Page last updated: 2024-09-04

cariporide and Myocardial Ischemia

cariporide has been researched along with Myocardial Ischemia in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	15 (26.79)	18.2507
2000's	40 (71.43)	29.6817
2010's	1 (1.79)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cho, NS; Lee, BH; Lee, H; Lee, K; Lee, S; Yi, KY; Yoo, SE	1
Kim, T; Lee, BH; Lee, K; Lee, S; Yi, KY; Yoo, SE	1
Jin, N; Wang, QJ; Xu, J; Xu, WT; Xu, YG; You, QD	1
Bourahla, V; Demaison, L; Dubouchaud, H; Faure, P; Migné, C; Mourmoura, E; Pujos-Guillot, E; Richardson, M; Vitiello, D	1
Cohen, MV; Downey, JM; Jiao, Z; Xu, Z	1
Sykes, J; Thompson, K; Thompson, RT; Wisenberg, G	1
Haist, JV; Hirst, CN; Karmazyn, M	1
Beresewicz, A; Maczewski, M	1
Cropper, JR; Feneley, MP; Garlick, SR; Hicks, M; Kesteven, SH; Macdonald, PS; Ryan, JB; Wilson, MK	1
Ayoub, IM; Gazmuri, RJ; Kolarova, J	1
Lin, H; Suleiman, MS	1
Chaitman, BR; Chi, E; Danchin, N; Erhardt, L; Gallo, R; Gavard, JA; Jessel, A; Sakai, S; Stocke, K; Théroux, P	1
Buckberg, GD; Castellá, M; Ignarro, LJ; Saleh, S; Tan, Z	1
Balshaw, D; Becker, L; Bolli, R; Gross, G; Lathrop, DA; Mentzer, R	1
Besse, S; Boucher, F; Le Page, C; Leiris, Jd; Riou, B; Rozenberg, S; Swynghedauw, B; Tanguy, S	1
Pisarenko, OI	1
Ayoub, IM; Gazmuri, RJ; Kantola, RL; Kolarova, J; Sanders, R	1
Bartels, C; Bechtel, JF; Eichler, W; Hernandez, M; Klotz, KF; Sievers, HH; Toerber, K; Weidtmann, B	1
Chen, J; Xia, Q; Zhang, F; Zhang, Y	1
Behrends, M; Brendt, P; Peters, J	1
Liu, KX; Wang, T; Xu, R; Yamamoto, F; Yamamoto, H; Zhang, S; Zhu, Z	1
Bartels, C; Bolli, R; Boyce, S; Buckberg, GD; Chaitman, B; Haverich, A; Knight, J; Menasché, P; Mentzer, RM; Myers, ML; Nicolau, J; Simoons, M; Thulin, L; Weisel, RD	1
Albus, U; Counillon, L; Gögelein, H; Lang, HJ; Linz, W; Schölkens, BA; Scholz, W; Weichert, A	1
Aye, NN; Hashimoto, K; Xue, YX	1
Gallois, Y; Kreher, P; Perchenet, L; Rochetaing, A	1
Bohle, RM; Klein, HH; Lindert-Heimberg, S; Nebendahl, K; Pich, S; Wollenweber, J	1
Chakrabarti, S; Hoque, AN; Karmazyn, M	1
Karmazyn, M; Mathur, S	1
Bohle, RM; Klein, HH; Lindert-Heimberg, S; Nebendahl, K; Pich, S; Schade-Brittinger, C; Wollenweber, J	1
Eng, S; Kardami, E; Maddaford, TG; Pierce, GN	1
Bernard, M; Cozzone, PJ; el Banani, H; Feuvray, D	1
Frishman, WH; Gurell, D; Levitsky, J	1
Berdeaux, A; Ghaleh, B; Giudicelli, JF; Parent de Curzon, O	1
Correa, SD; Schaefer, S; Symons, JD	1
Farhangkhoee, P; Karmazyn, M; Myers, ML	1
Karmazyn, M	1
Decking, UK; Hartmann, M	1
Jayachandran, JV; Olgin, JE; Weksler, J; Zipes, DP	1
Hashimoto, K	2
de Groot, MC; Faul, C; Horn, M; Leupold, A; Morgan, JP; Neubauer, S; Scholz, W; Strömer, H	1
Held, A; Ladilov, Y; Noll, T; Piper, HM; Schäfer, C; Schäfer, M	1
Aihara, K; Hisa, H; Kimura, T; Kogi, K; Mizuno, Y; Nagai, A; Sasamori, J; Sato, T; Satoh, S; Takahashi, A; Yamaguchi, F; Yoneyama, F; Yoneyama, S	1
Bohle, RM; Klein, HH; Lindert-Heimberg, S; Nebendahl, K; Pich, S	1
Ladilov, YV; Piper, HM; Schäfer, C; Schäfer, M	1
Allen, DG; Xiao, XH	1
Briand, V; Cremer, G; Duval, N; Favennec, E; Grosset, A; Hoornaert, C; Janiak, P; Latham, C; Lorrain, J; O'Connor, SE	1
Chaitman, BR; Danchin, N; Erhardt, L; Jessel, A; Meinertz, T; Schroeder, JS; Théroux, P; Tognoni, G; White, HD; Willerson, JT	1
Kevelaitis, E; Menasché, P; Mouas, C; Oubénaissa, A; Peynet, J	1
Anderson, DL; Ning, X; Panos, AL; Portman, MA; Xiao, Y	1
ten Hove, M; van Echteld, CJ; van Emous, JG	1
Gan, XT; Karmazyn, M; Sostaric, JV	1
Cingolani, HE; Mosca, SM	1
Asakura, M; Asanuma, H; Hori, M; Kitakaze, M; Kuzuya, T; Mori, H; Node, K; Sanada, S; Sato, H; Shinozaki, Y; Takashima, S	1
Abe, A; Fukumoto, S; Igata, H; Ikeda, S; Imamiya, E; Kusumoto, K; Shiraishi, M; Tsuboi, A; Watanabe, T	1
Gryshchenko, O; Nathan, RD; Qu, J	1

Reviews

8 review(s) available for cariporide and Myocardial Ischemia

Article	Year
Myocardial protection during resuscitation from cardiac arrest. Current opinion in critical care, 2003, Volume: 9, Issue:3 Topics: Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Contracture; Electric Countershock; Guanidines; Heart; Heart Arrest; Humans; Myocardial Ischemia; Sarcolemma; Secondary Prevention; Sodium-Hydrogen Exchangers; Sulfones; Vasoconstrictor Agents; Ventricular Fibrillation	2003
Myocardial protection at a crossroads: the need for translation into clinical therapy. Circulation research, 2004, Jul-23, Volume: 95, Issue:2 Topics: Animals; Cardiotonic Agents; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Coronary Artery Bypass; Drug Evaluation, Preclinical; Drug Utilization; Guanidines; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Prospective Studies; Sodium-Hydrogen Exchangers; Sulfones; Treatment Outcome	2004
[Na+/H+ exchange inhibitors: a new class of cardioprotectors]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2004, Volume: 90, Issue:9 Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Guanidines; Humans; Myocardial Ischemia; Reperfusion Injury; Sarcolemma; Sodium-Hydrogen Exchangers; Sulfones	2004
Sodium ion/hydrogen ion exchange inhibition: a new pharmacologic approach to myocardial ischemia and reperfusion injury. Journal of clinical pharmacology, 1998, Volume: 38, Issue:10 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Diuretics; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	1998
The role of the myocardial sodium-hydrogen exchanger in mediating ischemic and reperfusion injury. From amiloride to cariporide. Annals of the New York Academy of Sciences, 1999, Jun-30, Volume: 874 Topics: Amiloride; Animals; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Remodeling	1999
[Na+/H+ exchange inhibitors]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2000, Volume: 45, Issue:6 Suppl Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Clinical Trials as Topic; Drug Design; Guanidines; Humans; Myocardial Ischemia; Sodium-Hydrogen Exchangers; Sulfones	2000
The myocardial Na+/H+ exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure. Drugs, 2001, Volume: 61, Issue:3 Topics: Adenosine Triphosphate; Anti-Arrhythmia Agents; Cardiac Output, Low; Clinical Trials as Topic; Guanidines; Humans; Hydrogen-Ion Concentration; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Phosphorylation; Sodium-Hydrogen Exchangers; Sulfones	2001
[Na+/H+ exchange inhibitors for ischemic diseases]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001, Volume: 118, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cation Transport Proteins; Clinical Trials as Topic; Guanidines; Humans; Membrane Proteins; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sulfones	2001

Trials

2 trial(s) available for cariporide and Myocardial Ischemia

Article	Year
Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. The Annals of thoracic surgery, 2008, Volume: 85, Issue:4 Topics: Adult; Aged; Confidence Intervals; Coronary Angiography; Coronary Artery Bypass; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Guanidines; Hospital Mortality; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Ischemia; Postoperative Complications; Preoperative Care; Probability; Reference Values; Risk Assessment; Severity of Illness Index; Sodium-Hydrogen Exchangers; Sulfones; Survival Analysis; Treatment Outcome	2008
Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators. Circulation, 2000, Dec-19, Volume: 102, Issue:25 Topics: Aged; Angina Pectoris; Coronary Artery Bypass; Female; Guanidines; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Sodium-Hydrogen Exchangers; Sulfones	2000

Article

Year

Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study.

The Annals of thoracic surgery, 2008, Volume: 85, Issue:4

Topics: Adult; Aged; Confidence Intervals; Coronary Angiography; Coronary Artery Bypass; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Guanidines; Hospital Mortality; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Ischemia; Postoperative Complications; Preoperative Care; Probability; Reference Values; Risk Assessment; Severity of Illness Index; Sodium-Hydrogen Exchangers; Sulfones; Survival Analysis; Treatment Outcome

2008

Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators.

Circulation, 2000, Dec-19, Volume: 102, Issue:25

Topics: Aged; Angina Pectoris; Coronary Artery Bypass; Female; Guanidines; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Sodium-Hydrogen Exchangers; Sulfones

2000

Other Studies

46 other study(ies) available for cariporide and Myocardial Ischemia

Article	Year
4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na+/H+ exchanger isoform-1 (NHE-1) inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-15, Volume: 15, Issue:12 Topics: Animals; Blood Pressure; Cardiotonic Agents; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Protein Isoforms; Rats; Sodium-Hydrogen Exchangers; Structure-Activity Relationship	2005
3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors. Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5 Topics: Animals; Cardiotonic Agents; Guanidine; Heart; In Vitro Techniques; Inhibitory Concentration 50; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Sodium-Hydrogen Exchangers; Structure-Activity Relationship	2007
Design, synthesis and biological evaluation of novel substituted benzoylguanidine derivatives as potent Na+/H+ exchanger inhibitors. Bioorganic & medicinal chemistry letters, 2009, Jun-15, Volume: 19, Issue:12 Topics: Animals; Benzoates; Blood Platelets; Cardiotonic Agents; Dose-Response Relationship, Drug; Drug Design; Guanidines; Inhibitory Concentration 50; Myocardial Ischemia; Rats; Sodium-Hydrogen Exchangers	2009
Disruption of chronic cariporide treatment abrogates myocardial ion homeostasis during acute ischemia reperfusion. Journal of cardiovascular pharmacology, 2011, Volume: 58, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Chemical Analysis; Cardiotonic Agents; Drug Administration Schedule; Guanidines; Heart Function Tests; Homeostasis; Male; Monocarboxylic Acid Transporters; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; RNA, Messenger; Sodium-Bicarbonate Symporters; Sodium-Hydrogen Exchangers; Sulfones; Symporters; Time Factors	2011
Protection from AMP 579 can be added to that from either cariporide or ischemic preconditioning in ischemic rabbit heart. Journal of cardiovascular pharmacology, 2002, Volume: 40, Issue:4 Topics: Animals; Cardiotonic Agents; Drug Synergism; Drug Therapy, Combination; Female; Guanidines; Heart; Imidazoles; Ischemic Preconditioning, Myocardial; Male; Myocardial Ischemia; Pyridines; Rabbits; Sulfones	2002
MRI/MRS evaluation of cariporide in a canine long-term model of reperfused ischemic insults. Magnetic resonance imaging/magnetic resonance spectroscopy. Journal of magnetic resonance imaging : JMRI, 2003, Volume: 17, Issue:1 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Female; Guanidines; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Myocardial Ischemia; Reperfusion; Sulfones; Time Factors	2003
Effective protection by NHE-1 inhibition in ischemic and reperfused heart under preconditioning blockade. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Decanoic Acids; Diastole; Guanidines; Heart; Hydroxy Acids; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Recovery of Function; Sodium-Hydrogen Exchangers; Sulfones; Time Factors; Ventricular Function, Left	2003
Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart. European journal of pharmacology, 2003, Feb-14, Volume: 461, Issue:2-3 Topics: Animals; Coronary Circulation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radicals; Guanidines; Heart; Heart Rate; Hydroxyl Radical; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Perfusion; Rats; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones; Thiourea; Ventricular Function, Left	2003
Cariporide (HOE-642) improves cardiac allograft preservation in a porcine model of orthotopic heart transplantation. Transplantation, 2003, Mar-15, Volume: 75, Issue:5 Topics: Animals; Blood Pressure; Blood Volume; Control Groups; Cryopreservation; Guanidines; Heart; Heart Transplantation; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Stroke Volume; Sulfones; Swine; Transplantation, Homologous; Troponin I; Ventricular Function, Left	2003
Cariporide enhances lactate clearance upon reperfusion but does not alter lactate accumulation during global ischaemia. Pflugers Archiv : European journal of physiology, 2003, Volume: 447, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; In Vitro Techniques; Lactic Acid; Myocardial Ischemia; Myocardial Reperfusion Injury; Sulfones; Time Factors	2003
Prognostic significance of elevated creatine kinase MB after coronary bypass surgery and after an acute coronary syndrome: results from the GUARDIAN trial. The Journal of thoracic and cardiovascular surgery, 2003, Volume: 126, Issue:3 Topics: Acute Disease; Aged; Coronary Artery Bypass; Coronary Disease; Creatine Kinase; Creatine Kinase, MB Form; Female; Guanidines; Humans; Isoenzymes; Male; Middle Aged; Myocardial Ischemia; Postoperative Period; Prognosis; Sodium-Hydrogen Exchangers; Sulfones; Survival Rate; Syndrome	2003
A new role for cardioplegic buffering: should acidosis or calcium accumulation be counteracted to salvage jeopardized hearts? The Journal of thoracic and cardiovascular surgery, 2003, Volume: 126, Issue:5 Topics: Acidosis; Animals; Buffers; Calcium; Cardioplegic Solutions; Creatine Kinase; Creatine Kinase, MB Form; Disease Models, Animal; Female; Guanidines; Heart Arrest, Induced; Hydrogen-Ion Concentration; Ischemic Preconditioning, Myocardial; Isoenzymes; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Random Allocation; Reference Values; Sensitivity and Specificity; Sodium-Hydrogen Exchangers; Sulfones; Swine; Ventricular Function, Left	2003
Cardioprotection with cariporide, a sodium-proton exchanger inhibitor, after prolonged ischemia and reperfusion in senescent rats. Experimental gerontology, 2004, Volume: 39, Issue:9 Topics: Aging; Animals; Cardiotonic Agents; Coronary Circulation; Guanidines; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones; Vascular Resistance	2004
Cariporide minimizes adverse myocardial effects of epinephrine during resuscitation from ventricular fibrillation. Critical care medicine, 2005, Volume: 33, Issue:11 Topics: Adrenergic beta-Agonists; Animals; Anti-Arrhythmia Agents; Epinephrine; Guanidines; Male; Myocardial Ischemia; Resuscitation; Sulfones; Swine; Ventricular Fibrillation	2005
The Na+/H+ exchange inhibitor cariporide is washed out of the myocardium by crystalloid cardioplegia. The Thoracic and cardiovascular surgeon, 2006, Volume: 54, Issue:5 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiopulmonary Bypass; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guanidines; Heart Arrest, Induced; Heart Rate; Myocardial Contraction; Myocardial Ischemia; Myocardium; Postoperative Complications; Potassium Compounds; Research Design; Sodium-Hydrogen Exchangers; Stroke Volume; Sulfones; Swine; Troponin T; Ventricular Function, Left	2006
Cariporide attenuates myocardial ischaemia, reperfusion injury and apoptosis in isolated rat hearts. Acta cardiologica, 2006, Volume: 61, Issue:6 Topics: Animals; Apoptosis; Creatine Kinase, MB Form; DNA Nucleotidylexotransferase; Guanidines; Heart Ventricles; Male; Myocardial Ischemia; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sulfones	2006
Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration. Resuscitation, 2008, Volume: 76, Issue:1 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Guanidines; Guinea Pigs; Hydrazones; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Stunning; Prospective Studies; Pyridazines; Random Allocation; Simendan; Sulfones	2008
The effects of Na movement on surgical myocardial protection: the role of the Na+-H+ exchange system and Na-channel in the development of ischemia and reperfusion injury. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2007, Volume: 13, Issue:5 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Cardiac Output; Cardioplegic Solutions; Guanidines; Heart Arrest, Induced; Male; Mexiletine; Myocardial Ischemia; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sodium Channels; Sodium Chloride; Sulfones	2007
Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovascular research, 1995, Volume: 29, Issue:2 Topics: Animals; Blood Platelets; Cells, Cultured; Dose-Response Relationship, Drug; Erythrocytes; Guanidines; Hydrogen-Ion Concentration; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Perfusion; Rabbits; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones	1995
Antiarrhythmic effects of HOE642, a novel Na(+)-H+ exchange inhibitor, on ventricular arrhythmias in animal hearts. European journal of pharmacology, 1996, Dec-19, Volume: 317, Issue:2-3 Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Coronary Vessels; Digitalis Glycosides; Dogs; Dose-Response Relationship, Drug; Female; Guanidines; Injections, Intravenous; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Fibrillation	1996
Electrophysiological approach of the role of Na+/H+ exchange in low-flow global ischemia and in ischemic preconditioning. Canadian journal of physiology and pharmacology, 1997, Volume: 75, Issue:2 Topics: Action Potentials; Animals; Electrophysiology; Female; Glycogen; Guanidines; Heart; Hemodynamics; Myocardial Contraction; Myocardial Ischemia; Myocardium; Rats; Rats, Wistar; Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	1997
Time delay of cell death by Na+/H+-exchange inhibition in regionally ischemic, reperfused porcine hearts. Journal of cardiovascular pharmacology, 1997, Volume: 30, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Cell Death; Enzyme Inhibitors; Female; Guanidines; Hemodynamics; Histocytochemistry; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Sodium-Hydrogen Exchangers; Sulfones; Swine; Time Factors	1997
A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:11 Topics: Analysis of Variance; Animals; Apoptosis; Guanidines; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Time Factors	1997
Interaction between anesthetics and the sodium-hydrogen exchange inhibitor HOE 642 (cariporide) in ischemic and reperfused rat hearts. Anesthesiology, 1997, Volume: 87, Issue:6 Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Drug Interactions; Ethers; Guanidines; Hemodynamics; Isoflurane; Male; Methyl Ethers; Myocardial Ischemia; Myocardial Reperfusion; Rats; Rats, Sprague-Dawley; Sevoflurane; Sodium-Hydrogen Exchangers; Sufentanil; Sulfones	1997
Time-dependent protection by Na+/H+ exchange inhibition in a regionally ischemic, reperfused porcine heart preparation with low residual blood flow. Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Drug Administration Schedule; Female; Guanidines; Heart; Heart Rate; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Swine; Time Factors	1998
Protection against myocardial ischemic/reperfusion injury by inhibitors of two separate pathways of Na+ entry. Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:4 Topics: Animals; Drug Interactions; Guanidines; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Sodium-Hydrogen Exchangers; Sulfones; Tetrodotoxin	1998
Ionic and metabolic imbalance in various conditions of ischemia-reperfusion: a 31P- and 23Na-NMR study. Magma (New York, N.Y.), 1998, Volume: 6, Issue:2-3 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Diastole; Dichloroacetic Acid; Enzyme Inhibitors; Guanidines; Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nuclear Magnetic Resonance, Biomolecular; Palmitic Acid; Phosphorus; Rats; Sodium; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones; Trimetazidine; Vasodilator Agents	1998
Lack of effects of the Na+/H+ exchanger inhibitor, cariporide against myocardial stunning in exercise-induced ischemia in dogs. Fundamental & clinical pharmacology, 1998, Volume: 12, Issue:6 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Dogs; Guanidines; Myocardial Ischemia; Myocardial Stunning; Physical Exertion; Sodium-Hydrogen Exchangers; Sulfones	1998
Na-H exchange inhibition with cariporide limits functional impairment caused by repetitive ischemia. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:6 Topics: Adenosine; Animals; Blood Pressure; Guanidines; Heart Rate; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Swine	1998
Hydrogen peroxide induced impairment of post-ischemic ventricular function is prevented by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). Cardiovascular research, 1998, Volume: 40, Issue:2 Topics: Analysis of Variance; Animals; Guanidines; Hydrogen Peroxide; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidants; Perfusion; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Pressure	1998
Blocking Na(+)-H+ exchange by cariporide reduces Na(+)-overload in ischemia and is cardioprotective. Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:11 Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Guanidines; Guinea Pigs; Heart; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Sodium; Sodium-Hydrogen Exchangers; Sulfones	1999
Role of the Na(+)/H(+) exchanger in short-term atrial electrophysiological remodeling. Circulation, 2000, Apr-18, Volume: 101, Issue:15 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Dogs; Electrophysiology; Glyburide; Guanidines; Myocardial Ischemia; Sodium-Hydrogen Exchangers; Sulfones; Time Factors	2000
Na(+)/H(+) exchange inhibition with HOE642 improves postischemic recovery due to attenuation of Ca(2+) overload and prolonged acidosis on reperfusion. Circulation, 2000, Jun-13, Volume: 101, Issue:23 Topics: Acidosis; Aequorin; Animals; Anti-Arrhythmia Agents; Calcium; Guanidines; Hydrogen-Ion Concentration; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Phosphorus Isotopes; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Function, Left	2000
Mechanism of Ca(2+) overload in endothelial cells exposed to simulated ischemia. Cardiovascular research, 2000, Volume: 47, Issue:2 Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Cell Size; Cells, Cultured; Coronary Vessels; Cytosol; Endoplasmic Reticulum; Endothelium, Vascular; Enzyme Inhibitors; Guanidines; Hydrogen-Ion Concentration; Lactic Acid; Male; Manganese; Myocardial Ischemia; Rats; Rats, Wistar; Ryanodine; Sodium-Hydrogen Exchangers; Sulfones; Thapsigargin	2000
Cardioprotective effect of TY-12533, a novel Na(+)/H(+) exchange inhibitor, on ischemia/reperfusion injury. European journal of pharmacology, 2000, Sep-15, Volume: 404, Issue:1-2 Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Disease Models, Animal; Guanidines; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyridines; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones	2000
Na(+)/H(+) exchange inhibitor cariporide attenuates cell injury predominantly during ischemia and not at onset of reperfusion in porcine hearts with low residual blood flow. Circulation, 2000, Oct-17, Volume: 102, Issue:16 Topics: Animals; Blood Flow Velocity; Coronary Circulation; Cytoprotection; Guanidines; Heart; Infusions, Intra-Arterial; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Swine	2000
Inhibition of NHE protects reoxygenated cardiomyocytes independently of anoxic Ca(2+) overload and acidosis. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:5 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Calcium; Carrier Proteins; Cell Hypoxia; Cells, Cultured; Cytosol; Fluorescent Dyes; Guanidines; Hydrogen-Ion Concentration; Magnesium; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; Oxygen; Rats; Rats, Wistar; Sodium; Sodium-Bicarbonate Symporters; Sodium-Hydrogen Exchangers; Sulfones	2000
Activity of the Na(+)/H(+) exchanger is critical to reperfusion damage and preconditioning in the isolated rat heart. Cardiovascular research, 2000, Volume: 48, Issue:2 Topics: Analysis of Variance; Animals; Female; Guanidines; Hydrogen-Ion Concentration; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Perfusion; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Pressure	2000
Pharmacological profile of SL 59.1227, a novel inhibitor of the sodium/hydrogen exchanger. British journal of pharmacology, 2000, Volume: 131, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzamides; Blood Pressure; Coronary Disease; Guanidines; Heart Rate; Heart Ventricles; Hydrogen-Ion Concentration; Imidazoles; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Piperidines; Rabbits; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones	2000
Ischemic preconditioning with opening of mitochondrial adenosine triphosphate-sensitive potassium channels or Na/H exchange inhibition: which is the best protective strategy for heart transplants? The Journal of thoracic and cardiovascular surgery, 2001, Volume: 121, Issue:1 Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Creatine Kinase; Diazoxide; Disaccharides; Electrolytes; Glutamates; Glutathione; Guanidines; Heart Arrest, Induced; Heart Transplantation; Histidine; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Mannitol; Mitochondria, Heart; Myocardial Contraction; Myocardial Ischemia; Organ Preservation; Organ Preservation Solutions; Potassium Channels; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Sulfones; Transplantation, Homologous; Vasodilator Agents	2001
HOE-642 (cariporide) alters pH(i) and diastolic function after ischemia during reperfusion in pig hearts in situ. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:2 Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Diastole; Energy Metabolism; Guanidines; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Myocardial Ischemia; Myocardial Reperfusion Injury; Protons; Recovery of Function; Sulfones; Swine	2001
Na+-overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+-exchange blockers EIPA, HOE642 and EMD96785. Magma (New York, N.Y.), 2000, Volume: 11, Issue:1-2 Topics: Amiloride; Animals; Guanidines; In Vitro Techniques; Magnetic Resonance Spectroscopy; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Sodium; Sodium-Hydrogen Exchangers; Sulfones	2000
[The Na+/Ca2+ exchanger as responsible for myocardial stunning]. Medicina, 2001, Volume: 61, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Guanidines; Myocardial Contraction; Myocardial Ischemia; Myocardial Stunning; Rats; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones; Thiourea; Time Factors	2001
Role of cellular acidosis in production of nitric oxide in canine ischemic myocardium. Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:9 Topics: Acidosis; Animals; Anti-Arrhythmia Agents; Bicarbonates; Coronary Circulation; Coronary Vessels; Cyclic GMP; Dogs; Enzyme Inhibitors; Guanidines; Heart; Hydrochloric Acid; Myocardial Ischemia; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Sulfones	2001
In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559. British journal of pharmacology, 2002, Volume: 135, Issue:8 Topics: Animals; Blood Platelets; Cardiotonic Agents; Dose-Response Relationship, Drug; Guanidines; Humans; In Vitro Techniques; Injections, Intravenous; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Quinolines; Rabbits; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones	2002
Ischemia alters the electrical activity of pacemaker cells isolated from the rabbit sinoatrial node. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:6 Topics: Action Potentials; Animals; Benzopyrans; Cell Separation; Cells, Cultured; Electric Conductivity; Electrophysiology; Fluorescent Dyes; Guanidines; Hydrogen-Ion Concentration; Ion Channels; Male; Membrane Potentials; Myocardial Ischemia; Naphthols; Patch-Clamp Techniques; Rabbits; Rhodamines; Sinoatrial Node; Sodium-Hydrogen Exchangers; Sulfones	2002