Page last updated: 2024-09-04

cariporide and Cardiovascular Stroke

cariporide has been researched along with Cardiovascular Stroke in 60 studies

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (18.33)	18.2507
2000's	45 (75.00)	29.6817
2010's	4 (6.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fujiwara, S; Fukumoto, S; Imamiya, E; Kusumoto, K; Shiraishi, M; Watanabe, T	1
Hwang, SK; Lee, BH; Lee, K; Lee, S; Yi, KY; Yoo, SE	1
Cho, NS; Lee, BH; Lee, H; Lee, K; Lee, S; Yi, KY; Yoo, SE	1
Dong, J; Hua, WY; Wen, N; Xu, YG; You, QD; Zhang, R	1
Borras, M; Colpaert, F; Cuisiat, F; Le Grand, B; Létienne, R; Mas, A; Pignier, C; Rolland, F; Vacher, B	1
Bentzien, J; Boyer, SJ; Burke, J; De Lombaert, S; Eickmeier, C; Eldrup, AB; Guo, X; Haist, JV; Hickey, ER; Huber, JD; Kaplita, P; Karmazyn, M; Kemper, R; Kennedy, CA; Kirrane, T; Madwed, JB; Mainolfi, E; Nagaraja, N; Soleymanzadeh, F; Swinamer, A	1
Baartscheer, A; Buchholtz, N; Coronel, R; Eerbeek, O; Hollmann, MW; Nederlof, R; Schumacher, C; Uthman, L; Weber, NC; Zuurbier, CJ	1
Alhammouri, A; Cohen, MV; Cui, L; Downey, JM; Yang, XM	1
Erdogan, A; Fabiunk, V; Fritz, F; Möller, A; Neuhof, C; Neuhof, H; Speth, M; Tillmanns, H	1
Arbeláez, LF; Fantinelli, J; Mosca, SM; Nuñez, IP	1
Kloner, RA; Reffelmann, T	1
Budde, JM; Guyton, RA; Morris, CD; Muraki, S; Vinten-Johansen, J; Zhao, ZQ	1
Genda, S; Matsumoto, T; Miki, T; Miura, T; Shimamoto, K	1
Agulló, L; Garcia-Dorado, D; Inserte, J; Pina, P; Ruiz-Meana, M; Soler-Soler, J	1
Bartels, C; Bolli, R; Boyce, SW; Chaitman, B; Chen, JC; Chi, E; Jessel, A; Kereiakes, D; Knight, J; Theroux, P; Thulin, L	1
Dowdy, KB; Escobar, GP; Hendrick, JW; McLean, JE; Mingoia, JT; Mukherjee, R; Sample, JA; Spinale, FG; Stroud, RE; Yarbrough, WM	1
Beguier, B; Wajima, T; Yaguchi, M	1
Ten Hove, M; Van Echteld, CJ	1
Bilzer, M; Boekstegers, P; Deiss, M; Hinkel, R; Horstkotte, J; Kupatt, C; von Brühl, ML	1
Mercier, LA; Tardif, JC; Théroux, P	1
Busch, AE; Gerl, M; Licher, T; Ruetten, H; Rungwerth, K; Schäfer, S; Schindler, U	1
Albus, U; Busch, AE; Jung, O; Lang, HJ; Linz, W	1
Balshaw, D; Becker, L; Bolli, R; Gross, G; Lathrop, DA; Mentzer, R	1
Ferraris, SP; Jahania, SA; Kristo, G; Lasley, RD; Mentzer, RM; Yoshimura, Y	1
Kitano, M; Matsui, K; Mori, M; Ogawa, S; Ohashi, N; Yamada, K; Yamamoto, S	1
Busch, AE; Gehring, D; Gerl, M; Hiss, K; Ruetten, H; Schaefer, S; Schindler, U	1
Davies, JE; Digerness, SB; Goldberg, SP; Holman, WL; Justice, RK; Katholi, CR; Killingsworth, CR; Zaragoza, C	1
Mentzer, RM	1
Bel, L; Bessac, AM; Degryse, AD; Denais, D; John, GW; Le Grand, B; Létienne, R	1
Holman, W; Wang, P; Zaragoza, C	1
Anderson, S	1
Grosjean, N; Le Grand, B; Létienne, R; Vié, B	1
Goto, M; Miura, T; Ogawa, T; Shimamoto, K; Suzuki, K	1
Bohle, RM; Klein, HH; Lindert-Heimberg, S; Nebendahl, K; Pich, S; Wollenweber, J	1
Barrabés, JA; Blanco, J; Garcia-Dorado, D; González, MA; Lidon, RM; Piper, HM; Puigfel, Y; Ruiz-Meana, M; Solares, J; Soler-Soler, J	1
Bohle, RM; Klein, HH; Lindert-Heimberg, S; Nebendahl, K; Pich, S; Schade-Brittinger, C; Wollenweber, J	1
Albus, U; Crause, P; Jung, W; Linz, W; Schölkens, BA; Scholz, W; Weichert, A	1
Aye, NN; Hashimoto, K; Komori, S	1
Théroux, P	3
Avkiran, M	1
Buerke, M; Drexler, H; Richardt, G; Rupprecht, HJ; Schultheiss, HP; Seyfarth, M; Sheehan, FH; Terres, W; vom Dahl, J	1
Erhardt, LR	1
Karmazyn, M; Yoshida, H	1
Chung, O; Daemen, MJ; Illner, S; Jähnichen, G; Reinecke, A; Rossius, B; Sandmann, S; Spitznagel, H; Unger, T; Xia, Q	1
Buerke, M; Drexler, H; Richardt, G; Rupprecht, HJ; Schultheibeta, HP; Seyfarth, KM; Sheehan, FH; Terres, W; vom Dahl, J	1
Baxter, GF; Yellon, DM	1
Aihara, K; Hisa, H; Kimura, T; Kogi, K; Mizuno, Y; Nagai, A; Sasamori, J; Sato, T; Satoh, S; Takahashi, A; Yamaguchi, F; Yoneyama, F; Yoneyama, S	1
Bohle, RM; Klein, HH; Lindert-Heimberg, S; Nebendahl, K; Pich, S	1
Hale, SL; Kloner, RA	1
Chaitman, BR; Danchin, N; Erhardt, L; Jessel, A; Meinertz, T; Schroeder, JS; Théroux, P; Tognoni, G; White, HD; Willerson, JT	1
Haist, JV; Karmazyn, M; Kusumoto, K	1
Chin, B; Lip, GY	1
Gan, XT; Karmazyn, M; Sostaric, JV	1
Chen, W; Khan, S; Levitsky, S; McCully, JD; Parker, RA; Toyoda, Y	1
Adgey, AA; Menown, IB	1
Ellingsen, O; Falck, G; Loennechen, JP; Wisløff, U	1
Abe, A; Fukumoto, S; Igata, H; Ikeda, S; Imamiya, E; Kusumoto, K; Shiraishi, M; Tsuboi, A; Watanabe, T	1
Harnisch, L; Jessel, A; Weber, W	1

Reviews

7 review(s) available for cariporide and Cardiovascular Stroke

Article	Year
Myocardial protection at a crossroads: the need for translation into clinical therapy. Circulation research, 2004, Jul-23, Volume: 95, Issue:2 Topics: Animals; Cardiotonic Agents; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Coronary Artery Bypass; Drug Evaluation, Preclinical; Drug Utilization; Guanidines; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Prospective Studies; Sodium-Hydrogen Exchangers; Sulfones; Treatment Outcome	2004
Protection of the myocardial cell during ischemia. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Anti-Arrhythmia Agents; Cell Survival; Guanidines; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Oxygen Consumption; Sodium-Hydrogen Exchangers; Sulfones	1999
Rational basis for use of sodium-hydrogen exchange inhibitors in myocardial ischemia. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Animals; Anti-Arrhythmia Agents; Guanidines; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Oxygen Consumption; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Fibrillation	1999
Sodium-hydrogen exchange inhibition: novel strategy to prevent myocardial injury following ischemia and reperfusion. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Angioplasty, Balloon, Coronary; Animals; Anti-Arrhythmia Agents; Guanidines; Humans; Infusions, Intravenous; Myocardial Infarction; Myocardial Reperfusion Injury; Pilot Projects; Premedication; Rats; Sodium-Hydrogen Exchangers; Sulfones	1999
Myocardial cell protection : a challenging time for action and a challenging time for clinical research. Circulation, 2000, Jun-27, Volume: 101, Issue:25 Topics: Animals; Guanidines; Humans; Myocardial Infarction; Myocardium; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Dysfunction, Left	2000
Cariporide Aventis. Current opinion in investigational drugs (London, England : 2000), 2000, Volume: 1, Issue:3 Topics: Anti-Arrhythmia Agents; Clinical Trials as Topic; Contraindications; Drugs, Investigational; Enzyme Inhibitors; Guanidines; Humans; Myocardial Infarction; Sodium-Hydrogen Exchangers; Structure-Activity Relationship; Sulfones	2000
The myocardial Na+/H+ exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure. Drugs, 2001, Volume: 61, Issue:3 Topics: Adenosine Triphosphate; Anti-Arrhythmia Agents; Cardiac Output, Low; Clinical Trials as Topic; Guanidines; Humans; Hydrogen-Ion Concentration; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Phosphorylation; Sodium-Hydrogen Exchangers; Sulfones	2001

Trials

7 trial(s) available for cariporide and Cardiovascular Stroke

Article	Year
Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study. The Journal of thoracic and cardiovascular surgery, 2003, Volume: 126, Issue:2 Topics: Adolescent; Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Cause of Death; Cohort Studies; Coronary Artery Bypass; Creatine Kinase; Creatine Kinase, MB Form; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Double-Blind Method; Europe; Female; Follow-Up Studies; Guanidines; Humans; Incidence; Infusions, Intravenous; Isoenzymes; Male; Middle Aged; Myocardial Infarction; North America; Postoperative Complications; Risk Factors; Risk Reduction Behavior; Severity of Illness Index; Sodium-Hydrogen Exchangers; Sulfones; Survival Analysis; Time Factors; Treatment Outcome	2003
Effect of inhibition of the Na+/H+ exchanger with cariporide on left ventricular function in acute coronary syndromes: results from the echocardiographic substudy of the GUARDIAN trial. The Canadian journal of cardiology, 2004, Mar-01, Volume: 20, Issue:3 Topics: Anti-Arrhythmia Agents; Double-Blind Method; Echocardiography; Female; Guanidines; Humans; Male; Middle Aged; Myocardial Infarction; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Function, Left	2004
Sodium-hydrogen exchange inhibition: novel strategy to prevent myocardial injury following ischemia and reperfusion. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Angioplasty, Balloon, Coronary; Animals; Anti-Arrhythmia Agents; Guanidines; Humans; Infusions, Intravenous; Myocardial Infarction; Myocardial Reperfusion Injury; Pilot Projects; Premedication; Rats; Sodium-Hydrogen Exchangers; Sulfones	1999
GUARD During Ischemia Against Necrosis (GUARDIAN) trial in acute coronary syndromes. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Cause of Death; Coronary Artery Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Guanidines; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Prospective Studies; Sodium-Hydrogen Exchangers; Sulfones; Treatment Outcome	1999
Cardioprotective effects of the Na(+)/H(+) exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA. Circulation, 2000, Jun-27, Volume: 101, Issue:25 Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Female; Guanidines; Heart; Humans; Male; Middle Aged; Myocardial Infarction; Myocardium; Sodium-Hydrogen Exchangers; Sulfones; Treatment Outcome; Ventricular Function, Left	2000
Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators. Circulation, 2000, Dec-19, Volume: 102, Issue:25 Topics: Aged; Angina Pectoris; Coronary Artery Bypass; Female; Guanidines; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Sodium-Hydrogen Exchangers; Sulfones	2000
Lessons learned from a phase III population pharmacokinetic study of cariporide in coronary artery bypass graft surgery. Clinical pharmacology and therapeutics, 2002, Volume: 71, Issue:6 Topics: Aged; Anti-Arrhythmia Agents; Coronary Artery Bypass; Death, Sudden, Cardiac; Drug Administration Schedule; Female; Guanidines; Humans; Male; Middle Aged; Myocardial Infarction; Sulfones	2002

Other Studies

47 other study(ies) available for cariporide and Cardiovascular Stroke

Article	Year
Novel, non-acylguanidine-type Na(+)/H(+) exchanger inhibitors: synthesis and pharmacology of 5-tetrahydroquinolinylidene aminoguanidine derivatives. Journal of medicinal chemistry, 2002, Jul-04, Volume: 45, Issue:14 Topics: Animals; Blood Platelets; Cardiovascular Agents; Crystallography, X-Ray; Guanidines; Humans; Male; Molecular Structure; Myocardial Infarction; Quinolines; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Stereoisomerism; Structure-Activity Relationship	2002
(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. Journal of medicinal chemistry, 2005, Apr-21, Volume: 48, Issue:8 Topics: Animals; Cardiotonic Agents; Cation Transport Proteins; Cell Line; Furans; Guanidines; Humans; In Vitro Techniques; Membrane Proteins; Myocardial Infarction; Protein Isoforms; Rats; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Structure-Activity Relationship	2005
4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na+/H+ exchanger isoform-1 (NHE-1) inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-15, Volume: 15, Issue:12 Topics: Animals; Blood Pressure; Cardiotonic Agents; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Protein Isoforms; Rats; Sodium-Hydrogen Exchangers; Structure-Activity Relationship	2005
Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives. European journal of medicinal chemistry, 2009, Volume: 44, Issue:9 Topics: Animals; Blood Platelets; Cardiotonic Agents; Female; Guanidines; Indans; Male; Myocardial Infarction; Myocardium; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers	2009
Na+ currents in cardioprotection: better to be late. Journal of medicinal chemistry, 2009, Jul-23, Volume: 52, Issue:14 Topics: Animals; Benzothiepins; Benzoxazoles; Cardiotonic Agents; Cell Line; Electric Conductivity; Female; Guinea Pigs; Humans; Male; Myocardial Infarction; Rats; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship; Swine; Time Factors	2009
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. Journal of medicinal chemistry, 2012, Aug-23, Volume: 55, Issue:16 Topics: Animals; Benzamides; Biological Availability; Blood Platelets; Cell Line; Cell Membrane Permeability; Cell Size; Cytochrome P-450 Enzyme Inhibitors; Dogs; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guanidines; Humans; Male; Membranes, Artificial; Microsomes, Liver; Models, Molecular; Myocardial Infarction; Myocardial Reperfusion Injury; Permeability; Protein Isoforms; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Structure-Activity Relationship	2012
Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts. Cardiovascular research, 2019, Aug-01, Volume: 115, Issue:10 Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Glucosides; Guanidines; Insulin; Isolated Heart Preparation; Male; Mice, Inbred C57BL; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors; Sodium-Hydrogen Exchanger 1; Sulfones; Time Factors	2019
Triple therapy greatly increases myocardial salvage during ischemia/reperfusion in the in situ rat heart. Cardiovascular drugs and therapy, 2013, Volume: 27, Issue:5 Topics: Adenosine; Adenosine Monophosphate; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Guanidines; Hypothermia, Induced; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sulfones; Ticagrelor	2013
Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide in isolated perfused rabbit hearts. Biological chemistry, 2008, Volume: 389, Issue:12 Topics: Animals; Anti-Arrhythmia Agents; Benzamides; Blood Pressure; Calpain; Coronary Circulation; Female; Guanidines; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Infarction; Myocardium; Potassium; Rabbits; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Function, Left	2008
Mitochondrial KATP channels participate in the limitation of infarct size by cariporide. Naunyn-Schmiedeberg's archives of pharmacology, 2011, Volume: 383, Issue:6 Topics: Animals; Calcium; Cardiotonic Agents; Decanoic Acids; Diazoxide; Disease Models, Animal; Guanidines; Hydroxy Acids; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones	2011
Is microvascular protection by cariporide and ischemic preconditioning causally linked to myocardial salvage? American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:4 Topics: Animals; Constriction; Coronary Vessels; Guanidines; Ischemic Preconditioning; Male; Microcirculation; Myocardial Infarction; Myocardial Reperfusion Injury; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	2003
Blood cardioplegia supplementation with the sodium-hydrogen ion exchange inhibitor cariporide to attenuate infarct size and coronary artery endothelial dysfunction after severe regional ischemia in a canine model. The Journal of thoracic and cardiovascular surgery, 2003, Volume: 125, Issue:1 Topics: Animals; Blood; Dogs; Endothelium, Vascular; Female; Guanidines; Heart Arrest, Induced; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Neutrophil Activation; Sodium-Hydrogen Exchangers; Sulfones	2003
Blockade of the Na+-Ca2+ exchanger is more efficient than blockade of the Na+-H+ exchanger for protection of the myocardium from lethal reperfusion injury. Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:4 Topics: Animals; Guanidines; Hemodynamics; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Rabbits; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sulfones; Thiourea	2002
Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:3 Topics: Acids; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Cell Death; Cells, Cultured; Energy Metabolism; Guanidines; Mice; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protons; Sodium-Hydrogen Exchangers; Sulfones	2003
Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability. The Journal of thoracic and cardiovascular surgery, 2003, Volume: 126, Issue:5 Topics: Animals; Biopsy, Needle; Disease Models, Animal; Female; Guanidines; Heart Function Tests; Hemodynamics; Infusions, Intravenous; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Random Allocation; Recovery of Function; Reference Values; Sensitivity and Specificity; Sodium-Hydrogen Exchangers; Sulfones; Swine; Ventricular Function, Left	2003
Effects of cariporide (HOE642) on myocardial infarct size and ventricular arrhythmias in a rat ischemia/reperfusion model: comparison with other drugs. Pharmacology, 2004, Volume: 70, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Dose-Response Relationship, Drug; Electrocardiography; Guanidines; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Nifedipine; Propranolol; Rats; Rats, Sprague-Dawley; Sulfones; Tachycardia, Ventricular	2004
Limited effects of post-ischemic NHE blockade on [Na+]i and pHi in rat hearts explain its lack of cardioprotection. Cardiovascular research, 2004, Feb-15, Volume: 61, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Guanidines; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Rats; Rats, Wistar; Sodium; Sodium-Hydrogen Exchangers; Sulfones	2004
Selective retroinfusion of GSH and cariporide attenuates myocardial ischemia-reperfusion injury in a preclinical pig model. Cardiovascular research, 2004, Feb-15, Volume: 61, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Free Radical Scavengers; Glutathione; Guanidines; Models, Animal; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Rats; Rats, Wistar; Sulfones; Swine	2004
Inhibition of Na+-H+ exchange by cariporide reduces inflammation and heart failure in rabbits with myocardial infarction. British journal of pharmacology, 2004, Volume: 142, Issue:7 Topics: Aldosterone; Animals; C-Reactive Protein; Electrocardiography; Guanidines; Heart Failure; Inflammation; Male; Myocardial Infarction; Myocardium; Rabbits; Sodium-Hydrogen Exchangers; Sulfones; Survival Rate; Time Factors; Ventricular Function, Left	2004
Effects of acute and chronic treatment with the sodium hydrogen exchanger 1 (NHE-1) inhibitor cariporide on myocardial infarct mass in rabbits with hypercholesterolaemia. Basic & clinical pharmacology & toxicology, 2004, Volume: 95, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; Cholesterol; Diet, Atherogenic; Drug Administration Schedule; Guanidines; Hypercholesterolemia; Male; Myocardial Infarction; Myocardium; Papillary Muscles; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	2004
The preischemic combination of the sodium-hydrogen exchanger inhibitor cariporide and the adenosine agonist AMP579 acts additively to reduce porcine myocardial infarct size. Journal of the American College of Surgeons, 2004, Volume: 199, Issue:4 Topics: Animals; Cardiotonic Agents; Drug Synergism; Female; Guanidines; Imidazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Neutrophil Activation; Neutrophils; Purinergic P1 Receptor Agonists; Pyridines; Sodium-Hydrogen Exchangers; Sulfones; Swine	2004
Reduction of myocardial infarct size by SM-198110, a novel Na+/H+ exchange inhibitor, in rabbits. Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 371, Issue:5 Topics: Alkanesulfonic Acids; Animals; Blood Pressure; Creatine Kinase; Guanidines; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Necrosis; Phosphoproteins; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	2005
Effects of combined inhibition of the Na+-H+ exchanger and angiotensin-converting enzyme in rats with congestive heart failure after myocardial infarction. British journal of pharmacology, 2005, Volume: 146, Issue:5 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Guanidines; Heart; Heart Failure; Lung; Male; Myocardial Infarction; Organ Size; Peptidyl-Dipeptidase A; Ramipril; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones	2005
Multiple treatment approach to limit cardiac ischemia-reperfusion injury. The Annals of thoracic surgery, 2005, Volume: 80, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Combined Modality Therapy; Diazoxide; Disease Models, Animal; Drug Therapy, Combination; Female; Guanidines; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Recovery of Function; Reference Values; Sulfones; Swine; Treatment Outcome; Vasodilator Agents; Ventricular Dysfunction, Left	2005
Invited commentary. The Annals of thoracic surgery, 2005, Volume: 80, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Combined Modality Therapy; Diazoxide; Disease Models, Animal; Drug Therapy, Combination; Guanidines; Myocardial Infarction; Myocardial Reperfusion Injury; Sulfones; Swine; Treatment Outcome; Vasodilator Agents	2005
Cardioprotection of cariporide evaluated by plasma myoglobin and troponin I in myocardial infarction in pigs. Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:2 Topics: Animals; Biomarkers; Cardiotonic Agents; Guanidines; Male; Myocardial Infarction; Myocardial Reperfusion; Myoglobin; Sulfones; Swine; Troponin I	2006
Sodium-hydrogen exchange inhibition and beta-blockade additively decrease infarct size. The Annals of thoracic surgery, 2007, Volume: 83, Issue:3 Topics: Adrenergic beta-Antagonists; Animals; Calcium; Drug Combinations; Guanidines; Heart; Heart Ventricles; In Vitro Techniques; Male; Metoprolol; Mitochondria, Heart; Mitochondrial Proteins; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Sodium-Hydrogen Exchangers; Sulfones	2007
Invited commentary. The Annals of thoracic surgery, 2007, Volume: 83, Issue:3 Topics: Adrenergic beta-Antagonists; Animals; Drug Combinations; Guanidines; Metoprolol; Myocardial Infarction; Sodium-Hydrogen Exchangers; Sulfones	2007
Effects of SM-20550 against myocardial infarction-induced arrhythmias, late infarct expansion, and left ventricular dysfunction. Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:5 Topics: Amidines; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Cardiotonic Agents; Dobutamine; Guanidines; Heart; Heart Rate; Indoles; Male; Myocardial Infarction; Rats; Rats, Sprague-Dawley; Sulfones; Tachycardia, Ventricular; Ventricular Dysfunction, Left; Ventricular Remodeling	2007
Infarct size limitation by a new Na(+)-H+ exchange inhibitor, Hoe 642: difference from preconditioning in the role of protein kinase C. Journal of the American College of Cardiology, 1997, Mar-01, Volume: 29, Issue:3 Topics: Animals; Guanidines; Heart; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion; Polymyxin B; Protein Kinase C; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	1997
Time delay of cell death by Na+/H+-exchange inhibition in regionally ischemic, reperfused porcine hearts. Journal of cardiovascular pharmacology, 1997, Volume: 30, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Cell Death; Enzyme Inhibitors; Female; Guanidines; Hemodynamics; Histocytochemistry; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Sodium-Hydrogen Exchangers; Sulfones; Swine; Time Factors	1997
Prevention of ischemic rigor contracture during coronary occlusion by inhibition of Na(+)-H+ exchange. Cardiovascular research, 1997, Volume: 35, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Guanidines; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Sodium-Hydrogen Exchangers; Sulfones; Swine	1997
Time-dependent protection by Na+/H+ exchange inhibition in a regionally ischemic, reperfused porcine heart preparation with low residual blood flow. Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Drug Administration Schedule; Female; Guanidines; Heart; Heart Rate; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Swine; Time Factors	1998
Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642). Clinical and experimental hypertension (New York, N.Y. : 1993), 1998, Volume: 20, Issue:7 Topics: Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Guanidines; Male; Myocardial Infarction; Myocardial Reperfusion; Rabbits; Sodium-Hydrogen Exchangers; Sulfones	1998
Effects and interaction, of cariporide and preconditioning on cardiac arrhythmias and infarction in rat in vivo. British journal of pharmacology, 1999, Volume: 127, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Guanidines; Hydrogen-Ion Concentration; Ischemic Preconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Time Factors	1999
A symposium: sodium-hydrogen exchange inhibition. Introduction. The American journal of cardiology, 1999, May-20, Volume: 83, Issue:10A Topics: Anti-Arrhythmia Agents; Guanidines; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	1999
Na(+)/H(+) exchange inhibition attenuates hypertrophy and heart failure in 1-wk postinfarction rat myocardium. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:1 Topics: Adrenergic beta-Agonists; Animals; Cardiac Output, Low; Cardiomegaly; Guanidines; Hemodynamics; Isoproterenol; Male; Myocardial Infarction; Myocardium; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Time Factors; Ventricular Function, Left	2000
Cardioprotective effects of the Na(+)/H(+)-exchange inhibitor cariporide in infarct-induced heart failure. Cardiovascular research, 2000, Volume: 46, Issue:1 Topics: Analysis of Variance; Animals; Guanidines; Heart Failure; Male; Myocardial Contraction; Myocardial Infarction; Random Allocation; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Pressure; Ventricular Remodeling	2000
Sodium-hydrogen exchange in myocardial reperfusion injury. Lancet (London, England), 2000, Aug-12, Volume: 356, Issue:9229 Topics: Animals; Guanidines; Heart Arrest, Induced; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones	2000
Cardioprotective effect of TY-12533, a novel Na(+)/H(+) exchange inhibitor, on ischemia/reperfusion injury. European journal of pharmacology, 2000, Sep-15, Volume: 404, Issue:1-2 Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Disease Models, Animal; Guanidines; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyridines; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones	2000
Na(+)/H(+) exchange inhibitor cariporide attenuates cell injury predominantly during ischemia and not at onset of reperfusion in porcine hearts with low residual blood flow. Circulation, 2000, Oct-17, Volume: 102, Issue:16 Topics: Animals; Blood Flow Velocity; Coronary Circulation; Cytoprotection; Guanidines; Heart; Infusions, Intra-Arterial; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Swine	2000
Effect of combined K(ATP) channel activation and Na(+)/H(+) exchange inhibition on infarct size in rabbits. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Diazoxide; Guanidines; Heart Rate; Hydroxy Acids; Male; Myocardial Infarction; Necrosis; Potassium Channels; Rabbits; Sodium-Hydrogen Exchangers; Sulfones; Vasodilator Agents	2000
Na(+)/H(+) exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Volume; Cardiomegaly; Cell Survival; Guanidines; Heart Failure; Hydrogen-Ion Concentration; Incidence; Male; Muscle Fibers, Skeletal; Myocardial Infarction; Myocardium; Organ Size; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Sodium-Hydrogen Exchangers; Sulfones; Survival Analysis; Ventricular Fibrillation; Ventricular Pressure; Ventricular Remodeling	2001
Effects of NHE-1 inhibition on cardioprotection and impact on protection by K/Mg cardioplegia. The Annals of thoracic surgery, 2001, Volume: 72, Issue:3 Topics: Animals; Cardioplegic Solutions; Coronary Circulation; Guanidines; Heart Arrest, Induced; Hemodynamics; In Vitro Techniques; Magnesium; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Potassium; Rabbits; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Function, Left; Ventricular Pressure	2001
Cardioprotective therapy and sodium-hydrogen exchange inhibition: current concepts and future goals. Journal of the American College of Cardiology, 2001, Nov-15, Volume: 38, Issue:6 Topics: Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Apoptosis; Guanidines; Humans; Ischemic Preconditioning; Myocardial Infarction; Myocardial Reperfusion; Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Thrombolytic Therapy	2001
Effects of cariporide and losartan on hypertrophy, calcium transients, contractility, and gene expression in congestive heart failure. Circulation, 2002, Mar-19, Volume: 105, Issue:11 Topics: Angiotensins; Animals; Anti-Arrhythmia Agents; Calcium Signaling; Cardiomegaly; Cell Separation; Cell Size; Disease Models, Animal; Echocardiography; Electric Stimulation; Female; Gene Expression; Guanidines; Heart Failure; In Vitro Techniques; Losartan; Myocardial Contraction; Myocardial Infarction; Myocardium; Rats; Rats, Sprague-Dawley; Sulfones; Ventricular Remodeling	2002
In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559. British journal of pharmacology, 2002, Volume: 135, Issue:8 Topics: Animals; Blood Platelets; Cardiotonic Agents; Dose-Response Relationship, Drug; Guanidines; Humans; In Vitro Techniques; Injections, Intravenous; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Quinolines; Rabbits; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones	2002