carmustine has been researched along with Carcinoma, Epidermoid in 30 studies
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Considering the carcinogenesis model, we conclude that 2 or 4 weeks of N-nitroso-tris-chloroethylurea treatment may be suitable for investigating new chemicals for promotional or suppressive effects on lung squamous cell carcinoma." | 5.39 | Novel medium-term carcinogenesis model for lung squamous cell carcinoma induced by N-nitroso-tris-chloroethylurea in mice. ( Fujioka, M; Ishii, N; Kakehashi, A; Kitano, M; Tago, Y; Wanibuchi, H; Wei, M; Yamano, S, 2013) |
| " The addition of a nitrosourea appears to be an improvement over cyclophosphamide used alone in oat cell carcinoma and over the two drug combination of cyclophosphamide and methotrexate in both adenocarcinoma of the lung and oat cell disease." | 5.04 | Nitrosourea combinations in lung cancer. ( Livingston, RB, 1976) |
| "Female Swiss mice (Cr:NIH(S)) developed bronchiolar cell hyperplasia, dysplasia, metaplasia, and various morphologic types of bronchiolar cell tumors after topical (skin) application of N-nitroso-methyl-bis-chloroethylurea (NMBCU) or N-nitroso-tris-chloroethylurea (NTCU)." | 3.68 | Mouse bronchiolar cell carcinogenesis. Histologic characterization and expression of Clara cell antigen in lesions induced by N-nitrosobis-(2-chloroethyl) ureas. ( Katyal, SL; Lijinsky, W; Rehm, S; Singh, G, 1991) |
| "Lung cancer is the leading cause of cancer-related deaths, and squamous cell carcinoma (SCC) is one of the most common types of lung cancer." | 1.56 | Histopathological effect of pterostilbene as chemoprevention in N-nitroso-tri-chloroethylurea (NTCU)-induced lung squamous cell carcinoma (SCC) mouse model. ( Ghazali, AR; Masre, SF; Surien, O, 2020) |
| "Honokiol is an important bioactive compound found in the bark of Magnolia tree." | 1.40 | Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function. ( Kalyanaraman, B; Komas, SM; Liu, Q; Lubet, RA; Pan, J; Wang, Y; You, M; Zhang, Q, 2014) |
| "Considering the carcinogenesis model, we conclude that 2 or 4 weeks of N-nitroso-tris-chloroethylurea treatment may be suitable for investigating new chemicals for promotional or suppressive effects on lung squamous cell carcinoma." | 1.39 | Novel medium-term carcinogenesis model for lung squamous cell carcinoma induced by N-nitroso-tris-chloroethylurea in mice. ( Fujioka, M; Ishii, N; Kakehashi, A; Kitano, M; Tago, Y; Wanibuchi, H; Wei, M; Yamano, S, 2013) |
| "Heterogeneous RT dose-response relationships in the in vitro assay were demonstrated." | 1.31 | Development of an in vitro chemo-radiation response assay for cervical carcinoma. ( Burger, RA; Fruehauf, JP; Monk, BJ; Parker, R; Radany, EH; Redpath, L, 2002) |
| "Metronidazole, 1." | 1.27 | Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983) |
| "Thirty-one patients with metastatic brain tumors (MBT) from lung cancer and ten patients with MBT from melanoma received BCNU, 100 mg/m2, every four weeks by intracarotid and/or vertebral artery infusion into each involved site." | 1.26 | Phase II study--intra-arterial BCNU therapy for metastatic brain tumors. ( Avellanosa, AM; Caracandas, J; Ghoorah, J; Jennings, E; Karakousis, C; Madajewicz, S; Park, HC; Takita, H; Vincent, R; West, CR, 1981) |
| "HN2 was a potent carcinogen, producing squamous cell carcinomas in 9 of 33 mice in 1 series." | 1.26 | Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice. ( Smuckler, EA; Zackheim, HS, 1980) |
| "Osseous, visceral, and cutaneous metastases responded equally well." | 1.26 | Adriamycin, 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU-NSC 409462), and cyclophosphamide in refractory adenocarcinoma of the breast and other tumors. ( Klahr, C; Kolhouse, JF; Presant, CA, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (53.33) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 2 (6.67) | 29.6817 |
| 2010's | 7 (23.33) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zakaria, MA | 1 |
| Rajab, NF | 1 |
| Chua, EW | 1 |
| Selvarajah, GT | 1 |
| Masre, SF | 2 |
| Surien, O | 1 |
| Ghazali, AR | 1 |
| Riolobos, L | 1 |
| Gad, EA | 1 |
| Treuting, PM | 1 |
| Timms, AE | 1 |
| Hershberg, EA | 1 |
| Corulli, LR | 1 |
| Rodmaker, E | 1 |
| Disis, ML | 1 |
| Tago, Y | 2 |
| Yamano, S | 2 |
| Wei, M | 1 |
| Kakehashi, A | 1 |
| Kitano, M | 1 |
| Fujioka, M | 2 |
| Ishii, N | 2 |
| Wanibuchi, H | 2 |
| Pan, J | 2 |
| Zhang, Q | 1 |
| Liu, Q | 1 |
| Komas, SM | 1 |
| Kalyanaraman, B | 1 |
| Lubet, RA | 1 |
| Wang, Y | 2 |
| You, M | 1 |
| Song, JM | 1 |
| Qian, X | 1 |
| Teferi, F | 1 |
| Kassie, F | 1 |
| Ghosh, M | 1 |
| Dwyer-Nield, LD | 1 |
| Kwon, JB | 1 |
| Barthel, L | 1 |
| Janssen, WJ | 1 |
| Merrick, DT | 2 |
| Keith, RL | 2 |
| Gi, M | 1 |
| Doi, K | 1 |
| Okada, S | 1 |
| Hirayama, Y | 1 |
| Tachibana, H | 1 |
| Tatsumi, K | 1 |
| Hudish, TM | 1 |
| Opincariu, LI | 1 |
| Mozer, AB | 1 |
| Johnson, MS | 1 |
| Cleaver, TG | 1 |
| Malkoski, SP | 1 |
| Monk, BJ | 1 |
| Burger, RA | 1 |
| Parker, R | 1 |
| Radany, EH | 1 |
| Redpath, L | 1 |
| Fruehauf, JP | 1 |
| Veronesi, A | 1 |
| Magri, MD | 1 |
| Trovò, MG | 1 |
| Tirelli, U | 1 |
| Galligioni, E | 1 |
| Tumolo, S | 1 |
| Grigoletto, E | 1 |
| Presant, CA | 4 |
| Hillinger, S | 1 |
| Klahr, C | 3 |
| Madajewicz, S | 1 |
| West, CR | 1 |
| Park, HC | 1 |
| Ghoorah, J | 1 |
| Avellanosa, AM | 1 |
| Takita, H | 1 |
| Karakousis, C | 1 |
| Vincent, R | 1 |
| Caracandas, J | 1 |
| Jennings, E | 1 |
| Stewart, DJ | 1 |
| Maroun, JA | 1 |
| Young, V | 1 |
| Crook, AF | 1 |
| Hopkins, HS | 1 |
| Yan, RC | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Bélanger, R | 1 |
| Heringer, R | 1 |
| Rosso, R | 1 |
| Nobile, MT | 1 |
| Brema, F | 1 |
| Porcile, G | 1 |
| Cinquegrana, A | 1 |
| De Palma, M | 1 |
| Rubagotti, A | 1 |
| Denes, AE | 1 |
| Bartolucci, A | 1 |
| Zackheim, HS | 1 |
| Smuckler, EA | 1 |
| Brunet, J | 1 |
| Alonso, C | 1 |
| Llanos, M | 1 |
| Lacasta, A | 1 |
| Fuentes, J | 1 |
| Mendoza, LA | 1 |
| Badia, JM | 1 |
| Delgado, E | 1 |
| Ojeda, B | 1 |
| Sheehan, D | 1 |
| Meade, G | 1 |
| Livingston, RB | 1 |
| Moertel, CG | 1 |
| Ratkin, G | 1 |
| Brown, C | 1 |
| Epstein, JH | 1 |
| Slavik, M | 1 |
| Kolhouse, JF | 1 |
| Rehm, S | 1 |
| Lijinsky, W | 1 |
| Singh, G | 1 |
| Katyal, SL | 1 |
| Ushio, Y | 1 |
| Arita, N | 1 |
| Hayakawa, T | 1 |
| Mogami, H | 1 |
| Hasegawa, H | 1 |
| Bitoh, S | 1 |
| Oku, Y | 1 |
| Ikeda, H | 1 |
| Kanai, N | 1 |
| Kanoh, M | 1 |
| Marsh, JC | 1 |
| DeConti, RC | 1 |
| Hubbard, SP | 1 |
| Reyes, ES | 1 |
| Talley, RW | 1 |
| O'Bryan, RM | 1 |
| Gastesi, RA | 1 |
| Omura, GA | 1 |
| Roberts, GA | 1 |
6 trials available for carmustine and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Randomized trial of chemoimmunotherapy in advanced non-oat-cell lung cancer.
Topics: Adenocarcinoma; Adult; Aged; BCG Vaccine; Carcinoma, Squamous Cell; Carmustine; Clinical Trials as T | 1982 |
Chemotherapy and radiotherapy in locally advanced cervical cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Carmustine; C | 1995 |
Nitrosourea combinations in lung cancer.
Topics: Adenocarcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Carmustine; Clinical Trials as Topi | 1976 |
Chemotherapy of brain metastases from lung carcinoma: a controlled randomized study.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma; Carcinom | 1991 |
Treatment of Hodgkin's disease and other cancers with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962).
Topics: Adenocarcinoma; Adenoma, Islet Cell; Adolescent; Adrenal Gland Neoplasms; Adult; Alkylating Agents; | 1971 |
Clinical evaluation of 1,3-bis(2-chloroethyl)-nitrosourea (BCNU; NSC-409962) with fluoxymesterone (NSC-12165) in the treatment of solid tumors.
Topics: Breast Neoplasms; Carcinoma, Squamous Cell; Carmustine; Clinical Trials as Topic; Edema; Fluoxymeste | 1973 |
24 other studies available for carmustine and Carcinoma, Epidermoid
| Article | Year |
|---|---|
NTCU induced pre-malignant and malignant stages of lung squamous cell carcinoma in mice model.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; C | 2021 |
Histopathological effect of pterostilbene as chemoprevention in N-nitroso-tri-chloroethylurea (NTCU)-induced lung squamous cell carcinoma (SCC) mouse model.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Carmustine; Disease Models, Animal; Fema | 2020 |
The Effect of Mouse Strain, Sex, and Carcinogen Dose on Toxicity and the Development of Lung Dysplasia and Squamous Cell Carcinomas in Mice.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Carmustine; Cell Transformation, Neoplastic; Dose-Re | 2019 |
Novel medium-term carcinogenesis model for lung squamous cell carcinoma induced by N-nitroso-tris-chloroethylurea in mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogenesis; Carcinoma, Squamous Cell; Carmustine; Cytoch | 2013 |
Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function.
Topics: Adenosine Triphosphate; Animals; Anticarcinogenic Agents; Apoptosis; Biphenyl Compounds; Bronchi; Ca | 2014 |
Dietary diindolylmethane suppresses inflammation-driven lung squamous cell carcinoma in mice.
Topics: Animals; Carcinoma, Squamous Cell; Carmustine; Cytokines; Diet; Disease Models, Animal; Female; Gene | 2015 |
Tracheal dysplasia precedes bronchial dysplasia in mouse model of N-nitroso trischloroethylurea induced squamous cell lung cancer.
Topics: Animals; Biomarkers, Tumor; Bronchi; Carcinoma, Squamous Cell; Carmustine; Cell Transformation, Neop | 2015 |
Role of deltaNp63(pos)CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Carmustine; Disease Models, Animal; Disease Progress | 2016 |
N-nitroso-tris-chloroethylurea induces premalignant squamous dysplasia in mice.
Topics: Administration, Topical; Animals; Bronchial Neoplasms; Carcinogens; Carcinoma, Squamous Cell; Carmus | 2012 |
Development of an in vitro chemo-radiation response assay for cervical carcinoma.
Topics: Antineoplastic Agents; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Carmustine; Cell Division; | 2002 |
Combination chemotherapy with vincristine, carmustine, carmustine (BCNU), and bleomycin in patients with squamous cell bronchial carcinoma resistant to cyclophosphamide, doxorubicin, methotrexate, and procarbazine (CAMP).
Topics: Adult; Aged; Bleomycin; Bronchial Neoplasms; Carcinoma, Squamous Cell; Carmustine; Cyclophosphamide; | 1982 |
Phase II study of 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU, NSC No. 409962) with amphotericin B in bronchogenic carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Amphotericin B; Bone Marrow; Carcinoma, Bronchogenic; Carcinoma, Small | 1980 |
Phase II study--intra-arterial BCNU therapy for metastatic brain tumors.
Topics: Adenocarcinoma; Adult; Aged; Brain Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Carmu | 1981 |
Feasibility study of combining metronidazole with chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq | 1983 |
Combination chemotherapy for bronchogenic carcinoma with doxorubicin, BCNU, and cyclophosphamide (ABC): a pilot study of the Southeastern Cancer Study Group.
Topics: Adenocarcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Carmustine; Cyclophosphamide; Dox | 1982 |
Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Carmustine; Lomustine; Mechlorethamine; Mice; Neopla | 1980 |
Chemical modulation of chemotherapy resistance in cultured oesophageal carcinoma cells.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carcinoma, Squamous Cell; Carmustine; Cisp | 2000 |
Walter Hubert lecture Chemotherapy of upper gastrointestinal carcinoma.
Topics: Adenoma, Islet Cell; Antineoplastic Agents; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, S | 1976 |
Adriamycin, BCNU plus cyclophosphamide (ABC) in advanced carcinoma of the head and neck.
Topics: Antineoplastic Agents; Bone Marrow; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Carmustine; | 1979 |
Stimulation of ultraviolet-induced carcinogenesis by 1,3-Bis(2-chloroethyl)-1-nitrosourea.
Topics: Administration, Topical; Animals; Carcinoma, Squamous Cell; Carmustine; Female; Mice; Mice, Nude; My | 1979 |
Clinical studies with nitrosoureas in various solid tumors.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Squamous Cell; Carmustine; Female; Genital Neoplasms, F | 1976 |
Adriamycin, 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU-NSC 409462), and cyclophosphamide in refractory adenocarcinoma of the breast and other tumors.
Topics: Adenocarcinoma; Adolescent; Aged; Breast Neoplasms; Carcinoma, Squamous Cell; Carmustine; Cyclophosp | 1976 |
Mouse bronchiolar cell carcinogenesis. Histologic characterization and expression of Clara cell antigen in lesions induced by N-nitrosobis-(2-chloroethyl) ureas.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Carcinoma, Squamous Cell; Carmustine; Female; Immunohi | 1991 |
Combination therapy of solid tumors using 1,3-bis(2-chloroethyl)-1-nitrosourea (NCNU), vincristine, methotrexate, and 5-fluorouracil.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Carmustine; Female; Fluorouracil; Gastrointes | 1973 |