carboprost and Postoperative-Complications

The influence of intramyometrial injection of 125 micrograms of 15-s-15-methyl prostaglandin F2 alpha (carboprost tromethamine, Prostin/15M) versus 20 U of oxytocin immediately after delivery of placenta on blood loss at cesarean section was investigated by means of a double-blinded, randomized trial. Hematocrit decrease from the day before operation to the third postoperative day was used as an index of blood loss. Decreases in hematocrit were comparable for the oxytocin and carboprost tromethamine groups. Excess blood loss (hematocrit decrease more than 6 vol. %) was significantly associated with the indication for cesarean section (three of four for cephalopelvic disproportion versus 9 of 42 others, p less than 0.01), but not with age, parity, number of prior cesarean sections, or birthweight. Carboprost tromethamine does not appear to be more effective than oxytocin when given by intramyometrial injection at this dose for routine cesarean section; its prophylactic utility in higher doses or in cases at risk for hemorrhage from uterine atony remains to be investigated.

Topics: Adult; Carboprost; Cesarean Section; Double-Blind Method; Female; Hematocrit; Hemorrhage; Hemostatic Techniques; Humans; Injections; Labor Onset; Myometrium; Oxytocin; Postoperative Complications; Pregnancy; Prostaglandins F, Synthetic; Randomized Controlled Trials as Topic; Uterine Contraction

The study aims to explore the effect of low-frequency electric pulse technique combined with carboprost methylate suppositories on recovery of gastrointestinal function and postoperative complications of patients with scarred uterus undergoing secondary cesarean section (C-section). The clinical data of 120 patients with scarred uterus undergoing secondary C-section treated in our hospital from February 2019 to February 2020 were retrospectively analyzed, and the patients were equally divided into experimental and control groups according to their admission order, where each group included 60 patients. After the operation, patients in the control group received routine nursing and conducted breastfeeding, and carboprost methylate suppositories were used for postoperative hemostasis. Those in the experimental group received low-frequency electric pulse technique for comprehensive treatment to compare their coagulation function indicators, recovery of gastrointestinal function, incidence rates of postoperative complications, and involution of uterus. No significant between-group differences in patients' general information such as gestational weeks, gravidity, and number of times receiving C-section were observed (

Topics: Carboprost; Cesarean Section; Female; Humans; Postoperative Complications; Pregnancy; Retrospective Studies; Suppositories; Uterus

Topics: Adult; Blood Transfusion; Carboprost; Ergonovine; Female; Fetal Death; Gestational Age; Humans; Oxytocics; Postoperative Complications; Pregnancy; Suture Techniques; Uterine Hemorrhage; Vacuum Curettage

102 pregnant women with intra-uterine fetal death after the 12th week of gestation were treated with 15(S)-15-methyl-prostaglandin F2 alpha intramuscularly with doses of 125-250 micrograms at 2-3 hourly intervals. In all cases abortion or delivery was completed within 30 hours. The average time in primigravidae was 9 hours 43 minutes, and in multigravidae 9 hours and 59 minutes. In approximately two-thirds of the patients, mild or moderate gastrointestinal side effects were recorded in spite of prophylactic treatment with Retardin or Loperamide + Diphenoxylate. The therapy was found to be effective, easy to administer and the side effects acceptable. No serious side effects were recorded.

Topics: Abortion, Induced; Adult; Carboprost; Diphenoxylate; Female; Fetal Death; Gastrointestinal Diseases; Humans; Injections, Intramuscular; Labor, Induced; Loperamide; Postoperative Complications; Pregnancy; Prostaglandins F, Synthetic