cardiodilation-atrial-natriuretic-peptide and Acute-Kidney-Injury

Ularitide is a member of the natriuretic peptide family which is presumably synthesized in the kidney. In physiological experiments a correlation between Ularitide excretion and natriuresis has been found. Ularitide infusions and bolus injections in animals initiated profound diuresis and natriuresis as the most prominent effects. On the basis of findings in in-vitro and in-vivo experiments, Ularitide was used in clinical trials, and the results indicate that it could be a promising new drug to prevent and treat acute renal failure in patients after cardiac surgery and organ transplantation.

Topics: Acute Kidney Injury; Amino Acid Sequence; Animals; Atrial Natriuretic Factor; Cardiac Surgical Procedures; Clinical Trials as Topic; Diuretics; Humans; Kidney; Molecular Sequence Data; Muscle Proteins; Peptide Fragments; Postoperative Complications; Receptors, Atrial Natriuretic Factor; Second Messenger Systems; Transplantation; Vasodilator Agents