carbostyril has been researched along with Leukemia in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (26.92) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 11 (42.31) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kuo, SC; Lee, MR; Lin, C; Lin, MW; Lu, CC; Tsai, FJ; Yang, JS | 1 |
| Ho, CT; Huang, LJ; Kuo, DH; Kuo, SC; Lee, JC; Lin, YC; Liu, YJ; Way, TD | 1 |
| Eucker, J; Habbel, P; Li, X; Liu, H; Neumann, C; Scholz, C; Zang, C; Zhou, Y | 1 |
| Ahmed, TA; Hayslip, J; Leggas, M | 1 |
| Bhole, A; Cowell, JK; Karp, J; Malek, S; Qin, H; Ren, M; Wu, Q | 1 |
| Jantová, S; Milata, V; Pánik, M; Paulovičová, E; Paulovičová, L; Topoľská, D | 1 |
| Fujiwara, S; Nagai, T; Ohmine, K; Ozawa, K; Sakurai, C; Uesawa, M | 1 |
| Chung, JG; Gibson Wood, W; Huang, WW; Kuo, SC; Lai, TY; Ma, CY; Wu, PP; Yang, JS | 1 |
| Adamson, PC; Arceci, RJ; Balis, FM; Blaney, SM; Fox, E; Goodspeed, W; Goodwin, A; Jayaprakash, N; Widemann, BC; Wright, JJ; Zannikos, P | 1 |
| Chen, MH; Chinag, JH; Chou, LC; Hsu, MH; Huang, LJ; Huang, SM; Kuo, SC; Lee, KH; Lin, HY; Tsai, SC; Yang, JS | 1 |
| Cheng, YY; Chien, HC; Chung, JG; Huang, LJ; Kuo, SC; Lee, KH; Liaw, CC; Lu, CC; Tsai, SC; Tsuzuki, M; Yang, JS | 1 |
| Abboud, CN; Lancet, JE; Liesveld, JL; Lu, C; McNair, C; Menon, A; Rosell, KE; Rosenblatt, JD | 1 |
| Hasmann, M; Nüssler, V; Pelka-Fleischer, R; Pogrebniak, A; Schemainda, I | 1 |
| Flournoy, N; Paul, RK; Rosenberger, WF | 1 |
| Zhang, GS | 1 |
| Kano, Y; Komatsu, N; Miyoshi, T; Muroi, K; Nagai, T; Nakamura, M; Ohmine, K; Ozawa, K | 1 |
| Chen, W; Chow, A; Hayes, S; Perez-Ruixo, JJ; Zhang, S | 1 |
| Drexler, HG; Fleckenstein, E; Uphoff, CC | 1 |
| Bow, EJ; Loewen, R; Vaughan, D | 1 |
| Hamel, E; Kuo, SC; Lednicer, D; Lee, KH; Li, L; Lin, CM; Wang, HK; Wu, TS | 1 |
| Verhoef, J | 1 |
| Altschuler, E; Hacker, MP; Mayes, J; Satitpunwaycha, P; Tritton, TR; Zwelling, LA | 1 |
| Ager, S; Baglin, TP; Barker, P; Bass, G; Jacobson, SK; Johnson, D; Mahendra, P; Marcus, RE | 1 |
| Adjei, AA; End, DW; Karp, JE; Kaufmann, SH; Lancet, JE; Wright, JJ | 1 |
| Drexler, HG; Meyer, C; Uphoff, CC | 1 |
| Drexler, HG; Gignac, SM; Uphoff, CC | 1 |
1 review(s) available for carbostyril and Leukemia
| Article | Year |
|---|---|
Current status of clinical trials of farnesyltransferase inhibitors.
Topics: Alkyl and Aryl Transferases; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Leukemia; Neoplasms; Piperidines; Pyridines; Quinolones; Signal Transduction | 2001 |
3 trial(s) available for carbostyril and Leukemia
| Article | Year |
|---|---|
Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: a report from the Children's Oncology Group.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Farnesyltranstransferase; Female; Half-Life; Humans; Infant; Leukemia; Male; Maximum Tolerated Dose; Neoplasm Recurrence, Local; Quinolones | 2011 |
Exposure-toxicity relationships for tipifarnib in cancer patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Leukemia; Male; Middle Aged; Quinolones; Treatment Outcome | 2007 |
Reduced requirement for antibiotic therapy targeting gram-negative organisms in febrile, neutropenic patients with cancer who are receiving antibacterial chemoprophylaxis with oral quinolones.
Topics: Administration, Oral; Adult; Aged; Anti-Bacterial Agents; Drug Synergism; Female; Fever; Gram-Negative Bacterial Infections; Humans; Leukemia; Male; Middle Aged; Neutropenia; Pilot Projects; Quinolones | 1995 |
22 other study(ies) available for carbostyril and Leukemia
| Article | Year |
|---|---|
2-Phenyl-4-quinolone (YT-1) induces G2/M phase arrest and an intrinsic apoptotic mechanism in human leukemia cells.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Division; Cell Proliferation; G2 Phase; Humans; Leukemia; Membrane Potential, Mitochondrial; Quinolones; Tumor Cells, Cultured | 2018 |
CCT327 enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistant human leukemia cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Proliferation; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Leukemia; Organoselenium Compounds; Quinolines; Quinolones; Reactive Oxygen Species; Receptors, Death Domain; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2014 |
The multi-tyrosine kinase inhibitor TKI258, alone or in combination with RAD001, is effective for treatment of human leukemia with BCR-ABL translocation in vitro.
Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Everolimus; Fusion Proteins, bcr-abl; Humans; Leukemia; Protein Kinase Inhibitors; Quinolones; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia; Quinolones; ras Proteins; Simvastatin | 2014 |
SCLLTargeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models.
Topics: Animals; Benzamides; Benzimidazoles; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Gene Expression Profiling; Humans; Leukemia; Mice; Molecular Targeted Therapy; Neoplasm Transplantation; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Quinolones; Receptor, Fibroblast Growth Factor, Type 1; Xenograft Model Antitumor Assays | 2016 |
Assessment of Immunomodulatory Activities and in vitro Toxicity of New Quinolone 7-ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo[3,4-h]quinoline-7-carboxylate.
Topics: A549 Cells; Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Growth Processes; Fibroblasts; HL-60 Cells; Humans; Immunomodulation; Leukemia; Macrophages; Mice; Organoselenium Compounds; Quinolones; RAW 264.7 Cells | 2017 |
Combination of tipifarnib and rapamycin synergistically inhibits the growth of leukemia cells and overcomes resistance to tipifarnib via alteration of cellular signaling pathways.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Leukemia; Quinolones; Signal Transduction; Sirolimus; Tumor Cells, Cultured | 2010 |
The quinolone derivative CHM-1 inhibits murine WEHI-3 leukemia in BALB/c mice in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dioxoles; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; Leukemia; Male; Mice; Mice, Inbred BALB C; Models, Biological; Neoplasm Transplantation; Quinolones; Survival Analysis | 2010 |
The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; Caspases; CDC2 Protein Kinase; Cell Division; G2 Phase; HL-60 Cells; Humans; Leukemia; Mitochondria; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrrolidines; Quinolones; Reactive Oxygen Species | 2011 |
The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Benzodioxoles; Caspases; Cell Survival; fas Receptor; Free Radical Scavengers; HL-60 Cells; Humans; Leukemia; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Quinolones; Reactive Oxygen Species; Signal Transduction; Up-Regulation | 2012 |
Effects of the farnesyl transferase inhibitor R115777 on normal and leukemic hematopoiesis.
Topics: Alkyl and Aryl Transferases; Animals; Antigens, CD34; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Adhesion; Cell Cycle; Cell Movement; Colony-Forming Units Assay; Enzyme Inhibitors; Farnesyltranstransferase; Hematopoiesis; Humans; Leukemia; Mice; Mice, Inbred NOD; Mice, SCID; Poly(ADP-ribose) Polymerases; Quinolones; Time Factors; Tumor Cells, Cultured | 2003 |
Poly ADP-ribose polymerase (PARP) inhibitors transiently protect leukemia cells from alkylating agent induced cell death by three different effects.
Topics: 1-Naphthylamine; Adenosine Triphosphate; Alkylating Agents; Apoptosis; Benzamides; Cell Death; Cell Line, Tumor; Cell Size; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Melphalan; Methylnitronitrosoguanidine; NAD; Naphthalimides; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinolones | 2003 |
Quantile estimation following non-parametric phase I clinical trials with ordinal response.
Topics: Antineoplastic Agents; Clinical Trials, Phase I as Topic; Computer Simulation; Data Interpretation, Statistical; Humans; Leukemia; Maximum Tolerated Dose; Quinolones; Regression Analysis; Statistics, Nonparametric | 2004 |
[New targets for molecular therapy of acute leukemia: a "single-hit" or "multiple-hit" strategy against signaling pathway].
Topics: Acute Disease; Antineoplastic Agents; Carbazoles; Furans; Humans; Indoles; Leukemia; Leukemia, Myeloid, Acute; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Quinolones; ras Proteins; Staurosporine | 2005 |
Relative importance of apoptosis and cell cycle blockage in the synergistic effect of combined R115777 and imatinib treatment in BCR/ABL-positive cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Blast Crisis; Cell Cycle; Cell Line, Tumor; Drug Resistance; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Fusion Proteins, bcr-abl; Growth Inhibitors; Humans; Imatinib Mesylate; Leukemia; Piperazines; Pyrimidines; Quinolones | 2005 |
Effective treatment of mycoplasma contamination in cell lines with enrofloxacin (Baytril).
Topics: Anti-Bacterial Agents; Anti-Infective Agents; B-Lymphocytes; Cell Line; Culture Media; Culture Techniques; Decontamination; DNA, Bacterial; Enrofloxacin; Fluoroquinolones; Humans; Leukemia; Lymphoma; Mycoplasma; Polymerase Chain Reaction; Quinolones; RNA, Bacterial; T-Lymphocytes; Tumor Cells, Cultured | 1994 |
Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Small Cell; Cattle; Cell Division; Central Nervous System Neoplasms; Colonic Neoplasms; Female; Humans; Leukemia; Lung Neoplasms; Molecular Structure; Polymers; Quinolones; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 1994 |
Prevention of infections in the neutropenic patient.
Topics: Acute Disease; Bacterial Infections; Communicable Diseases; Humans; Infection Control; Leukemia; Neutropenia; Quinolones; Trimethoprim, Sulfamethoxazole Drug Combination | 1993 |
Activity of two novel anthracene-9,10-diones against human leukemia cells containing intercalator-sensitive or -resistant forms of topoisomerase II.
Topics: Anthraquinones; DNA; DNA Topoisomerases, Type II; Drug Resistance; Humans; Intercalating Agents; Isoquinolines; Leukemia; Quinolones; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1993 |
Short-course intravenous antibiotics with oral quinolone prophylaxis in the treatment of neutropenic fever in autologous bone marrow or peripheral blood progenitor cell transplant recipients.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacteremia; Bone Marrow Transplantation; Female; Fever; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Leukemia; Lymphoma, Non-Hodgkin; Male; Middle Aged; Multiple Myeloma; Neutropenia; Pseudomonas aeruginosa; Quinolones; Staphylococcus; Streptococcus; Transplantation, Autologous | 1996 |
Elimination of mycoplasma from leukemia-lymphoma cell lines using antibiotics.
Topics: Algorithms; Anti-Bacterial Agents; Anti-Infective Agents; Cell Culture Techniques; Ciprofloxacin; Culture Media; Diterpenes; Drug Resistance; Drug Resistance, Multiple, Bacterial; Enrofloxacin; Fluoroquinolones; Humans; Leukemia; Lymphoma; Minocycline; Mycoplasma; Quinolones; Suspensions; Tumor Cells, Cultured | 2002 |
Mycoplasma contamination in human leukemia cell lines. II. Elimination with various antibiotics.
Topics: Anti-Bacterial Agents; Cell Division; Cell Line; Ciprofloxacin; Diterpenes; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Leukemia; Minocycline; Mycoplasma Infections; Quinolones | 1992 |