cardiovascular-agents and Pleural-Effusion

Drug-induced pleural disease is uncommon and less known to clinicians than drug-induced parenchymal lung disease. Pleural reactions from drugs manifest as pleural effusions, pleural thickening, or pleuritic chest pain, and may occur in the absence of parenchymal infiltrates. The clinician should be cognizant of the possibility of a drug-induced pleural reaction. A detailed drug history, temporal relationship between symptom onset and initiation of therapy, and pleural fluid eosinophilia should raise the suspicion of a drug-related process. We suspect that as new drugs are marketed in the United States, the number of drugs that result in pleuropulmonary toxicity will continue to increase. Moreover, if the cause of an exudative pleural effusion is not clinically obvious after pleural fluid analysis, drug therapy withdrawal should be a consideration if clinically appropriate before initiating an extensive diagnostic evaluation that may entail unnecessary economic burden and discomfort for the patient.

Topics: Anti-Infective Agents, Urinary; Antimetabolites, Antineoplastic; Bleomycin; Cardiovascular Agents; Clozapine; Cyclophosphamide; Eosinophilia; Humans; Immunosuppressive Agents; Interleukin-2; Methotrexate; Methysergide; Nitrofurantoin; Penicillamine; Pleural Diseases; Pleural Effusion; Serotonin Antagonists

Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Bronchial Spasm; Cardiovascular Agents; Humans; Illicit Drugs; Lung Diseases; Pleural Effusion

Topics: Aged, 80 and over; Cardiovascular Agents; Heart Failure; Humans; Lung Diseases; Male; Pleural Effusion; Radiography; Time Factors; Treatment Outcome

Topics: Aged, 80 and over; Cardiovascular Agents; Catheterization, Central Venous; Heart Failure; Humans; Jugular Veins; Male; Mediastinal Cyst; Pleural Effusion; Punctures; Thyroid Diseases; Thyroid Gland; Tomography, X-Ray Computed; Ultrasonography, Interventional; Wounds and Injuries

Topics: Aged; Cardiomyopathy, Dilated; Cardiovascular Agents; Chronic Disease; Coronary Disease; Disease Progression; Drug Therapy, Combination; Dyspnea; Fatal Outcome; Heart Failure; Humans; Leukemia, Lymphoid; Male; Myocardial Stunning; Pleural Effusion

Topics: Aged; Atrial Fibrillation; Carcinoma, Squamous Cell; Cardiovascular Agents; Chylothorax; Combined Modality Therapy; Drainage; Hemodynamics; Humans; Hypotension; Laryngeal Neoplasms; Laryngectomy; Male; Neck Dissection; Parenteral Nutrition; Pleural Effusion; Postoperative Complications

Topics: Body Fluids; Body Water; Cardiovascular Agents; Dyspnea; Heart; Heart Failure; Humans; Lung; Lung Diseases; Mitral Valve Stenosis; Pleural Effusion; Positive-Pressure Respiration; Pulmonary Edema