carboprostacyclin and Vascular-Diseases

carboprostacyclin has been researched along with Vascular-Diseases* in 2 studies

Reviews

1 review(s) available for carboprostacyclin and Vascular-Diseases

Article	Year
Platelet actions of stable carbocyclic analogues of prostacyclin. Circulation, 1985, Volume: 72, Issue:6 Topics: Animals; Blood Pressure; Clinical Trials as Topic; Drug Stability; Epoprostenol; Heart Rate; Humans; Platelet Aggregation; Prostaglandins, Synthetic; Vascular Diseases	1985

Trials

1 trial(s) available for carboprostacyclin and Vascular-Diseases

Article	Year
Platelet actions of stable carbocyclic analogues of prostacyclin. Circulation, 1985, Volume: 72, Issue:6 Topics: Animals; Blood Pressure; Clinical Trials as Topic; Drug Stability; Epoprostenol; Heart Rate; Humans; Platelet Aggregation; Prostaglandins, Synthetic; Vascular Diseases	1985

Other Studies

1 other study(ies) available for carboprostacyclin and Vascular-Diseases

Article	Year
Reduced angiotensin II levels cause generalized vascular dysfunction via oxidant stress in hamster cheek pouch arterioles. Microvascular research, 2013, Volume: 89 We investigated the effect of suppressing plasma angiotensin II (ANG II) levels on arteriolar relaxation in the hamster cheek pouch.. Arteriolar diameters were measured via television microscopy during short-term (3-6days) high salt (HS; 4% NaCl) diet and angiotensin converting enzyme (ACE) inhibition with captopril (100mg/kg/day).. ACE inhibition and/or HS diet eliminated endothelium-dependent arteriolar dilation to acetylcholine, endothelium-independent dilation to the NO donor sodium nitroprusside, the prostacyclin analogs carbacyclin and iloprost, and the KATP channel opener cromakalim; and eliminated arteriolar constriction during KATP channel blockade with glibenclamide. Scavenging of superoxide radicals and low dose ANG II infusion (25ng/kg/min, subcutaneous) reduced oxidant stress and restored arteriolar dilation in arterioles of HS-fed hamsters. Vasoconstriction to topically-applied ANG II was unaffected by HS diet while arteriolar responses to elevation of superfusion solution PO2 were unaffected (5% O2, 10% O2) or reduced (21% O2) by HS diet.. These findings indicate that sustained exposure to low levels of circulating ANG II leads to widespread dysfunction in endothelium-dependent and independent vascular relaxation mechanisms in cheek pouch arterioles by increasing vascular oxidant stress, but does not potentiate O2- or ANG II-induced constriction of arterioles in the distal microcirculation of normotensive hamsters. Topics: Acetylcholine; Angiotensin II; Animals; Arterioles; Blood Pressure; Captopril; Cheek; Cricetinae; Cromakalim; Endothelium, Vascular; Epoprostenol; Glyburide; Iloprost; Male; Mesocricetus; Microscopy; Microscopy, Video; Nitroprusside; Oxidants; Oxygen; Peptidyl-Dipeptidase A; Superoxides; Vascular Diseases	2013

Article

Year

Reduced angiotensin II levels cause generalized vascular dysfunction via oxidant stress in hamster cheek pouch arterioles.

Microvascular research, 2013, Volume: 89

We investigated the effect of suppressing plasma angiotensin II (ANG II) levels on arteriolar relaxation in the hamster cheek pouch.. Arteriolar diameters were measured via television microscopy during short-term (3-6days) high salt (HS; 4% NaCl) diet and angiotensin converting enzyme (ACE) inhibition with captopril (100mg/kg/day).. ACE inhibition and/or HS diet eliminated endothelium-dependent arteriolar dilation to acetylcholine, endothelium-independent dilation to the NO donor sodium nitroprusside, the prostacyclin analogs carbacyclin and iloprost, and the KATP channel opener cromakalim; and eliminated arteriolar constriction during KATP channel blockade with glibenclamide. Scavenging of superoxide radicals and low dose ANG II infusion (25ng/kg/min, subcutaneous) reduced oxidant stress and restored arteriolar dilation in arterioles of HS-fed hamsters. Vasoconstriction to topically-applied ANG II was unaffected by HS diet while arteriolar responses to elevation of superfusion solution PO2 were unaffected (5% O2, 10% O2) or reduced (21% O2) by HS diet.. These findings indicate that sustained exposure to low levels of circulating ANG II leads to widespread dysfunction in endothelium-dependent and independent vascular relaxation mechanisms in cheek pouch arterioles by increasing vascular oxidant stress, but does not potentiate O2- or ANG II-induced constriction of arterioles in the distal microcirculation of normotensive hamsters.

Topics: Acetylcholine; Angiotensin II; Animals; Arterioles; Blood Pressure; Captopril; Cheek; Cricetinae; Cromakalim; Endothelium, Vascular; Epoprostenol; Glyburide; Iloprost; Male; Mesocricetus; Microscopy; Microscopy, Video; Nitroprusside; Oxidants; Oxygen; Peptidyl-Dipeptidase A; Superoxides; Vascular Diseases

2013