carbostyril has been researched along with Breast Neoplasms in 65 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (4.62) | 18.2507 |
| 2000's | 27 (41.54) | 29.6817 |
| 2010's | 30 (46.15) | 24.3611 |
| 2020's | 5 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Božić, B; Jelača, S; Kaluđerović, GN; Kasalović, MP; Lađarević, J; Maksimović-Ivanić, D; Mijatović, S; Pantelić, NĐ; Radovanović, L | 1 |
| Anandam, A; Jain, P; Jayshree, BS; Kar, SS; Kumar, N; Rai, A; Raj, VP; Rao, CM; Thomas, S | 1 |
| Rafiroiu, S; Valente, SA; Vassil, A | 1 |
| Gong, L; Han, S; He, C; Lei, Y; Luo, Z; Ma, J; Tan, X; Tang, H; Xie, L | 1 |
| Boström, P; Eigéliené, N; Härkönen, PL; Ivaska, KK; Kähkönen, TE; Kaivola, J; Koskivuo, I; Maher, A; Nees, M; Petruk, N; Toriseva, M; Tuomela, JM; Virta, AR | 1 |
| Ahmed, NS; Alghamdi, KS; Bakhotmah, D; Mokhtar, M; Saleh, TS | 1 |
| Jayaprakasam, M; Murali, S; Padmanaban, VP; Sekar, AK; Sesurajan, BP; Vethakanraj, HS | 1 |
| Cortes, J; Muñoz-Couselo, E; Perez-Garcia, J; Racca, F; Soberino, J | 1 |
| Arun, B; Buzdar, AU; Hortobagyi, GN; Moulder, SL; Murray, JL; Murthy, RK; Shroff, GS; Stalzer, CJ; Szklaruk, J; Valero, V; Yam, C; Yang, W | 1 |
| Ho, CT; Hung, CH; Hung, CM; Kuo, SC; Lin, YC; Liu, BL; Liu, CW; Way, TD | 1 |
| Chen, ST; Ho, CT; Kuo, SC; Liu, LC; Way, TD; Wu, YC | 1 |
| Boechat, FCS; Branco, JR; Chipoline, IC; da Silva, FC; de Souza, MCBV; Esteves, AM; Ferreira, VF; Lima, MFO; Oliveira, VG; Sola-Penna, M; Zancan, P | 1 |
| Day, AG; Elliott, BE; Ghaffari, A; Greer, PA; Hoskin, V; Kiefer, F; Madarnas, Y; Mewburn, J; Mullins, G; SenGupta, S; Turashvili, G; Varma, S | 1 |
| Li, A; Li, S; Lu, J; Wang, R; Wang, W; Xiao, X; Zhang, J; Zhang, X; Zhou, S | 1 |
| Chen, D; Murugesan, S; Nadkarni, DH; Qin, JJ; Velu, SE; Wang, H; Wang, MH; Wang, W; Zhang, R | 1 |
| André, F; Bachelot, T; Baselga, J; Campone, M; Dalenc, F; Deudon, S; Hurvitz, SA; Kay, A; Perez-Garcia, JM; Porta, DG; Rugo, H; Shi, M; Smith, JW; Turner, N; Yovine, A; Zhang, Y | 1 |
| Liu, H; Wang, L; Wang, T; Xiang, H; Xiao, H; Zeng, Y | 1 |
| Abe, M; Bamba, N; Enami, A; Makihara, K; Masaoka, M; Masuda, N; Mizutani, M; Shikata, A; Takada, S; Yamamoto, M; Yamamura, J; Yasojima, H | 1 |
| Abdelhamid, IA; Ahmed, AG; Attia, YM; Ghozlan, SA; Mohamed, MF; Shouman, SA | 1 |
| Bangemann, N; Eucker, J; Habbel, P; Kissner, L; Liu, H; Neumann, C; Riess, H; Schulz, CO; Zang, C | 1 |
| Chen, YL; Cheng, CM; Hsu, CY; Tseng, CH; Tzeng, CC; Yang, CN | 1 |
| Ashok Kumar, S; Babu, TA; Duraisamy, PK; Sudarsanan, GB; Vethakanraj, HS | 1 |
| Alvarez, M; Califano, A; Castillo-Martin, M; Castro, V; Collazo-Lorduy, A; Cordon-Cardo, C; Kalinsky, K; Llobet-Navas, D; Maurer, M; Murga-Penas, EM; Olivan, M; Putcha, P; Rodriguez-Barrueco, R; Saucedo-Cuevas, LP; Silva, JM; Yu, J | 1 |
| Desco, M; Hernández-Agudo, E; Hidalgo, M; Lopez-Casas, PP; Megías, D; Mondejar, T; Mouron, S; Mulero, F; Quintela-Fandino, M; Sanchez, J; Soto-Montenegro, ML | 1 |
| Feng, Q; Gao, T; Lei, Q; Shi, Y; Song, X; Wang, N; Wei, Y; Xia, Y; Xiong, M; Yang, F; Ye, T; You, X; Yu, L; Zhang, L; Zhu, Y | 1 |
| André, F; Barrios, CH; Blackwell, K; Bonnefoi, H; Campone, M; Cortes, J; Denduluri, N; Deudon, S; Kahan, Z; Musolino, A; Neven, P; Shi, MM; Soliman, H; Squires, M; Zhang, Y | 1 |
| Cheng, L; Feng, W; LaVoie, EJ; Liu, AA; Liu, LF; Satyanarayana, M; Tsai, YC | 1 |
| Christos, PJ; Hershman, DL; Hoschander, S; Li, T; O'Brien, K; Sparano, JA; Vahdat, LT; Wright, JJ | 1 |
| Coppola, D; Fineberg, S; Hershman, D; Hopkins, U; Hoschander, S; Kazi, A; Kleer, C; Lee, D; Li, T; Malafa, M; Merajver, S; Moulder, S; Munster, P; Negassa, A; Pellegrino, C; Sebti, SM; Sparano, JA; Vahdat, L; Wright, JJ | 1 |
| Murugesan, S; Nadkarni, DH; Rayburn, ER; Velu, SE; Wang, W; Zhang, R | 1 |
| Schiemann, WP; Wendt, MK | 1 |
| Chen, D; Murugesan, S; Nadkarni, DH; Rayburn, ER; Velu, SE; Wang, W; Zhang, R | 1 |
| Allal, BC; Chaoui, K; Dalenc, F; Doisneau-Sixou, SF; Favre, G; Filleron, T; Lauwers-Cances, V; Malissein, E; Marsili, S; Meunier, E; Monsarrat, B; Renée, N; Roché, H; Schiltz, O | 1 |
| Barnfather, P; Barrett-Lee, P; Bramble, P; Christensen, J; Hayes, E; Hiscox, S; Nicholson, RI | 1 |
| Gao, M; Hutchins, GD; Miller, KD; Sledge, GW; Wang, M; Zheng, QH | 1 |
| Brackett, DJ; Brueggemeier, RW; Kesinger, JW; Lerner, ML; Li, PK; Mehta, M; Pento, JT; Zang, XP | 1 |
| Gradishar, WJ; Guo, M; Li, T; Perez, EA; Sledge, GW; Sparano, JA; Wang, M | 1 |
| Hartmann, RW; Hu, Q; Yin, L | 2 |
| Ghorab, MM; Ghorab, WM; Heiba, HI; Nissan, YM; Ragab, FA | 1 |
| Adjei, AA; Dy, GK | 1 |
| Kelland, LR | 1 |
| Li, T; Sparano, JA | 1 |
| Dowsett, M; Ellis, P; Hickish, T; Houston, S; Howes, A; Johnston, SR; Kelland, L; Michiels, B; Palmer, P; Perez-Ruixo, JJ; Salter, J | 1 |
| de Bono, JS; Rowinsky, EK; Tolcher, AW | 1 |
| Castañeda-Partida, L; Contreras-Sousa, M; Dueñas-García, I; Durán-Díaz, A; Graf, U; Heres-Pulido, ME; Sánchez-García, A | 1 |
| Aguilar-Quesada, R; Cañuelo, A; De Murcia, G; Martín-Oliva, D; Muñoz-Gámez, JA; Nuñez, MI; Oliver, FJ; Ruiz de Almodóvar, JM; Valenzuela, MT | 1 |
| Balis, FM; Chow, C; Clark, G; Eng-Wong, J; Gantz, SB; Jayaprakash, N; Lebowitz, PF; Venzon, D; Widemann, BC; Zujewski, J | 1 |
| Dalenc, F; Favre, G; Faye, JC; Giamarchi, C; Petit, M; Poirot, M | 1 |
| Anderson, E; Bundred, NJ; Clarke, RB; Knox, F; Morris, J; Wärnberg, F; White, D | 1 |
| Jiang, D; Zhang, M | 1 |
| Hershman, D; Hopkins, U; Hoschander, S; Kazi, A; Lee, D; Li, T; Malafa, M; Moulder, S; Munster, P; Pellegrino, C; Sebti, SM; Sparano, JA; Vahdat, L; Wright, JJ | 1 |
| Abdel-Aziz, LM; Badawy, RH; Husseiny, MI; Lashine, el-SM; Metwally, KA | 1 |
| Chen, W; Chow, A; Hayes, S; Perez-Ruixo, JJ; Zhang, S | 1 |
| Autry, C; Cooper, B; Iwanicki, M; Kath, JC; Luzzio, MJ; Martin, KH; Parsons, JT; Roberts, WG; Slack-Davis, JK; Tilghman, RW; Ung, EJ | 1 |
| Awada, A; De Porre, P; de Valeriola, D; Gil, T; Lalami, Y; Piccart-Gebhart, MJ; Zhang, S | 1 |
| Bessems, A; De Porre, PM; Dodwell, DJ; Howes, AJ; Johnston, SR; Manikhas, GM; Neven, P; Park, YC; Perez Ruixo, JJ; Romieu, G; Semiglazov, VF; Spaeth, D; Wardley, AM | 1 |
| Detre, S; Dowsett, M; Head, JE; Howes, A; Johnston, SR; Kaye, S; Martin, LA; Pancholi, S; Quinn, E; Salter, J | 1 |
| Hamel, E; Kuo, SC; Lednicer, D; Lee, KH; Li, L; Lin, CM; Wang, HK; Wu, TS | 1 |
| Arakawa, H; Hakoda, N; Mano, E; Nakagawa, S; Okura, A; Yoshinari, T | 1 |
| Jones, TK; Mais, DE; Marschke, KB; Tegley, CM; Zhi, L | 1 |
| Boothman, DA; Dubyak, GR; Nieminen, AL; Pink, JJ; Tagliarino, C | 1 |
| Kong Thoo Lin, P; Pavlov, V; Rodilla, V | 1 |
| Clarke, PA; Detre, S; Dowsett, M; End, D; Howes, AJ; Johnston, SR; Kelland, LR; Patterson, L; Smith, V; Valenti, M; Workman, P | 1 |
| Ackland, ML; Allen, J; Blomeley, RC; Michalczyk, AA | 1 |
6 review(s) available for carbostyril and Breast Neoplasms
| Article | Year |
|---|---|
Targeting FGFR pathway in breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Breast Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Female; Fibroblast Growth Factors; Humans; Naphthalenes; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Quinolines; Quinolones; Quinoxalines; Receptors, Fibroblast Growth Factor; Signal Transduction | 2018 |
Farnesyltransferase inhibitors in breast cancer therapy.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Farnesyltranstransferase; Female; Fluorouracil; Humans; Mice; Neoplasm Proteins; Paclitaxel; Piperidines; Protein Prenylation; Protein Processing, Post-Translational; Pyridines; Quinolones; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2002 |
Farnesyl transferase inhibitors in the treatment of breast cancer.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Female; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins | 2003 |
Inhibiting Ras signaling in the therapy of breast cancer.
Topics: Alkyl and Aryl Transferases; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Female; GTP-Binding Proteins; Humans; Mutation; Neoplasm Metastasis; Quinolones; ras Proteins; Signal Transduction | 2003 |
Farnesyltransferase inhibitors and their potential in the treatment of breast carcinoma.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Piperidines; Protein Prenylation; Proto-Oncogene Mas; Pyridines; Quinolones; ras Proteins; Signal Transduction | 2003 |
[Farnesyl transferase inhibitors--a novel agent for breast cancer].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Humans; Piperidines; Protein Prenylation; Pyridines; Quinolones; ras Proteins | 2006 |
14 trial(s) available for carbostyril and Breast Neoplasms
| Article | Year |
|---|---|
A phase II study of tipifarnib and gemcitabine in metastatic breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Humans; Kaplan-Meier Estimate; Middle Aged; Neoplasm Metastasis; Quinolones; Treatment Outcome | 2018 |
Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fibroblast Growth Factor 3; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Gene Amplification; Humans; Mice; Middle Aged; Neoplasm Staging; Quinolones; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Signal Transduction; Treatment Outcome; Xenograft Model Antitumor Assays | 2013 |
Phase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Breast Neoplasms; Disease Progression; Estradiol; Female; Fulvestrant; Humans; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Postmenopause; Quinolones; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Retreatment; Survival Analysis; Treatment Outcome | 2017 |
Phase II trial of the farnesyltransferase inhibitor tipifarnib plus fulvestrant in hormone receptor-positive metastatic breast cancer: New York Cancer Consortium Trial P6205.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Estradiol; Farnesyltranstransferase; Female; Fulvestrant; Humans; Middle Aged; Neoplasm Metastasis; Quinolones; Receptors, Estrogen; Receptors, Progesterone; Treatment Outcome | 2009 |
Phase II trial of tipifarnib plus neoadjuvant doxorubicin-cyclophosphamide in patients with clinical stage IIB-IIIC breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Farnesyltranstransferase; Female; Humans; Ki-67 Antigen; Middle Aged; Neoadjuvant Therapy; Quinolones; rho GTP-Binding Proteins; STAT3 Transcription Factor | 2009 |
Tipifarnib plus tamoxifen in tamoxifen-resistant metastatic breast cancer: a negative phase II and screening of potential therapeutic markers by proteomic analysis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Resistance, Neoplasm; Farnesyltranstransferase; Female; Humans; Middle Aged; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Postmenopause; Protein Array Analysis; Quinolones; Tamoxifen | 2010 |
A phase II trial of capecitabine in combination with the farnesyltransferase inhibitor tipifarnib in patients with anthracycline-treated and taxane-resistant metastatic breast cancer: an Eastern Cooperative Oncology Group Study (E1103).
Topics: Adenocarcinoma; Adult; Aged; Anthracyclines; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Middle Aged; Quinolones; Taxoids; Treatment Outcome | 2012 |
Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Middle Aged; Neoplasm Metastasis; Neutropenia; Quinolones; Thrombocytopenia; Treatment Outcome | 2003 |
A phase I trial and pharmacokinetic study of tipifarnib, a farnesyltransferase inhibitor, and tamoxifen in metastatic breast cancer.
Topics: Adult; Aged; Alkyl and Aryl Transferases; Anemia; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Breast Neoplasms; Dose-Response Relationship, Drug; Exanthema; Farnesyltranstransferase; Fatigue; Female; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Neoplasm Metastasis; Quinolones; Tamoxifen; Treatment Outcome | 2005 |
[Farnesyl transferase inhibitors--a novel agent for breast cancer].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Humans; Piperidines; Protein Prenylation; Pyridines; Quinolones; ras Proteins | 2006 |
Targeted inhibition of farnesyltransferase in locally advanced breast cancer: a phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Enzyme Inhibitors; Farnesyltranstransferase; Female; Humans; Male; Middle Aged; Quinolones; Treatment Outcome | 2006 |
Exposure-toxicity relationships for tipifarnib in cancer patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Leukemia; Male; Middle Aged; Quinolones; Treatment Outcome | 2007 |
A phase I clinical and pharmacokinetic study of tipifarnib in combination with docetaxel in patients with advanced solid malignancies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Docetaxel; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Female; Humans; Immune System; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Quinolones; Taxoids; Treatment Outcome | 2007 |
A phase II, randomized, blinded study of the farnesyltransferase inhibitor tipifarnib combined with letrozole in the treatment of advanced breast cancer after antiestrogen therapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Double-Blind Method; Estrogen Receptor Modulators; Farnesyltranstransferase; Female; Humans; Letrozole; Middle Aged; Nitriles; Quinolones; Time Factors; Treatment Outcome; Triazoles | 2008 |
46 other study(ies) available for carbostyril and Breast Neoplasms
| Article | Year |
|---|---|
Novel diphenyltin(IV) complexes with carboxylato N-functionalized 2-quinolone ligands: Synthesis, characterization and in vitro anticancer studies.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Coordination Complexes; Female; Humans; Ligands; Melanoma; Mice; Spectroscopy, Fourier Transform Infrared | 2024 |
Elucidation of structure-activity relationship of 2-quinolone derivatives and exploration of their antitumor potential through Bax-induced apoptotic pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxyquinolines; Mice; Neoplasms; Quinolones | 2012 |
Quinolone-induced radiation recall dermatitis in breast cancer patient.
Topics: Breast; Breast Neoplasms; Female; Humans; Quinolones; Radiodermatitis | 2020 |
Integrative, genome-wide association study identifies chemicals associated with common women's malignancies.
Topics: Breast Neoplasms; Environmental Exposure; Female; Fenofibrate; Gene Expression Profiling; Genome-Wide Association Study; Glafenine; Humans; Incidence; Methylnitronitrosoguanidine; Ovarian Neoplasms; Parabens; Phenols; Quinolones; Uterine Cervical Neoplasms | 2020 |
Effects of FGFR inhibitors TKI258, BGJ398 and AZD4547 on breast cancer cells in 2D, 3D and tissue explant cultures.
Topics: Benzamides; Benzimidazoles; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Female; Humans; Neoplasm Invasiveness; Organoids; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Quinolones; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tissue Culture Techniques | 2021 |
Design and green synthesis of novel quinolinone derivatives of potential anti-breast cancer activity against MCF-7 cell line targeting multi-receptor tyrosine kinases.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line; Drug Design; Drug Screening Assays, Antitumor; Female; Green Chemistry Technology; Humans; MCF-7 Cells; Molecular Docking Simulation; Protein Kinase Inhibitors; Quinolones; Receptor Protein-Tyrosine Kinases; Spectrum Analysis | 2021 |
Anticancer effect of acid ceramidase inhibitor ceranib-2 in human breast cancer cell lines MCF-7, MDA MB-231 by the activation of SAPK/JNK, p38 MAPK apoptotic pathways, inhibition of the Akt pathway, downregulation of ERα.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Estrogen Receptor alpha; Female; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; MCF-7 Cells; Membrane Potential, Mitochondrial; Proto-Oncogene Proteins c-akt; Quinolones; Tamoxifen | 2018 |
CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells.
Topics: Acetylation; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dioxoles; Electrophoresis, Gel, Two-Dimensional; Female; Histone Deacetylases; Humans; Mice, SCID; Microtubules; Mitosis; NAD; Polymerization; Quinolones; Sirtuin 2; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tubulin; Xenograft Model Antitumor Assays | 2018 |
2-Phenylnaphthyridin-4-one Derivative LYF-11 Inhibits Interleukin-6-mediated Epithelial-to-Mesenchymal Transition
Topics: Antineoplastic Agents; Breast Neoplasms; Epithelial-Mesenchymal Transition; Fluorobenzenes; Humans; Interleukin-6; Janus Kinase 2; MCF-7 Cells; Naphthyridines; Quinolones; Signal Transduction; STAT3 Transcription Factor | 2018 |
A Novel Naphthotriazolyl-4-oxoquinoline Derivative that Selectively Controls Breast Cancer Cells Survival Through the Induction of Apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Molecular Structure; Quinolones; Reactive Oxygen Species; Structure-Activity Relationship | 2018 |
Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cohort Studies; Cytoskeletal Proteins; Disease Models, Animal; Female; Genes, Reporter; Humans; Intravital Microscopy; Lung; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Neoplasm Recurrence, Local; Phenols; Quinolones; Tissue Array Analysis | 2019 |
HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Down-Regulation; Endoplasmic Reticulum Chaperone BiP; Female; Gene Expression Regulation, Neoplastic; Glucose; Heat-Shock Proteins; Humans; MCF-7 Cells; Quinolones; Transcription, Genetic; Tumor Microenvironment; Unfolded Protein Response | 2019 |
Identification of the ZAK-MKK4-JNK-TGFβ signaling pathway as a molecular target for novel synthetic iminoquinone anticancer compound BA-TPQ.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line; Cell Proliferation; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mammary Glands, Human; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; MCF-7 Cells; Neoplasm Proteins; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Stability; Pyrroles; Quinolones; Transforming Growth Factor beta2; Ubiquitination; Up-Regulation | 2013 |
Evaluating the potential bioactivity of a novel compound ER1626.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Movement; Cell Proliferation; Chick Embryo; Endometrial Neoplasms; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Indenes; Isoquinolines; Ketones; MCF-7 Cells; Molecular Structure; Quinolones; Receptors, Estrogen; Tetrazolium Salts; Thiazoles | 2014 |
[Therapeutic effect of rebamipide for oral mucositis associated with FEC therapy for breast cancer].
Topics: Adult; Aged; Alanine; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Female; Fluorouracil; Humans; Middle Aged; Quinolones; Stomatitis | 2014 |
Cytotoxic and antimicrobial evaluations of novel apoptotic and anti-angiogenic spiro cyclic 2-oxindole derivatives of 2-amino-tetrahydroquinolin-5-one.
Topics: Angiogenesis Inhibitors; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase 9; Cell Proliferation; Disk Diffusion Antimicrobial Tests; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Design; Hep G2 Cells; Humans; Indoles; MCF-7 Cells; Molecular Structure; Neovascularization, Pathologic; Oxindoles; Quinolones; Signal Transduction; Structure-Activity Relationship; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A | 2015 |
Targeting multiple tyrosine kinase receptors with Dovitinib blocks invasion and the interaction between tumor cells and cancer-associated fibroblasts in breast cancer.
Topics: Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chemokine CCL2; Chemokine CCL5; Coculture Techniques; Culture Media, Conditioned; Female; Fibroblasts; Humans; MCF-7 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolones; Receptor Protein-Tyrosine Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2015 |
Discovery of 3-phenylquinolinylchalcone derivatives as potent and selective anticancer agents against breast cancers.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Proliferation; Chalcone; Cyclin B1; Cyclin-Dependent Kinases; Drug Discovery; Female; Fluorescent Antibody Technique; G2 Phase Cell Cycle Checkpoints; Humans; Immunoblotting; Models, Molecular; Molecular Structure; Proto-Oncogene Proteins c-bcl-2; Quinolines; Quinolones; Tumor Cells, Cultured | 2015 |
Targeting ceramide metabolic pathway induces apoptosis in human breast cancer cell lines.
Topics: Acid Ceramidase; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Survival; Ceramides; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; MCF-7 Cells; Metabolic Networks and Pathways; Molecular Targeted Therapy; Quinolones; Tamoxifen | 2015 |
Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Heterografts; Humans; Interleukin-6; Janus Kinase 2; Mice; Mice, SCID; Quinolines; Quinolones; RNA Interference; STAT3 Transcription Factor | 2015 |
Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.
Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Benzimidazoles; Breast; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Deoxycytidine; Female; Fluorine Radioisotopes; Gemcitabine; Humans; Mice; Mice, Nude; Misonidazole; Neovascularization, Pathologic; Pancreas; Pancreatic Neoplasms; Positron-Emission Tomography; Quinolones | 2016 |
Selective inhibition of EZH2 by ZLD1039 blocks H3K27 methylation and leads to potent anti-tumor activity in breast cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Female; Histones; Humans; Intracellular Space; Methylation; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Polycomb Repressive Complex 2; Pyridones; Quinolones; Small Molecule Libraries; Transcriptional Activation; Xenograft Model Antitumor Assays | 2016 |
Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Female; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Nude; Neoplasms; Quinolones; Topoisomerase I Inhibitors; Xenograft Model Antitumor Assays | 2008 |
In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Molecular Structure; Pyrroles; Quinolones; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2009 |
Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis.
Topics: Animals; Breast Neoplasms; Cell Movement; Drug Delivery Systems; Focal Adhesion Protein-Tyrosine Kinases; Humans; Indoles; Integrin beta3; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Quinolones; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Small Interfering; Signal Transduction; Sulfonamides; Sulfones; Transforming Growth Factor beta | 2009 |
A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Oligonucleotide Array Sequence Analysis; Pyrroles; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Xenograft Model Antitumor Assays | 2010 |
Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Endocrine System; Enzyme Inhibitors; Estradiol; Focal Adhesion Protein-Tyrosine Kinases; Fulvestrant; Humans; Inhibitory Concentration 50; Phenotype; Quinolones; Sulfones; Tamoxifen | 2011 |
Synthesis of carbon-11-labeled casimiroin analogues as new potential PET agents for imaging of quinone reductase 2 and aromatase expression in breast cancer.
Topics: Aromatase; Aromatase Inhibitors; Benzodioxoles; Breast Neoplasms; Carbon Radioisotopes; Gene Expression Regulation, Neoplastic; Inhibitory Concentration 50; NAD(P)H Dehydrogenase (Quinone); Positron-Emission Tomography; Quinolones; Radioactive Tracers; Radiochemistry | 2010 |
Influence of novel KGFR tyrosine kinase inhibitors on KGF-mediated proliferation of breast cancer.
Topics: Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblast Growth Factor 7; Humans; Indoles; MAP Kinase Signaling System; Protein Kinase Inhibitors; Quinolones; Receptor, Fibroblast Growth Factor, Type 2 | 2010 |
Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer.
Topics: Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Cytochrome P-450 CYP11B2; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Female; Humans; In Vitro Techniques; Liver; Quinolones; Solubility; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship | 2012 |
Novel brominated quinoline and pyrimidoquinoline derivatives as potential cytotoxic agents with synergistic effects of γ-radiation.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Screening Assays, Antitumor; Female; Gamma Rays; Humans; Inhibitory Concentration 50; Quinolones; Radiation-Sensitizing Agents | 2012 |
Tetrahydropyrroloquinolinone type dual inhibitors of aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks.
Topics: Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Cytochrome P-450 CYP11B2; Female; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Quinolones; Risk Factors; Spectrometry, Mass, Electrospray Ionization | 2013 |
Genotoxicity of tamoxifen citrate and 4-nitroquinoline-1-oxide in the wing spot test of Drosophila melanogaster.
Topics: 4-Nitroquinoline-1-oxide; Animals; Breast Neoplasms; Carcinogens; Dimethylnitrosamine; Drosophila melanogaster; Female; Humans; Larva; Nitrosamines; Quinolones; Tamoxifen; Wings, Animal | 2004 |
PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis.
Topics: 1-Naphthylamine; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Caspases; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Female; Genes, p53; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Naphthalimides; Neoplasm Proteins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Quinolones; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2005 |
Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways.
Topics: Antineoplastic Agents, Hormonal; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Drug Screening Assays, Antitumor; Female; Humans; Pyrrolidines; Quinolones; Receptors, Estrogen; Tamoxifen | 2005 |
Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo.
Topics: Animals; Breast Neoplasms; Calcinosis; Carcinoma, Intraductal, Noninfiltrating; Cell Division; Cell Line, Tumor; Farnesyltranstransferase; Female; Humans; Mammography; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Quinolones; Transplantation, Heterologous | 2006 |
Hydrazones of 2-aryl-quinoline-4-carboxylic acid hydrazides: synthesis and preliminary evaluation as antimicrobial agents.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Breast Neoplasms; Candida albicans; Carboxylic Acids; Carcinoma, Hepatocellular; Cell Proliferation; Escherichia coli; Hemolysis; Humans; Hydrazones; Liver Neoplasms; Microbial Sensitivity Tests; Molecular Structure; Quinolones; Staphylococcus aureus; Structure-Activity Relationship; Tumor Cells, Cultured | 2006 |
Cellular characterization of a novel focal adhesion kinase inhibitor.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Dose-Response Relationship, Drug; Female; Focal Adhesion Protein-Tyrosine Kinases; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinolones; Signal Transduction; Sulfones | 2007 |
The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Drug Therapy, Combination; Farnesyltranstransferase; Female; Flow Cytometry; Fluorescent Antibody Technique; G1 Phase; Humans; In Situ Nick-End Labeling; Mice; Mice, Nude; Quinolones; Receptors, Estrogen; Tamoxifen; Transcription, Genetic; Transplantation, Heterologous | 2007 |
Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Small Cell; Cattle; Cell Division; Central Nervous System Neoplasms; Colonic Neoplasms; Female; Humans; Leukemia; Lung Neoplasms; Molecular Structure; Polymers; Quinolones; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 1994 |
Potent antitumor activity of quinolone compounds with an unsaturated aminoazabicyclo group at the C-7 position of the quinolone ring.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; DNA; Female; Humans; Leukemia L1210; Leukemia P388; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasm Transplantation; Quinolones; Structure-Activity Relationship; Tumor Cells, Cultured | 1996 |
5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a novel class of nonsteroidal progesterone receptor agonists: effect of A-ring modification.
Topics: Animals; Binding, Competitive; Breast Neoplasms; Cell Line; Chlorocebus aethiops; Humans; Ligands; Quinolones; Receptors, Progesterone; Structure-Activity Relationship; Tumor Cells, Cultured | 1999 |
Calcium is a key signaling molecule in beta-lapachone-mediated cell death.
Topics: 4-Nitroquinoline-1-oxide; Adenosine Triphosphate; Apoptosis; Blotting, Western; Breast Neoplasms; Calcium; Cell Death; Cell Division; Chelating Agents; Cytosol; DNA Fragmentation; Dose-Response Relationship, Drug; Egtazic Acid; Endoplasmic Reticulum; Female; Flow Cytometry; Humans; In Situ Nick-End Labeling; Male; Membrane Potentials; Microscopy, Confocal; Mitochondria; Models, Biological; Naphthoquinones; Prostatic Neoplasms; Quinolones; Signal Transduction; Time Factors; Tumor Cells, Cultured | 2001 |
Cytotoxicity, DNA binding and localisation of novel bis-naphthalimidopropyl polyamine derivatives.
Topics: Breast Neoplasms; Cell Division; DNA; Female; Humans; Microscopy, Fluorescence; Molecular Structure; Polyamines; Quinolones; Spectrometry, Fluorescence; Spermidine; Tumor Cells, Cultured | 2001 |
Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; HT29 Cells; Humans; Immunohistochemistry; Ki-67 Antigen; Lamin Type A; Mice; Mice, Nude; Neoplasm Transplantation; Nuclear Proteins; Protein Precursors; Quinolones; Time Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells.
Topics: Blotting, Western; Breast Neoplasms; Carrier Proteins; Cation Transport Proteins; Cells, Cultured; Epithelial Cells; Humans; Immunohistochemistry; Oligonucleotides, Antisense; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Tosyl Compounds; Tumor Cells, Cultured; Zinc | 2002 |