carboxypeptidase-b has been researched along with Leg-Ulcer* in 1 studies
1 other study(ies) available for carboxypeptidase-b and Leg-Ulcer
| Article | Year |
|---|---|
Biochemical and biological profile of a new enzyme preparation from Antarctic krill (E. superba) suitable for debridement of ulcerative lesions.
A protease extract from Antarctic krill (E. superba) intended as a new enzymatic debrider for necrotic ulcers has been characterized by sodium dodecyl sulphate polyacrylamide gradient gel electrophoresis and fast protein liquid chromatography. The predominant enzymes in the preparation represent trypsin-like activity associated with three serine proteinases. In addition two carboxypeptidases A and B are present as cooperative enzymes for a more complete breakdown of complex proteinaceous substrates. Biological studies on a well-defined substrate (fibrin) originating from leg ulcers, demonstrated more effective degradation by krill enzymes than bovine trypsin, a common component in marketed enzymatic debriders. These findings support previously in vitro/in vivo studies in an animal model (rat) using excised rat skin as "necrotic" tissue. Topics: Animals; Carboxypeptidase B; Carboxypeptidases; Carboxypeptidases A; Chromatography, High Pressure Liquid; Crustacea; Electrophoresis, Polyacrylamide Gel; Enzyme Therapy; Enzymes; Fibrin; Humans; Leg Ulcer; Trypsin | 1989 |