carmustine has been researched along with Brain Swelling in 10 studies
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This New Approaches to Brain Tumor Therapy CNS Consortium study sought to determine the maximum-tolerated dose (MTD) of carmustine (BCNU) that can be implanted in biodegradable polymers following resection of recurrent high-grade gliomas and the systemic BCNU exposure with increasing doses of interstitial BCNU." | 9.10 | Dose escalation of carmustine in surgically implanted polymers in patients with recurrent malignant glioma: a New Approaches to Brain Tumor Therapy CNS Consortium trial. ( Barker, F; Bruce, J; Fisher, J; Grossman, SA; Hilt, D; Judy, K; Olivi, A; Olsen, J; Piantadosi, S; Tatter, S, 2003) |
| "Carmustine (BCNU) wafer (Gliadel(®) Wafer) implantation after tumor resection is an approved treatment for high-grade glioma (HGG)." | 7.83 | Early Postoperative Expansion of Parenchymal High-intensity Areas on T2-weighted Imaging Predicts Delayed Cerebral Edema Caused by Carmustine Wafer Implantation in Patients with High-grade Glioma. ( Akutsu, H; Ishikawa, E; Kohzuki, H; Masuda, Y; Masumoto, T; Matsuda, M; Matsumura, A; Nakai, K; Okamoto, E; Takano, S; Yamamoto, T, 2016) |
| "The development of perifocal edema and tumor bed cyst has been reported after implantation of biodegradable carmustine wafers for the treatment of malignant gliomas." | 7.83 | The influence of carmustine wafer implantation on tumor bed cysts and peritumoral brain edema. ( Hasegawa, Y; Iuchi, T; Kawasaki, K; Sakaida, T; Yokoi, S, 2016) |
| "This New Approaches to Brain Tumor Therapy CNS Consortium study sought to determine the maximum-tolerated dose (MTD) of carmustine (BCNU) that can be implanted in biodegradable polymers following resection of recurrent high-grade gliomas and the systemic BCNU exposure with increasing doses of interstitial BCNU." | 5.10 | Dose escalation of carmustine in surgically implanted polymers in patients with recurrent malignant glioma: a New Approaches to Brain Tumor Therapy CNS Consortium trial. ( Barker, F; Bruce, J; Fisher, J; Grossman, SA; Hilt, D; Judy, K; Olivi, A; Olsen, J; Piantadosi, S; Tatter, S, 2003) |
| "Factors predicting adverse events following implantation with wafers containing 1,3-bis(2-chloroethyl)-1-nitrosourea (carmustine, BCNU), which is used in local chemotherapy for malignant gliomas (MGs), are unknown." | 4.12 | Cerebral Edema Due to Chemotherapeutic Wafer Implantation for Malignant Glioma: Registry Study of Correlation with Perioperative Epileptic Seizures. ( Fujii, Y; Goto, T; Hanaoka, Y; Hardian, RF; Hongo, K; Horiuchi, T; Kato, H; Ogiwara, T, 2022) |
| "Carmustine (BCNU) wafer (Gliadel(®) Wafer) implantation after tumor resection is an approved treatment for high-grade glioma (HGG)." | 3.83 | Early Postoperative Expansion of Parenchymal High-intensity Areas on T2-weighted Imaging Predicts Delayed Cerebral Edema Caused by Carmustine Wafer Implantation in Patients with High-grade Glioma. ( Akutsu, H; Ishikawa, E; Kohzuki, H; Masuda, Y; Masumoto, T; Matsuda, M; Matsumura, A; Nakai, K; Okamoto, E; Takano, S; Yamamoto, T, 2016) |
| "The development of perifocal edema and tumor bed cyst has been reported after implantation of biodegradable carmustine wafers for the treatment of malignant gliomas." | 3.83 | The influence of carmustine wafer implantation on tumor bed cysts and peritumoral brain edema. ( Hasegawa, Y; Iuchi, T; Kawasaki, K; Sakaida, T; Yokoi, S, 2016) |
| "While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect." | 3.73 | Cerebral edema associated with Gliadel wafers: two case studies. ( Goebel, EA; Weber, EL, 2005) |
| " It has been shown previously that implantation of controlled-release polymers impregnated with the nitrosourea carmustine (BCNU) extended the period of survival in rats bearing the 9L glioma compared with similar rats treated with systemically administered BCNU." | 3.69 | Biodegradable polymers for controlled delivery of chemotherapy with and without radiation therapy in the monkey brain. ( Brem, H; Epstein, JI; Olivi, A; Pinn, M; Tamargo, RJ; Weingart, JD; Wharam, M, 1994) |
| "With respect to the cerebral edema that can be associated with the carmustine implants, there can appear images in follow-up that are suggestive of relapse." | 1.33 | Patient with resected anaplastic astrocytoma and an image suggestive of relapse. ( Carrato Mena, A; Guillén Ponce, C; Maciá Escalante, S; Rodríguez Lescure, A; Sáez Castán, J; Segura Ibáñez, JM, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujii, Y | 1 |
| Ogiwara, T | 1 |
| Kato, H | 1 |
| Hanaoka, Y | 1 |
| Hardian, RF | 1 |
| Goto, T | 1 |
| Hongo, K | 1 |
| Horiuchi, T | 1 |
| Beez, T | 1 |
| Burgula, S | 1 |
| Kamp, M | 1 |
| Rapp, M | 1 |
| Steiger, HJ | 1 |
| Sabel, M | 1 |
| Masuda, Y | 1 |
| Ishikawa, E | 1 |
| Yamamoto, T | 1 |
| Matsuda, M | 1 |
| Akutsu, H | 1 |
| Kohzuki, H | 1 |
| Nakai, K | 1 |
| Okamoto, E | 1 |
| Takano, S | 1 |
| Masumoto, T | 1 |
| Matsumura, A | 1 |
| Hasegawa, Y | 1 |
| Iuchi, T | 1 |
| Sakaida, T | 1 |
| Yokoi, S | 1 |
| Kawasaki, K | 1 |
| Murai, S | 1 |
| Ichikawa, T | 1 |
| Kurozumi, K | 1 |
| Shimazu, Y | 1 |
| Oka, T | 1 |
| Otani, Y | 1 |
| Shimizu, T | 1 |
| Date, I | 1 |
| Olivi, A | 2 |
| Grossman, SA | 1 |
| Tatter, S | 1 |
| Barker, F | 1 |
| Judy, K | 1 |
| Olsen, J | 1 |
| Bruce, J | 1 |
| Hilt, D | 1 |
| Fisher, J | 1 |
| Piantadosi, S | 1 |
| Weber, EL | 1 |
| Goebel, EA | 1 |
| Maciá Escalante, S | 1 |
| Rodríguez Lescure, A | 1 |
| Segura Ibáñez, JM | 1 |
| Sáez Castán, J | 1 |
| Guillén Ponce, C | 1 |
| Carrato Mena, A | 1 |
| Brem, H | 1 |
| Tamargo, RJ | 1 |
| Pinn, M | 1 |
| Weingart, JD | 1 |
| Wharam, M | 1 |
| Epstein, JI | 1 |
| Nagata, K | 1 |
| Gross, CE | 1 |
| Kindt, GW | 1 |
| Geier, JM | 1 |
| Adey, GR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PHASE I, OPEN LABEL, MULTICENTER DOSE ESCALATION STUDY OF GLIADEL IN PATIENTS WITH RECURRENT MALIGNANT GLIOMA[NCT00004028] | Phase 1 | 0 participants | Interventional | 1996-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for carmustine and Brain Swelling
| Article | Year |
|---|---|
Dose escalation of carmustine in surgically implanted polymers in patients with recurrent malignant glioma: a New Approaches to Brain Tumor Therapy CNS Consortium trial.
Topics: Absorbable Implants; Adult; Aged; Antineoplastic Agents, Alkylating; Biocompatible Materials; Brain | 2003 |
9 other studies available for carmustine and Brain Swelling
| Article | Year |
|---|---|
Cerebral Edema Due to Chemotherapeutic Wafer Implantation for Malignant Glioma: Registry Study of Correlation with Perioperative Epileptic Seizures.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Edema; Brain Neoplasms; Carmustine; Combined Modalit | 2022 |
Space-Occupying Tumor Bed Cysts as a Complication of Modern Treatment for High-Grade Glioma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Edema; Carmustine; Central Nervous System Cysts; C | 2017 |
Early Postoperative Expansion of Parenchymal High-intensity Areas on T2-weighted Imaging Predicts Delayed Cerebral Edema Caused by Carmustine Wafer Implantation in Patients with High-grade Glioma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Edema; Brain Neoplasms; Carmustine; Female; Gl | 2016 |
The influence of carmustine wafer implantation on tumor bed cysts and peritumoral brain edema.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Edema; Brain Neoplasms; Carmustine; Cysts; Female; Gl | 2016 |
Quantitative analysis of brain edema in patients with malignant glioma treated with BCNU wafers.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Brain Edema; Brain Neoplasms; Carmustine | 2016 |
Cerebral edema associated with Gliadel wafers: two case studies.
Topics: Antineoplastic Agents, Alkylating; Biocompatible Materials; Brain Edema; Brain Neoplasms; Carmustine | 2005 |
Patient with resected anaplastic astrocytoma and an image suggestive of relapse.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Edema; Brain Neoplasms; Carmustine; Com | 2006 |
Biodegradable polymers for controlled delivery of chemotherapy with and without radiation therapy in the monkey brain.
Topics: Animals; Brain Edema; Brain Neoplasms; Carmustine; Decanoic Acids; Dicarboxylic Acids; Drug Combinat | 1994 |
Topographic electroencephalographic study with power ratio index mapping in patients with malignant brain tumors.
Topics: Adult; Aged; Brain Edema; Brain Neoplasms; Carmustine; Cerebral Cortex; Electroencephalography; Fema | 1985 |