carmofur has been researched along with Colonic Neoplasms in 28 studies
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "1-Hexylcarbamoyl-5-fluorouracil (HCFU) and its parent compound 5-fluorouracil (5-FU) were tested PO for antitumor activity against mouse colon adenocarcinoma 26 (colon 26), colon adenocarcinoma 38 (colon 38), and Lewis lung carcinoma." | 7.66 | Inhibition of murine colon adenocarcinomas and Lewis lung carcinoma by 1-hexylcarbamoyl-5-fluorouracil. ( Iida, H; Naganuma, K; Sakurai, Y; Tsukagoshi, S; Tsuruo, T, 1980) |
| "Experimental chemotherapy with 5-fluorouracil (5-FU; 60 mg/kg), 1-hexylcarbamoyl-5-fluorouracil (HCFU; 70 mg/kg), 3-(3-(6-benzoyloxy-3-cyano-2-pyridyloxycarbonyl)benzoyl)-1-ethoxym ethyl-5- fluorouracil (BOF-A2; 30 mg/kg) and UFT (20 mg/kg as tegafur with uracil at a molar ratio of 1:4) was performed using human gastric (H-111) and colon (Co-4) carcinoma strains in nude mice." | 3.68 | Antitumor activity of fluoropyrimidines and thymidylate synthetase inhibition. ( Abe, O; Arisawa, Y; Fujita, S; Ishibiki, K; Josui, K; Kodaira, S; Kubota, T; Mabuchi, K; Suto, A; Yamamoto, T, 1991) |
| "1-Hexylcarbamoyl-5-fluorouracil (HCFU) and its parent compound 5-fluorouracil (5-FU) were tested PO for antitumor activity against mouse colon adenocarcinoma 26 (colon 26), colon adenocarcinoma 38 (colon 38), and Lewis lung carcinoma." | 3.66 | Inhibition of murine colon adenocarcinomas and Lewis lung carcinoma by 1-hexylcarbamoyl-5-fluorouracil. ( Iida, H; Naganuma, K; Sakurai, Y; Tsukagoshi, S; Tsuruo, T, 1980) |
| "A total of 760 patients with colon cancer and 669 patients with rectal cancer were entered into this randomized clinical trial (RCT)." | 2.71 | Randomized controlled trial of the efficacy of adjuvant immunochemotherapy and adjuvant chemotherapy for colorectal cancer, using different combinations of the intracutaneous streptococcal preparation OK-432 and the oral pyrimidines 1-hexylcarbamoyl-5-flu ( Hojyo, K; Isomoto, H; Kato, T; Kodaira, S; Kunii, Y; Kunitomo, K; Niimoto, M; Nishida, O; Ohashi, Y; Takahashi, T; Tominaga, T; Watanabe, M; Yasutomi, M, 2004) |
| "Some 978 patients with colon cancer and 713 patients with rectal cancer were enrolled in the study, 85 (5." | 2.68 | [Prospective controlled study on the usefulness of Carmofur as a postoperative adjuvant chemotherapy for colorectal cancer]. ( Hojo, K; Ichihashi, H; Kato, T; Kikuchi, K; Kodaira, S; Kunii, Y; Ogawa, M; Takahashi, T; Tamada, R; Tominaga, T; Yasutomi, M, 1997) |
| "Adjuvant therapy of colorectal cancer with oral fluorinated pyrimidines is attractive because of its ease of administration and good tolerability." | 2.42 | Efficacy of oral adjuvant therapy after resection of colorectal cancer: 5-year results from three randomized trials. ( Burzykowski, T; Buyse, M; Hamada, C; Ohashi, Y; Piedbois, P; Sakamoto, J, 2004) |
| "The sensitivity of human colorectal cancer to 5-fluorouracil (5-FU) and its derivatives: 1-(tetrahydro-2-furyl)-5-FU (tegafur) and 1-hexylcarbamoyl-5-FU (HCFU) was determined by in vitro succinate dehydrogenase inhibition (SDI) test and in vivo subrenal capsule (SRC) assay." | 1.27 | [Human colorectal carcinoma is more sensitive to HCFU than 5-FU and tegafur in in vitro and in vivo drug sensitivity tests]. ( Anai, H; Fukuchi, K; Kusumoto, H; Kusumoto, T; Maehara, Y; Miyamoto, K; Sugimachi, K, 1988) |
| "Since colorectal cancer tissues are resistant to various antitumor drugs, the chemosensitivity test of HCFU should aid in determining the effects of a particular drug for an individual patient." | 1.27 | Colorectal carcinoma in vitro is more sensitive to 1-hexylcarbamoyl-5-fluorouracil compared with six other antitumor drugs: carboquone, Adriamycin, mitomycin C, aclacinomycin A, cisplatin, 5-fluorouracil. ( Anai, H; Kusumoto, H; Kusumoto, T; Maehara, Y; Sugimachi, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (42.86) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 8 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ito, K | 2 |
| Okushiba, S | 1 |
| Morikawa, T | 1 |
| Kondo, S | 1 |
| Katoh, H | 1 |
| Sakamoto, J | 2 |
| Ohashi, Y | 4 |
| Hamada, C | 2 |
| Buyse, M | 1 |
| Burzykowski, T | 1 |
| Piedbois, P | 1 |
| Tomita, N | 1 |
| Monden, M | 1 |
| Kikkawa, N | 2 |
| Imamura, M | 1 |
| Ohtoshi, M | 1 |
| Ohhashi, S | 1 |
| Sakamoto, T | 1 |
| Tanigawa, N | 1 |
| Nakano, H | 1 |
| Hioki, K | 2 |
| Hirakawa, K | 1 |
| Yasutomi, M | 6 |
| Yamamura, T | 2 |
| Kameyama, M | 2 |
| Iwanaga, T | 2 |
| Watanabe, M | 2 |
| Nishida, O | 1 |
| Kunii, Y | 2 |
| Kodaira, S | 5 |
| Takahashi, T | 4 |
| Tominaga, T | 3 |
| Hojyo, K | 1 |
| Kato, T | 4 |
| Niimoto, M | 2 |
| Kunitomo, K | 2 |
| Isomoto, H | 2 |
| Sadahiro, S | 1 |
| Mitomi, T | 1 |
| Noto, T | 1 |
| Kumada, K | 1 |
| Hiki, Y | 1 |
| Yamakawa, T | 1 |
| Amano, T | 1 |
| Oki, S | 1 |
| Otani, Y | 1 |
| Oka, H | 1 |
| Takemiya, S | 1 |
| Nishiyama, K | 1 |
| Tsuchiya, S | 1 |
| Ogawa, N | 3 |
| Rahman, M | 1 |
| Nakazato, H | 1 |
| Hojo, K | 2 |
| Koyama, Y | 1 |
| Tsuruo, T | 1 |
| Iida, H | 1 |
| Naganuma, K | 1 |
| Tsukagoshi, S | 1 |
| Sakurai, Y | 1 |
| Ogawa, M | 1 |
| Ichihashi, H | 3 |
| Tamada, R | 2 |
| Kikuchi, K | 1 |
| Maeda, M | 1 |
| Nagawa, H | 1 |
| Maeda, T | 1 |
| Koike, H | 1 |
| Kasai, H | 1 |
| Matsuda, T | 1 |
| Mabuchi, K | 2 |
| Kitaoka, H | 1 |
| Hirata, N | 1 |
| Kitaoka, U | 1 |
| Sato, S | 1 |
| Ueyama, T | 1 |
| Fukui, H | 2 |
| Miyazaki, K | 1 |
| Kuwano, M | 1 |
| Tokuda, C | 1 |
| Miyama, Y | 1 |
| Takeda, H | 1 |
| Kuroda, Y | 1 |
| Ohkuma, R | 1 |
| Ohsato, K | 1 |
| Utsunomiya, J | 1 |
| Mori, T | 1 |
| Fukuda, I | 1 |
| Kubota, T | 1 |
| Fujita, S | 1 |
| Yamamoto, T | 1 |
| Josui, K | 1 |
| Arisawa, Y | 1 |
| Suto, A | 1 |
| Ishibiki, K | 1 |
| Abe, O | 1 |
| Gröhn, P | 1 |
| Heinonen, E | 1 |
| Kumpulainen, E | 1 |
| Länsimies, H | 1 |
| Lantto, A | 1 |
| Salmi, R | 1 |
| Pyrhönen, S | 1 |
| Numminen, S | 1 |
| Saitoh, H | 1 |
| Shinohara, Y | 1 |
| Fujita, H | 1 |
| Aoki, Y | 1 |
| Takagi, S | 1 |
| Morioka, Y | 1 |
| Muto, T | 1 |
| Kusama, S | 1 |
| Kimura, T | 1 |
| Tomiyama, J | 1 |
| Fukushima, K | 1 |
| Terabe, K | 1 |
| Yamauchi, M | 2 |
| Watanabe, T | 2 |
| Takagi, H | 2 |
| Imaizumi, M | 1 |
| Kondo, T | 2 |
| Anai, H | 3 |
| Maehara, Y | 3 |
| Kusumoto, H | 3 |
| Masuda, H | 1 |
| Sugimachi, K | 4 |
| Hattori, T | 1 |
| Inokuchi, K | 1 |
| Kusumoto, T | 2 |
| Miyamoto, K | 1 |
| Fukuchi, K | 1 |
| Takashima, S | 1 |
| Kinami, Y | 1 |
| Kiriyama, M | 1 |
| Tomita, F | 1 |
| Ueno, K | 1 |
| Miyazaki, I | 1 |
2 reviews available for carmofur and Colonic Neoplasms
| Article | Year |
|---|---|
Efficacy of oral adjuvant therapy after resection of colorectal cancer: 5-year results from three randomized trials.
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; | 2004 |
An individual patient data meta-analysis of adjuvant therapy with carmofur in patients with curatively resected colon cancer.
Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Colonic Neoplasms; Digestive System Surgical Procedur | 2005 |
9 trials available for carmofur and Colonic Neoplasms
| Article | Year |
|---|---|
[Appropriate duration of postoperative oral adjuvant chemotherapy with HCFU for colorectal cancer].
Topics: Administration, Oral; Aged; Antineoplastic Agents; Chemotherapy, Adjuvant; Colonic Neoplasms; Diseas | 2004 |
Randomized controlled trial of the efficacy of adjuvant immunochemotherapy and adjuvant chemotherapy for colorectal cancer, using different combinations of the intracutaneous streptococcal preparation OK-432 and the oral pyrimidines 1-hexylcarbamoyl-5-flu
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; | 2004 |
[Multicenter comparative study of the recurrence-inhibitory effect of oral fluoropyrimidine drugs in patients with colorectal cancer following curative resection].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Pr | 2005 |
Randomized trial of the efficacy of adjuvant chemotherapy for colon cancer with combination therapy incorporating the oral pyrimidine 1-hexylcarbamoyl-5-fluorouracil.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Com | 2006 |
[Prospective controlled study on the usefulness of Carmofur as a postoperative adjuvant chemotherapy for colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Admi | 1997 |
[Outcome of adjuvant mifurol chemotherapy in patients with resected colonic carcinoma].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Th | 1989 |
[Prospective adjuvant chemotherapy, with mitomycin C plus long-term carmofur in colorectal cancer].
Topics: Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; D | 1986 |
Mitomycin C plus carmofur (HCFU) adjuvant chemotherapy for noncuratively resected cases of colorectal carcinoma (interim report).
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; | 1987 |
[Prospective adjuvant chemotherapy of mitomycin C plus HCFU for colorectal cancer (2d report)--6-year survival after surgery: Tokai Cooperative Study Group of Surgical Adjuvant Chemotherapy].
Topics: Adjuvants, Immunologic; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colect | 1988 |
17 other studies available for carmofur and Colonic Neoplasms
| Article | Year |
|---|---|
[Analysis of microsatellite instability and p53 LOH in advanced colorectal cancers--first report of the No. 3 protocol].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Admi | 2004 |
[Phase II study of carmofur (HCFU) fine granules].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Child; Child, Preschool; Colonic N | 1982 |
Inhibition of murine colon adenocarcinomas and Lewis lung carcinoma by 1-hexylcarbamoyl-5-fluorouracil.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Fluorouracil; In Vitro Techniques | 1980 |
Alcohol consumption enhances liver metastasis in colorectal carcinoma patients.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Analysis of Variance; Antineoplastic Agents; Blood | 1998 |
[A case of multiple liver metastases showing good response by administration of carmofur alone in an aged patient with colorectal cancer].
Topics: Adenocarcinoma; Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents; Colonic Neopla | 1999 |
[Anti-tumor effects of carmofur on human 5-FU resistant cells].
Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; | 1999 |
[Antitumor activity of 1-hexylcarbamoyluracil which is carmofur substituted fluorine for hydrogen].
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorouracil; Mice; Mice, Inbred BALB C; | 2000 |
[Serum concentration of HCFU and 5-FU after oral administration of HCFU in postoperative digestive cancer patients].
Topics: Administration, Oral; Antineoplastic Agents; Colonic Neoplasms; Fluorouracil; Gastrectomy; Humans; S | 1992 |
[Potentiation of thymidylate synthetase (TS) inhibition by combined administration of HCFU and dipyridamole: preliminary report. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dipyridamole; Female; Fluor | 1992 |
Antitumor activity of fluoropyrimidines and thymidylate synthetase inhibition.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma; Colonic Neoplasms; Enzyme Activation; Flu | 1991 |
Oral carmofur in advanced gastrointestinal cancer.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Admini | 1990 |
A case of carmofur-induced leukoencephalopathy--MR images and CT findings.
Topics: Aged; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorouracil; Humans; Leukoencephalopathy, P | 1989 |
[Antitumor effects of 5-fluorouracil-bound organic silicon compound].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Ethyla | 1989 |
[Chemosensitivity testing for 5-FU and 5-FU derivatives using subrenal capsule assay].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colony-Forming Units Assay; Fluor | 1987 |
[Human colorectal carcinoma is more sensitive to HCFU than 5-FU and tegafur in in vitro and in vivo drug sensitivity tests].
Topics: Animals; Colonic Neoplasms; Fluorouracil; Humans; Mice; Rectal Neoplasms; Subrenal Capsule Assay; Te | 1988 |
Colorectal carcinoma in vitro is more sensitive to 1-hexylcarbamoyl-5-fluorouracil compared with six other antitumor drugs: carboquone, Adriamycin, mitomycin C, aclacinomycin A, cisplatin, 5-fluorouracil.
Topics: Aclarubicin; Antineoplastic Agents; Carbazilquinone; Cisplatin; Colonic Neoplasms; Doxorubicin; Drug | 1988 |
[Distribution of 1-hexycarbamoyl-5-fluorouracil in rats and human patients, and clinical results in patients with colorectal cancer].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorouracil; Humans; Mal | 1986 |