourea combinations in lung cancer. ( Livingston, RB, 1976) |
| "In small cell lung cancer initial high dose therapy followed by non-cross-resistant regimens may prove effective." | 2.37 | High dose chemotherapy in solid tumours in adults. ( Peters, W; Souhami, R, 1986) |
| "Small cell carcinoma is predominantly found in the lung and only about 5% of small cell carcinoma cases have been noted to be extrapulmonary; these are commonly found in the esophagus, pancreas, skin, uterus, and breast." | 1.34 | Small cell carcinoma of the nasopharynx. ( Chien, CY; Huang, HY; Hwang, CF; Lin, IH, 2007) |
| "Cyclocreatine was not very cytotoxic upon 24 h of exposure of human SW2 small-cell lung cancer cells to concentrations of up to 5 mM." | 1.29 | Cyclocreatine in cancer chemotherapy. ( Kaddurah-Daouk, R; Kufe, DW; Liu, J; Menon, K; Northey, D; Teicher, BA, 1995) |
| " In the dosage range of 600 to 1000 mg/m2 in heavily pretreated patients, BCNU is not recommended, but additional investigation may be warranted in patients with central nervous system metastases who previously were treated with radiation therapy." | 1.28 | High-dose carmustine and autologous bone marrow reinfusion in the treatment of refractory or relapsed small cell lung carcinoma. ( Baldauf, MC; Broste, S; Friedenberg, WR; Gehlsen, JA; Koontz, DP; Kriesel, DH; Rodvold, KA; Rushing, DA, 1991) |
| "Thirty-one patients with metastatic brain tumors (MBT) from lung cancer and ten patients with MBT from melanoma received BCNU, 100 mg/m2, every four weeks by intracarotid and/or vertebral artery infusion into each involved site." | 1.26 | Phase II study--intra-arterial BCNU therapy for metastatic brain tumors. ( Avellanosa, AM; Caracandas, J; Ghoorah, J; Jennings, E; Karakousis, C; Madajewicz, S; Park, HC; Takita, H; Vincent, R; West, CR, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (50.00) | 18.7374 |
| 1990's | 11 (42.31) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, IH | 1 |
| Hwang, CF | 1 |
| Huang, HY | 1 |
| Chien, CY | 1 |
| Presant, CA | 1 |
| Hillinger, S | 1 |
| Klahr, C | 1 |
| Madajewicz, S | 1 |
| West, CR | 1 |
| Park, HC | 1 |
| Ghoorah, J | 1 |
| Avellanosa, AM | 1 |
| Takita, H | 1 |
| Karakousis, C | 1 |
| Vincent, R | 1 |
| Caracandas, J | 1 |
| Jennings, E | 1 |
| Carney, DN | 1 |
| Mitchell, JB | 1 |
| Kinsella, TJ | 1 |
| Stewart, P | 1 |
| Buckner, CD | 1 |
| Thomas, ED | 1 |
| Bagley, C | 1 |
| Bensinger, W | 1 |
| Clift, RA | 1 |
| Appelbaum, FR | 1 |
| Sanders, J | 1 |
| Teicher, BA | 1 |
| Menon, K | 1 |
| Northey, D | 1 |
| Liu, J | 1 |
| Kufe, DW | 1 |
| Kaddurah-Daouk, R | 1 |
| Aabo, K | 2 |
| Vindeløv, LL | 3 |
| Christensen, IJ | 3 |
| Spang-Thomsen, M | 3 |
| Roed, H | 3 |
| Gridelli, C | 1 |
| Perrone, F | 1 |
| D'Aprile, M | 1 |
| Rossi, A | 1 |
| Palmeri, S | 1 |
| Curcio, C | 1 |
| Veltri, E | 1 |
| Ianniello, G | 1 |
| Lorusso, V | 1 |
| Palmieri, G | 1 |
| Shaw, GL | 1 |
| Gazdar, AF | 1 |
| Phelps, R | 1 |
| Steinberg, SM | 1 |
| Linnoila, RI | 1 |
| Johnson, BE | 1 |
| Oie, HK | 1 |
| Russell, EK | 1 |
| Ghosh, BC | 1 |
| Pass, HI | 1 |
| Minna, JD | 1 |
| Mulshine, JL | 1 |
| Ihde, DC | 1 |
| de Crevoisier, R | 1 |
| le Cesne, A | 1 |
| le Chevalier, T | 2 |
| Kiss, I | 1 |
| Tomasek, J | 1 |
| Protheroe, AS | 1 |
| Pickard, C | 1 |
| Johnson, PW | 1 |
| Craddock, T | 1 |
| Shefta, J | 1 |
| Short, K | 1 |
| Lancaster, F | 1 |
| Selby, PJ | 1 |
| Henwood, J | 1 |
| Boylston, AW | 1 |
| Eridani, S | 1 |
| Burdick, L | 1 |
| Maggio, L | 1 |
| Cunietti, E | 1 |
| Periti, M | 1 |
| Arosio, A | 1 |
| Perrone, G | 1 |
| Abeloff, MD | 2 |
| Ettinger, DS | 2 |
| Baylin, SB | 1 |
| Hazra, T | 1 |
| Livingston, RB | 1 |
| Khouri, NF | 1 |
| Lenhard, RE | 1 |
| Jensen, PB | 1 |
| Sehested, M | 1 |
| Demant, EJ | 1 |
| Vindeløv, L | 1 |
| Hansen, HH | 2 |
| Rushing, DA | 1 |
| Friedenberg, WR | 1 |
| Baldauf, MC | 1 |
| Broste, S | 1 |
| Gehlsen, JA | 1 |
| Kriesel, DH | 1 |
| Koontz, DP | 1 |
| Rodvold, KA | 1 |
| Egyházi, S | 1 |
| Bergh, J | 1 |
| Hansson, J | 1 |
| Karran, P | 1 |
| Ringborg, U | 1 |
| O'Bryan, RM | 1 |
| Crowley, JJ | 1 |
| Kim, PN | 1 |
| Epstein, RB | 1 |
| Neilan, B | 1 |
| Coltman, CA | 1 |
| Stuckey, WJ | 1 |
| Pazdur, R | 1 |
| Cha, RJ | 1 |
| Pico, JL | 1 |
| Baume, D | 1 |
| Ostronoff, M | 1 |
| Beaujean, F | 1 |
| Gouyette, A | 1 |
| Arriagada, R | 1 |
| Rebattu, P | 1 |
| Hayat, M | 1 |
| Lange, OF | 1 |
| Souhami, R | 1 |
| Peters, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Randomized Study of Hypofractionated vs Conventionally Fractionated Concurrent Chemo-radiotherapy for Limited Disease Small Cell Lung Cancer[NCT02688036] | Phase 3 | 860 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for carmustine and Carcinoma, Small Cell
| Article | Year |
|---|---|
[Dose-effect of chemotherapy in bronchial small-cell cancer].
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineo | 1997 |
High dose chemotherapy in solid tumours in adults.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marr | 1986 |
5 trials available for carmustine and Carcinoma, Small Cell
| Article | Year |
|---|---|
Phase II study of intensive CEV (carboplatin, epirubicin and VP-16) plus G-CSF (granulocyte-colony stimulating factor) in extensive small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Small Cell; Car | 1995 |
Correlation of in vitro drug sensitivity testing results with response to chemotherapy and survival: comparison of non-small cell lung cancer and small cell lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cel | 1996 |
Combined chemotherapy for unresectable carcinoma of the lung: a randomized trial.
Topics: Adult; Aged; Antineoplastic Agents; Bleomycin; Carcinoma; Carcinoma, Small Cell; Carmustine; Cycloph | 1978 |
Nitrosourea combinations in lung cancer.
Topics: Adenocarcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Carmustine; Clinical Trials as Topi | 1976 |
Comparison of etoposide and cisplatin with bis-chloro-ethylnitrosourea, thiotepa, vincristine, and cyclophosphamide for salvage treatment in small cell lung cancer. A Southwest Oncology Group Study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Carmustine; Cisp | 1990 |
19 other studies available for carmustine and Carcinoma, Small Cell
| Article | Year |
|---|---|
Small cell carcinoma of the nasopharynx.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Carmustine; Cisplatin; | 2007 |
Phase II study of 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU, NSC No. 409962) with amphotericin B in bronchogenic carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Amphotericin B; Bone Marrow; Carcinoma, Bronchogenic; Carcinoma, Small | 1980 |
Phase II study--intra-arterial BCNU therapy for metastatic brain tumors.
Topics: Adenocarcinoma; Adult; Aged; Brain Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Carmu | 1981 |
In vitro radiation and chemotherapy sensitivity of established cell lines of human small cell lung cancer and its large cell morphological variants.
Topics: Antineoplastic Agents; Carcinoma, Small Cell; Carmustine; Cell Line; Cell Survival; Dose-Response Re | 1983 |
Intensive chemoradiotherapy with autologous marrow transplantation for small cell carcinoma of the lung.
Topics: Autopsy; Bone Marrow Transplantation; Carcinoma, Small Cell; Carmustine; Combined Modality Therapy; | 1983 |
Cyclocreatine in cancer chemotherapy.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Small Cell; Carmustine; Cell Division; Ce | 1995 |
Low-dose chemotherapy delays relapse of a dominated and resistant sub-population in a heterogeneous human SCLC xenograft in nude mice.
Topics: Animals; Carcinoma, Small Cell; Carmustine; DNA, Neoplasm; Drug Resistance; Humans; Lung Neoplasms; | 1994 |
A dominated and resistant subpopulation causes regrowth after response to 1,3-bis(2-chloroethyl)-1-nitrosourea treatment of a heterogeneous small cell lung cancer xenograft in nude mice.
Topics: Animals; Biopsy, Needle; Carcinoma, Small Cell; Carmustine; Cell Division; DNA, Neoplasm; Drug Resis | 1994 |
Sodium and potassium excretion changes and bone marrow recovery after chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carcinoma, Small Cell; | 1999 |
Persistence of clonal T-cell expansions following high-dose chemotherapy and autologous peripheral blood progenitor cell rescue.
Topics: Amino Acid Sequence; Antineoplastic Agents, Alkylating; Bone Marrow Purging; Breast Neoplasms; Carci | 2000 |
Management of small cell carcinoma of the lung: therapy, staging, and biochemical markers.
Topics: Adult; Aged; Amine Oxidase (Copper-Containing); Carcinoma, Small Cell; Carmustine; Cyclophosphamide; | 1976 |
Intensive induction therapy for small cell carcinoma of the lung.
Topics: Aged; Antineoplastic Agents; Bone Marrow; Carcinoma, Small Cell; Carmustine; Cyclophosphamide; Doxor | 1979 |
Doxorubicin sensitivity pattern in a panel of small-cell lung-cancer cell lines: correlation to etoposide and vincristine sensitivity and inverse correlation to carmustine sensitivity.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cel | 1992 |
High-dose carmustine and autologous bone marrow reinfusion in the treatment of refractory or relapsed small cell lung carcinoma.
Topics: Adult; Aged; Bone Marrow Transplantation; Carcinoma, Small Cell; Carmustine; Combined Modality Thera | 1991 |
Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines.
Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Carmustine; Cell Line; Cell Survival; DNA, Ne | 1991 |
[Combined modality treatment of small cell lung cancer by chemotherapy, radiotherapy, immunotherapy and Chinese traditional medicine].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Carmustine; Comb | 1989 |
[High-doses chemotherapy followed by bone marrow autograft in the treatment of small cell bronchial cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carcinoma, Small Cell; | 1987 |
Concurrent chemo-radiotherapy in small cell lung cancer.
Topics: Adult; Aged; Carcinoma, Small Cell; Carmustine; Combined Modality Therapy; Female; Humans; Ifosfamid | 1988 |
In vitro evaluation of a new nitrosourea, TCNU, against human small cell lung cancer cell lines.
Topics: Carcinoma, Small Cell; Carmustine; Cell Cycle; Cell Line; Colony-Forming Units Assay; Drug Evaluatio | 1987 |