carisoprodol has been researched along with Substance-Related Disorders in 45 studies
Carisoprodol: A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)
carisoprodol : A carbamate ester that is the mono-N-isopropyl derivative of meprobamate (which is a significant metabolite). Carisoprodol interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alteration in pain perception. It is used as a muscle relaxant in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.
Substance-Related Disorders: Disorders related to substance use or abuse.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This report-the second of a series on codeine and its alternates for pain and cough relief-contains a detailed evaluation of experimental and clinical data on newer substances having analgesic properties comparable to and in approximately the same range as those of codeine." | 8.74 | Codeine and its alternates for pain and cough relief. 2. Alternates for pain relief. ( Eddy, NB; Friebel, H; Hahn, KJ; Halbach, H, 1969) |
| "To determine whether codeine is primarily used for acute pain or whether there is a prescription pattern indicating problematic opioid use." | 7.75 | Prescription pattern of codeine for non-malignant pain: a pharmacoepidemiological study from the Norwegian Prescription Database. ( Borchgrevink, PC; Breivik, H; Fredheim, OM; Moroz, A; Skurtveit, S, 2009) |
| "This report-the second of a series on codeine and its alternates for pain and cough relief-contains a detailed evaluation of experimental and clinical data on newer substances having analgesic properties comparable to and in approximately the same range as those of codeine." | 4.74 | Codeine and its alternates for pain and cough relief. 2. Alternates for pain relief. ( Eddy, NB; Friebel, H; Hahn, KJ; Halbach, H, 1969) |
| "To determine whether codeine is primarily used for acute pain or whether there is a prescription pattern indicating problematic opioid use." | 3.75 | Prescription pattern of codeine for non-malignant pain: a pharmacoepidemiological study from the Norwegian Prescription Database. ( Borchgrevink, PC; Breivik, H; Fredheim, OM; Moroz, A; Skurtveit, S, 2009) |
| "Carisoprodol is a centrally acting skeletal muscle relaxant of which meprobamate, a controlled substance, is the primary active metabolite." | 2.48 | Carisoprodol: update on abuse potential and legal status. ( Burke, RS; Kose, S; Reeves, RR, 2012) |
| "Carisoprodol has been classified as a controlled substance in several states in the US and restrictions on the use of the drug have been imposed in some European countries." | 2.46 | Carisoprodol: abuse potential and withdrawal syndrome. ( Burke, RS; Reeves, RR, 2010) |
| "The primary analysis quantified opioid overdose risk across 7 prescription opioid-skeletal muscle relaxant therapies and a negative control outcome (sepsis) to assess potential confounding by unmeasured illicit opioid use." | 1.72 | Comparative Risk of Opioid Overdose With Concomitant Use of Prescription Opioids and Skeletal Muscle Relaxants. ( Barnett, ML; Bykov, K; Gagne, JJ; Glynn, RJ; Khan, NF; Vine, SM, 2022) |
| "Treatment with carisoprodol and phenobarbital provided additional benefit and can be considered in cases of severe carisoprodol withdrawal." | 1.46 | Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. ( Benowitz, NL; Horng, H; Smollin, CG; Vo, KT, 2017) |
| "Carisoprodol is a widely prescribed muscle relaxant, abuse of which has grown considerably in recent years." | 1.42 | Assessment of subunit-dependent direct gating and allosteric modulatory effects of carisoprodol at GABA(A) receptors. ( Dillon, GH; González, LA; Kumar, M, 2015) |
| "Reports of chronic pain and associated opioid use, abuse, and fatalities continue to increase at an alarming rate, not only in the United States but also across the globe." | 1.39 | A prospective evaluation of psychotherapeutic and illicit drug use in patients presenting with chronic pain at the time of initial evaluation. ( Cash, KA; Fellows, B; Malla, Y; Manchikanti, L; Pampati, V, 2013) |
| "Carisoprodol is a therapeutic and occasionally abused centrally acting muscle relaxant." | 1.38 | Postmortem carisoprodol and meprobamate concentrations in blood and liver: lack of significant redistribution. ( Lucas, J; McIntyre, IM; Sherrard, J, 2012) |
| "Carisoprodol was developed to create a drug with less potential for abuse than meprobamate." | 1.34 | Carisoprodol use and abuse in Norway: a pharmacoepidemiological study. ( Bramness, JG; Engeland, A; Furu, K; Skurtveit, S, 2007) |
| "Carisoprodol is a muscle relaxant indicated as adjunctive therapy in acute, painful musculoskeletal conditions." | 1.34 | Abuse potential of carisoprodol: a retrospective review of Idaho Medicaid pharmacy and medical claims data. ( Cady, P; Culbertson, V; Force, R; Owens, C; Pugmire, B; Salness, T; Steiner, J, 2007) |
| " This result indicates a gene dosage effect where the carisoprodol : meprobamate ratio reflects the number of active CYP2C19 alleles." | 1.32 | Association between blood carisoprodol:meprobamate concentration ratios and CYP2C19 genotype in carisoprodol-drugged drivers: decreased metabolic capacity in heterozygous CYP2C19*1/CYP2C19*2 subjects? ( Bramness, JG; Fauske, L; Grung, M; Molven, A; Mørland, J; Skurtveit, S; Steen, VM, 2003) |
| "Carisoprodol is a centrally acting muscle relaxant commonly used for lower back pain." | 1.32 | Impairment due to intake of carisoprodol. ( Bramness, JG; Mørland, J; Skurtveit, S, 2004) |
| "Carisoprodol (Soma) is a noncontrolled, skeletal-muscle relaxant whose active metabolite is meprobamate." | 1.30 | Carisoprodol: a drug of continuing abuse. ( Carter, OS; Pinkofsky, HB; Reeves, RR, 1997) |
| "Carisoprodol is a noncontrolled skeletal muscle relaxant whose active metabolite is meprobamate, a Schedule IV controlled substance." | 1.30 | Carisoprodol (soma): abuse potential and physician unawareness. ( Bennett, DM; Carter, OS; Pinkofsky, HB; Reeves, RR; Struve, FA, 1999) |
| "Data from the National Institute on Drug Abuse reveal that overdose and abuse of carisoprodol may be more common than previously suspected." | 1.29 | Carisoprodol as a drug of abuse. ( Gums, JG; Hatch, R; Rust, GS, 1993) |
| "Carisoprodol was started by the majority of patients as a substitute for opiates, although its independent distinct effects, similar to the features of hypomania, were recognized and described by most users." | 1.29 | Carisoprodol abuse: a report from India. ( Basu, D; Malhotra, AK; Mattoo, SK; Sikdar, S; Varma, VK, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.44) | 18.7374 |
| 1990's | 12 (26.67) | 18.2507 |
| 2000's | 20 (44.44) | 29.6817 |
| 2010's | 10 (22.22) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Khan, NF | 1 |
| Bykov, K | 1 |
| Barnett, ML | 1 |
| Glynn, RJ | 1 |
| Vine, SM | 1 |
| Gagne, JJ | 1 |
| Sun, C | 1 |
| Hollenbach, KA | 1 |
| Cantrell, FL | 1 |
| Hardon, AP | 1 |
| Ihsan, A | 1 |
| Kumar, M | 1 |
| González, LA | 1 |
| Dillon, GH | 1 |
| Vo, KT | 1 |
| Horng, H | 1 |
| Smollin, CG | 1 |
| Benowitz, NL | 1 |
| Bramness, JG | 7 |
| Skurtveit, S | 8 |
| Furu, K | 3 |
| Kaasa, S | 1 |
| Borchgrevink, PC | 2 |
| Winther, RB | 1 |
| Reeves, RR | 8 |
| Henderson, RH | 1 |
| Ladner, ME | 1 |
| Fredheim, OM | 1 |
| Moroz, A | 1 |
| Breivik, H | 1 |
| Burke, RS | 3 |
| Fass, JA | 1 |
| Chung, H | 1 |
| Engeland, A | 2 |
| McIntyre, IM | 1 |
| Sherrard, J | 1 |
| Lucas, J | 1 |
| Kose, S | 1 |
| Manchikanti, L | 1 |
| Cash, KA | 1 |
| Malla, Y | 1 |
| Pampati, V | 1 |
| Fellows, B | 1 |
| Fauske, L | 1 |
| Grung, M | 2 |
| Molven, A | 1 |
| Mørland, J | 3 |
| Steen, VM | 1 |
| Parente, ST | 1 |
| Kim, SS | 1 |
| Finch, MD | 1 |
| Schloff, LA | 1 |
| Rector, TS | 1 |
| Seifeldin, R | 1 |
| Haddox, JD | 1 |
| Rohatgi, G | 1 |
| Rissmiller, DJ | 1 |
| Gorman, JM | 1 |
| Owens, C | 1 |
| Pugmire, B | 1 |
| Salness, T | 1 |
| Culbertson, V | 1 |
| Force, R | 1 |
| Cady, P | 1 |
| Steiner, J | 1 |
| Forrester, MB | 1 |
| Dougherty, RJ | 1 |
| Chop, WM | 1 |
| Rust, GS | 1 |
| Hatch, R | 1 |
| Gums, JG | 1 |
| Sikdar, S | 1 |
| Basu, D | 1 |
| Malhotra, AK | 1 |
| Varma, VK | 1 |
| Mattoo, SK | 1 |
| Littrell, RA | 2 |
| Hayes, LR | 1 |
| Stillner, V | 1 |
| Sage, T | 1 |
| Miller, W | 1 |
| Pinkofsky, HB | 3 |
| Carter, OS | 3 |
| Struve, FA | 1 |
| Bennett, DM | 1 |
| Lindberg, N | 1 |
| Lauerma, H | 1 |
| Logan, BK | 1 |
| Case, GA | 1 |
| Gordon, AM | 1 |
| Reiestad, F | 2 |
| Fagerlund, B | 2 |
| Liberto, V | 1 |
| Morse, RM | 1 |
| Chua, L | 1 |
| Elder, NC | 1 |
| Luehr, JG | 1 |
| Meyerle, KA | 1 |
| Larson, EW | 1 |
| Eddy, NB | 1 |
| Friebel, H | 1 |
| Hahn, KJ | 1 |
| Halbach, H | 1 |
5 reviews available for carisoprodol and Substance-Related Disorders
| Article | Year |
|---|---|
Carisoprodol: abuse potential and withdrawal syndrome.
Topics: Anxiety; Carisoprodol; Hallucinations; Humans; Hypnotics and Sedatives; Muscle Relaxants, Central; S | 2010 |
Carisoprodol legal status and patterns of abuse.
Topics: Carisoprodol; Drug and Narcotic Control; Humans; Muscle Relaxants, Central; Norway; Substance-Relate | 2010 |
Carisoprodol: update on abuse potential and legal status.
Topics: Carisoprodol; Controlled Substances; Drug and Narcotic Control; Europe; Humans; Muscle Relaxants, Ce | 2012 |
Carisoprodol (Soma): a new and cautious perspective on an old agent.
Topics: Carisoprodol; Drug and Narcotic Control; Humans; Muscle Relaxants, Central; Substance-Related Disord | 1993 |
Codeine and its alternates for pain and cough relief. 2. Alternates for pain relief.
Topics: Amides; Analgesics; Animals; Antitussive Agents; Azepines; Carisoprodol; Cats; Chickens; Codeine; Co | 1969 |
40 other studies available for carisoprodol and Substance-Related Disorders
| Article | Year |
|---|---|
Comparative Risk of Opioid Overdose With Concomitant Use of Prescription Opioids and Skeletal Muscle Relaxants.
Topics: Amitriptyline; Analgesics, Opioid; Baclofen; Benzodiazepines; Carisoprodol; Chlorzoxazone; Cohort St | 2022 |
Trends in carisoprodol abuse and misuse after regulatory scheduling: a retrospective review of California poison control calls from 2008 to 2015.
Topics: Adult; California; Carisoprodol; Drug and Narcotic Control; Female; Humans; Male; Muscle Relaxants, | 2018 |
Somadril and edgework in South Sulawesi.
Topics: Carisoprodol; Developing Countries; Female; Humans; Indonesia; Male; Muscle Relaxants, Central; Self | 2014 |
Assessment of subunit-dependent direct gating and allosteric modulatory effects of carisoprodol at GABA(A) receptors.
Topics: Carisoprodol; Dose-Response Relationship, Drug; GABA Agents; gamma-Aminobutyric Acid; HEK293 Cells; | 2015 |
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose.
Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Se | 2017 |
Carisoprodol should be taken off the market.
Topics: Carisoprodol; Drug Approval; European Union; Humans; Muscle Relaxants, Central; Substance-Related Di | 2008 |
Introduction of low dose transdermal buprenorphine -- did it influence use of potentially addictive drugs in chronic non-malignant pain patients?
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Buprenorp | 2009 |
[Prescription shopping of addictive drugs in Norway].
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Carisoprodol; Codeine; Diazepam; Drug Prescriptions; Family | 2009 |
Carisoprodol abuse in Mississippi.
Topics: Adult; Carisoprodol; Humans; Male; Mississippi; Muscle Relaxants, Central; Prescription Drugs; Psych | 2007 |
Prescription pattern of codeine for non-malignant pain: a pharmacoepidemiological study from the Norwegian Prescription Database.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Benzodiazepines; Carisoprodol; Child | 2009 |
Role of drug testing as an early warning programme: the experience of the Republic of Korea.
Topics: Adolescent; Adult; Autopsy; Body Fluids; Carisoprodol; Child; Cross-Cultural Comparison; Dextrometho | 2005 |
Effect of the market withdrawal of carisoprodol on use of other prescribed drugs with abuse potential.
Topics: Behavior, Addictive; Carisoprodol; Female; Humans; Longitudinal Studies; Male; Middle Aged; Muscle R | 2012 |
Postmortem carisoprodol and meprobamate concentrations in blood and liver: lack of significant redistribution.
Topics: Carisoprodol; Diagnosis; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Liver; M | 2012 |
A prospective evaluation of psychotherapeutic and illicit drug use in patients presenting with chronic pain at the time of initial evaluation.
Topics: Adult; Aged; Analgesics, Opioid; Benzodiazepines; Carisoprodol; Chronic Pain; Female; Humans; Illici | 2013 |
Association between blood carisoprodol:meprobamate concentration ratios and CYP2C19 genotype in carisoprodol-drugged drivers: decreased metabolic capacity in heterozygous CYP2C19*1/CYP2C19*2 subjects?
Topics: Adult; Alleles; Aryl Hydrocarbon Hydroxylases; Carisoprodol; Cytochrome P-450 CYP2C19; Female; Gene | 2003 |
Impairment due to intake of carisoprodol.
Topics: Analysis of Variance; Automobile Driving; Carisoprodol; Chi-Square Distribution; Confidence Interval | 2004 |
Identifying controlled substance patterns of utilization requiring evaluation using administrative claims data.
Topics: Adolescent; Adult; Analgesics, Opioid; Benzodiazepines; Butorphanol; Carisoprodol; Clinical Pharmacy | 2004 |
Treatment of carisoprodol dependence: a case report.
Topics: Carisoprodol; Cognitive Behavioral Therapy; Humans; Male; Middle Aged; Muscle Relaxants, Central; Su | 2005 |
Carisoprodol use and abuse in Norway: a pharmacoepidemiological study.
Topics: Adolescent; Adult; Carisoprodol; Drug Prescriptions; Female; Humans; Male; Meprobamate; Muscle Relax | 2007 |
Abuse potential of carisoprodol: a retrospective review of Idaho Medicaid pharmacy and medical claims data.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Carisoprodol; Drug Therapy, Combination | 2007 |
Carisoprodol abuse in Texas, 1998-2003.
Topics: Adolescent; Adult; Age Distribution; Age Factors; Carisoprodol; Female; Humans; Male; Muscle Relaxan | 2006 |
Is it time for carisoprodol to become a controlled substance at the federal level?
Topics: Carisoprodol; Drug and Narcotic Control; Humans; Muscle Relaxants, Central; Substance-Related Disord | 2008 |
Carisoprodol should be a controlled substance.
Topics: Adult; Carisoprodol; Drug and Narcotic Control; Female; Humans; Male; Physician Impairment; Substanc | 1995 |
Should carisoprodol be a controlled substance?
Topics: Carisoprodol; Drug and Narcotic Control; Humans; Substance-Related Disorders | 1993 |
Carisoprodol as a drug of abuse.
Topics: Behavior, Addictive; Carisoprodol; Humans; Substance-Related Disorders | 1993 |
Carisoprodol abuse: a report from India.
Topics: Adolescent; Adult; Carisoprodol; Humans; India; Male; Substance-Related Disorders | 1993 |
Meprobamate dependence secondary to carisoprodol (Soma) use.
Topics: Adult; Biotransformation; Carisoprodol; Female; Humans; Meprobamate; Metabolic Clearance Rate; Neuro | 1993 |
Carisoprodol: a drug of continuing abuse.
Topics: Adult; Carisoprodol; Drug and Narcotic Control; Drug Prescriptions; Female; Humans; Male; Muscle Rel | 1997 |
Use of carisoprodol by substance abusers to modify the effects of illicit drugs.
Topics: Carisoprodol; Drug Interactions; Humans; Muscle Relaxants, Central; Substance-Related Disorders | 1999 |
Carisoprodol (soma): abuse potential and physician unawareness.
Topics: Adult; Carisoprodol; Health Knowledge, Attitudes, Practice; Humans; Muscle Relaxants, Central; Physi | 1999 |
[Abuse of Carisoprodol].
Topics: Adult; Behavior, Addictive; Carisoprodol; Chronic Disease; Finland; Humans; Male; Muscle Relaxants, | 1996 |
Carisoprodol, meprobamate, and driving impairment.
Topics: Accidents, Traffic; Adult; Alcohol Drinking; Automobile Driving; Carisoprodol; Female; Forensic Medi | 2000 |
[Centrally acting muscle relaxants and traffic hazards].
Topics: Accidents, Traffic; Adolescent; Adult; Aged; Carisoprodol; Drug and Narcotic Control; Female; Forens | 2000 |
[Is carisoprodol justified as a muscle relaxant?].
Topics: Carisoprodol; Humans; Muscle Relaxants, Central; Risk Factors; Substance-Related Disorders | 2000 |
Abuse of combinations of carisoprodol and tramadol.
Topics: Adult; Analgesics, Opioid; Carisoprodol; Drug Interactions; Female; Humans; Male; Muscle Relaxants, | 2001 |
WHO Expert Committee on Drug Dependence. Thirty-second report.
Topics: Amphetamines; Buprenorphine; Carisoprodol; Diazepam; Dibenzocycloheptenes; Diethylpropion; Dronabino | 2001 |
[Carisoprodol--one more time].
Topics: Carisoprodol; Drug Prescriptions; Humans; Muscle Relaxants, Central; Substance-Related Disorders | 2002 |
Carisoprodol dependence: a case report.
Topics: Adult; Carisoprodol; Female; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1978 |
Abuse of skeletal muscle relaxants.
Topics: Adult; Carisoprodol; Humans; Male; Substance-Related Disorders | 1991 |
Mail-order (veterinary) drug dependence.
Topics: Carisoprodol; Female; Humans; Middle Aged; Postal Service; Substance-Related Disorders; Veterinary M | 1990 |