carmustine has been researched along with Bone Marrow Diseases in 23 studies
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Bone Marrow Diseases: Diseases involving the BONE MARROW.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a dose-finding study of mitoxantrone (MITO) in combination with high-dose cyclophosphamide, carmustine (BCNU), and etoposide (CBV) in refractory lymphoma undergoing autologous bone marrow transplantation (ABMT)." | 9.07 | Escalating dose of mitoxantrone with high-dose cyclophosphamide, carmustine, and etoposide in patients with refractory lymphoma undergoing autologous bone marrow transplantation. ( Attal, M; Canal, P; Chatelut, E; Dezeuze, A; Huguet, F; Laurent, G; Payen, C; Pris, J; Schlaifer, D, 1994) |
| "We conducted a dose-finding study of mitoxantrone (MITO) in combination with high-dose cyclophosphamide, carmustine (BCNU), and etoposide (CBV) in refractory lymphoma undergoing autologous bone marrow transplantation (ABMT)." | 5.07 | Escalating dose of mitoxantrone with high-dose cyclophosphamide, carmustine, and etoposide in patients with refractory lymphoma undergoing autologous bone marrow transplantation. ( Attal, M; Canal, P; Chatelut, E; Dezeuze, A; Huguet, F; Laurent, G; Payen, C; Pris, J; Schlaifer, D, 1994) |
| "High-dose chemotherapy with BCNU, melphalan, or both, followed by autologous bone marrow transplantation (ABMT) has been reported to produce response rates in excess of 60% in patients with advanced melanoma." | 3.67 | High-dose chemotherapy without autologous bone marrow transplantation in melanoma. ( Aisner, J; Tait, N; Tchekmedyian, NS; Van Echo, D, 1986) |
| "Patients with Hodgkin's disease (HD) who fail to enter a complete remission after an initial course of combination chemotherapy are usually considered to have an induction failure (IF); this subset of patients has an extremely poor outcome with further conventional therapy." | 2.68 | High-dose cyclophosphamide, carmustine (BCNU), and etoposide (VP16-213) with or without cisplatin (CBV +/- P) and autologous transplantation for patients with Hodgkin's disease who fail to enter a complete remission after combination chemotherapy. ( Barnett, MJ; Fairey, RN; Hogge, DE; Klasa, RJ; Klingemann, HG; Nantel, SH; Reece, DE; Shepherd, JD; Sutherland, HJ; Voss, NJ, 1995) |
| " With local delivery of O6BG, the MTD of BCNU in combination with O6BG was increased." | 1.31 | Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model. ( Biser-Rohrbaugh, A; Bunton, TE; Carson, BS; Gabikian, P; Guarnieri, M; Tyler, BM; Weingart, J; Wu, QZ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (43.48) | 18.7374 |
| 1990's | 9 (39.13) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cairo, M | 1 |
| Auperin, A | 1 |
| Perkins, SL | 1 |
| Pinkerton, R | 1 |
| Harrison, L | 1 |
| Goldman, S | 1 |
| Patte, C | 2 |
| Guarnieri, M | 1 |
| Biser-Rohrbaugh, A | 1 |
| Tyler, BM | 1 |
| Gabikian, P | 1 |
| Bunton, TE | 1 |
| Wu, QZ | 1 |
| Weingart, J | 1 |
| Carson, BS | 1 |
| Adams, DM | 1 |
| Zhou, T | 1 |
| Berg, SL | 1 |
| Bernstein, M | 1 |
| Neville, K | 1 |
| Blaney, SM | 1 |
| Rubin, P | 1 |
| Robustelli della Cuna, G | 1 |
| Paoletti, P | 1 |
| Bernardo, G | 1 |
| Knerich, R | 1 |
| Butti, G | 1 |
| Cuzzoni, Q | 1 |
| Lohrmann, HP | 1 |
| Antman, K | 1 |
| Ayash, L | 1 |
| Elias, A | 1 |
| Wheeler, C | 1 |
| Schwartz, G | 1 |
| Mazanet, R | 1 |
| Tepler, I | 1 |
| Schnipper, LE | 1 |
| Frei, E | 1 |
| Fuchsberger, P | 1 |
| Lakota, J | 1 |
| Reece, DE | 2 |
| Barnett, MJ | 1 |
| Shepherd, JD | 1 |
| Hogge, DE | 1 |
| Klasa, RJ | 1 |
| Nantel, SH | 1 |
| Sutherland, HJ | 1 |
| Klingemann, HG | 1 |
| Fairey, RN | 1 |
| Voss, NJ | 1 |
| Scheid, C | 1 |
| Pettengell, R | 1 |
| Ghielmini, M | 1 |
| Radford, JA | 1 |
| Morgenstern, GR | 1 |
| Stern, PL | 1 |
| Crowther, D | 1 |
| Phillips, GL | 1 |
| Attal, M | 1 |
| Canal, P | 1 |
| Schlaifer, D | 1 |
| Chatelut, E | 1 |
| Dezeuze, A | 1 |
| Huguet, F | 1 |
| Payen, C | 1 |
| Pris, J | 1 |
| Laurent, G | 1 |
| Haas, R | 1 |
| Moos, M | 1 |
| Möhle, R | 1 |
| Döhner, H | 1 |
| Witt, B | 1 |
| Goldschmidt, H | 1 |
| Murea, S | 1 |
| Flentje, M | 1 |
| Wannenmacher, M | 1 |
| Hunstein, W | 1 |
| Deisseroth, AB | 1 |
| Holmes, F | 1 |
| Hortobagyi, G | 1 |
| Champlin, R | 1 |
| Fernández-Jiménez, MC | 1 |
| Canales, MA | 1 |
| Ojeda, E | 1 |
| de Bustos, JG | 1 |
| Aguado, MJ | 1 |
| Hernández-Navarro, F | 1 |
| Steingrimsdottir, H | 1 |
| Gruber, A | 1 |
| Björkholm, M | 1 |
| Svensson, A | 1 |
| Hansson, M | 1 |
| Wilson, CB | 1 |
| Gutin, P | 1 |
| Boldrey, EB | 1 |
| Drafts, D | 1 |
| Levin, VA | 1 |
| Enot, KJ | 1 |
| Trainor, KJ | 1 |
| Morley, AA | 1 |
| LoRusso, PM | 1 |
| Tapazoglou, E | 1 |
| Zarbo, RJ | 1 |
| Cullis, PA | 1 |
| Austin, D | 1 |
| Al-Sarraf, M | 1 |
| Hartmann, O | 1 |
| Benhamou, E | 1 |
| Beaujean, F | 1 |
| Kalifa, C | 1 |
| Lejars, O | 1 |
| Behard, C | 1 |
| Flamant, F | 1 |
| Thyss, A | 1 |
| Deville, A | 1 |
| Tchekmedyian, NS | 1 |
| Tait, N | 1 |
| Van Echo, D | 1 |
| Aisner, J | 1 |
| Carella, AM | 1 |
| Santini, G | 1 |
| Santoro, A | 1 |
| Coser, P | 1 |
| Frassoni, F | 1 |
| Martinengo, M | 1 |
| Nati, S | 1 |
| Congiu, A | 1 |
| Giordano, D | 1 |
| Cerri, R | 1 |
| Moertel, CG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Trial of 06-BG and BCNU in Children With CNS Tumors[NCT00003765] | Phase 1 | 36 participants (Actual) | Interventional | 1999-05-31 | Completed | ||
| Does Varenicline Influence Alcohol Consumption in Alcohol Dependent Individuals?[NCT00846859] | Phase 2 | 162 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for carmustine and Bone Marrow Diseases
| Article | Year |
|---|---|
The Franz Buschke lecture: late effects of chemotherapy and radiation therapy: a new hypothesis.
Topics: Antineoplastic Agents; Bleomycin; Bone Marrow Diseases; Brain Diseases; Cardiomyopathies; Carmustine | 1984 |
The problem of permanent bone marrow damage after cytotoxic drug treatment.
Topics: Animals; Antineoplastic Agents; Bone Marrow Diseases; Busulfan; Carmustine; Cell Division; Cell Surv | 1984 |
Intensive therapy and autotransplantation in Hodgkin's disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bone Marrow Transplantation; C | 1994 |
Intracranial astrocytoma with diffuse bone marrow metastasis: a case report and review of the literature.
Topics: Adult; Astrocytoma; Bone Marrow Diseases; Brain Neoplasms; Carmustine; Glial Fibrillary Acidic Prote | 1988 |
6 trials available for carmustine and Bone Marrow Diseases
| Article | Year |
|---|---|
Phase 1 trial of O6-benzylguanine and BCNU in children with CNS tumors: a Children's Oncology Group study.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone | 2008 |
High-dose cyclophosphamide, thiotepa, and carboplatin with autologous marrow support in women with measurable advanced breast cancer responding to standard-dose therapy: analysis by age.
Topics: Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bone Marro | 1994 |
High-dose cyclophosphamide, carmustine (BCNU), and etoposide (VP16-213) with or without cisplatin (CBV +/- P) and autologous transplantation for patients with Hodgkin's disease who fail to enter a complete remission after combination chemotherapy.
Topics: Actuarial Analysis; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bo | 1995 |
Escalating dose of mitoxantrone with high-dose cyclophosphamide, carmustine, and etoposide in patients with refractory lymphoma undergoing autologous bone marrow transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bone Marrow Transplanta | 1994 |
High-dose therapy with peripheral blood progenitor cell transplantation in low-grade non-Hodgkin's lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Bone Marrow Diseases; Carmu | 1996 |
Salvage chemotherapy with mini-BEAM for relapsed or refractory Hodgkin's disease prior to autologous peripheral blood stem cell transplantation.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carmustine; | 1999 |
13 other studies available for carmustine and Bone Marrow Diseases
| Article | Year |
|---|---|
Overall survival of children and adolescents with mature B cell non-Hodgkin lymphoma who had refractory or relapsed disease during or after treatment with FAB/LMB 96: A report from the FAB/LMB 96 study group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carmustine; Child; | 2018 |
Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carmustine; Dose-Resp | 2002 |
Clinical toxicity of combined modality treatment with nitrosourea derivatives for central nervous system tumors.
Topics: Bone Marrow Diseases; Brain Neoplasms; Carmustine; Gastrointestinal Diseases; Glioblastoma; Glioma; | 1982 |
High-dose chemotherapy and autologous peripheral stem cell transplantation in patients with relapsing malignant lymphomas--first experience in the Slovak Republic.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carboplatin; Carmustine; Cyclo | 1995 |
Time-course of the recovery of cellular immune function after high-dose chemotherapy and peripheral blood progenitor cell transplantation for high-grade non-Hodgkin's lymphoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Diseases; | 1995 |
Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of breast cancer: a pilot trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B | 1996 |
Immune reconstitution after autologous hematopoietic stem cell transplantation in relation to underlying disease, type of high-dose therapy and infectious complications.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Breast Neoplasms; Carmu | 2000 |
Single-agent chemotherapy of brain tumors. A five-year review.
Topics: Astrocytoma; Bone Marrow Diseases; Brain Neoplasms; Carmustine; Glioma; Humans; Imidazoles; Lomustin | 1976 |
Screening of cytotoxic drugs for residual bone marrow damage.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Diseases; Busulfan; Carmustine; Cell Surviv | 1976 |
Repeated high-dose chemotherapy followed by purged autologous bone marrow transplantation as consolidation therapy in metastatic neuroblastoma.
Topics: Abdominal Neoplasms; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Disease | 1987 |
High-dose chemotherapy without autologous bone marrow transplantation in melanoma.
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Di | 1986 |
Massive chemotherapy with non-frozen autologous bone marrow transplantation in 13 cases of refractory Hodgkin's disease.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Bone Marrow Dis | 1985 |
Therapy of advanced gastrointestinal cancer with the nitrosoureas.
Topics: Adenocarcinoma; Antineoplastic Agents; Bone Marrow Diseases; Carmustine; Colonic Neoplasms; Cyclohex | 1973 |