cardiovascular-agents and Gangrene

Topics: Aged, 80 and over; Angioplasty, Balloon; Cardiovascular Agents; Coated Materials, Biocompatible; Femoral Artery; Gangrene; Humans; Paclitaxel; Peripheral Arterial Disease; Pharmaceutical Preparations; Popliteal Artery; Retrospective Studies; Treatment Outcome

To assess the current 'real-world' management of hospitalised patients with lower-extremity peripheral artery disease (LE-PAD) and to assess the 1-year outcome.. The prospective and multicentre registry COhorte des Patients ARTériopathes (COPART) recruited consecutive patients from the departments of vascular medicine of three academic hospitals in Southwestern France.. Among the 940 patients, 27.4% had intermittent claudication (IC), 9.3% ischaemic rest pain, 54.3% ulceration or gangrene and 9.3% acute limb ischaemia (ALI). Patients with IC were younger and more likely to be men, with a history of smoking (89.5%) and chronic obstructive pulmonary disease (17%). Among those with IC, 8.9% had bypass surgery and 41.5% were treated with percutaneous angioplasty. Those with tissue loss had higher rates of cardiovascular disease (CVD) risk factors and co-morbidities. At entry to the study, the level of control of the CVD risk factors was poor. The 1-year mortality rate was of 5.7% in patients with IC, 23.1% in patients with ischaemic rest pain, 28.7% in patients with tissue loss and 23% in those with ALI. Compliance with evidence-based medicine and pharmacological treatment was sub-optimal.. This registry underscores the differences in patient profiles in the daily clinical setting, compared to those enrolled in several trials.

Topics: Aged; Aged, 80 and over; Amputation, Surgical; Angioplasty, Balloon; Cardiovascular Agents; Cardiovascular Diseases; Chi-Square Distribution; Evidence-Based Medicine; Female; France; Gangrene; Guideline Adherence; Hospital Mortality; Hospitalization; Hospitals, University; Humans; Intermittent Claudication; Ischemia; Kaplan-Meier Estimate; Leg Ulcer; Length of Stay; Lower Extremity; Male; Middle Aged; Outcome and Process Assessment, Health Care; Peripheral Vascular Diseases; Practice Guidelines as Topic; Proportional Hazards Models; Prospective Studies; Registries; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Vascular Surgical Procedures

A 4 year-old boy was admitted to our clinic with symptoms of pain and ecchymosis in his right leg and foot after injection of benzathine penicilline. There was a localized gangrenous area at the femoral injection site. Doppler ultrasonography showed no arterial flow in the femoral artery and clear evidence of acute thrombosis of the superficial femoral and popliteal veins. Femoral arterial and venous thrombectomy and fasciotomy were performed immediately. After surgery the boy was treated by Iloprost infusion and enoxaparine. One week later necrotic changes had regressed, fasciotomies were closed and only the distal phalanx of the third toe needed amputation. Early surgical intervention and standard management combined with Iloprost infusion may help in healing the lesions by increasing extremity perfusion and may prevent extremity loss.

Topics: Amputation, Surgical; Anti-Bacterial Agents; Anticoagulants; Cardiovascular Agents; Child, Preschool; Combined Modality Therapy; Drug Eruptions; Enoxaparin; Fasciotomy; Gangrene; Humans; Iloprost; Infusions, Intravenous; Injections; Leg; Male; Penicillin G Benzathine; Thrombectomy; Toes; Treatment Outcome; Venous Thrombosis

Topics: Atmospheric Pressure; Cardiovascular Agents; Ergot Alkaloids; Foot Diseases; Gangrene; Humans; Hyperbaric Oxygenation; Oxygen; Toxicology; Vascular Diseases

Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Cardiovascular Agents; Dermatologic Agents; Diabetes Complications; Gangrene; Humans

Topics: Cardiovascular Agents; Disasters; Ergot Alkaloids; Ergotamine; Ergotism; Fires; Gangrene; Humans; Oxytocics

Topics: Alkaloids; Animals; Cardiovascular Agents; Claviceps; Ergonovine; Ergot Alkaloids; Gangrene; Incidence; Rats; Thyroxine

Topics: Animals; Cardiovascular Agents; Ergot Alkaloids; Ergotamine; Gangrene; Oxytocics; Rats; Sympathomimetics

Topics: Cardiovascular Agents; Ergoloid Mesylates; Ergot Alkaloids; Flavonoids; Frostbite; Gangrene; Nicotine; Rutin; Vitamins

Topics: Animals; Cardiovascular Agents; Dihydroergotoxine; Ergot Alkaloids; Ergotamine; Gangrene; Oxytocics; Rats