carmustine has been researched along with Acute Liver Injury, Drug-Induced in 23 studies
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Autologous stem cell transplantation after high-dose melphalan for the treatment with multiple myeloma has resulted in prolonged progression-free survival and overall survival in patients under 65 years." | 5.09 | The role of autologous transplantation in patients with multiple myeloma aged 65 years and over. ( Bhagwati, N; Horton, C; Kulkarni, S; Mainwaring, P; Mehta, J; Pandha, H; Powles, R; Singhal, S; Sirohi, B; Treleaven, J, 2000) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (39.13) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Brandes, AA | 1 |
| Tosoni, A | 1 |
| Amistà, P | 1 |
| Nicolardi, L | 1 |
| Grosso, D | 1 |
| Berti, F | 1 |
| Ermani, M | 1 |
| Phillips, GL | 1 |
| Fay, JW | 1 |
| Herzig, GP | 1 |
| Herzig, RH | 1 |
| Weiner, RS | 1 |
| Wolff, SN | 2 |
| Lazarus, HM | 1 |
| Karanes, C | 1 |
| Ross, WE | 1 |
| Kramer, BS | 1 |
| Reed, DJ | 2 |
| Fariss, MW | 2 |
| McIntyre, RE | 1 |
| Magidson, JG | 1 |
| Austin, GE | 1 |
| Gale, RP | 1 |
| Ellouk-Achard, S | 1 |
| Levresse, V | 1 |
| Martin, C | 1 |
| Pham-Huy, C | 1 |
| Dutertre-Catella, H | 1 |
| Thevenin, M | 1 |
| Warnet, JM | 1 |
| Claude, JR | 1 |
| Arguello, F | 1 |
| Alexander, MA | 1 |
| Greene, JF | 1 |
| Stinson, SF | 1 |
| Jorden, JL | 1 |
| Smith, EM | 1 |
| Kalavar, NT | 1 |
| Alvord, WG | 1 |
| Klabansky, RL | 1 |
| Sausville, EA | 1 |
| Sirohi, B | 1 |
| Powles, R | 1 |
| Treleaven, J | 1 |
| Mainwaring, P | 1 |
| Kulkarni, S | 1 |
| Pandha, H | 1 |
| Bhagwati, N | 1 |
| Horton, C | 1 |
| Singhal, S | 1 |
| Mehta, J | 1 |
| Papadakis, V | 1 |
| Dunkel, IJ | 1 |
| Cramer, LD | 1 |
| Kramer, E | 1 |
| Papadopoulos, E | 1 |
| Goldman, S | 1 |
| Packer, RJ | 1 |
| Willoughby, M | 1 |
| Baker, D | 1 |
| Garvin, J | 1 |
| Strandjord, S | 1 |
| Coccia, P | 1 |
| Kaplan, AM | 1 |
| Klemperer, M | 1 |
| Finlay, JL | 1 |
| Jaeschke, H | 1 |
| Benzick, AE | 1 |
| Nakae, D | 2 |
| Yamamoto, K | 1 |
| Yoshiji, H | 1 |
| Kinugasa, T | 1 |
| Maruyama, H | 1 |
| Farber, JL | 2 |
| Konishi, Y | 1 |
| Oakes, JW | 1 |
| Wright, KC | 1 |
| Stephens, LC | 1 |
| Wallace, S | 1 |
| Savaraj, N | 1 |
| Feun, LG | 1 |
| van de Straat, R | 1 |
| de Vries, J | 1 |
| Debets, AJ | 1 |
| Vermeulen, NP | 1 |
| Haghbin, M | 1 |
| Tan, CC | 1 |
| Clarkson, BD | 1 |
| Miké, V | 1 |
| Burchenal, JH | 1 |
| Murphy, ML | 1 |
1 review available for carmustine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Glutathione depletion and susceptibility.
Topics: Animals; Calcium; Carmustine; Chemical and Drug Induced Liver Injury; Cystathionine; Doxorubicin; Gl | 1984 |
2 trials available for carmustine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
How effective is BCNU in recurrent glioblastoma in the modern era? A phase II trial.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; C | 2004 |
The role of autologous transplantation in patients with multiple myeloma aged 65 years and over.
Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Carmustine; Chem | 2000 |
20 other studies available for carmustine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Intensive 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), NSC #4366650 and cryopreserved autologous marrow transplantation for refractory cancer. A phase I-II study.
Topics: Adolescent; Adult; Aged; Bone Marrow Transplantation; Brain Neoplasms; Carmustine; Central Nervous S | 1983 |
Fatal veno-occlusive disease of the liver following high-dose 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and autologous bone marrow transplantation.
Topics: Adult; Bone Marrow Transplantation; Carmustine; Chemical and Drug Induced Liver Injury; Female; Huma | 1981 |
Ex vivo and in vitro models in acetaminophen hepatotoxicity studies. Relationship between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism.
Topics: Acetaminophen; Animals; Calcium; Carmustine; Chemical and Drug Induced Liver Injury; Cytosol; Energy | 1995 |
Preclinical evaluation of 9-chloro-2-methylellipticinium acetate alone and in combination with conventional anticancer drugs for the treatment of human brain tumor xenografts.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; | 1998 |
High-dose carmustine, thiotepa and etoposide followed by autologous bone marrow rescue for the treatment of high risk central nervous system tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carm | 2000 |
Pathophysiological consequences of enhanced intracellular superoxide formation in isolated perfused rat liver.
Topics: Animals; Bile; Carmustine; Chemical and Drug Induced Liver Injury; Diquat; Ferrous Compounds; Glutat | 1992 |
Liposome-encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen.
Topics: Acetaminophen; Animals; Carmustine; Chemical and Drug Induced Liver Injury; Drug Synergism; Glutathi | 1990 |
Mechanism of chemical-induced toxicity. II. Role of extracellular calcium.
Topics: Animals; Calcimycin; Calcium; Carbon Tetrachloride; Carmustine; Cell Separation; Cell Survival; Chem | 1985 |
Potentiation in the intact rat of the hepatotoxicity of acetaminophen by 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Acetaminophen; Animals; Carmustine; Chemical and Drug Induced Liver Injury; Deferoxamine; Drug Syner | 1988 |
Experimental combination chemotherapy: intracarotid versus intravenous administration of aziridinylbenzoquinone, BCNU, and cisplatin in dogs.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aziridines; Benzoqui | 1987 |
The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress.
Topics: Acetaminophen; Animals; Benzoquinones; Carmustine; Chemical and Drug Induced Liver Injury; Glutathio | 1987 |
High-dose carmustine and high-dose etoposide: a treatment regimen resulting in enhanced hepatic toxicity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Chemical a | 1986 |
Intensive chemotherapy in children with acute lymphoblastic leukemia (L-2 protocol).
Topics: Administration, Oral; Adolescent; Age Factors; Antineoplastic Agents; Asparaginase; Carmustine; Chem | 1974 |