Page last updated: 2024-09-04

cariporide and Injury, Myocardial Reperfusion

cariporide has been researched along with Injury, Myocardial Reperfusion in 99 studies

Research

Studies (99)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	27 (27.27)	18.2507
2000's	59 (59.60)	29.6817
2010's	13 (13.13)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cho, NS; Lee, BH; Lee, H; Lee, K; Lee, S; Yi, KY; Yoo, SE	1
Kim, T; Lee, BH; Lee, K; Lee, S; Yi, KY; Yoo, SE	1
Bentzien, J; Boyer, SJ; Burke, J; De Lombaert, S; Eickmeier, C; Eldrup, AB; Guo, X; Haist, JV; Hickey, ER; Huber, JD; Kaplita, P; Karmazyn, M; Kemper, R; Kennedy, CA; Kirrane, T; Madwed, JB; Mainolfi, E; Nagaraja, N; Soleymanzadeh, F; Swinamer, A	1
Coles, JA; Iaizzo, PA; Seewald, M; Sigg, DC	1
Baartscheer, A; Buchholtz, N; Coronel, R; Eerbeek, O; Hollmann, MW; Nederlof, R; Schumacher, C; Uthman, L; Weber, NC; Zuurbier, CJ	1
Alhammouri, A; Cohen, MV; Cui, L; Downey, JM; Yang, XM	1
Bartos, JA; Debaty, G; Matsuura, T; Yannopoulos, D	1
Akiyama, T; Kawada, T; Kuroko, Y; Sakurai, S; Sano, S; Shimizu, S; Sugimachi, M; Yamazaki, T	1
Bartling, B; Friedrich, I; Gursinsky, T; Scheubel, RJ; Silber, RE; Simm, A	1
Hou, FQ; Liu, H; Wu, BW	1
Caldiz, CI; Chiappe de Cingolani, G; Cingolani, HE; Ennis, IL; Fantinelli, JC; Garciarena, CD; Mosca, SM; Pérez, NG	1
Gao, L; Graham, RM; Hicks, M; Jabbour, A; Kwan, J; Liu, X; MacDonald, PS; Qiu, MR; Sun, L; Watson, A; Zhou, MD	1
Allen, BS; Buckberg, GD; Hristov, N; Liakopoulos, OJ; Triana, J; Trummer, G	1
Arbeláez, LF; Fantinelli, J; Mosca, SM; Nuñez, IP	1
Bourahla, V; Demaison, L; Dubouchaud, H; Faure, P; Migné, C; Mourmoura, E; Pujos-Guillot, E; Richardson, M; Vitiello, D	1
Bian, JS; Hu, LF; Lee, SW; Li, Y; Neo, KL; Tan, BK; Yong, QC	1
Anzawa, R; Feuvray, D; Nagoshi, T; Seki, S; Taniguchi, I; Yoshimura, M	1
Kloner, RA; Reffelmann, T	1
Buckberg, GD; Castellá, M; Ignarro, LJ; Tan, Z	1
Baba, A; Hamano-Takahashi, A; Kameo, K; Matsuda, T; Onishi, M; Ota, T; Suzuki, T; Takahashi, K; Takahashi, T; Tanaka, Y	1
Das, DK	1
Budde, JM; Guyton, RA; Morris, CD; Muraki, S; Vinten-Johansen, J; Zhao, ZQ	1
Beresewicz, A; Maczewski, M	1
Jessel, A; Karmazyn, M; Lasley, RD; Mentzer, RM	1
Cropper, JR; Feneley, MP; Garlick, SR; Hicks, M; Kesteven, SH; Macdonald, PS; Ryan, JB; Wilson, MK	2
Genda, S; Matsumoto, T; Miki, T; Miura, T; Shimamoto, K	1
Sykes, J; Thompson, K; Thompson, RT; Wisenberg, G	1
Ayoub, IM; Deshmukh, H; Franz, MR; Gazmuri, RJ; Kolarova, J; Lubell, DL; Maldonado, FA; Trevedi, A; Yi, Z	1
Agulló, L; Barrabés, JA; García-Dorado, D; Inserte, J; Padilla, F; Rodríguez-Sinovas, A; Ruiz-Meana, M; Soler-Soler, J	1
Buckberg, GD; Castellá, M; Tan, Z	1
Lin, H; Suleiman, MS	1
Agulló, L; Garcia-Dorado, D; Inserte, J; Pina, P; Ruiz-Meana, M; Soler-Soler, J	1
Allen, DG; Xiao, XH	2
Cingolani, HE; Ennis, IL; Mosca, SM	1
Fedalen, PA; Fisher, C; Furukawa, S; Goldman, BI; Greene, J; Houser, SR; Jeevanandam, V; Margulies, KB; Piacentino, V; Singhal, AK	1
Buckberg, GD; Castellá, M; Ignarro, LJ; Saleh, S; Tan, Z	1
Dowdy, KB; Escobar, GP; Hendrick, JW; McLean, JE; Mingoia, JT; Mukherjee, R; Sample, JA; Spinale, FG; Stroud, RE; Yarbrough, WM	1
Beguier, B; Wajima, T; Yaguchi, M	1
Galanopoulos, PT; Kashihara, H; LeBlanc, JG; Sett, SS; Talling, DN; Tibbits, GF	1
Chen, X; Yang, JA; Yu, YF; Zhang, XH	1
Ten Hove, M; Van Echteld, CJ	1
Bilzer, M; Boekstegers, P; Deiss, M; Hinkel, R; Horstkotte, J; Kupatt, C; von Brühl, ML	1
Boysen, PG; Criswell, HE; Ji, X; Xu, Z	1
Avkiran, M; Chambers, DJ; Fujii, M	1
Balshaw, D; Becker, L; Bolli, R; Gross, G; Lathrop, DA; Mentzer, R	1
Ferraris, SP; Jahania, SA; Kristo, G; Lasley, RD; Mentzer, RM; Yoshimura, Y	1
Besse, S; Boucher, F; Le Page, C; Leiris, Jd; Riou, B; Rozenberg, S; Swynghedauw, B; Tanguy, S	1
Kitano, M; Matsui, K; Mori, M; Ogawa, S; Ohashi, N; Yamada, K; Yamamoto, S	1
Dhalla, NS; Hryshko, LV; Lee, C	1
Davies, JE; Digerness, SB; Goldberg, SP; Holman, WL; Justice, RK; Katholi, CR; Killingsworth, CR; Zaragoza, C	1
Mentzer, RM	1
Liu, HM; Yang, YJ; Zhang, X; Zhou, TF	1
Peters, SC; Piper, HM	1
Holman, W; Wang, P; Zaragoza, C	1
Liu, B; Liu, J; Long, C; Zhou, RH	2
Albus, U; Counillon, L; Gögelein, H; Lang, HJ; Linz, W; Schölkens, BA; Scholz, W; Weichert, A	1
Aye, NN; Hashimoto, K; Xue, YX	2
Bohle, RM; Klein, HH; Lindert-Heimberg, S; Nebendahl, K; Pich, S; Wollenweber, J	1
Barrabés, JA; Blanco, J; Garcia-Dorado, D; González, MA; Lidon, RM; Piper, HM; Puigfel, Y; Ruiz-Meana, M; Solares, J; Soler-Soler, J	1
Chakrabarti, S; Hoque, AN; Karmazyn, M	1
Garcia-Dorado, D; Inserte, J; Ruiz-Meana, M; Soler-Soler, J; Tritto, FP	1
Flameng, W; Herijgers, P; Kim, YI; Van Lommel, A; Verbeken, E	1
Bohle, RM; Klein, HH; Lindert-Heimberg, S; Nebendahl, K; Pich, S; Schade-Brittinger, C; Wollenweber, J	1
Eng, S; Kardami, E; Maddaford, TG; Pierce, GN	1
Dhein, S; Engelmann, F; Gottwald, M; Krusemann, K	1
Bernard, M; Cozzone, PJ; el Banani, H; Feuvray, D	1
Frishman, WH; Gurell, D; Levitsky, J	1
Correa, SD; Schaefer, S; Symons, JD	1
Beyersdorf, F; Haberstroh, J; Lutter, G; Martin, J; Sarai, K; Takahashi, N; Yoshitake, M	1
Aye, NN; Hashimoto, K; Sawada, N; Sugiyama, A	1
Farhangkhoee, P; Karmazyn, M; Myers, ML	1
Arnold, JM; Chakrabarti, S; Feng, Q; Haist, JV; Humphreys, RA; Karmazyn, M	1
Karmazyn, M	2
Aye, NN; Hashimoto, K; Komori, S	1
Théroux, P	2
Avkiran, M	1
Buerke, M; Drexler, H; Richardt, G; Rupprecht, HJ; Schultheiss, HP; Seyfarth, M; Sheehan, FH; Terres, W; vom Dahl, J	1
Erhardt, LR	1
Farhangkhgoee, P; Karmazyn, M; Mathur, S	1
Ladilov, YV; Piper, HM; Schäfer, C; Siegmund, B	1
de Groot, MC; Faul, C; Horn, M; Leupold, A; Morgan, JP; Neubauer, S; Scholz, W; Strömer, H	1
Baxter, GF; Yellon, DM	1
Aihara, K; Hisa, H; Kimura, T; Kogi, K; Mizuno, Y; Nagai, A; Sasamori, J; Sato, T; Satoh, S; Takahashi, A; Yamaguchi, F; Yoneyama, F; Yoneyama, S	1
Briand, V; Cremer, G; Duval, N; Favennec, E; Grosset, A; Hoornaert, C; Janiak, P; Latham, C; Lorrain, J; O'Connor, SE	1
Anderson, DL; Ning, X; Panos, AL; Portman, MA; Xiao, Y	1
ten Hove, M; van Echteld, CJ; van Emous, JG	1
Gan, XT; Karmazyn, M; Sostaric, JV	1
Busch, AE; Maier, T; Wirth, KJ	1
Hattori, R; Imamura, H; Matsubara, H; Moriguchi, Y; Nakao, Y; Omiya, H; Osako, M; Otani, H; Yamamura, T	1
Chen, W; Khan, S; Levitsky, S; McCully, JD; Parker, RA; Toyoda, Y	1
Goto, M; Liu, Y; Miki, T; Miura, T; Nakano, A; Nishino, Y; Ohnuma, Y; Shimamoto, K; Tsuchida, A	1
Hashimoto, K	1
Abe, A; Fukumoto, S; Igata, H; Ikeda, S; Imamiya, E; Kusumoto, K; Shiraishi, M; Tsuboi, A; Watanabe, T	1

Reviews

12 review(s) available for cariporide and Injury, Myocardial Reperfusion

Article	Year
Post-conditioning to improve cardiopulmonary resuscitation. Current opinion in critical care, 2014, Volume: 20, Issue:3 Topics: Adenosine; Analgesics, Opioid; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Cyclosporine; Guanidines; Humans; Mitochondria, Heart; Myocardial Reperfusion Injury; Out-of-Hospital Cardiac Arrest; Reactive Oxygen Species; Risk Assessment; Sulfones; Survival Analysis; Time Factors; Treatment Outcome	2014
Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection. The Annals of thoracic surgery, 2003, Volume: 75, Issue:2 Topics: Amiloride; Animals; Coronary Artery Bypass; Creatine Kinase; Diuretics; Guanidines; Humans; Immunohistochemistry; Ischemic Preconditioning, Myocardial; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	2003
Myocardial protection at a crossroads: the need for translation into clinical therapy. Circulation research, 2004, Jul-23, Volume: 95, Issue:2 Topics: Animals; Cardiotonic Agents; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Coronary Artery Bypass; Drug Evaluation, Preclinical; Drug Utilization; Guanidines; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Prospective Studies; Sodium-Hydrogen Exchangers; Sulfones; Treatment Outcome	2004
Therapeutic potential of novel Na+-Ca2+ exchange inhibitors in attenuating ischemia-reperfusion injury. The Canadian journal of cardiology, 2005, May-01, Volume: 21, Issue:6 Topics: Aniline Compounds; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Guanidines; Humans; Myocardial Reperfusion Injury; Phenyl Ethers; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones; Thiourea	2005
Sodium ion/hydrogen ion exchange inhibition: a new pharmacologic approach to myocardial ischemia and reperfusion injury. Journal of clinical pharmacology, 1998, Volume: 38, Issue:10 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Diuretics; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	1998
The role of the myocardial sodium-hydrogen exchanger in mediating ischemic and reperfusion injury. From amiloride to cariporide. Annals of the New York Academy of Sciences, 1999, Jun-30, Volume: 874 Topics: Amiloride; Animals; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Remodeling	1999
Mechanisms of protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibition. Journal of thrombosis and thrombolysis, 1999, Volume: 8, Issue:1 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Diuretics; Guanidines; Humans; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	1999
Protection of the myocardial cell during ischemia. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Anti-Arrhythmia Agents; Cell Survival; Guanidines; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Oxygen Consumption; Sodium-Hydrogen Exchangers; Sulfones	1999
Rational basis for use of sodium-hydrogen exchange inhibitors in myocardial ischemia. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Animals; Anti-Arrhythmia Agents; Guanidines; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Oxygen Consumption; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Fibrillation	1999
Sodium-hydrogen exchange inhibition: novel strategy to prevent myocardial injury following ischemia and reperfusion. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Angioplasty, Balloon, Coronary; Animals; Anti-Arrhythmia Agents; Guanidines; Humans; Infusions, Intravenous; Myocardial Infarction; Myocardial Reperfusion Injury; Pilot Projects; Premedication; Rats; Sodium-Hydrogen Exchangers; Sulfones	1999
The myocardial Na+/H+ exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure. Drugs, 2001, Volume: 61, Issue:3 Topics: Adenosine Triphosphate; Anti-Arrhythmia Agents; Cardiac Output, Low; Clinical Trials as Topic; Guanidines; Humans; Hydrogen-Ion Concentration; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Phosphorylation; Sodium-Hydrogen Exchangers; Sulfones	2001
[Na+/H+ exchange inhibitors for ischemic diseases]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001, Volume: 118, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cation Transport Proteins; Clinical Trials as Topic; Guanidines; Humans; Membrane Proteins; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sulfones	2001

Trials

2 trial(s) available for cariporide and Injury, Myocardial Reperfusion

Article	Year
Sodium-hydrogen exchange inhibition: novel strategy to prevent myocardial injury following ischemia and reperfusion. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Angioplasty, Balloon, Coronary; Animals; Anti-Arrhythmia Agents; Guanidines; Humans; Infusions, Intravenous; Myocardial Infarction; Myocardial Reperfusion Injury; Pilot Projects; Premedication; Rats; Sodium-Hydrogen Exchangers; Sulfones	1999
GUARD During Ischemia Against Necrosis (GUARDIAN) trial in acute coronary syndromes. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Cause of Death; Coronary Artery Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Guanidines; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Prospective Studies; Sodium-Hydrogen Exchangers; Sulfones; Treatment Outcome	1999

Article

Year

Sodium-hydrogen exchange inhibition: novel strategy to prevent myocardial injury following ischemia and reperfusion.

The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A

Topics: Angioplasty, Balloon, Coronary; Animals; Anti-Arrhythmia Agents; Guanidines; Humans; Infusions, Intravenous; Myocardial Infarction; Myocardial Reperfusion Injury; Pilot Projects; Premedication; Rats; Sodium-Hydrogen Exchangers; Sulfones

1999

GUARD During Ischemia Against Necrosis (GUARDIAN) trial in acute coronary syndromes.

The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A

Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Cause of Death; Coronary Artery Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Guanidines; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Prospective Studies; Sodium-Hydrogen Exchangers; Sulfones; Treatment Outcome

1999

Other Studies

86 other study(ies) available for cariporide and Injury, Myocardial Reperfusion

Article	Year
4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na+/H+ exchanger isoform-1 (NHE-1) inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-15, Volume: 15, Issue:12 Topics: Animals; Blood Pressure; Cardiotonic Agents; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Protein Isoforms; Rats; Sodium-Hydrogen Exchangers; Structure-Activity Relationship	2005
3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors. Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5 Topics: Animals; Cardiotonic Agents; Guanidine; Heart; In Vitro Techniques; Inhibitory Concentration 50; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Sodium-Hydrogen Exchangers; Structure-Activity Relationship	2007
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. Journal of medicinal chemistry, 2012, Aug-23, Volume: 55, Issue:16 Topics: Animals; Benzamides; Biological Availability; Blood Platelets; Cell Line; Cell Membrane Permeability; Cell Size; Cytochrome P-450 Enzyme Inhibitors; Dogs; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guanidines; Humans; Male; Membranes, Artificial; Microsomes, Liver; Models, Molecular; Myocardial Infarction; Myocardial Reperfusion Injury; Permeability; Protein Isoforms; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Structure-Activity Relationship	2012
Featured Article: Pharmacological postconditioning with delta opioid attenuates myocardial reperfusion injury in isolated porcine hearts. Experimental biology and medicine (Maywood, N.J.), 2017, Volume: 242, Issue:9 Topics: Animals; Guanidines; Heart; Ischemic Postconditioning; Myocardial Reperfusion Injury; Oligopeptides; Sulfones; Swine	2017
Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts. Cardiovascular research, 2019, Aug-01, Volume: 115, Issue:10 Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Glucosides; Guanidines; Insulin; Isolated Heart Preparation; Male; Mice, Inbred C57BL; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors; Sodium-Hydrogen Exchanger 1; Sulfones; Time Factors	2019
Triple therapy greatly increases myocardial salvage during ischemia/reperfusion in the in situ rat heart. Cardiovascular drugs and therapy, 2013, Volume: 27, Issue:5 Topics: Adenosine; Adenosine Monophosphate; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Guanidines; Hypothermia, Induced; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sulfones; Ticagrelor	2013
Effects of intravenous cariporide on release of norepinephrine and myoglobin during myocardial ischemia/reperfusion in rabbits. Life sciences, 2014, Oct-02, Volume: 114, Issue:2 Topics: Administration, Intravenous; Animals; Chromatography, High Pressure Liquid; Guanidines; Microdialysis; Myocardial Reperfusion Injury; Myoglobin; Norepinephrine; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	2014
Age dependency of the cariporide-mediated cardio-protection after simulated ischemia in isolated human atrial heart muscles. Experimental gerontology, 2008, Volume: 43, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Aging; Anti-Arrhythmia Agents; Cardiotonic Agents; Cation Transport Proteins; Drug Evaluation, Preclinical; Guanidines; Heart; Heart Atria; Humans; Ischemic Preconditioning, Myocardial; Middle Aged; Myocardial Contraction; Myocardial Reperfusion Injury; Organ Culture Techniques; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sulfones	2008
[The protective effect of pharmacological postconditioning of cariporide and GSH on ischemia/reperfusion injury]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2009, Volume: 25, Issue:2 Topics: Animals; Glutathione; Guanidines; Ischemic Postconditioning; Male; Myocardial Reperfusion Injury; Random Allocation; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones	2009
Myocardial reperfusion injury: reactive oxygen species vs. NHE-1 reactivation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2011, Volume: 27, Issue:1 Topics: Animals; Glycine; Guanidines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Reperfusion Injury; Phosphorylation; Piperazines; Purines; Rats; Reactive Oxygen Species; Ribosomal Protein S6 Kinases, 90-kDa; Sildenafil Citrate; Sodium-Hydrogen Exchangers; Sulfhydryl Compounds; Sulfones; Thiobarbituric Acid Reactive Substances; Vasodilator Agents	2011
A recombinant human neuregulin-1 peptide improves preservation of the rodent heart after prolonged hypothermic storage. Transplantation, 2011, May-15, Volume: 91, Issue:9 Topics: Animals; Apoptosis; Cardiac Output; Cold Ischemia; Disaccharides; Electrolytes; Glutamates; Glutathione; Guanidines; Heart; Heart Transplantation; Histidine; Humans; In Vitro Techniques; Male; Mannitol; Models, Animal; Myocardial Reperfusion Injury; Myocytes, Cardiac; Neuregulin-1; Nitroglycerin; Organ Preservation; Organ Preservation Solutions; Rats; Rats, Wistar; Recombinant Proteins; Signal Transduction; Sulfones; Time Factors	2011
Resuscitation after prolonged cardiac arrest: effects of cardiopulmonary bypass and sodium-hydrogen exchange inhibition on myocardial and neurological recovery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2011, Volume: 40, Issue:4 Topics: Animals; Cardiopulmonary Bypass; Cardiopulmonary Resuscitation; Combined Modality Therapy; Disease Models, Animal; Guanidines; Heart Arrest; Hemodynamics; Myocardial Reperfusion Injury; Nervous System Diseases; Seizures; Sodium-Hydrogen Exchangers; Sulfones; Sus scrofa; Treatment Outcome	2011
Mitochondrial KATP channels participate in the limitation of infarct size by cariporide. Naunyn-Schmiedeberg's archives of pharmacology, 2011, Volume: 383, Issue:6 Topics: Animals; Calcium; Cardiotonic Agents; Decanoic Acids; Diazoxide; Disease Models, Animal; Guanidines; Hydroxy Acids; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones	2011
Disruption of chronic cariporide treatment abrogates myocardial ion homeostasis during acute ischemia reperfusion. Journal of cardiovascular pharmacology, 2011, Volume: 58, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Chemical Analysis; Cardiotonic Agents; Drug Administration Schedule; Guanidines; Heart Function Tests; Homeostasis; Male; Monocarboxylic Acid Transporters; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; RNA, Messenger; Sodium-Bicarbonate Symporters; Sodium-Hydrogen Exchangers; Sulfones; Symporters; Time Factors	2011
Hydrogen sulfide regulates Na+/H+ exchanger activity via stimulation of phosphoinositide 3-kinase/Akt and protein kinase G pathways. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Arrhythmia Agents; Cell Survival; Chloride-Bicarbonate Antiporters; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Guanidines; Heart; Hydrogen-Ion Concentration; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinase; Phosphoproteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfides; Sulfones	2011
The role of Na+/H+ exchanger in Ca2+ overload and ischemic myocardial damage in hearts from type 2 diabetic db/db mice. Cardiovascular diabetology, 2012, Apr-11, Volume: 11 Topics: Animals; Calcium; Diabetes Mellitus, Type 2; Disease Models, Animal; Guanidines; Male; Mice; Mice, Mutant Strains; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Dysfunction, Left	2012
Is microvascular protection by cariporide and ischemic preconditioning causally linked to myocardial salvage? American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:4 Topics: Animals; Constriction; Coronary Vessels; Guanidines; Ischemic Preconditioning; Male; Microcirculation; Myocardial Infarction; Myocardial Reperfusion Injury; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	2003
Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na/H exchange. The Journal of thoracic and cardiovascular surgery, 2002, Volume: 124, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Cardiopulmonary Bypass; Creatine Kinase; Creatine Kinase, MB Form; Endothelin-1; Guanidines; Ischemic Preconditioning, Myocardial; Isoenzymes; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Peroxidase; Sulfones; Swine; Time Factors	2002
Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries. European journal of pharmacology, 2003, Jan-01, Volume: 458, Issue:1-2 Topics: Aniline Compounds; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cell Survival; Cells, Cultured; Dogs; Guanidines; Heart; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Phenyl Ethers; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sarcolemma; Sodium-Calcium Exchanger; Sulfones; Thiourea	2003
Attenuation of postischemic myocardial injury by cariporide. The Journal of thoracic and cardiovascular surgery, 2003, Volume: 125, Issue:1 Topics: Animals; Guanidines; Heart Arrest, Induced; Humans; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	2003
Blood cardioplegia supplementation with the sodium-hydrogen ion exchange inhibitor cariporide to attenuate infarct size and coronary artery endothelial dysfunction after severe regional ischemia in a canine model. The Journal of thoracic and cardiovascular surgery, 2003, Volume: 125, Issue:1 Topics: Animals; Blood; Dogs; Endothelium, Vascular; Female; Guanidines; Heart Arrest, Induced; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Neutrophil Activation; Sodium-Hydrogen Exchangers; Sulfones	2003
Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart. European journal of pharmacology, 2003, Feb-14, Volume: 461, Issue:2-3 Topics: Animals; Coronary Circulation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radicals; Guanidines; Heart; Heart Rate; Hydroxyl Radical; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Perfusion; Rats; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones; Thiourea; Ventricular Function, Left	2003
Cariporide (HOE-642) improves cardiac allograft preservation in a porcine model of orthotopic heart transplantation. Transplantation, 2003, Mar-15, Volume: 75, Issue:5 Topics: Animals; Blood Pressure; Blood Volume; Control Groups; Cryopreservation; Guanidines; Heart; Heart Transplantation; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Stroke Volume; Sulfones; Swine; Transplantation, Homologous; Troponin I; Ventricular Function, Left	2003
Blockade of the Na+-Ca2+ exchanger is more efficient than blockade of the Na+-H+ exchanger for protection of the myocardium from lethal reperfusion injury. Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:4 Topics: Animals; Guanidines; Hemodynamics; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Rabbits; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones; Thiourea	2002
Long-term magnetic resonance imaging/spectroscopy study of cariporide in a canine cardiac ischemia/reperfusion model. Journal of cardiovascular pharmacology, 2003, Volume: 41, Issue:4 Topics: Animals; Disease Models, Animal; Dogs; Female; Guanidines; Hemodynamics; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Myocardial Reperfusion Injury; Sulfones	2003
Sodium-hydrogen exchange inhibition during ventricular fibrillation: Beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability. Circulation, 2003, Apr-08, Volume: 107, Issue:13 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Combined Modality Therapy; Echocardiography, Transesophageal; Guanidines; Heart; Male; Myocardial Reperfusion Injury; Resuscitation; Secondary Prevention; Sodium-Hydrogen Exchangers; Sulfones; Swine; Ventricular Fibrillation; Ventricular Function, Left	2003
Pre-treatment with the Na+/H+ exchange inhibitor cariporide delays cell-to-cell electrical uncoupling during myocardial ischemia. Cardiovascular research, 2003, Apr-01, Volume: 58, Issue:1 Topics: Action Potentials; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Electric Impedance; Guanidines; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Perfusion; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Swine	2003
Blood cardioplegic protection in profoundly damaged hearts: role of Na+-H+ exchange inhibition during pretreatment or during controlled reperfusion supplementation. The Annals of thoracic surgery, 2003, Volume: 75, Issue:4 Topics: Animals; Blood; Cardioplegic Solutions; Creatine Kinase; Creatine Kinase, MB Form; Endothelin-1; Guanidines; Isoenzymes; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Swine; Ventricular Function, Left	2003
The initial rate of troponin I release post-reperfusion reflects the effectiveness of myocardial protection during cardiac allograft preservation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2003, Volume: 23, Issue:6 Topics: Animals; Animals, Inbred Strains; Guanidines; Heart Transplantation; Models, Animal; Myocardial Contraction; Myocardial Reperfusion Injury; Postoperative Period; Sodium-Hydrogen Exchangers; Sulfones; Swine; Time Factors; Tissue Preservation; Transplantation, Homologous; Troponin I	2003
Cariporide enhances lactate clearance upon reperfusion but does not alter lactate accumulation during global ischaemia. Pflugers Archiv : European journal of physiology, 2003, Volume: 447, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; In Vitro Techniques; Lactic Acid; Myocardial Ischemia; Myocardial Reperfusion Injury; Sulfones; Time Factors	2003
Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:3 Topics: Acids; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Cell Death; Cells, Cultured; Energy Metabolism; Guanidines; Mice; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protons; Sodium-Hydrogen Exchangers; Sulfones	2003
The cardioprotective effects of Na+/H+ exchange inhibition and mitochondrial KATP channel activation are additive in the isolated rat heart. Pflugers Archiv : European journal of physiology, 2003, Volume: 447, Issue:3 Topics: Animals; Cardiotonic Agents; Female; Guanidines; In Vitro Techniques; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Tachycardia	2003
NHE-1 and NHE-6 activities: ischemic and reperfusion injury. Circulation research, 2003, Oct-17, Volume: 93, Issue:8 Topics: Animals; Calcium; Guanidines; Membrane Proteins; Mice; Mice, Knockout; Myocardial Reperfusion Injury; Myocardium; Rats; Sodium-Hydrogen Exchangers; Sulfones	2003
Pharmacologic pre-conditioning and controlled reperfusion prevent ischemia-reperfusion injury after 30 minutes of hypoxia/ischemia in porcine hearts. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2003, Volume: 22, Issue:11 Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Creatine Kinase; Guanidines; Heart; Hypoxia; Ischemic Preconditioning, Myocardial; Myocardial Reperfusion Injury; Myocardium; Sulfones; Swine; Vasodilator Agents	2003
A new role for cardioplegic buffering: should acidosis or calcium accumulation be counteracted to salvage jeopardized hearts? The Journal of thoracic and cardiovascular surgery, 2003, Volume: 126, Issue:5 Topics: Acidosis; Animals; Buffers; Calcium; Cardioplegic Solutions; Creatine Kinase; Creatine Kinase, MB Form; Disease Models, Animal; Female; Guanidines; Heart Arrest, Induced; Hydrogen-Ion Concentration; Ischemic Preconditioning, Myocardial; Isoenzymes; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Random Allocation; Reference Values; Sensitivity and Specificity; Sodium-Hydrogen Exchangers; Sulfones; Swine; Ventricular Function, Left	2003
Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability. The Journal of thoracic and cardiovascular surgery, 2003, Volume: 126, Issue:5 Topics: Animals; Biopsy, Needle; Disease Models, Animal; Female; Guanidines; Heart Function Tests; Hemodynamics; Infusions, Intravenous; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Random Allocation; Recovery of Function; Reference Values; Sensitivity and Specificity; Sodium-Hydrogen Exchangers; Sulfones; Swine; Ventricular Function, Left	2003
Effects of cariporide (HOE642) on myocardial infarct size and ventricular arrhythmias in a rat ischemia/reperfusion model: comparison with other drugs. Pharmacology, 2004, Volume: 70, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Dose-Response Relationship, Drug; Electrocardiography; Guanidines; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Nifedipine; Propranolol; Rats; Rats, Sprague-Dawley; Sulfones; Tachycardia, Ventricular	2004
Na+/H+ exchange inhibition with HOE 642 improves recovery of the injured neonatal rabbit heart. The Canadian journal of cardiology, 2003, Volume: 19, Issue:13 Topics: Animals; Animals, Newborn; Aorta; Blood Flow Velocity; Cardiac Output; Coronary Circulation; Guanidines; Heart Rate; Myocardial Reperfusion Injury; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	2003
[Effect of cariporide on immature rabbit heart]. Zhonghua wai ke za zhi [Chinese journal of surgery], 2003, Volume: 41, Issue:10 Topics: Animals; Arrhythmias, Cardiac; Calcium; Female; Guanidines; Male; Myocardial Reperfusion Injury; Rabbits; Sodium; Sodium-Hydrogen Exchangers; Sulfones	2003
Limited effects of post-ischemic NHE blockade on [Na+]i and pHi in rat hearts explain its lack of cardioprotection. Cardiovascular research, 2004, Feb-15, Volume: 61, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Guanidines; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Rats; Rats, Wistar; Sodium; Sodium-Hydrogen Exchangers; Sulfones	2004
Selective retroinfusion of GSH and cariporide attenuates myocardial ischemia-reperfusion injury in a preclinical pig model. Cardiovascular research, 2004, Feb-15, Volume: 61, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Free Radical Scavengers; Glutathione; Guanidines; Models, Animal; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Rats; Rats, Wistar; Sulfones; Swine	2004
Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury. Life sciences, 2004, Apr-30, Volume: 74, Issue:24 Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Guanidines; Ion Channel Gating; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Parabens; Patch-Clamp Techniques; Propidium; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Channels; Sulfones	2004
Experimental studies on myocardial protection with intermittent cross-clamp fibrillation: additive effect of the sodium-hydrogen exchanger inhibitor, cariporide. The Annals of thoracic surgery, 2004, Volume: 77, Issue:4 Topics: Animals; Aorta; Constriction; Creatine Kinase; Guanidines; In Vitro Techniques; Male; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardial Revascularization; Myocardium; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Fibrillation; Ventricular Function, Left; Ventricular Pressure	2004
The preischemic combination of the sodium-hydrogen exchanger inhibitor cariporide and the adenosine agonist AMP579 acts additively to reduce porcine myocardial infarct size. Journal of the American College of Surgeons, 2004, Volume: 199, Issue:4 Topics: Animals; Cardiotonic Agents; Drug Synergism; Female; Guanidines; Imidazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Neutrophil Activation; Neutrophils; Purinergic P1 Receptor Agonists; Pyridines; Sodium-Hydrogen Exchangers; Sulfones; Swine	2004
Cardioprotection with cariporide, a sodium-proton exchanger inhibitor, after prolonged ischemia and reperfusion in senescent rats. Experimental gerontology, 2004, Volume: 39, Issue:9 Topics: Aging; Animals; Cardiotonic Agents; Coronary Circulation; Guanidines; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones; Vascular Resistance	2004
Reduction of myocardial infarct size by SM-198110, a novel Na+/H+ exchange inhibitor, in rabbits. Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 371, Issue:5 Topics: Alkanesulfonic Acids; Animals; Blood Pressure; Creatine Kinase; Guanidines; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Necrosis; Phosphoproteins; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	2005
Multiple treatment approach to limit cardiac ischemia-reperfusion injury. The Annals of thoracic surgery, 2005, Volume: 80, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Combined Modality Therapy; Diazoxide; Disease Models, Animal; Drug Therapy, Combination; Female; Guanidines; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Recovery of Function; Reference Values; Sulfones; Swine; Treatment Outcome; Vasodilator Agents; Ventricular Dysfunction, Left	2005
Invited commentary. The Annals of thoracic surgery, 2005, Volume: 80, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Combined Modality Therapy; Diazoxide; Disease Models, Animal; Drug Therapy, Combination; Guanidines; Myocardial Infarction; Myocardial Reperfusion Injury; Sulfones; Swine; Treatment Outcome; Vasodilator Agents	2005
[Protection of HOE642 against cardiomyocyte injury caused by anoxia and reoxygenation]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2005, Volume: 36, Issue:5 Topics: Animals; Animals, Newborn; Anti-Arrhythmia Agents; Calpain; Cell Hypoxia; Cells, Cultured; Guanidines; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats; Rats, Wistar; Sulfones	2005
Reoxygenation-induced Ca2+ rise is mediated via Ca2+ influx and Ca2+ release from the endoplasmic reticulum in cardiac endothelial cells. Cardiovascular research, 2007, Jan-01, Volume: 73, Issue:1 Topics: Animals; Biological Transport; Calcium; Cell Hypoxia; Cells, Cultured; Cytosol; Endoplasmic Reticulum; Endothelial Cells; Guanidines; Hydrogen-Ion Concentration; Ion Channels; Male; Microcirculation; Myocardial Reperfusion Injury; Myocardium; Ouabain; Rats; Rats, Wistar; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Sulfones; Thapsigargin	2007
Sodium-hydrogen exchange inhibition and beta-blockade additively decrease infarct size. The Annals of thoracic surgery, 2007, Volume: 83, Issue:3 Topics: Adrenergic beta-Antagonists; Animals; Calcium; Drug Combinations; Guanidines; Heart; Heart Ventricles; In Vitro Techniques; Male; Metoprolol; Mitochondria, Heart; Mitochondrial Proteins; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Sodium-Hydrogen Exchangers; Sulfones	2007
Inhibition of the Na+/H+ exchanger protects the immature rabbit myocardium from ischemia and reperfusion injury. Pediatric cardiology, 2008, Volume: 29, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Guanidines; Ischemic Preconditioning, Myocardial; Myocardial Reperfusion Injury; Rabbits; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sulfones	2008
[Cardioprotective effects of cariporide as an adjunct in different cardioplegic solutions: an experiment with rabbits]. Zhonghua yi xue za zhi, 2007, Sep-04, Volume: 87, Issue:33 Topics: Animals; Calcium; Cardioplegic Solutions; Cardiotonic Agents; Chromatography, High Pressure Liquid; Coronary Circulation; Creatine Kinase, MB Form; Guanidines; Heart Arrest, Induced; In Vitro Techniques; Ion Transport; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Rabbits; Random Allocation; Spectrophotometry, Atomic; Sulfones	2007
Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovascular research, 1995, Volume: 29, Issue:2 Topics: Animals; Blood Platelets; Cells, Cultured; Dose-Response Relationship, Drug; Erythrocytes; Guanidines; Hydrogen-Ion Concentration; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Perfusion; Rabbits; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones	1995
Antiarrhythmic effects of HOE642, a novel Na(+)-H+ exchange inhibitor, on ventricular arrhythmias in animal hearts. European journal of pharmacology, 1996, Dec-19, Volume: 317, Issue:2-3 Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Coronary Vessels; Digitalis Glycosides; Dogs; Dose-Response Relationship, Drug; Female; Guanidines; Injections, Intravenous; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Fibrillation	1996
Time delay of cell death by Na+/H+-exchange inhibition in regionally ischemic, reperfused porcine hearts. Journal of cardiovascular pharmacology, 1997, Volume: 30, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Cell Death; Enzyme Inhibitors; Female; Guanidines; Hemodynamics; Histocytochemistry; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Sodium-Hydrogen Exchangers; Sulfones; Swine; Time Factors	1997
Prevention of ischemic rigor contracture during coronary occlusion by inhibition of Na(+)-H+ exchange. Cardiovascular research, 1997, Volume: 35, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Guanidines; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Sodium-Hydrogen Exchangers; Sulfones; Swine	1997
A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:11 Topics: Analysis of Variance; Animals; Apoptosis; Guanidines; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Time Factors	1997
Antiarrhythmic effects of cariporide, a novel Na+-H+ exchange inhibitor, on reperfusion ventricular arrhythmias in rat hearts. European journal of pharmacology, 1997, Nov-27, Volume: 339, Issue:2-3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Guanidines; Heart; Hemodynamics; Male; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Function	1997
Sodium/hydrogen exchanger inhibition reduces myocardial reperfusion edema after normothermic cardioplegia. The Journal of thoracic and cardiovascular surgery, 1998, Volume: 115, Issue:3 Topics: Animals; Edema, Cardiac; Guanidines; Heart Arrest, Induced; Hemodynamics; In Vitro Techniques; L-Lactate Dehydrogenase; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Function, Left	1998
Na+/H+ exchange inhibition improves post-transplant myocardial compliance in 4-hour stored donor hearts. Cardiovascular surgery (London, England), 1998, Volume: 6, Issue:1 Topics: Animals; Brain Death; Dogs; Guanidines; Heart; Heart Transplantation; Myocardial Contraction; Myocardial Reperfusion Injury; Organ Preservation; Sodium-Hydrogen Exchangers; Sulfones; Time Factors	1998
Time-dependent protection by Na+/H+ exchange inhibition in a regionally ischemic, reperfused porcine heart preparation with low residual blood flow. Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Drug Administration Schedule; Female; Guanidines; Heart; Heart Rate; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Swine; Time Factors	1998
Protection against myocardial ischemic/reperfusion injury by inhibitors of two separate pathways of Na+ entry. Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:4 Topics: Animals; Drug Interactions; Guanidines; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; Sodium-Hydrogen Exchangers; Sulfones; Tetrodotoxin	1998
Effects of the type-1 Na+/H+-exchange inhibitor cariporide (Hoe 642) on cardiac tissue. Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:6 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Electrophysiology; Enzyme Inhibitors; Guanidines; Heart; Heart Rate; In Vitro Techniques; Luminescent Measurements; Male; Myocardial Reperfusion Injury; Myocardium; Papillary Muscles; Pericardium; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	1998
Ionic and metabolic imbalance in various conditions of ischemia-reperfusion: a 31P- and 23Na-NMR study. Magma (New York, N.Y.), 1998, Volume: 6, Issue:2-3 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Diastole; Dichloroacetic Acid; Enzyme Inhibitors; Guanidines; Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nuclear Magnetic Resonance, Biomolecular; Palmitic Acid; Phosphorus; Rats; Sodium; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones; Trimetazidine; Vasodilator Agents	1998
Na-H exchange inhibition with cariporide limits functional impairment caused by repetitive ischemia. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:6 Topics: Adenosine; Animals; Blood Pressure; Guanidines; Heart Rate; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Swine	1998
Orthotopic transplantation of pig hearts harvested after 30 min of normothermic ischemia: controlled reperfusion with blood cardioplegia containing the Na+-H+-exchange inhibitor HOE 642. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1998, Volume: 14, Issue:6 Topics: Animals; Blood; Cardioplegic Solutions; Creatine Kinase; Guanidines; Heart Arrest, Induced; Heart Transplantation; Isoenzymes; L-Lactate Dehydrogenase; Myocardial Reperfusion; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Stroke Volume; Sulfones; Swine; Time Factors	1998
Cariporide, a highly selective Na+/H+ exchange inhibitor, suppresses the reperfusion-induced lethal arrhythmias and "overshoot" phenomenon of creatine phosphate in situ rat heart. Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:1 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Glucose; Blood Pressure; Coronary Vessels; Electrocardiography; Guanidines; Heart; Heart Rate; Male; Myocardial Reperfusion Injury; Myocardium; Phosphocreatine; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Fibrillation	1999
Hydrogen peroxide induced impairment of post-ischemic ventricular function is prevented by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). Cardiovascular research, 1998, Volume: 40, Issue:2 Topics: Analysis of Variance; Animals; Guanidines; Hydrogen Peroxide; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidants; Perfusion; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Pressure	1998
Orally administered NHE1 inhibitor cariporide reduces acute responses to coronary occlusion and reperfusion. The American journal of physiology, 1999, Volume: 276, Issue:2 Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Apoptosis; Arrhythmias, Cardiac; bcl-2-Associated X Protein; Coronary Disease; Guanidines; Incidence; Male; Myocardial Reperfusion Injury; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium-Hydrogen Exchangers; Sulfones	1999
Effects and interaction, of cariporide and preconditioning on cardiac arrhythmias and infarction in rat in vivo. British journal of pharmacology, 1999, Volume: 127, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Guanidines; Hydrogen-Ion Concentration; Ischemic Preconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Time Factors	1999
A symposium: sodium-hydrogen exchange inhibition. Introduction. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Anti-Arrhythmia Agents; Guanidines; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	1999
Cardioprotective effects of propofol and sevoflurane in ischemic and reperfused rat hearts: role of K(ATP) channels and interaction with the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). Anesthesiology, 1999, Volume: 91, Issue:5 Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Biotransformation; Drug Interactions; Energy Metabolism; Glyburide; Guanidines; Hemodynamics; In Vitro Techniques; Male; Methyl Ethers; Myocardial Reperfusion Injury; Potassium Channels; Propofol; Rats; Rats, Sprague-Dawley; Sevoflurane; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Function, Left	1999
Importance of bicarbonate transport for protection of cardiomyocytes against reoxygenation injury. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:5 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anti-Arrhythmia Agents; Bicarbonates; Calcium; Carrier Proteins; Cell Hypoxia; Cell Size; Cells, Cultured; Guanidines; Hydrogen-Ion Concentration; Intracellular Fluid; Ion Transport; Male; Muscle Contraction; Myocardial Reperfusion Injury; Myocardium; Oxygen; Rats; Rats, Wistar; Sodium; Sodium-Bicarbonate Symporters; Sodium-Hydrogen Exchangers; Sulfones	2000
Na(+)/H(+) exchange inhibition with HOE642 improves postischemic recovery due to attenuation of Ca(2+) overload and prolonged acidosis on reperfusion. Circulation, 2000, Jun-13, Volume: 101, Issue:23 Topics: Acidosis; Aequorin; Animals; Anti-Arrhythmia Agents; Calcium; Guanidines; Hydrogen-Ion Concentration; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Phosphorus Isotopes; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Function, Left	2000
Sodium-hydrogen exchange in myocardial reperfusion injury. Lancet (London, England), 2000, Aug-12, Volume: 356, Issue:9229 Topics: Animals; Guanidines; Heart Arrest, Induced; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	2000
Cardioprotective effect of TY-12533, a novel Na(+)/H(+) exchange inhibitor, on ischemia/reperfusion injury. European journal of pharmacology, 2000, Sep-15, Volume: 404, Issue:1-2 Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Disease Models, Animal; Guanidines; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyridines; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones	2000
Activity of the Na(+)/H(+) exchanger is critical to reperfusion damage and preconditioning in the isolated rat heart. Cardiovascular research, 2000, Volume: 48, Issue:2 Topics: Analysis of Variance; Animals; Female; Guanidines; Hydrogen-Ion Concentration; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Perfusion; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Pressure	2000
Pharmacological profile of SL 59.1227, a novel inhibitor of the sodium/hydrogen exchanger. British journal of pharmacology, 2000, Volume: 131, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzamides; Blood Pressure; Coronary Disease; Guanidines; Heart Rate; Heart Ventricles; Hydrogen-Ion Concentration; Imidazoles; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Piperidines; Rabbits; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones	2000
HOE-642 (cariporide) alters pH(i) and diastolic function after ischemia during reperfusion in pig hearts in situ. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:2 Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Diastole; Energy Metabolism; Guanidines; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Myocardial Ischemia; Myocardial Reperfusion Injury; Protons; Recovery of Function; Sulfones; Swine	2001
Na+-overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+-exchange blockers EIPA, HOE642 and EMD96785. Magma (New York, N.Y.), 2000, Volume: 11, Issue:1-2 Topics: Amiloride; Animals; Guanidines; In Vitro Techniques; Magnetic Resonance Spectroscopy; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Sodium; Sodium-Hydrogen Exchangers; Sulfones	2000
NHE1-inhibitor cariporide prevents the transient reperfusion-induced shortening of the monophasic action potential after coronary ischemia in pigs. Basic research in cardiology, 2001, Volume: 96, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Blood Pressure; Guanidines; Heart Rate; Male; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Swine; Tachycardia, Ventricular	2001
NHE and ICAM-1 expression in hypoxic/reoxygenated coronary microvascular endothelial cells. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:6 Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Calcium; Carbocyanines; Cell Hypoxia; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Flow Cytometry; Guanidines; Hydrogen-Ion Concentration; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Male; Microcirculation; Myocardial Reperfusion Injury; Oxygen; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones	2001
Effects of NHE-1 inhibition on cardioprotection and impact on protection by K/Mg cardioplegia. The Annals of thoracic surgery, 2001, Volume: 72, Issue:3 Topics: Animals; Cardioplegic Solutions; Coronary Circulation; Guanidines; Heart Arrest, Induced; Hemodynamics; In Vitro Techniques; Magnesium; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Potassium; Rabbits; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Function, Left; Ventricular Pressure	2001
Mitochondrial ATP-sensitive K+ channels play a role in cardioprotection by Na+-H+ exchange inhibition against ischemia/reperfusion injury. Journal of the American College of Cardiology, 2001, Mar-01, Volume: 37, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Guanidines; Hemodynamics; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardial Stunning; Potassium Channels; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	2001
In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559. British journal of pharmacology, 2002, Volume: 135, Issue:8 Topics: Animals; Blood Platelets; Cardiotonic Agents; Dose-Response Relationship, Drug; Guanidines; Humans; In Vitro Techniques; Injections, Intravenous; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Quinolines; Rabbits; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones	2002