Page last updated: 2024-08-17

carbostyril and Leukemia

carbostyril has been researched along with Leukemia in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (26.92)18.2507
2000's8 (30.77)29.6817
2010's11 (42.31)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kuo, SC; Lee, MR; Lin, C; Lin, MW; Lu, CC; Tsai, FJ; Yang, JS1
Ho, CT; Huang, LJ; Kuo, DH; Kuo, SC; Lee, JC; Lin, YC; Liu, YJ; Way, TD1
Eucker, J; Habbel, P; Li, X; Liu, H; Neumann, C; Scholz, C; Zang, C; Zhou, Y1
Ahmed, TA; Hayslip, J; Leggas, M1
Bhole, A; Cowell, JK; Karp, J; Malek, S; Qin, H; Ren, M; Wu, Q1
Jantová, S; Milata, V; Pánik, M; Paulovičová, E; Paulovičová, L; Topoľská, D1
Fujiwara, S; Nagai, T; Ohmine, K; Ozawa, K; Sakurai, C; Uesawa, M1
Chung, JG; Gibson Wood, W; Huang, WW; Kuo, SC; Lai, TY; Ma, CY; Wu, PP; Yang, JS1
Adamson, PC; Arceci, RJ; Balis, FM; Blaney, SM; Fox, E; Goodspeed, W; Goodwin, A; Jayaprakash, N; Widemann, BC; Wright, JJ; Zannikos, P1
Chen, MH; Chinag, JH; Chou, LC; Hsu, MH; Huang, LJ; Huang, SM; Kuo, SC; Lee, KH; Lin, HY; Tsai, SC; Yang, JS1
Cheng, YY; Chien, HC; Chung, JG; Huang, LJ; Kuo, SC; Lee, KH; Liaw, CC; Lu, CC; Tsai, SC; Tsuzuki, M; Yang, JS1
Abboud, CN; Lancet, JE; Liesveld, JL; Lu, C; McNair, C; Menon, A; Rosell, KE; Rosenblatt, JD1
Hasmann, M; Nüssler, V; Pelka-Fleischer, R; Pogrebniak, A; Schemainda, I1
Flournoy, N; Paul, RK; Rosenberger, WF1
Zhang, GS1
Kano, Y; Komatsu, N; Miyoshi, T; Muroi, K; Nagai, T; Nakamura, M; Ohmine, K; Ozawa, K1
Chen, W; Chow, A; Hayes, S; Perez-Ruixo, JJ; Zhang, S1
Drexler, HG; Fleckenstein, E; Uphoff, CC1
Bow, EJ; Loewen, R; Vaughan, D1
Hamel, E; Kuo, SC; Lednicer, D; Lee, KH; Li, L; Lin, CM; Wang, HK; Wu, TS1
Verhoef, J1
Altschuler, E; Hacker, MP; Mayes, J; Satitpunwaycha, P; Tritton, TR; Zwelling, LA1
Ager, S; Baglin, TP; Barker, P; Bass, G; Jacobson, SK; Johnson, D; Mahendra, P; Marcus, RE1
Adjei, AA; End, DW; Karp, JE; Kaufmann, SH; Lancet, JE; Wright, JJ1
Drexler, HG; Meyer, C; Uphoff, CC1
Drexler, HG; Gignac, SM; Uphoff, CC1

Reviews

1 review(s) available for carbostyril and Leukemia

ArticleYear
Current status of clinical trials of farnesyltransferase inhibitors.
    Current opinion in oncology, 2001, Volume: 13, Issue:6

    Topics: Alkyl and Aryl Transferases; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Leukemia; Neoplasms; Piperidines; Pyridines; Quinolones; Signal Transduction

2001

Trials

3 trial(s) available for carbostyril and Leukemia

ArticleYear
Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: a report from the Children's Oncology Group.
    Pediatric blood & cancer, 2011, Volume: 56, Issue:2

    Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Farnesyltranstransferase; Female; Half-Life; Humans; Infant; Leukemia; Male; Maximum Tolerated Dose; Neoplasm Recurrence, Local; Quinolones

2011
Exposure-toxicity relationships for tipifarnib in cancer patients.
    British journal of clinical pharmacology, 2007, Volume: 64, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Leukemia; Male; Middle Aged; Quinolones; Treatment Outcome

2007
Reduced requirement for antibiotic therapy targeting gram-negative organisms in febrile, neutropenic patients with cancer who are receiving antibacterial chemoprophylaxis with oral quinolones.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 20, Issue:4

    Topics: Administration, Oral; Adult; Aged; Anti-Bacterial Agents; Drug Synergism; Female; Fever; Gram-Negative Bacterial Infections; Humans; Leukemia; Male; Middle Aged; Neutropenia; Pilot Projects; Quinolones

1995

Other Studies

22 other study(ies) available for carbostyril and Leukemia

ArticleYear
2-Phenyl-4-quinolone (YT-1) induces G2/M phase arrest and an intrinsic apoptotic mechanism in human leukemia cells.
    Oncology reports, 2018, Volume: 39, Issue:3

    Topics: Apoptosis; Cell Cycle Checkpoints; Cell Division; Cell Proliferation; G2 Phase; Humans; Leukemia; Membrane Potential, Mitochondrial; Quinolones; Tumor Cells, Cultured

2018
CCT327 enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistant human leukemia cells.
    Oncology reports, 2014, Volume: 32, Issue:3

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Proliferation; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Leukemia; Organoselenium Compounds; Quinolines; Quinolones; Reactive Oxygen Species; Receptors, Death Domain; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation

2014
The multi-tyrosine kinase inhibitor TKI258, alone or in combination with RAD001, is effective for treatment of human leukemia with BCR-ABL translocation in vitro.
    Anticancer research, 2014, Volume: 34, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Everolimus; Fusion Proteins, bcr-abl; Humans; Leukemia; Protein Kinase Inhibitors; Quinolones; Sirolimus; TOR Serine-Threonine Kinases

2014
Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition.
    Leukemia research, 2014, Volume: 38, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia; Quinolones; ras Proteins; Simvastatin

2014
SCLLTargeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models.
    Oncotarget, 2016, Aug-02, Volume: 7, Issue:31

    Topics: Animals; Benzamides; Benzimidazoles; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Gene Expression Profiling; Humans; Leukemia; Mice; Molecular Targeted Therapy; Neoplasm Transplantation; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Quinolones; Receptor, Fibroblast Growth Factor, Type 1; Xenograft Model Antitumor Assays

2016
Assessment of Immunomodulatory Activities and in vitro Toxicity of New Quinolone 7-ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo[3,4-h]quinoline-7-carboxylate.
    Immunological investigations, 2017, Volume: 46, Issue:4

    Topics: A549 Cells; Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Growth Processes; Fibroblasts; HL-60 Cells; Humans; Immunomodulation; Leukemia; Macrophages; Mice; Organoselenium Compounds; Quinolones; RAW 264.7 Cells

2017
Combination of tipifarnib and rapamycin synergistically inhibits the growth of leukemia cells and overcomes resistance to tipifarnib via alteration of cellular signaling pathways.
    Leukemia research, 2010, Volume: 34, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Leukemia; Quinolones; Signal Transduction; Sirolimus; Tumor Cells, Cultured

2010
The quinolone derivative CHM-1 inhibits murine WEHI-3 leukemia in BALB/c mice in vivo.
    Leukemia & lymphoma, 2010, Volume: 51, Issue:11

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dioxoles; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; Leukemia; Male; Mice; Mice, Inbred BALB C; Models, Biological; Neoplasm Transplantation; Quinolones; Survival Analysis

2010
The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.
    International journal of oncology, 2011, Volume: 38, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; Caspases; CDC2 Protein Kinase; Cell Division; G2 Phase; HL-60 Cells; Humans; Leukemia; Mitochondria; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrrolidines; Quinolones; Reactive Oxygen Species

2011
The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells.
    Oncology reports, 2012, Volume: 28, Issue:4

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Benzodioxoles; Caspases; Cell Survival; fas Receptor; Free Radical Scavengers; HL-60 Cells; Humans; Leukemia; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Quinolones; Reactive Oxygen Species; Signal Transduction; Up-Regulation

2012
Effects of the farnesyl transferase inhibitor R115777 on normal and leukemic hematopoiesis.
    Leukemia, 2003, Volume: 17, Issue:9

    Topics: Alkyl and Aryl Transferases; Animals; Antigens, CD34; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Adhesion; Cell Cycle; Cell Movement; Colony-Forming Units Assay; Enzyme Inhibitors; Farnesyltranstransferase; Hematopoiesis; Humans; Leukemia; Mice; Mice, Inbred NOD; Mice, SCID; Poly(ADP-ribose) Polymerases; Quinolones; Time Factors; Tumor Cells, Cultured

2003
Poly ADP-ribose polymerase (PARP) inhibitors transiently protect leukemia cells from alkylating agent induced cell death by three different effects.
    European journal of medical research, 2003, Oct-22, Volume: 8, Issue:10

    Topics: 1-Naphthylamine; Adenosine Triphosphate; Alkylating Agents; Apoptosis; Benzamides; Cell Death; Cell Line, Tumor; Cell Size; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Melphalan; Methylnitronitrosoguanidine; NAD; Naphthalimides; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinolones

2003
Quantile estimation following non-parametric phase I clinical trials with ordinal response.
    Statistics in medicine, 2004, Aug-30, Volume: 23, Issue:16

    Topics: Antineoplastic Agents; Clinical Trials, Phase I as Topic; Computer Simulation; Data Interpretation, Statistical; Humans; Leukemia; Maximum Tolerated Dose; Quinolones; Regression Analysis; Statistics, Nonparametric

2004
[New targets for molecular therapy of acute leukemia: a "single-hit" or "multiple-hit" strategy against signaling pathway].
    Zhonghua yi xue za zhi, 2005, Feb-23, Volume: 85, Issue:7

    Topics: Acute Disease; Antineoplastic Agents; Carbazoles; Furans; Humans; Indoles; Leukemia; Leukemia, Myeloid, Acute; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Quinolones; ras Proteins; Staurosporine

2005
Relative importance of apoptosis and cell cycle blockage in the synergistic effect of combined R115777 and imatinib treatment in BCR/ABL-positive cell lines.
    Biochemical pharmacology, 2005, Jun-01, Volume: 69, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Blast Crisis; Cell Cycle; Cell Line, Tumor; Drug Resistance; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Fusion Proteins, bcr-abl; Growth Inhibitors; Humans; Imatinib Mesylate; Leukemia; Piperazines; Pyrimidines; Quinolones

2005
Effective treatment of mycoplasma contamination in cell lines with enrofloxacin (Baytril).
    Leukemia, 1994, Volume: 8, Issue:8

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; B-Lymphocytes; Cell Line; Culture Media; Culture Techniques; Decontamination; DNA, Bacterial; Enrofloxacin; Fluoroquinolones; Humans; Leukemia; Lymphoma; Mycoplasma; Polymerase Chain Reaction; Quinolones; RNA, Bacterial; T-Lymphocytes; Tumor Cells, Cultured

1994
Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
    Journal of medicinal chemistry, 1994, Apr-15, Volume: 37, Issue:8

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Small Cell; Cattle; Cell Division; Central Nervous System Neoplasms; Colonic Neoplasms; Female; Humans; Leukemia; Lung Neoplasms; Molecular Structure; Polymers; Quinolones; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured

1994
Prevention of infections in the neutropenic patient.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1993, Volume: 17 Suppl 2

    Topics: Acute Disease; Bacterial Infections; Communicable Diseases; Humans; Infection Control; Leukemia; Neutropenia; Quinolones; Trimethoprim, Sulfamethoxazole Drug Combination

1993
Activity of two novel anthracene-9,10-diones against human leukemia cells containing intercalator-sensitive or -resistant forms of topoisomerase II.
    Biochemical pharmacology, 1993, Jul-20, Volume: 46, Issue:2

    Topics: Anthraquinones; DNA; DNA Topoisomerases, Type II; Drug Resistance; Humans; Intercalating Agents; Isoquinolines; Leukemia; Quinolones; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1993
Short-course intravenous antibiotics with oral quinolone prophylaxis in the treatment of neutropenic fever in autologous bone marrow or peripheral blood progenitor cell transplant recipients.
    Acta haematologica, 1996, Volume: 96, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacteremia; Bone Marrow Transplantation; Female; Fever; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Leukemia; Lymphoma, Non-Hodgkin; Male; Middle Aged; Multiple Myeloma; Neutropenia; Pseudomonas aeruginosa; Quinolones; Staphylococcus; Streptococcus; Transplantation, Autologous

1996
Elimination of mycoplasma from leukemia-lymphoma cell lines using antibiotics.
    Leukemia, 2002, Volume: 16, Issue:2

    Topics: Algorithms; Anti-Bacterial Agents; Anti-Infective Agents; Cell Culture Techniques; Ciprofloxacin; Culture Media; Diterpenes; Drug Resistance; Drug Resistance, Multiple, Bacterial; Enrofloxacin; Fluoroquinolones; Humans; Leukemia; Lymphoma; Minocycline; Mycoplasma; Quinolones; Suspensions; Tumor Cells, Cultured

2002
Mycoplasma contamination in human leukemia cell lines. II. Elimination with various antibiotics.
    Journal of immunological methods, 1992, Apr-27, Volume: 149, Issue:1

    Topics: Anti-Bacterial Agents; Cell Division; Cell Line; Ciprofloxacin; Diterpenes; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Leukemia; Minocycline; Mycoplasma Infections; Quinolones

1992