carmustine has been researched along with Benign Cerebellar Neoplasms in 16 studies
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Transcriptional profiling revealed the upregulation of several metallothionein (MT) genes in a BCNU-resistant medulloblastoma cell line [D341 MED (OBR)] relative to its parental line." | 7.75 | BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line. ( Bacolod, MD; Bigner, DD; Bullock, NS; Colvin, M; Fehdrau, R; Friedman, HS; Johnson, SP, 2009) |
| "O6-Benzyl-2'-deoxyguanosine (dBG), a water-soluble inhibitor of O6-methylguanine-DNA methyltransferase (MGMT), potentiates the efficacy of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) against MGMT-positive, BCNU-resistant Daoy human medulloblastoma tumor xenografts in athymic mice (S." | 7.70 | Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea. ( Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC, 1999) |
| "Fotemustine is a chloroethylnitrosourea with antitumor activity in disseminated melanoma and adult primary brain tumors." | 5.30 | Activity of fotemustine in medulloblastoma and malignant glioma xenografts in relation to O6-alkylguanine-DNA alkyltransferase and alkylpurine-DNA N-glycosylase activity. ( Boland, I; Gouyette, A; Lacroix, C; Lellouch-Tubiana, A; Margison, GP; Morizet, J; Parker, F; Pierre-Kahn, A; Poullain, MG; Terrier-Lacombe, MJ; Vassal, G; Vénuat, AM; Watson, AJ, 1998) |
| "Within 3 weeks of definitive surgery, 571 adult patients with histologically confirmed, supratentorial malignant gliomas were randomly assigned to receive one of three chemotherapy regimens: BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) alone, alternating courses (every 8 weeks) of BCNU and procarbazine, or BCNU plus hydroxyurea alternating with procarbazine plus VM-26 (epipodophyllotoxin)." | 5.06 | Randomized trial of three chemotherapy regimens and two radiotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. Brain Tumor Cooperative Group Trial 8001. ( Burger, PC; Green, SB; Mahaley, MS; Mealey, J; Ransohoff, J; Robertson, JT; Selker, RG; Shapiro, WR; Strike, TA; VanGilder, JC, 1989) |
| " Transcriptional profiling revealed the upregulation of several metallothionein (MT) genes in a BCNU-resistant medulloblastoma cell line [D341 MED (OBR)] relative to its parental line." | 3.75 | BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line. ( Bacolod, MD; Bigner, DD; Bullock, NS; Colvin, M; Fehdrau, R; Friedman, HS; Johnson, SP, 2009) |
| "O6-Benzyl-2'-deoxyguanosine (dBG), a water-soluble inhibitor of O6-methylguanine-DNA methyltransferase (MGMT), potentiates the efficacy of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) against MGMT-positive, BCNU-resistant Daoy human medulloblastoma tumor xenografts in athymic mice (S." | 3.70 | Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea. ( Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC, 1999) |
| "Fotemustine is a chloroethylnitrosourea with antitumor activity in disseminated melanoma and adult primary brain tumors." | 1.30 | Activity of fotemustine in medulloblastoma and malignant glioma xenografts in relation to O6-alkylguanine-DNA alkyltransferase and alkylpurine-DNA N-glycosylase activity. ( Boland, I; Gouyette, A; Lacroix, C; Lellouch-Tubiana, A; Margison, GP; Morizet, J; Parker, F; Pierre-Kahn, A; Poullain, MG; Terrier-Lacombe, MJ; Vassal, G; Vénuat, AM; Watson, AJ, 1998) |
| "A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy." | 1.26 | Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy. ( Bailey, CC; Jones, PH; Marsden, HB, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (56.25) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bacolod, MD | 1 |
| Fehdrau, R | 1 |
| Johnson, SP | 2 |
| Bullock, NS | 1 |
| Bigner, DD | 2 |
| Colvin, M | 1 |
| Friedman, HS | 3 |
| Horvath, Z | 1 |
| Höchtl, T | 1 |
| Bauer, W | 1 |
| Fritzer-Szekeres, M | 1 |
| Elford, HL | 1 |
| Szekeres, T | 1 |
| Tihan, T | 1 |
| Casotto, A | 1 |
| Buoncristiani, P | 1 |
| Vassal, G | 1 |
| Boland, I | 1 |
| Terrier-Lacombe, MJ | 1 |
| Watson, AJ | 1 |
| Margison, GP | 1 |
| Vénuat, AM | 1 |
| Morizet, J | 1 |
| Parker, F | 1 |
| Lacroix, C | 1 |
| Lellouch-Tubiana, A | 1 |
| Pierre-Kahn, A | 1 |
| Poullain, MG | 1 |
| Gouyette, A | 1 |
| Dong, Q | 1 |
| Colvin, OM | 1 |
| Bullock, N | 1 |
| Kilborn, C | 1 |
| Runyon, G | 1 |
| Sullivan, DM | 1 |
| Easton, J | 1 |
| Nahta, R | 1 |
| Marks, J | 1 |
| Modrich, P | 1 |
| Kokkinakis, DM | 1 |
| Moschel, RC | 1 |
| Pegg, AE | 1 |
| Schold, SC | 2 |
| Fiorillo, A | 1 |
| Maggi, G | 1 |
| Martone, A | 1 |
| Migliorati, R | 1 |
| D'Amore, R | 1 |
| Alfieri, E | 1 |
| Greco, N | 1 |
| Cirillo, S | 1 |
| Marano, I | 1 |
| Bailey, CC | 1 |
| Marsden, HB | 1 |
| Jones, PH | 1 |
| Silber, JR | 1 |
| Bobola, MS | 1 |
| Ewers, TG | 1 |
| Muramoto, M | 1 |
| Berger, MS | 1 |
| Shapiro, WR | 2 |
| Green, SB | 1 |
| Burger, PC | 2 |
| Mahaley, MS | 2 |
| Selker, RG | 1 |
| VanGilder, JC | 1 |
| Robertson, JT | 1 |
| Ransohoff, J | 1 |
| Mealey, J | 1 |
| Strike, TA | 1 |
| Vick, NA | 1 |
| DeLong, ER | 1 |
| Albright, RE | 1 |
| Bullard, DE | 1 |
| Khandekar, JD | 1 |
| Cairncross, JG | 1 |
| Hughes, EN | 1 |
| Shillito, J | 1 |
| Sallan, SE | 1 |
| Loeffler, JS | 1 |
| Cassady, JR | 1 |
| Tarbell, NJ | 1 |
| Constine, LS | 1 |
| Rubin, P | 1 |
| Woolf, PD | 1 |
| Doane, K | 1 |
| Lush, CM | 1 |
| Vetter, N | 1 |
| Berger, E | 1 |
| Otupal, I | 1 |
| Jürgenssen, OA | 1 |
| Chernik, NL | 1 |
| Posner, JB | 1 |
1 trial available for carmustine and Benign Cerebellar Neoplasms
| Article | Year |
|---|---|
Randomized trial of three chemotherapy regimens and two radiotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. Brain Tumor Cooperative Group Trial 8001.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cerebellar Neoplasms; Clinical Trials as | 1989 |
15 other studies available for carmustine and Benign Cerebellar Neoplasms
| Article | Year |
|---|---|
BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line.
Topics: Carmustine; Cerebellar Neoplasms; Drug Resistance, Neoplasm; Humans; Medulloblastoma; Metallothionei | 2009 |
Synergistic cytotoxicity of the ribonucleotide reductase inhibitor didox (3,4-dihydroxy-benzohydroxamic acid) and the alkylating agent carmustine (BCNU) in 9L rat gliosarcoma cells and DAOY human medulloblastoma cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cere | 2004 |
Medulloblastoma in childhood. Multidisciplinary treatment.
Topics: Adolescent; Carmustine; Cerebellar Neoplasms; Cerebellum; Child; Child, Preschool; Female; Humans; I | 1982 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 41-1980.
Topics: Astrocytoma; Carmustine; Cerebellar Neoplasms; Child, Preschool; Diagnosis, Differential; Female; Hu | 1980 |
Activity of fotemustine in medulloblastoma and malignant glioma xenografts in relation to O6-alkylguanine-DNA alkyltransferase and alkylpurine-DNA N-glycosylase activity.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cere | 1998 |
Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR).
Topics: Antineoplastic Agents, Alkylating; Blotting, Northern; Blotting, Southern; Blotting, Western; Carmus | 1999 |
Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Cerebellar Neoplasms | 1999 |
Shunt-related abdominal metastases in an infant with medulloblastoma: long-term remission by systemic chemotherapy and surgery.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carmustine; Cerebellar Neoplasms; Combi | 2001 |
Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.
Topics: Carmustine; Cerebellar Neoplasms; Female; Humans; Infant; Medulloblastoma; Pneumonia, Pneumococcal; | 1978 |
O6-alkylguanine DNA-alkyltransferase is not a major determinant of sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea in four medulloblastoma cell lines.
Topics: Carmustine; Cell Survival; Cerebellar Neoplasms; Drug Resistance; Guanine; Humans; Medulloblastoma; | 1992 |
Phase II diaziquone-based chemotherapy trials in patients with anaplastic supratentorial astrocytic neoplasms.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Aziridines; Be | 1987 |
Medulloblastoma at the joint center for radiation therapy between 1968 and 1984. The influence of radiation dose on the patterns of failure and survival.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cerebellar Neoplasms; | 1988 |
Hyperprolactinemia and hypothyroidism following cytotoxic therapy for central nervous system malignancies.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Carmustine; Cerebellar Neoplasms; Child; Child, Preschool; | 1987 |
[Recurrent bilateral pneumothorax in progressive lung fibrosis following combination therapy with BCNU].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cerebellar Neoplasms; Humans; Mal | 1985 |
Necrotizing encephalopathy following intraventricular instillation of methotrexate.
Topics: Adolescent; Brain; Brain Diseases; Brain Neoplasms; Carmustine; Cerebellar Neoplasms; Cerebral Ventr | 1973 |