cardiovascular-agents and Pulmonary-Eosinophilia

Lung injury is an increasing cause of morbidity and mortality in patients treated with cytotoxic and noncytotoxic drugs. Prompt diagnosis is important because early drug-induced lung injury will often regress with the cessation of therapy. Diagnosis requires a high index of suspicion because infection, radiation pneumonitis, and recurrence of the underlying disease can manifest clinically and radiologically in a similar manner. Because the lungs have only a limited number of histopathologic responses to injury, including pulmonary edema/diffuse alveolar damage, NSIP, BOOP, EP, and pulmonary hemorrhage, knowledge of these manifestations and the corresponding radiologic manifestations can often be useful in suggesting a diagnosis of drug-induced lung injury. An understanding of the drugs most commonly associated with lung injury can also facilitate diagnosis.

Topics: Anti-Infective Agents; Antineoplastic Agents; Cardiovascular Agents; Cryptogenic Organizing Pneumonia; Diagnosis, Differential; Hemorrhage; Humans; Lung; Lung Diseases; Lung Diseases, Interstitial; Pulmonary Edema; Pulmonary Eosinophilia; Radiography

Drug-induced pulmonary toxicity is increasing and early diagnosis is important because of the associated morbidity and mortality. Diagnosis is often difficult and is usually based on a history of drug therapy and exclusion of infection, radiation pneumonitis, and recurrence of the underlying disease. Although HRCT findings are frequently nonspecific, diagnosis can be facilitated by an understanding of the most common histopathologic and radiologic manifestations of drug-induced lung injury and knowledge of the drugs usually involved.

Topics: Adult; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Cardiovascular Agents; Cryptogenic Organizing Pneumonia; Female; Hemorrhage; Humans; Lung; Lung Diseases; Lung Diseases, Interstitial; Male; Middle Aged; Pulmonary Eosinophilia; Radiography, Thoracic; Tomography, X-Ray Computed